JPH05503530A - 置換ベンジル成分を含むアンギオテンシン2拮抗物質 - Google Patents
置換ベンジル成分を含むアンギオテンシン2拮抗物質Info
- Publication number
- JPH05503530A JPH05503530A JP3504721A JP50472191A JPH05503530A JP H05503530 A JPH05503530 A JP H05503530A JP 3504721 A JP3504721 A JP 3504721A JP 50472191 A JP50472191 A JP 50472191A JP H05503530 A JPH05503530 A JP H05503530A
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- substituted
- unsubstituted
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47978690A | 1990-02-13 | 1990-02-13 | |
US479,786 | 1990-02-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH05503530A true JPH05503530A (ja) | 1993-06-10 |
Family
ID=23905431
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3504721A Pending JPH05503530A (ja) | 1990-02-13 | 1991-02-11 | 置換ベンジル成分を含むアンギオテンシン2拮抗物質 |
JP3505964A Pending JPH05504969A (ja) | 1990-02-13 | 1991-02-11 | 置換ベンジル要素を含有するアンギオテンシン2アンタゴニスト類 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3505964A Pending JPH05504969A (ja) | 1990-02-13 | 1991-02-11 | 置換ベンジル要素を含有するアンギオテンシン2アンタゴニスト類 |
Country Status (4)
Country | Link |
---|---|
EP (2) | EP0515535A4 (fr) |
JP (2) | JPH05503530A (fr) |
CA (2) | CA2075627A1 (fr) |
WO (2) | WO1991012001A1 (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995024410A1 (fr) * | 1994-03-08 | 1995-09-14 | Otsuka Pharmaceutical Factory, Inc. | Derive de diester phosphonique |
WO2010137336A1 (fr) | 2009-05-29 | 2010-12-02 | 興和株式会社 | NOUVEAU DÉRIVÉ D'ACIDE α-PHÉNOXYBENZÈNEACÉTIQUE ET PRÉPARATION PHARMACEUTIQUE LE CONTENANT |
JP2011520969A (ja) * | 2008-05-19 | 2011-07-21 | シェーリング コーポレイション | 二環式ヘテロ環誘導体およびgpr119モジュレーターとしてのその使用 |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5177095A (en) * | 1990-02-13 | 1993-01-05 | Merck & Co., Inc. | Triazole angiotensin II antagonists incorporating a substituted benzyl element |
US5240938A (en) * | 1991-02-13 | 1993-08-31 | Merck & Co., Inc. | Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring |
US5183810A (en) * | 1990-02-13 | 1993-02-02 | Merck & Co., Inc. | Imidazole angiotensin II antagonists incorporating a substituted benzyl element |
US5449682A (en) * | 1990-02-13 | 1995-09-12 | Merck & Co., Inc. | Angiotensin II antagonists incorporating a substituted benzyl element |
US5246944A (en) * | 1991-08-13 | 1993-09-21 | Merck & Co., Inc. | Quinoline angiotensin ii antagonists incorporating a substituted benzyl element |
IL103020A (en) * | 1991-09-10 | 1998-10-30 | Tanabe Seiyaku Co | History of acid 3) 1, '1 in biphenyl 4 Methyl (4,5,6,7 tetrahydro H3 imidazo] C 4,5 [pyridine 4 carboxylic acid, preparation and pharmaceutical preparations containing them |
US5187159A (en) * | 1991-10-07 | 1993-02-16 | Merck & Co., Inc. | Angiotensin II antagonists incorporating a substituted 1,3-benzodioxole or 1,3-benzodithiole |
GB9121727D0 (en) * | 1991-10-14 | 1991-11-27 | Ici Plc | Heterocyclic compounds |
US5442062A (en) * | 1991-10-24 | 1995-08-15 | The Upjohn Company | Imidazole derivatives and pharmaceutical compositions containing the same |
TW226375B (fr) * | 1991-10-24 | 1994-07-11 | American Home Prod | |
AU4348593A (en) * | 1992-06-25 | 1994-01-24 | Zeneca Limited | Chromanderivatives as angiotensin ii antagonists |
GB9218449D0 (en) | 1992-08-29 | 1992-10-14 | Boots Co Plc | Therapeutic agents |
CA2139930A1 (fr) * | 1992-07-10 | 1994-01-20 | Alan Martin Birch | Derives du dioxycyclobutene comme antagonistes de l'angiotensine ii |
DE4302956A1 (de) * | 1993-02-03 | 1994-08-04 | Bayer Ag | Substituierte Imidazo(4,5-b)pyridine und Benzimidazole |
US5300668A (en) * | 1993-03-10 | 1994-04-05 | Pfizer Inc. | Certain esters of 1-(4-X-methylphenyl)cyclopent-3-ene-1-carboxylic acid, wherein X is a trialkylsilyloxy, bromo or hydroxy group, as intermediates |
US5334598A (en) * | 1993-03-19 | 1994-08-02 | Merck & Co., Inc. | Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives |
US5401745A (en) * | 1993-03-19 | 1995-03-28 | Merck & Co., Inc. | Quinazolinones substituted with phenoxyphenylacetic acid derivatives |
US5420133A (en) * | 1993-03-19 | 1995-05-30 | Merck & Co., Inc. | Quinazolinones substituted with phenoxyphenylacetic acid derivatives |
US5491172A (en) * | 1993-05-14 | 1996-02-13 | Warner-Lambert Company | N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and N-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents |
IL109431A (en) * | 1993-05-14 | 2001-01-11 | Warner Lambert Co | Pharmaceutical compositions containing n-acyl sulfamic acid esters (or thioesters), n-acyl sulfonamides, and n-sulfonyl carbamic acid esters (or thioesters), for regulating plasma cholesterol concentration, and certain such novel compounds |
AP9400651A0 (en) * | 1993-07-15 | 1995-12-30 | Pfizer | Azacyclic-heterocyclic compounds as angiotensin II receptor antagonists. |
DE4327256A1 (de) * | 1993-08-13 | 1995-02-16 | Bayer Ag | Sulfonylbenzyl-substituierte Benzimidazole, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln |
ES2079315B1 (es) * | 1994-02-24 | 1996-10-16 | Uriach & Cia Sa J | Nuevas imidazopiridinas. |
BR9507106A (pt) * | 1994-04-06 | 1997-11-18 | Shionogi & Co | Derivado de ácido fenilacético alfa-substituido sua produção e fungicida agricola contendo o mesmo |
JPH11509838A (ja) * | 1995-06-07 | 1999-08-31 | ジー.ディー.サール アンド カンパニー | 充血性心不全症を処置するためのスピロノラクトン化合物とアンギオテンシンii拮抗物質との組合わせ治療 |
WO1996040255A2 (fr) * | 1995-06-07 | 1996-12-19 | G.D. Searle & Co. | Procede de traitement de la fibrose cardiaque par une combinaison therapeutique d'un antagoniste de l'angiotensine ii et d'un antagoniste de l'aldosterone epoxy-steroide |
GB9716446D0 (en) * | 1997-08-05 | 1997-10-08 | Agrevo Uk Ltd | Fungicides |
AU767456B2 (en) | 1998-07-06 | 2003-11-13 | Bristol-Myers Squibb Company | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
US6174912B1 (en) | 1998-08-21 | 2001-01-16 | Dupont Pharmaceuticals Company | Nitrogen substituted imidazo[4,5-C]pyrazoles as corticotropin releasing hormone antagonists |
SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
GB0328295D0 (en) * | 2003-12-05 | 2004-01-07 | Muscagen Ltd | Therapeutic compounds |
CN1933832A (zh) * | 2004-03-08 | 2007-03-21 | 惠氏公司 | 离子通道调节剂 |
NZ566799A (en) | 2005-09-14 | 2011-04-29 | Takeda Pharmaceutical | Dipeptidyl peptidase inhibitors for treating diabetes |
CN101360723A (zh) | 2005-09-16 | 2009-02-04 | 武田药品工业株式会社 | 制备嘧啶二酮衍生物的方法 |
TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
US7879802B2 (en) | 2007-06-04 | 2011-02-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
EP3239170B1 (fr) | 2008-06-04 | 2019-03-20 | Synergy Pharmaceuticals Inc. | Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles |
EP3241839B1 (fr) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres |
WO2011138657A1 (fr) * | 2010-05-04 | 2011-11-10 | Glenmark Pharmaceuticals S.A. | Composés oléfiniques à substitution aryle en tant qu'inhibiteurs de la pde10a |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
CA2905435A1 (fr) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions utiles pour le traitement de troubles gastro-intestinaux |
JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼcの超高純度アゴニスト、その作成および使用方法 |
TWI731317B (zh) * | 2013-12-10 | 2021-06-21 | 美商健臻公司 | 原肌球蛋白相關之激酶(trk)抑制劑 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3962244A (en) * | 1971-01-23 | 1976-06-08 | Hoechst Aktiengesellschaft | Benzene sulfonyl ureas |
US4420487A (en) * | 1978-04-10 | 1983-12-13 | The Purdue Frederick Company | Diuretic and antihypertensive benzimidazoles |
NZ192392A (en) * | 1978-12-19 | 1983-02-15 | M Ishikawa | 3-(substituted (phenyl or pyridyl)) -3,4-dihydroquinazolin-4-ones |
US4728741A (en) * | 1985-01-08 | 1988-03-01 | Smithkline Beckman Corporation | 1-substituted-2-mercapto benzimidazole compounds and intermediates |
US4772600A (en) * | 1986-06-09 | 1988-09-20 | A. H. Robins Company, Inc. | Fused imidazoheterocyclic compounds and pharmaceutical compositions |
EP0260621A3 (fr) * | 1986-09-18 | 1989-03-15 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | 3-Aryluracides-énoléthers et leur utilisation comme herbicides |
JPH07107056B2 (ja) * | 1987-01-30 | 1995-11-15 | 日清製粉株式会社 | 4(3h)−キナゾリノン誘導体、その製造方法およびそれを有効成分とする抗潰瘍剤 |
KR890701567A (ko) * | 1987-09-23 | 1989-12-21 | 쟝-쟈크 오가이, 프리돌린 클라우스너 | 헤테로사이클릭 화합물 |
GB8904174D0 (en) * | 1989-02-23 | 1989-04-05 | British Bio Technology | Compounds |
-
1991
- 1991-02-11 CA CA002075627A patent/CA2075627A1/fr not_active Abandoned
- 1991-02-11 JP JP3504721A patent/JPH05503530A/ja active Pending
- 1991-02-11 EP EP91905007A patent/EP0515535A4/en not_active Withdrawn
- 1991-02-11 JP JP3505964A patent/JPH05504969A/ja active Pending
- 1991-02-11 EP EP91905733A patent/EP0517812A4/en not_active Withdrawn
- 1991-02-11 WO PCT/US1991/000993 patent/WO1991012001A1/fr not_active Application Discontinuation
- 1991-02-11 WO PCT/US1991/000957 patent/WO1991011999A1/fr not_active Application Discontinuation
- 1991-02-11 CA CA002075637A patent/CA2075637A1/fr not_active Abandoned
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995024410A1 (fr) * | 1994-03-08 | 1995-09-14 | Otsuka Pharmaceutical Factory, Inc. | Derive de diester phosphonique |
