JPH0529365B2 - - Google Patents
Info
- Publication number
- JPH0529365B2 JPH0529365B2 JP63084985A JP8498588A JPH0529365B2 JP H0529365 B2 JPH0529365 B2 JP H0529365B2 JP 63084985 A JP63084985 A JP 63084985A JP 8498588 A JP8498588 A JP 8498588A JP H0529365 B2 JPH0529365 B2 JP H0529365B2
- Authority
- JP
- Japan
- Prior art keywords
- dipyridamole
- huifn
- interferon
- cells
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 claims abstract description 104
- 229960002768 dipyridamole Drugs 0.000 claims abstract description 100
- 108010050904 Interferons Proteins 0.000 claims abstract description 36
- 102000014150 Interferons Human genes 0.000 claims abstract description 36
- 229940079322 interferon Drugs 0.000 claims abstract description 32
- 150000003839 salts Chemical class 0.000 claims description 13
- 230000002401 inhibitory effect Effects 0.000 claims description 5
- 239000003623 enhancer Substances 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
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- 238000011160 research Methods 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 230000000694 effects Effects 0.000 description 13
- 239000000203 mixture Substances 0.000 description 11
- 239000000243 solution Substances 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 201000011510 cancer Diseases 0.000 description 8
- 239000003153 chemical reaction reagent Substances 0.000 description 8
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
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- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 4
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- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 3
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- OLXZPDWKRNYJJZ-UHFFFAOYSA-N 5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol Chemical compound C1=NC=2C(N)=NC=NC=2N1C1CC(O)C(CO)O1 OLXZPDWKRNYJJZ-UHFFFAOYSA-N 0.000 description 2
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- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 2
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- CKTSBUTUHBMZGZ-ULQXZJNLSA-N 4-amino-1-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-tritiopyrimidin-2-one Chemical compound O=C1N=C(N)C([3H])=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 CKTSBUTUHBMZGZ-ULQXZJNLSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP87108708.6 | 1987-06-16 | ||
| EP87108708A EP0295317A1 (en) | 1987-06-16 | 1987-06-16 | Pharmaceutical composition for the treatment of tumors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63316722A JPS63316722A (ja) | 1988-12-26 |
| JPH0529365B2 true JPH0529365B2 (enExample) | 1993-04-30 |
Family
ID=8197069
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63084985A Granted JPS63316722A (ja) | 1987-06-16 | 1988-04-06 | インターフェロンの腫瘍成長抑制作用増強剤 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4997645A (enExample) |
| EP (2) | EP0295317A1 (enExample) |
| JP (1) | JPS63316722A (enExample) |
| KR (1) | KR890000108A (enExample) |
| AT (1) | ATE59780T1 (enExample) |
| AU (1) | AU622404B2 (enExample) |
| DE (1) | DE3861494D1 (enExample) |
| DK (1) | DK328088A (enExample) |
| HU (1) | HU200942B (enExample) |
| PH (1) | PH27069A (enExample) |
| ZA (1) | ZA884262B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5215744A (en) * | 1987-06-16 | 1993-06-01 | Boehringer Ingelheim Gmbh | Methods for the treatment of tumors |
| GB8813032D0 (en) * | 1988-06-02 | 1988-07-06 | Boehringer Ingelheim Int | Antiviral pharmaceutical composition |
| US6003516A (en) * | 1992-06-03 | 1999-12-21 | Maxim Pharmaceuticals, Inc. | Method for treatment of cancer and infectious disease |
| SE513429C2 (sv) * | 1992-06-03 | 2000-09-11 | Syntello Inc | Preparat för aktivering av naturliga mördarceller, vilket preparat innehåller interferon alfa och biogena aminer |
| US5480640A (en) * | 1995-05-02 | 1996-01-02 | Schering Corporation | Alpha interferon for treating prostate cancer |
| US6155266A (en) * | 1995-05-08 | 2000-12-05 | Maxim Pharmaceuticals, Inc. | Method for treatment of cancer and infectious disease |
| US20020099003A1 (en) | 1997-10-28 | 2002-07-25 | Wilson Leland F. | Treatment of female sexual dysfunction with vasoactive agents, particularly vasoactive intestinal polypeptide and agonists thereof |
| US7064130B2 (en) * | 2001-04-20 | 2006-06-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of radical-scavenging compounds for treatment and prevention of NO-dependent microcirculation disorders |
| JP7641894B2 (ja) * | 2018-09-27 | 2025-03-07 | アイテオ ベルギウム エスエー | がん治療におけるｅｎｔファミリートランスポーター阻害剤の使用及びそのアデノシン受容体アンタゴニストとの組み合わせ |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3031450A (en) * | 1959-04-30 | 1962-04-24 | Thomae Gmbh Dr K | Substituted pyrimido-[5, 4-d]-pyrimidines |
| BG36086A1 (en) * | 1982-01-19 | 1984-09-14 | Glbov | Method for inducing interferon |
-
1987
- 1987-06-16 EP EP87108708A patent/EP0295317A1/en not_active Withdrawn
-
1988
- 1988-04-06 JP JP63084985A patent/JPS63316722A/ja active Granted
- 1988-06-08 AT AT88109121T patent/ATE59780T1/de active
- 1988-06-08 EP EP88109121A patent/EP0295559B1/en not_active Expired - Lifetime
- 1988-06-08 DE DE8888109121T patent/DE3861494D1/de not_active Expired - Fee Related
- 1988-06-14 KR KR1019880007101A patent/KR890000108A/ko not_active Ceased
- 1988-06-15 ZA ZA884262A patent/ZA884262B/xx unknown
- 1988-06-15 HU HU883081A patent/HU200942B/hu not_active IP Right Cessation
- 1988-06-15 AU AU17681/88A patent/AU622404B2/en not_active Ceased
- 1988-06-15 DK DK328088A patent/DK328088A/da unknown
- 1988-06-16 US US07/207,622 patent/US4997645A/en not_active Expired - Fee Related
- 1988-06-16 PH PH37080A patent/PH27069A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU622404B2 (en) | 1992-04-09 |
| HUT47033A (en) | 1989-01-30 |
| ATE59780T1 (de) | 1991-01-15 |
| EP0295559A2 (en) | 1988-12-21 |
| EP0295559A3 (en) | 1989-03-08 |
| EP0295317A1 (en) | 1988-12-21 |
| DK328088D0 (da) | 1988-06-15 |
| PH27069A (en) | 1993-02-01 |
| EP0295559B1 (en) | 1991-01-09 |
| US4997645A (en) | 1991-03-05 |
| KR890000108A (ko) | 1989-03-11 |
| DK328088A (da) | 1988-12-17 |
| ZA884262B (en) | 1990-02-28 |
| JPS63316722A (ja) | 1988-12-26 |
| HU200942B (en) | 1990-09-28 |
| AU1768188A (en) | 1988-12-22 |
| DE3861494D1 (de) | 1991-02-14 |
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