JPH0522547B2 - - Google Patents

Info

Publication number
JPH0522547B2
JPH0522547B2 JP60127014A JP12701485A JPH0522547B2 JP H0522547 B2 JPH0522547 B2 JP H0522547B2 JP 60127014 A JP60127014 A JP 60127014A JP 12701485 A JP12701485 A JP 12701485A JP H0522547 B2 JPH0522547 B2 JP H0522547B2
Authority
JP
Japan
Prior art keywords
collagen
crosslinking agent
formaldehyde
bone substitute
mineral component
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP60127014A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6145768A (ja
Inventor
Riizu Piitaa
Baumugaruto Furanku
Mitsuterumeiyaa Haintsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
OSUKOBAARU AG
Original Assignee
OSUKOBAARU AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by OSUKOBAARU AG filed Critical OSUKOBAARU AG
Publication of JPS6145768A publication Critical patent/JPS6145768A/ja
Publication of JPH0522547B2 publication Critical patent/JPH0522547B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Composite Materials (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials For Medical Uses (AREA)
JP60127014A 1984-06-12 1985-06-11 骨代替物質の製造方法 Granted JPS6145768A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP84810288.5 1984-06-12
EP84810288A EP0164483B1 (de) 1984-06-12 1984-06-12 Verfahren zur Herstellung von Knochenersatzmaterial

Publications (2)

Publication Number Publication Date
JPS6145768A JPS6145768A (ja) 1986-03-05
JPH0522547B2 true JPH0522547B2 (enExample) 1993-03-29

Family

ID=8193023

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60127014A Granted JPS6145768A (ja) 1984-06-12 1985-06-11 骨代替物質の製造方法

Country Status (5)

Country Link
US (1) US4623553A (enExample)
EP (1) EP0164483B1 (enExample)
JP (1) JPS6145768A (enExample)
CA (1) CA1259266A (enExample)
DE (1) DE3479402D1 (enExample)

Families Citing this family (90)

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DE3325111A1 (de) * 1983-07-12 1985-01-24 Merck Patent Gmbh, 6100 Darmstadt Implantationsmaterialien
DE3447583A1 (de) * 1984-12-28 1986-07-10 Battelle-Institut E.V., 6000 Frankfurt Verfahren zur herstellung implantierbarer knochenersatzwerkstoffe
US5246457A (en) * 1985-03-28 1993-09-21 Collagen Corporation Xenogeneic collagen/mineral preparations in bone repair
CA1260391A (en) * 1985-03-28 1989-09-26 Karl A. Piez Xenogeneic collagen/mineral preparations in bone repair
US4992226A (en) * 1985-03-28 1991-02-12 Collagen Corporation Method of making molds with xenogeneic collagen/mineral preparations for bone repair
FR2585576B1 (fr) * 1985-07-30 1992-01-03 Bioetica Sa Produit de remplacement de la matrice osseuse favorisant l'osteogenese
US5904718A (en) * 1986-03-27 1999-05-18 Biocoll Laboratories, Inc. Delayed drug delivery system
GB8616416D0 (en) * 1986-07-04 1986-08-13 Ethicon Inc Polyurethane medical prostheses
FI80605C (fi) * 1986-11-03 1990-07-10 Biocon Oy Benkirurgisk biokompositmaterial.
US4865602A (en) * 1986-11-06 1989-09-12 Collagen Corporation Gamma irradiation of collagen/mineral mixtures
US4944754A (en) * 1987-04-29 1990-07-31 Vent-Plant Corporation Method of manufacturing synthetic bone coated surgical implants
DE3865421D1 (de) * 1987-12-23 1991-11-14 Sumitomo Chemical Co Hydroxyapatit enthaltende beschichtungsfluessigkeit und verfahren zur herstellung eines hydroxyapatitueberzugs unter verwendung derselben.
US5073114A (en) * 1988-02-23 1991-12-17 Detsch Steven G Bone growing method and composition
JPH085712B2 (ja) * 1988-09-15 1996-01-24 旭光学工業株式会社 配向性リン酸カルシウム系化合物成形体及び焼結体並びにそれらの製造方法
WO1990009152A1 (en) * 1989-02-15 1990-08-23 Microtek Medical, Inc. Biocompatible material and prosthesis
US5196201A (en) * 1989-10-20 1993-03-23 Bioapatite Ab Implant material composition, preparation thereof as well as uses thereof and implant product obtainable therefrom
JP2830262B2 (ja) * 1990-01-08 1998-12-02 住友化学工業株式会社 ハイドロキシアパタイト皮膜の形成方法
US6990982B1 (en) 1990-06-28 2006-01-31 Bonutti Ip, Llc Method for harvesting and processing cells from tissue fragments
US5269785A (en) 1990-06-28 1993-12-14 Bonutti Peter M Apparatus and method for tissue removal
US5330826A (en) * 1990-08-13 1994-07-19 Mcdonnell Douglas Corporation Preparation of ceramic-metal coatings
US5356629A (en) * 1991-07-12 1994-10-18 United States Surgical Corporation Composition for effecting bone repair
US6503277B2 (en) 1991-08-12 2003-01-07 Peter M. Bonutti Method of transplanting human body tissue
US5320844A (en) * 1992-03-12 1994-06-14 Liu Sung Tsuen Composite materials for hard tissue replacement
US5554188A (en) * 1993-04-29 1996-09-10 Xomed, Inc. Universal middle ear prosthesis
US5397352A (en) * 1993-08-27 1995-03-14 Burres; Steven Method of recollagenation
US5707962A (en) * 1994-09-28 1998-01-13 Gensci Regeneration Sciences Inc. Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof
US6180606B1 (en) 1994-09-28 2001-01-30 Gensci Orthobiologics, Inc. Compositions with enhanced osteogenic potential, methods for making the same and uses thereof
GB2301362B (en) * 1995-05-30 1999-01-06 Johnson & Johnson Medical Absorbable implant materials having controlled porosity
US6423095B1 (en) * 1995-10-16 2002-07-23 Sdgi Holdings, Inc. Intervertebral spacers
US5989289A (en) 1995-10-16 1999-11-23 Sdgi Holdings, Inc. Bone grafts
US5718717A (en) 1996-08-19 1998-02-17 Bonutti; Peter M. Suture anchor
DE19641775A1 (de) * 1996-08-22 1998-02-26 Merck Patent Gmbh Verfahren zur Herstellung von wirkstoffhaltigen Knochenzementen
AU732421B2 (en) * 1996-10-23 2001-04-26 Warsaw Orthopedic, Inc. Spinal spacer
EP0842670A1 (en) * 1996-11-13 1998-05-20 Katsunari Nishihara Biomedical materials
US6713527B2 (en) 1997-02-07 2004-03-30 Queen's University At Kingston Anaesthetic bone cement
US6355705B1 (en) 1997-02-07 2002-03-12 Queen's University At Kingston Anaesthetic bone cement
AU7080098A (en) * 1997-04-24 1998-11-13 Takeda Chemical Industries Ltd. Apatite-coated solid composition
US5899939A (en) * 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
US6123731A (en) * 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
US6045551A (en) 1998-02-06 2000-04-04 Bonutti; Peter M. Bone suture
US7094282B2 (en) * 2000-07-13 2006-08-22 Calcitec, Inc. Calcium phosphate cement, use and preparation thereof
US6960249B2 (en) 1999-07-14 2005-11-01 Calcitec, Inc. Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface
US7169373B2 (en) * 1999-07-14 2007-01-30 Calcitec, Inc. Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface and process for preparing the same
US6840995B2 (en) 1999-07-14 2005-01-11 Calcitec, Inc. Process for producing fast-setting, bioresorbable calcium phosphate cements
US7270705B2 (en) * 1999-07-14 2007-09-18 Jiin-Huey Chern Lin Method of increasing working time of tetracalcium phosphate cement paste
US6368343B1 (en) 2000-03-13 2002-04-09 Peter M. Bonutti Method of using ultrasonic vibration to secure body tissue
US6447516B1 (en) 1999-08-09 2002-09-10 Peter M. Bonutti Method of securing tissue
US20030228288A1 (en) 1999-10-15 2003-12-11 Scarborough Nelson L. Volume maintaining osteoinductive/osteoconductive compositions
US6635073B2 (en) 2000-05-03 2003-10-21 Peter M. Bonutti Method of securing body tissue
US7156915B2 (en) 2000-07-13 2007-01-02 Calcitec, Inc. Tetracalcium phosphate (TTCP) with surface whiskers and method of making same
US7160382B2 (en) * 2000-07-13 2007-01-09 Calcitec, Inc. Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
JP4202749B2 (ja) 2000-10-24 2008-12-24 クライオライフ、インコーポレイテッド 特に生体人工椎間板の原位置形成のための原位置生体人工フィラー及び方法
AU2001297782B2 (en) * 2000-11-07 2006-03-02 Cryolife, Inc. Expandable foam-like biomaterials and methods
US7323193B2 (en) 2001-12-14 2008-01-29 Osteotech, Inc. Method of making demineralized bone particles
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
US20020115742A1 (en) * 2001-02-22 2002-08-22 Trieu Hai H. Bioactive nanocomposites and methods for their use
US20030003127A1 (en) * 2001-06-27 2003-01-02 Ethicon, Inc. Porous ceramic/porous polymer layered scaffolds for the repair and regeneration of tissue
JP4204772B2 (ja) * 2001-08-30 2009-01-07 独立行政法人科学技術振興機構 生体内薬物徐放材料の製造方法
EP2295088B1 (en) 2001-10-12 2016-12-07 Warsaw Orthopedic, Inc. Improved bone graft
US6719765B2 (en) 2001-12-03 2004-04-13 Bonutti 2003 Trust-A Magnetic suturing system and method
US7229971B2 (en) * 2002-03-11 2007-06-12 Japan Science And Technology Agency Regulation of biodegradability of composite biomaterials
TW200400062A (en) 2002-04-03 2004-01-01 Mathys Medizinaltechnik Ag Kneadable, pliable bone replacement material
US7166133B2 (en) * 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
AU2004247143B2 (en) * 2003-06-11 2010-09-23 Warsaw Orthopedic, Inc. Osteoimplants and methods for their manufacture
US7118705B2 (en) * 2003-08-05 2006-10-10 Calcitec, Inc. Method for making a molded calcium phosphate article
US6994726B2 (en) 2004-05-25 2006-02-07 Calcitec, Inc. Dual function prosthetic bone implant and method for preparing the same
US7163651B2 (en) 2004-02-19 2007-01-16 Calcitec, Inc. Method for making a porous calcium phosphate article
US20070190101A1 (en) * 2004-03-31 2007-08-16 Chunlin Yang Flowable bone grafts
US8137450B2 (en) * 2004-07-08 2012-03-20 Symatese Collagen-based lyophilised glue and the use thereof for producing an adhesive prosthesis
FR2872822B1 (fr) * 2004-07-08 2006-09-22 Symatese Soc Par Actions Simpl Colle lyophilisee a base de collagene et son utilisation pour la fabrication de protheses collantes
FR2873927B1 (fr) * 2004-08-05 2007-05-11 Symatese Soc Par Actions Simpl Procede de preparation de collagene reticule et substitut osseux comprenant ledit collagene ainsi reticule
US8721722B2 (en) 2004-10-18 2014-05-13 Ebi, Llc Intervertebral implant and associated method
GB2424223C (en) * 2005-03-07 2011-02-02 Massachusetts Inst Technology Biomaterial.
WO2007056671A1 (en) 2005-11-02 2007-05-18 Osteotech, Inc. Hemostatic bone graft
DE102006026592A1 (de) * 2005-12-01 2007-06-06 Ossacur Ag Träger mit Colloss
CN101495065B (zh) 2006-04-25 2014-07-23 泰里福来克斯医学公司 磷酸钙聚合物复合材料及其制备方法
US7780676B2 (en) 2006-07-11 2010-08-24 Ebi, Llc Intervertebral implantation apparatus
DE102006048833A1 (de) 2006-10-16 2008-04-17 Universität Rostock Behandlung von Osteoporose
US8048857B2 (en) 2006-12-19 2011-11-01 Warsaw Orthopedic, Inc. Flowable carrier compositions and methods of use
US7718616B2 (en) 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
US9616153B2 (en) 2008-04-17 2017-04-11 Warsaw Orthopedic, Inc. Rigid bone graft substitute
US20090263507A1 (en) * 2008-04-18 2009-10-22 Warsaw Orthopedic, Inc. Biological markers and response to treatment for pain, inflammation, neuronal or vascular injury and methods of use
ATE547130T1 (de) * 2008-04-21 2012-03-15 Ao Technology Ag Biokompatibles implantat
EP2358352B1 (en) 2008-10-24 2018-08-29 Warsaw Orthopedic, Inc. Compositions and methods for promoting bone formation
JP2013542837A (ja) 2010-11-15 2013-11-28 ジンマー オーソバイオロジクス，インコーポレイティド 骨空隙充填剤
EP2529764A1 (de) 2011-05-31 2012-12-05 Curasan AG Biologisch degradierbares kompositmaterial
US8697107B2 (en) * 2012-04-27 2014-04-15 Warsaw Orthopedic, Inc. Flowable implant with crosslinkable surface membrane
CN105727369B (zh) * 2016-03-21 2019-01-08 中国科学院化学研究所 一种明胶/碳酸化羟基磷灰石骨支架的制备方法
KR20190017513A (ko) * 2017-08-11 2019-02-20 주식회사 바이오알파 대체골용 그래뉼 응집체 및 그 제조방법

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US3443261A (en) * 1967-09-01 1969-05-13 Fmc Corp Prosthetic structures from microcrystalline collagen
DE2905878A1 (de) * 1979-02-16 1980-08-28 Merck Patent Gmbh Implantationsmaterialien und verfahren zu ihrer herstellung
EP0030583B1 (de) * 1979-12-18 1984-06-13 Oscobal Ag Knochenersatzmaterial und Verfahren zur Herstellung eines Knochenersatzmaterials
CA1190855A (en) * 1980-09-03 1985-07-23 Rolf W. Pfirrmann Treatment of osteitis
US4430760A (en) * 1981-12-18 1984-02-14 Collagen Corporation Nonstress-bearing implantable bone prosthesis

Also Published As

Publication number Publication date
EP0164483B1 (de) 1989-08-16
EP0164483A1 (de) 1985-12-18
JPS6145768A (ja) 1986-03-05
DE3479402D1 (en) 1989-09-21
CA1259266A (en) 1989-09-12
US4623553A (en) 1986-11-18

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