CN1066739C (zh) * | 1994-03-08 | 2001-06-06 | 株式会社大塚制药工场 | 膦酸二酯衍生物 |
JP2011520969A (ja) * | 2008-05-19 | 2011-07-21 | シェーリング コーポレイション | 二環式ヘテロ環誘導体およびgpr119モジュレーターとしてのその使用 |
WO2010137336A1 (fr) | 2009-05-29 | 2010-12-02 | 興和株式会社 | NOUVEAU DÉRIVÉ D'ACIDE α-PHÉNOXYBENZÈNEACÉTIQUE ET PRÉPARATION PHARMACEUTIQUE LE CONTENANT |
Also Published As
Publication number | Publication date |
---|---|
WO1991011999A1 (fr) | 1991-08-22 |
JPH05504969A (ja) | 1993-07-29 |
CA2075637A1 (fr) | 1991-08-14 |
EP0515535A1 (fr) | 1992-12-02 |
WO1991012001A1 (fr) | 1991-08-22 |
EP0517812A1 (fr) | 1992-12-16 |
EP0517812A4 (en) | 1995-10-18 |
CA2075627A1 (fr) | 1991-08-14 |
EP0515535A4 (en) | 1996-01-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPH05503530A (ja) | 置換ベンジル成分を含むアンギオテンシン2拮抗物質 | |
US5162325A (en) | Angiotensin ii antagonists incorporating a substituted benzyl element | |
EP0628032B1 (fr) | Agents antiangineux a base de quinazolinone | |
US5430148A (en) | Antiproliferative quinazolines | |
EP2699550B1 (fr) | Dérivés de tétrahydroquinoline utiles comme inhibiteurs de bromodomaine | |
EP0218999B1 (fr) | Dérivés de quinazoline, leur procédé de production et compositions pharmaceutiques les comprenant | |
ES2334326T3 (es) | Compuestos de triazol con afinidad al receptor de pomada d3. | |
US5238942A (en) | Substituted quinazolinones bearing acidic functional groups as angiotensin ii antagonists | |
US5264439A (en) | Quinazolinone, triazolinone and pyrimidinone angiotensin II antagonists incorporating a substituted benzyl element | |
MXPA04008807A (es) | Derivados de 4-(imidazol-5-il)-2-(4-sulfonilanilino)pirimidina con actividad inhibidora de cdk. | |
US20060122188A1 (en) | Platelet adenosine diphosphate receptor antagonists | |
EP0409332A2 (fr) | Triazoles substitués comme antagonistes d'angiotensine II | |
US5252574A (en) | Angiotensin II antagonists incorporating a substituted thiophene or furan | |
JP2003507476A (ja) | Nos阻害剤としてのn−複素環式誘導体 | |
CZ280597A3 (cs) | 6-substituované pyrazolo(3,4-d)pyrimidin-4ony a kompozice je obsahující, a jejich použití | |
JPS61282367A (ja) | 2−チオもしくはオキソ−4−アリ−ルまたはヘテロシクロ−1,5(2h)−ピリミジンジカルボン酸ジエステル類並びに3−アシル−5−ピリミジンカルボン酸類およびエステル類 | |
EP0497516A1 (fr) | Antagonistes d'angiotensine II du type pyrrolo condensé à un hétérocycle à 6 chaînons substitués | |
EP0116769B1 (fr) | Dihydropyridines | |
US5175164A (en) | Angiotensin ii antagonists incorporating a substituted indole or dihydroindole | |
US5385894A (en) | Disubstituted 6-aminoquinazolinones | |
JPS62240668A (ja) | 1,2,3,4−テトラヒドロ−6−置換−4−アリ−ル(またはヘテロシクロ)−3−置換−2−チオキソ(またはオキソ)−5−ピリミジンカルボン酸類およびエステル類 | |
US4618609A (en) | Anti-ischaemic and antihypertensive 2-[pyrimidyloxy alhoxymethyl]-1,4-dihydropyridines | |
JPS60214778A (ja) | Ν置換3,4−ジヒドロピリミジン誘導体ならびにその製造法および用途 | |
Rostom et al. | Synthesis and in vitro anti-HIV screening of certain 2-(benzoxazol-2-ylamino)-3H-4-oxopyrimidines | |
US6562839B1 (en) | 6-substituted heteroquinolinecarboxylic acid derivatives and addition salts thereof and processes for the preparation of both |