JPH05294837A - Sebum-secretion promoting agent - Google Patents

Abstract

PURPOSE:To provide a sebum-secretion promoting agent for internal use, composed of a maltooligosaccharide, capable of radically and systemically improving dermatic symptoms and diseases caused by the lowering of sebum-secretion function and having high safety. CONSTITUTION:The objective sebum-secretion promoting agent for internal use is composed of a maltooligosaccharide (especially preferably maltotriose, maltotetraose, maltopentaose, etc., having a glucose polymerization degree of 3-5). The agent is effective in radically, systemically and safely improving the function of dermatic oil gland simply by oral administration to improve the chapped skin, dry skin, crack, loss of moistness, gloss, smoothness, springiness and softness of the skin, senile xeroderma, strong itchiness, desquamation, crack, etc., without causing disagreeable feeling such as stickiness and oiliness in contrast with an agent for external application. The agent can be used not only as an internal agent but also as a component for foods and drinks such as dietary food and health food and various pharmaceuticals, etc.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a sebum secretagogue for internal use, and more specifically, it can fundamentally and systemically improve skin symptoms and diseases associated with a decrease in sebum secretory function and is safe. Highly effective oral sebum secretagogue.

[0002]

2. Description of the Related Art Maintaining healthy and beautiful skin is a very interesting problem, especially for women. However, the condition of the skin is constantly affected by factors such as humidity, ultraviolet rays, cosmetics, aging, diseases, stress, and eating habits, and as a result, various functions of the skin are diminished or excessively increased, and various skin conditions are caused. Trouble occurs. It is well known that an excessive increase in the sebum secretion function causes the development of acne vulgaris (acne) and the like, and a sebum secretion inhibitor has been vigorously developed for this.

On the other hand, when the function of secreting sebum decreases, the formation of the sebum film becomes insufficient and the amount of water retained on the skin evaporates, so that the skin becomes rough, rough, cracked,
It is known to cause diseases such as cracks caused by dryness. Particularly in the winter when the air is dry, even people with normal skin or oily skin often exhibit such symptoms due to a decrease in sebum secretion function. In addition, since the sebum secretory function decreases with aging, symptoms such as skin roughness and bulkiness become prominent after the middle age period, and further moisturization of the skin,
Properties such as gloss, smoothness, beam, and flexibility are also reduced. Senile xerosis is an example of a more severe skin condition, which may be accompanied by intense pruritus, skin scaling, and fissures.

[0004] Conventionally, as a measure to improve such skin symptoms, a method of applying a skin moisturizer such as sebum-like components, glycerin, propylene glycol or the like, or an external preparation such as various sebum secretagogues to the skin has been proposed. Has been. Examples of substances that have been reported as sebum secretagogues include γ-oryzanol (Toshio Kobayashi, Ritsuko Hayakawa: skin,
21, 123,1979), pantethine fatty acid esters (JP 54-160315), branched fatty cholesteryl esters (JP-60-16927), activated vitamin D ₃ (JP 62-263125) , Propolis extract (JP-A-1-290614), and the like.

[0005]

However, even if a sebum-like component or a moisturizer is applied, the improving effect is temporary,
It was local and did not represent a fundamental solution. In addition, the effects obtained from the sebum secretagogues known so far have not been sufficiently satisfactory. Furthermore, since these external preparations are applied to the skin as creams, ointments, etc., they have the drawback that they are uncomfortable to be used, such as being sticky or oily, or they are quickly washed off with water.

[0006] Therefore, there has been a demand for a sebum secretagogue which fundamentally and systemically improves skin symptoms and diseases associated with a decrease in sebum secretory function.

Under the circumstances, the inventors of the present invention have conducted diligent research and as a result, found that the sebaceous gland function can be fundamentally, systemically and safely improved by taking a sebum secretagogue consisting of maltooligosaccharide. The present invention has been completed.

[0008] That is, the present invention provides a sebum secretagogue for internal use, which comprises maltooligosaccharides.

The maltooligosaccharide used in the present invention is a known substance, and glucose has 2 to 10 molecules, α-1,4.
It is an oligosaccharide polymerized linearly by a glucoside bond. Maltose in which two molecules of glucose are polymerized naturally exists as the main component of malt syrup, and malto-oligosaccharide in which three or more molecules are polymerized is also contained in syrup. Among these maltooligosaccharides, those having a degree of polymerization of glucose of 3 to 5,
That is, maltotriose, maltotetraose, and maltopentaose are preferable.

The method for producing maltooligosaccharides is not particularly limited, but for example, a method of partially hydrolyzing starch or the like with an acid, α-amylase or the like, a maltooligosaccharide of a microorganism origin that specifically produces maltooligosaccharides having a specific degree of polymerization It can be produced by a method utilizing a sugar-forming amylase. These malto-oligosaccharides have their usages, uses, dosage forms,
Although it may be purified according to other purposes, it is desirable to use as high a purity of maltooligosaccharide as possible in consideration of the dose for oral administration, its effect and the like.

The maltooligosaccharide thus obtained is generally a colorless and transparent liquid or white powder. Malto-oligosaccharides are odorless, have excellent taste, have a mellow sweetness, and are also sugars excellent in acid resistance and heat resistance. In addition, LD ₅₀ is 20 g / kg or more in rats, which is excellent in safety. Therefore, it can be used as it is as a sebum secretagogue, and can also be used in combination with a pharmaceutically acceptable additive or other drug.

The dosage form of the sebum secretagogue of the present invention is not particularly limited as long as it is suitable for obtaining the effect, and may be, for example, powder, powder, granules, tablets, capsules, liquids and the like. it can.

The dose of the sebum secretagogue of the present invention varies depending on age, symptoms and the like, but generally, as maltooligosaccharide, 1 kg of body weight, 10 to 3000 mg per day, particularly 1
The amount is preferably 0.00 to 1000 mg, and this can be administered once or several times a day.

The sebum secretagogue of the present invention can improve sebaceous gland function by oral administration and is excellent in food processing characteristics. Therefore, it can be used as foods such as beauty foods and health foods, beverages and other pharmaceuticals. And so on.

[0015]

INDUSTRIAL APPLICABILITY The sebum secretagogue for oral administration of the present invention is capable of fundamentally and systemically improving skin symptoms and diseases associated with a decrease in sebum secretory function, and is highly safe. Further, since it is an internal medicine, it does not have an unpleasant feeling due to application or the drawback of being removed by washing with water.

[0016]

EXAMPLES Next, the present invention will be further described with reference to examples. Example 1 Female Wister rats (6 weeks old) were allowed to freely ingest a powder feed containing maltooligosaccharides, and were bred for one month. The composition of the powdered feed is as shown in Table 1. As the maltooligosaccharide, maltotriose syrup containing 80% or more of maltotriose was used, and glucose was used instead of maltooligosaccharide as a control. The dose of malto-oligosaccharide is 1kg body weight, 150, 450 per day, 1
It was adjusted to be 500 mg. One month after administration, the back of the rat was shaved and 4 ml of acetone: diethyl ether (1:
1) Sebum was extracted with the liquid by the cup method over time. The extracted sebum was collected in a weighing bottle, dried, and then the amount of sebum secreted was measured by a gravimetric method. The results are shown in Table 2.

[0017]

[Table 1]

[0018]

[Table 2]

As is clear from the results shown in Table 2, the sebum secretion tended to increase in the maltooligosaccharide-administered group. No significant difference in food intake or body weight gain was observed between the feed groups.

Example 2 A golden hamster (7 weeks old, female) was orally administered with 1 ml of an aqueous maltooligosaccharide solution once a day for 3 weeks. The composition of the malto-oligosaccharide aqueous solution is as shown in Table 3, and the malto-oligosaccharide used was maltotriose powder containing 80% or more of maltotriose, and glucose was used instead of malto-oligosaccharide as a control. Malto-oligosaccharide dosage is 1kg body weight, 100,20 per day
It was set to 0, 400, and 1000 mg. Three weeks after the administration, a 6 mmφ skin piece was cut out from the inner part of the pinna of the hamster to remove cartilage, and then suspended in Krebs-Ringer-phosphate buffer containing ¹⁴ C-sodium acetate, and organ culture was performed.
Organ culture was carried out at 37 ° C for 3 hours. After culturing, the skin pieces were washed with Krebs-Ringer-phosphate buffer solution, treated with 10% potassium hydroxide ethanol solution, and then extracted with 2 ml of hexane to measure the radioactivity in the lipid. The results are shown in Figure 1.

[0021]

[Table 3]

As is clear from the results shown in FIG. 1, the maltooligosaccharide-administered group tended to have a higher lipid-synthesizing ability, which is indicated by the amount of ¹⁴ C-sodium acetate incorporated, as compared with the control group. . No significant difference in food intake or body weight gain was observed between the feed groups.

Example 3 Female Wister rats (6 weeks old) were allowed to freely ingest a powdered feed containing various oligosaccharides and bred for one month. The composition of the powdered feed is shown in Table 4, and the oligosaccharides include
In addition to maltooligosaccharides, fructooligosaccharides, isomaltooligosaccharides, palatinose oligosaccharides, and xylooligosaccharides were used. As a control, glucose was used instead of oligosaccharides. The dosage of each oligosaccharide is 1 kg body weight,
It was adjusted to 1500 mg per day. One month after the administration, the amount of sebum secretion was measured by the same method as in Example 1.
Table 5 shows the sebum secretion amount of each oligosaccharide administration group when the sebum secretion amount of the control group was 100.

[0024]

[Table 4]

[0025]

[Table 5]

As is clear from the results of Table 5, no oligosaccharides other than maltooligosaccharides were found to have a sebum secretion promoting effect. No significant difference in food intake or body weight gain was observed between the feed groups.

[Brief description of drawings]

FIG. 1 is a drawing showing the amount of ¹⁴ C-sodium acetate uptake in Example 2.

Claims (2)

[Claims] 1. A sebum secretagogue for internal use, which comprises maltooligosaccharide. 2. The sebum secretagogue according to claim 1, wherein the maltooligosaccharide is a maltooligosaccharide having a glucose polymerization degree of 3 to 5.