JPH0451537B2 - - Google Patents

Info

Publication number
JPH0451537B2
JPH0451537B2 JP57014399A JP1439982A JPH0451537B2 JP H0451537 B2 JPH0451537 B2 JP H0451537B2 JP 57014399 A JP57014399 A JP 57014399A JP 1439982 A JP1439982 A JP 1439982A JP H0451537 B2 JPH0451537 B2 JP H0451537B2
Authority
JP
Japan
Prior art keywords
group
prostaglandin
carba
tetradehydro
didehydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP57014399A
Other languages
English (en)
Japanese (ja)
Other versions
JPS57176924A (en
Inventor
Sukubara Uerunaa
Raadeyuhieru Berunto
Shuarutsu Noruberuto
Kazarusuusutentsueru Yoruge
Fuoaburyutsugen Herumuuto
Shiringaa Etsukeharuto
Harorudo Ton Mihyaeru
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of JPS57176924A publication Critical patent/JPS57176924A/ja
Publication of JPH0451537B2 publication Critical patent/JPH0451537B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP57014399A 1981-02-02 1982-02-02 Novel carbacycline derivative, manufacture and drug containing same for peripheral blood circulation trouble and cardiac blockade Granted JPS57176924A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813104044 DE3104044A1 (de) 1981-02-02 1981-02-02 Neue prostacyclin-derivate, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Publications (2)

Publication Number Publication Date
JPS57176924A JPS57176924A (en) 1982-10-30
JPH0451537B2 true JPH0451537B2 (en, 2012) 1992-08-19

Family

ID=6124154

Family Applications (1)

Application Number Title Priority Date Filing Date
JP57014399A Granted JPS57176924A (en) 1981-02-02 1982-02-02 Novel carbacycline derivative, manufacture and drug containing same for peripheral blood circulation trouble and cardiac blockade

Country Status (14)

Country Link
EP (1) EP0057660B1 (en, 2012)
JP (1) JPS57176924A (en, 2012)
AT (1) ATE15029T1 (en, 2012)
AU (1) AU7995782A (en, 2012)
DD (1) DD201884A5 (en, 2012)
DE (2) DE3104044A1 (en, 2012)
DK (1) DK43482A (en, 2012)
ES (1) ES8301912A1 (en, 2012)
FI (1) FI820327L (en, 2012)
GR (1) GR74746B (en, 2012)
IE (1) IE820228L (en, 2012)
IL (1) IL64902A0 (en, 2012)
NO (1) NO820298L (en, 2012)
ZA (1) ZA82670B (en, 2012)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3237200A1 (de) * 1982-10-05 1984-04-05 Schering AG, 1000 Berlin und 4709 Bergkamen 5-fluorcarbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3204443A1 (de) * 1982-02-08 1983-08-18 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3221193A1 (de) * 1982-05-28 1983-12-01 Schering AG, 1000 Berlin und 4709 Bergkamen Neue carbacyclinester, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
JPS59141536A (ja) * 1983-02-01 1984-08-14 Sumitomo Chem Co Ltd 新規ビシクロオクタン誘導体
JPS60181041A (ja) * 1984-02-29 1985-09-14 Sankyo Co Ltd カルバサイクリン誘導体
JPS60172941A (ja) * 1984-02-16 1985-09-06 Sankyo Co Ltd カルバサイクリン類
ATE306256T1 (de) 1999-08-05 2005-10-15 Teijin Ltd Mittel zur besserung der neuropathie, die als wirkstoff stickstoffhaltige verbindungen enthalten

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4705806A (en) * 1978-02-13 1987-11-10 Morton Jr Douglas R Prostacyclin analogs
DE2845770A1 (de) * 1978-10-19 1980-04-30 Schering Ag Neue prostacyclin-derivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
EP0057660A3 (en) 1982-09-01
FI820327A7 (fi) 1982-08-03
GR74746B (en, 2012) 1984-07-11
IL64902A0 (en) 1982-03-31
NO820298L (no) 1982-08-03
DE3104044A1 (de) 1982-08-26
JPS57176924A (en) 1982-10-30
ES509265A0 (es) 1983-01-16
DD201884A5 (de) 1983-08-17
ES8301912A1 (es) 1983-01-16
EP0057660A2 (de) 1982-08-11
AU7995782A (en) 1982-08-12
EP0057660B1 (de) 1985-08-21
DE3265495D1 (en) 1985-09-26
IE820228L (en) 1982-08-02
ZA82670B (en) 1982-12-29
ATE15029T1 (de) 1985-09-15
FI820327L (fi) 1982-08-03
DK43482A (da) 1982-08-03

Similar Documents

Publication Publication Date Title
JPS6228937B2 (en, 2012)
JPS6312051B2 (en, 2012)
JPS6259700B2 (en, 2012)
JPS6220989B2 (en, 2012)
JPH0611726B2 (ja) （５Ｅ）−１３，１４，１８，１８，１９，１９−ヘキサデヒドロ−３−オキサ−６ａ−カルバプロスタグランジン−Ｉ▲下２▼−誘導体、その製法並びに該化合物を含有する血圧降下剤
HU191057B (en) Process for the production of new carbacycline-derivatives and of the pharmaceutical preparations containing them
JPH0451537B2 (en, 2012)
US4497830A (en) Carbacyclins, their preparation and pharmacological use
HU187466B (en) Process for producing new 5-cyano-prostacycline derivatives and pharmaceutical compositions containing them
US4552875A (en) Novel carbacyclinamides, their preparation and use as medicinal agents
EP0105288B1 (de) Carbacycline, herstellung und verwendung
US5023273A (en) 6-oxoprostaglandin E derivatives, process for their production and their pharmaceutical use
US4532236A (en) Certain prostacyclins and their blood-pressure-lowering and thrombocyte-aggregation-inhibiting compositions and methods
HU191197B (en) Process for preparing new carbacycline derivatives and pharmaceutical compositions containing thereof
JPH0355461B2 (en, 2012)
US5190973A (en) 20-alkyl-7-oxoprostacyclin derivatives useful as pharmaceuticals
US5104861A (en) 7-oxoprostacyclin derivatives which are useful as pharmaceuticals
EP0113311B1 (de) 5-Fluorcarbacycline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
JPH0564147B2 (en, 2012)
JPH0437817B2 (en, 2012)
CS252481B2 (en) Method of new carbacyclines production
HU207715B (en) Process for producing 9-substituted carbacyclin derivatives and pharmaceutical compositions containing them as active components
JPH036145B2 (en, 2012)
HU206317B (en) Process for producing carbacyclines and pharmaceutical compositions containing them
JPH0723336B2 (ja) カルバサイクリン誘導体及びその製法