JPH0463053B2 - - Google Patents

Info

Publication number
JPH0463053B2
JPH0463053B2 JP57169160A JP16916082A JPH0463053B2 JP H0463053 B2 JPH0463053 B2 JP H0463053B2 JP 57169160 A JP57169160 A JP 57169160A JP 16916082 A JP16916082 A JP 16916082A JP H0463053 B2 JPH0463053 B2 JP H0463053B2
Authority
JP
Japan
Prior art keywords
copolymer
minutes
polyoxyethylene
urokinase
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP57169160A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5959629A (ja
Inventor
Hajime Hiratani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JCR Pharmaceuticals Co Ltd
Original Assignee
JCR Pharmaceuticals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JCR Pharmaceuticals Co Ltd filed Critical JCR Pharmaceuticals Co Ltd
Priority to JP57169160A priority Critical patent/JPS5959629A/ja
Priority to US06/507,154 priority patent/US4609546A/en
Priority to EP83303636A priority patent/EP0098110B1/en
Priority to DE8383303636T priority patent/DE3380726D1/de
Publication of JPS5959629A publication Critical patent/JPS5959629A/ja
Publication of JPH0463053B2 publication Critical patent/JPH0463053B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP57169160A 1982-06-24 1982-09-27 効力持続性組成物 Granted JPS5959629A (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP57169160A JPS5959629A (ja) 1982-09-27 1982-09-27 効力持続性組成物
US06/507,154 US4609546A (en) 1982-06-24 1983-06-23 Long-acting composition
EP83303636A EP0098110B1 (en) 1982-06-24 1983-06-23 Long-acting composition
DE8383303636T DE3380726D1 (en) 1982-06-24 1983-06-23 Long-acting composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57169160A JPS5959629A (ja) 1982-09-27 1982-09-27 効力持続性組成物

Publications (2)

Publication Number Publication Date
JPS5959629A JPS5959629A (ja) 1984-04-05
JPH0463053B2 true JPH0463053B2 (enrdf_load_stackoverflow) 1992-10-08

Family

ID=15881383

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57169160A Granted JPS5959629A (ja) 1982-06-24 1982-09-27 効力持続性組成物

Country Status (1)

Country Link
JP (1) JPS5959629A (enrdf_load_stackoverflow)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59172425A (ja) * 1983-03-18 1984-09-29 Nippon Chemiphar Co Ltd 新規な血液凝固因子誘導体およびその製造法ならびにそれを含有する血液凝固促進剤
US4496689A (en) * 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
GB8430252D0 (en) * 1984-11-30 1985-01-09 Beecham Group Plc Compounds
JPS61176532A (ja) * 1985-01-30 1986-08-08 Green Cross Corp:The プラスミノ−ゲンアクチベ−タ−前駆体の安定化方法
KR880701107A (ko) * 1986-05-15 1988-07-25 원본미기재 피브린용해 조성물
JPH07103158B2 (ja) * 1989-01-24 1995-11-08 電気化学工業株式会社 コロニー刺激因子―ゼラチン結合体
PT744409E (pt) 1994-02-23 2008-11-03 Kyowa Hakko Kogyo Kk Acelerador do crescimento das plaquetas
JP4610154B2 (ja) * 2002-05-30 2011-01-12 大塚製薬株式会社 注射用製剤
US7879320B2 (en) * 2004-05-17 2011-02-01 Ares Trading S.A. Hydrogel interferon formulations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6023084B2 (ja) * 1979-07-11 1985-06-05 味の素株式会社 代用血液
JPS58225025A (ja) * 1982-06-24 1983-12-27 Nippon Chem Res Kk 効力持続性組成物

Also Published As

Publication number Publication date
JPS5959629A (ja) 1984-04-05

Similar Documents

Publication Publication Date Title
US4609546A (en) Long-acting composition
JP7054407B2 (ja) オキシム連結のための求核触媒
EA014103B1 (ru) Конъюгат, включающий белок и полимер или его производное (варианты), способ его получения, применение конъюгата и содержащая его фармацевтическая композиция
AU2005225513B2 (en) Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination
KR101832937B1 (ko) 혈액 응고 단백질 복합체
JP7304402B2 (ja) オキシム連結のための求核触媒
EP0200467B1 (en) Superoxide dismutase combined with a poly(alkylene oxide)
JP3173794B2 (ja) タンパク質またはポリペプチド類とその製造法および中間化合物
CN103497247A (zh) 缀合的因子viii分子
US10350301B2 (en) Blood coagulation protein conjugates
JP2015512927A (ja) 最適化された皮下治療薬
JPH0463053B2 (enrdf_load_stackoverflow)
US20190240295A1 (en) Factor viii with extended half-life and reduced ligand-binding properties
JPS58225025A (ja) 効力持続性組成物
HK1230975A (en) Blood coagulation protein conjugates
HK1230975A1 (en) Blood coagulation protein conjugates
HK1156332A (en) Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination
HK1171691B (en) Blood coagulation protein conjugates
MXPA06010189A (en) Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination