JPH0412272B2 - - Google Patents

Info

Publication number
JPH0412272B2
JPH0412272B2 JP59148766A JP14876684A JPH0412272B2 JP H0412272 B2 JPH0412272 B2 JP H0412272B2 JP 59148766 A JP59148766 A JP 59148766A JP 14876684 A JP14876684 A JP 14876684A JP H0412272 B2 JPH0412272 B2 JP H0412272B2
Authority
JP
Japan
Prior art keywords
group
reaction
compound
lower alkyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP59148766A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6127986A (ja
Inventor
Kunyuki Tomita
Yasuo Shimoji
Seiji Kumakura
Hiroyuki Koike
Takayoshi Iwata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP14876684A priority Critical patent/JPS6127986A/ja
Priority to US06/755,474 priority patent/US4716162A/en
Priority to EP85305152A priority patent/EP0171217B1/en
Priority to ES545361A priority patent/ES8705887A1/es
Priority to CA000487050A priority patent/CA1291754C/en
Priority to AT85305152T priority patent/ATE42748T1/de
Priority to DE8585305152T priority patent/DE3569927D1/de
Publication of JPS6127986A publication Critical patent/JPS6127986A/ja
Publication of JPH0412272B2 publication Critical patent/JPH0412272B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP14876684A 1984-07-18 1984-07-18 縮環複素環化合物 Granted JPS6127986A (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP14876684A JPS6127986A (ja) 1984-07-18 1984-07-18 縮環複素環化合物
US06/755,474 US4716162A (en) 1984-07-18 1985-07-16 Fused 5 ring heterocyclic compounds, their preparation, and their anti-arrhythmic and diuretic use
EP85305152A EP0171217B1 (en) 1984-07-18 1985-07-18 Fused-ring heterocyclic compounds a process for their production and their pharmaceutical use
ES545361A ES8705887A1 (es) 1984-07-18 1985-07-18 Un procedimiento para la preparacion de derivados de oxobenzo (d,e) indolo (3,2,1-i,j) quinolina.
CA000487050A CA1291754C (en) 1984-07-18 1985-07-18 Fused five-ring heterocyclic compounds, their production, and their pharmaceutical use
AT85305152T ATE42748T1 (de) 1984-07-18 1985-07-18 Kondensierte heterocyclische verbindungen, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung.
DE8585305152T DE3569927D1 (en) 1984-07-18 1985-07-18 Fused-ring heterocyclic compounds a process for their production and their pharmaceutical use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14876684A JPS6127986A (ja) 1984-07-18 1984-07-18 縮環複素環化合物

Publications (2)

Publication Number Publication Date
JPS6127986A JPS6127986A (ja) 1986-02-07
JPH0412272B2 true JPH0412272B2 (enExample) 1992-03-04

Family

ID=15460169

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14876684A Granted JPS6127986A (ja) 1984-07-18 1984-07-18 縮環複素環化合物

Country Status (7)

Country Link
US (1) US4716162A (enExample)
EP (1) EP0171217B1 (enExample)
JP (1) JPS6127986A (enExample)
AT (1) ATE42748T1 (enExample)
CA (1) CA1291754C (enExample)
DE (1) DE3569927D1 (enExample)
ES (1) ES8705887A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5049563A (en) * 1988-07-07 1991-09-17 Duphar International Research B.V. Annelated indoleketones with an imidazolylalkyl substituent
RU2045528C1 (ru) * 1989-08-30 1995-10-10 Санкио Компани Лимитед Способ получения оптически активного производного индолобензохинолина или его фармацевтически приемлемых солей
FR2713644B1 (fr) * 1993-12-14 1996-02-09 Adir Nouveaux analogues de l'éburnane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985751A (en) * 1972-04-10 1976-10-12 Ayerst Mckenna And Harrison Ltd. Benzocycloheptaisoquinoline derivatives

Also Published As

Publication number Publication date
ATE42748T1 (de) 1989-05-15
CA1291754C (en) 1991-11-05
ES8705887A1 (es) 1987-05-01
JPS6127986A (ja) 1986-02-07
EP0171217B1 (en) 1989-05-03
DE3569927D1 (en) 1989-06-08
EP0171217A2 (en) 1986-02-12
ES545361A0 (es) 1987-05-01
US4716162A (en) 1987-12-29
EP0171217A3 (en) 1986-11-26

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