JPH05345020A - 溶血を検出する装置および方法 - Google Patents
溶血を検出する装置および方法Info
- Publication number
- JPH05345020A JPH05345020A JP5019209A JP1920993A JPH05345020A JP H05345020 A JPH05345020 A JP H05345020A JP 5019209 A JP5019209 A JP 5019209A JP 1920993 A JP1920993 A JP 1920993A JP H05345020 A JPH05345020 A JP H05345020A
- Authority
- JP
- Japan
- Prior art keywords
- blood
- plasma
- compartment
- membrane
- outer shell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010018910 Haemolysis Diseases 0.000 title claims abstract description 18
- 230000008588 hemolysis Effects 0.000 title claims abstract description 18
- 238000000034 method Methods 0.000 title claims description 14
- 210000004369 blood Anatomy 0.000 claims abstract description 118
- 239000008280 blood Substances 0.000 claims abstract description 118
- 239000012528 membrane Substances 0.000 claims abstract description 53
- 230000003287 optical effect Effects 0.000 claims abstract description 24
- 210000003743 erythrocyte Anatomy 0.000 claims abstract description 12
- 210000000601 blood cell Anatomy 0.000 claims abstract description 11
- 230000008859 change Effects 0.000 claims abstract description 5
- 238000001514 detection method Methods 0.000 claims description 6
- 230000017531 blood circulation Effects 0.000 claims description 5
- 238000005259 measurement Methods 0.000 claims description 2
- 210000002381 plasma Anatomy 0.000 abstract description 88
- 210000004027 cell Anatomy 0.000 abstract description 6
- 210000003677 hemocyte Anatomy 0.000 abstract 1
- 229940000351 hemocyte Drugs 0.000 abstract 1
- 239000000306 component Substances 0.000 description 8
- 239000012510 hollow fiber Substances 0.000 description 8
- 210000004712 air sac Anatomy 0.000 description 6
- 238000002616 plasmapheresis Methods 0.000 description 6
- 230000037452 priming Effects 0.000 description 6
- 102000001554 Hemoglobins Human genes 0.000 description 4
- 108010054147 Hemoglobins Proteins 0.000 description 4
- 229920000915 polyvinyl chloride Polymers 0.000 description 4
- 239000004800 polyvinyl chloride Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 239000012503 blood component Substances 0.000 description 3
- 230000001413 cellular effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000002949 hemolytic effect Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000012982 microporous membrane Substances 0.000 description 2
- 238000004382 potting Methods 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 241001631434 Ermia Species 0.000 description 1
- 206010020843 Hyperthermia Diseases 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 210000001754 blood buffy coat Anatomy 0.000 description 1
- 230000008081 blood perfusion Effects 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- UQMRAFJOBWOFNS-UHFFFAOYSA-N butyl 2-(2,4-dichlorophenoxy)acetate Chemical compound CCCCOC(=O)COC1=CC=C(Cl)C=C1Cl UQMRAFJOBWOFNS-UHFFFAOYSA-N 0.000 description 1
- 230000002612 cardiopulmonary effect Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000006727 cell loss Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000036031 hyperthermia Effects 0.000 description 1
- 230000002631 hypothermal effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/22—Controlling or regulating
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3607—Regulation parameters
- A61M1/3609—Physical characteristics of the blood, e.g. haematocrit, urea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/367—Circuit parts not covered by the preceding subgroups of group A61M1/3621
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0429—Red blood cells; Erythrocytes
- A61M2202/0433—Free haemoglobin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Anesthesiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Water Supply & Treatment (AREA)
- Cardiology (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Ecology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- External Artificial Organs (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US820102 | 1992-01-13 | ||
| US07/820,102 US5330420A (en) | 1992-01-13 | 1992-01-13 | Hemolysis detector |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH05345020A true JPH05345020A (ja) | 1993-12-27 |
Family
ID=25229883
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5019209A Pending JPH05345020A (ja) | 1992-01-13 | 1993-01-12 | 溶血を検出する装置および方法 |
Country Status (13)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112512689A (zh) * | 2018-06-12 | 2021-03-16 | 那乌达耶歌诺斯蒂克有限责任公司 | 采集血浆的装置和方法 |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USD361616S (en) | 1993-11-05 | 1995-08-22 | Baxter International Inc. | Portable hemapheresis device |
| WO1996023223A1 (en) * | 1995-01-25 | 1996-08-01 | Therakos, Inc. | Disposable hemolysis detector |
| US6989240B2 (en) * | 1995-04-13 | 2006-01-24 | Albert Einstein College Of Medicine Of Yeshiva University | Method for detecting hemolysis |
| US6495366B1 (en) | 1999-09-03 | 2002-12-17 | Therakos, Inc. | Uninterrupted flow pump apparatus and method |
| US8722422B2 (en) | 1999-09-03 | 2014-05-13 | Therakos, Inc. | Uninterrupted flow pump apparatus and method |
| US6793643B1 (en) | 2000-04-21 | 2004-09-21 | Therakos, Inc. | Low extracorporeal volume treatment system |
| AU2002351177A1 (en) * | 2001-11-29 | 2003-06-10 | Therakos, Inc. | Methods for pretreating a subject with extracorporeal photopheresis and/or apoptotic cells |
| AU2002357825A1 (en) * | 2001-12-12 | 2003-07-09 | Hydration Technologies, Inc. | Direct osmotic hydration devices |
| MXPA05000816A (es) | 2002-07-19 | 2005-04-28 | Baxter Int | Sistemas y metodos para realizar dialisis peritoneal. |
| US7278650B2 (en) * | 2004-03-29 | 2007-10-09 | Heartland Recreational Vehicles, Llc | Travel trailer having improved turning radius |
| US7790464B2 (en) * | 2006-05-04 | 2010-09-07 | Blaze Medical Devices, LLC | Blood hemolysis analyzer |
| US8114276B2 (en) | 2007-10-24 | 2012-02-14 | Baxter International Inc. | Personal hemodialysis system |
| US8057679B2 (en) | 2008-07-09 | 2011-11-15 | Baxter International Inc. | Dialysis system having trending and alert generation |
| EP2580590A1 (en) | 2010-06-10 | 2013-04-17 | Hemcheck Sweden Aktiebolag | Arrangement for detection of hemolysis |
| US9999717B2 (en) | 2011-05-24 | 2018-06-19 | Deka Products Limited Partnership | Systems and methods for detecting vascular access disconnection |
| JP5816014B2 (ja) * | 2011-07-14 | 2015-11-17 | 旭化成メディカル株式会社 | 血漿浄化装置及び血漿浄化装置の作動方法 |
| SE536634C2 (sv) | 2011-12-09 | 2014-04-15 | Hemcheck Sweden Ab | Anordning för detektion av hemolys |
| SG11201507325XA (en) * | 2013-03-15 | 2015-10-29 | Theranos Inc | Methods and devices for sample collection and sample separation |
| DE102013103335A1 (de) * | 2013-04-03 | 2014-10-09 | B. Braun Avitum Ag | System zur Erfassung eines Zustands einer Dialysatorvorrichtung, und hierfür verwendbare Sensorvorrichtung |
| CN116206744A (zh) | 2015-06-25 | 2023-06-02 | 甘布罗伦迪亚股份公司 | 具有分布式数据库的医疗装置系统和方法 |
| ITUB20161189A1 (it) * | 2016-03-01 | 2017-09-01 | Scuola Superiore Santanna | Dispositivo impiantabile minimamente invasivo per la rilevazione ottica dell'emolisi |
| JP7153017B2 (ja) | 2016-12-21 | 2022-10-13 | ガンブロ・ルンディア・エービー | 外部ドメインをサポートするセキュアクラスタドメインを有する情報技術インフラストラクチャを含む医療機器システム |
| CN107436163A (zh) * | 2017-08-28 | 2017-12-05 | 上海理工大学 | 心肺流转血泵血细胞损伤监测装置 |
| US12326442B2 (en) | 2018-12-07 | 2025-06-10 | Siemens Healthcare Diagnostics Inc. | Device with a fluid component assessment feature |
| EP3999848B1 (en) | 2019-07-19 | 2025-01-29 | Siemens Healthcare Diagnostics, Inc. | Tangent flow hemolysis detection blood testing device |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1943684A (en) * | 1930-06-07 | 1934-01-16 | Harold S Martin | Method and apparatus for controlling the hydrogen-ion concentration of solutions |
| US3705100A (en) * | 1970-08-25 | 1972-12-05 | Amicon Corp | Blood fractionating process and apparatus for carrying out same |
| SE383258B (sv) * | 1970-12-11 | 1976-03-08 | V H Hyden | Anordning for att i terapeutiskt syfte selektivt och under kontroll avskilja icke onskade bestandsdelar ur blod |
| US3799672A (en) * | 1972-09-15 | 1974-03-26 | Us Health Education & Welfare | Oximeter for monitoring oxygen saturation in blood |
| DE2456011A1 (de) * | 1974-11-27 | 1976-08-12 | Degussa | Vorrichtung und verfahren zur ueberwachung und steuerung der schwebstoff- freiheit von ruhebeckenueberlauffluessigkeit bei mechanischen trennverfahren fuer fluessig-feste phasen |
| FR2330654A1 (fr) * | 1975-11-06 | 1977-06-03 | Degremont | Procede et installation pour la regulation automatique de l'extraction des boues d'un appareil de traitement des eaux |
| US4128313A (en) * | 1977-08-18 | 1978-12-05 | General Electric Company | Liquid crystal display with dark characters on light background |
| US4191182A (en) * | 1977-09-23 | 1980-03-04 | Hemotherapy Inc. | Method and apparatus for continuous plasmaphersis |
| US4136818A (en) * | 1977-10-25 | 1979-01-30 | Union Carbide Corporation | Light-shielding tube holder for use with blood washing apparatus |
| US4374731A (en) * | 1980-03-06 | 1983-02-22 | Baxter Travenol Laboratories, Inc. | Method and apparatus for obtaining a desired rate of plasma collection from a membrane plasmapheresis filter |
| US4350156A (en) * | 1980-05-29 | 1982-09-21 | Japan Foundation For Artificial Organs | Method and apparatus for on-line filtration removal of macromolecules from a physiological fluid |
| US4466804A (en) * | 1981-09-25 | 1984-08-21 | Tsunekazu Hino | Extracorporeal circulation of blood |
| EP0112094B1 (en) * | 1982-11-30 | 1987-06-03 | Takeda Chemical Industries, Ltd. | Apparatus for blood treatment |
| IT1183599B (it) * | 1985-05-10 | 1987-10-22 | Inphardial Spa | Dispositivo per determinare la quantita'di acqua plasmatica rimossa durante una seduta di dialisi extra - corporea |
| US4621038A (en) * | 1985-06-24 | 1986-11-04 | Xerox Corporation | Photoconductive imaging members with novel symmetrical fluorinated squaraine compounds |
| JPS62838A (ja) * | 1985-06-26 | 1987-01-06 | Kawasumi Lab Inc | 溶血測定装置 |
| EP0217624A3 (en) * | 1985-10-03 | 1988-01-20 | Gelman Sciences, Inc. | Method and device for obtaining blood plasma samples |
| JPS63103945A (ja) * | 1986-10-21 | 1988-05-09 | Toshiba Corp | 血清情報測定方法 |
| US4735613A (en) * | 1986-10-23 | 1988-04-05 | Biomedical Dynamics Corporation | Pressure infusion device |
| US4807886A (en) * | 1987-09-11 | 1989-02-28 | Atari Games | Amusement game with dispensed targets |
| US5116308A (en) * | 1989-01-13 | 1992-05-26 | Terumo Kabushiki Kaisha | Apparatus for processing fluid and method of driving the same |
-
1992
- 1992-01-13 US US07/820,102 patent/US5330420A/en not_active Expired - Lifetime
- 1992-12-30 GR GR920100583A patent/GR920100583A/el not_active IP Right Cessation
-
1993
- 1993-01-05 TW TW082100022A patent/TW263432B/zh active
- 1993-01-11 KR KR1019930000250A patent/KR100232782B1/ko not_active Expired - Fee Related
- 1993-01-12 MX MX9300140A patent/MX9300140A/es unknown
- 1993-01-12 SG SG9601758A patent/SG82524A1/en unknown
- 1993-01-12 JP JP5019209A patent/JPH05345020A/ja active Pending
- 1993-01-12 CA CA002087123A patent/CA2087123C/en not_active Expired - Lifetime
- 1993-01-12 AT AT93300172T patent/ATE152919T1/de not_active IP Right Cessation
- 1993-01-12 ES ES93300172T patent/ES2101221T3/es not_active Expired - Lifetime
- 1993-01-12 DE DE69310554T patent/DE69310554T2/de not_active Expired - Lifetime
- 1993-01-12 EP EP93300172A patent/EP0552014B1/en not_active Expired - Lifetime
-
1997
- 1997-06-26 HK HK117797A patent/HK117797A/en not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112512689A (zh) * | 2018-06-12 | 2021-03-16 | 那乌达耶歌诺斯蒂克有限责任公司 | 采集血浆的装置和方法 |
| CN112512689B (zh) * | 2018-06-12 | 2023-09-01 | 那乌达耶歌诺斯蒂克有限责任公司 | 采集血浆的装置和方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| HK117797A (en) | 1997-09-05 |
| DE69310554D1 (de) | 1997-06-19 |
| ES2101221T3 (es) | 1997-07-01 |
| KR100232782B1 (ko) | 1999-12-01 |
| MX9300140A (es) | 1993-07-01 |
| EP0552014B1 (en) | 1997-05-14 |
| CA2087123C (en) | 2006-03-21 |
| EP0552014A1 (en) | 1993-07-21 |
| GR920100583A (el) | 1993-09-30 |
| ATE152919T1 (de) | 1997-05-15 |
| DE69310554T2 (de) | 1997-09-18 |
| TW263432B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1995-11-21 |
| US5330420A (en) | 1994-07-19 |
| SG82524A1 (en) | 2001-08-21 |
| KR930016778A (ko) | 1993-08-30 |
| CA2087123A1 (en) | 1993-07-14 |
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