JPH038197B2 - - Google Patents

Info

Publication number
JPH038197B2
JPH038197B2 JP56101161A JP10116181A JPH038197B2 JP H038197 B2 JPH038197 B2 JP H038197B2 JP 56101161 A JP56101161 A JP 56101161A JP 10116181 A JP10116181 A JP 10116181A JP H038197 B2 JPH038197 B2 JP H038197B2
Authority
JP
Japan
Prior art keywords
streptomyces
antibiotic
enzyme
coa
acyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP56101161A
Other languages
English (en)
Japanese (ja)
Other versions
JPS585189A (ja
Inventor
Katsuro Kubo
Yasuo Fukagawa
Tomoyuki Ishikura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MERUSHAN KK
Original Assignee
MERUSHAN KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MERUSHAN KK filed Critical MERUSHAN KK
Priority to JP56101161A priority Critical patent/JPS585189A/ja
Priority to EP82105733A priority patent/EP0068486B1/en
Priority to DE8282105733T priority patent/DE3271129D1/de
Priority to US06/394,169 priority patent/US4438201A/en
Publication of JPS585189A publication Critical patent/JPS585189A/ja
Publication of JPH038197B2 publication Critical patent/JPH038197B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system
    • C12P17/184—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system containing a beta-lactam ring, e.g. thienamycin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
JP56101161A 1981-07-01 1981-07-01 新規なアミドヒドロラ−ゼ Granted JPS585189A (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP56101161A JPS585189A (ja) 1981-07-01 1981-07-01 新規なアミドヒドロラ−ゼ
EP82105733A EP0068486B1 (en) 1981-07-01 1982-06-28 Novel amidohydrolase
DE8282105733T DE3271129D1 (de) 1981-07-01 1982-06-28 Novel amidohydrolase
US06/394,169 US4438201A (en) 1981-07-01 1982-07-01 Amidohydrolase having ability to depantothenylate an antibiotic

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56101161A JPS585189A (ja) 1981-07-01 1981-07-01 新規なアミドヒドロラ−ゼ

Publications (2)

Publication Number Publication Date
JPS585189A JPS585189A (ja) 1983-01-12
JPH038197B2 true JPH038197B2 (en:Method) 1991-02-05

Family

ID=14293315

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56101161A Granted JPS585189A (ja) 1981-07-01 1981-07-01 新規なアミドヒドロラ−ゼ

Country Status (4)

Country Link
US (1) US4438201A (en:Method)
EP (1) EP0068486B1 (en:Method)
JP (1) JPS585189A (en:Method)
DE (1) DE3271129D1 (en:Method)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3741723A1 (de) * 1987-12-09 1989-06-22 Uniroyal Englebert Gmbh Fahrzeugluftreifen
DE69739532D1 (de) * 1996-03-08 2009-09-24 Astellas Pharma Inc Prozess für die deacylierung von zyklischen lipopeptiden.
EP1013663A1 (en) * 1998-12-22 2000-06-28 Holland Sweetener Company V.O.F. Synthesis and recovery of aspartame involving enzymatic deformylation step
US6617127B2 (en) 1998-12-22 2003-09-09 Holland Sweetener Company, V.O.F. Synthesis and recovery of aspartame involving enzymatic deformylation step
WO2000037486A1 (en) * 1998-12-22 2000-06-29 Holland Sweetener Company V.O.F. Synthesis and recovery of aspartame involving enzymatic deformylation step
US9637746B2 (en) 2008-12-15 2017-05-02 Greenlight Biosciences, Inc. Methods for control of flux in metabolic pathways
CN105132387A (zh) * 2008-12-22 2015-12-09 绿光生物科学公司 用于制造化合物的组合物和方法
JP2013526277A (ja) 2010-05-07 2013-06-24 グリーンライト バイオサイエンシーズ インコーポレーテッド 酵素リロケーションにより代謝経路のフラックスを制御する方法
KR101988063B1 (ko) 2010-08-31 2019-09-30 그린라이트 바이오사이언시스, 아이엔씨. 프로테아제 조작을 통한 대사 경로에서 유동의 제어 방법
EP2753702B1 (en) 2011-09-09 2021-12-15 GreenLight Biosciences, Inc. Cell-free preparation of carbapenems
US9688977B2 (en) 2013-08-05 2017-06-27 Greenlight Biosciences, Inc. Engineered phosphoglucose isomerase proteins with a protease cleavage site
RU2017137788A (ru) 2015-03-30 2019-04-30 Гринлайт Байосайенсис, Инк. Бесклеточное получение рибонуклеиновой кислоты
SG11201808721YA (en) 2016-04-06 2018-11-29 Greenlight Biosciences Inc Cell-free production of ribonucleic acid
JP7792196B2 (ja) 2017-10-11 2025-12-25 グリーンライト バイオサイエンシーズ インコーポレーテッド ヌクレオシド三リン酸およびリボ核酸の生成のための方法および組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282322A (en) * 1975-11-24 1981-08-04 Merck & Co., Inc. Process for enzymatic deacylation of antibiotics
US4135978A (en) * 1977-08-19 1979-01-23 Merck & Co., Inc. Production of n-acyl-thienamycins
JPS5473788A (en) * 1977-11-17 1979-06-13 Sanraku Inc Antibiotic n-desacetyl ps-5
US4207395A (en) * 1978-11-02 1980-06-10 Merck & Co., Inc. Process for deacylating N-acyl-6-substituted-2-[2-aminoethylthio]-1-carbadethiapen-2-em-3-carboxylic acids

Also Published As

Publication number Publication date
DE3271129D1 (de) 1986-06-19
JPS585189A (ja) 1983-01-12
EP0068486A2 (en) 1983-01-05
US4438201A (en) 1984-03-20
EP0068486A3 (en) 1983-06-29
EP0068486B1 (en) 1986-05-14

Similar Documents

Publication Publication Date Title
JPH038197B2 (en:Method)
KR970000185B1 (ko) 아실아미노산 라세마제, 그의 제조방법 및 용도
JPS6121097A (ja) ７−アミノセフアロスポラン酸及びその誘導体の製造法
AU615661B2 (en) Acid urease and production thereof
HU202916B (en) Process for microbiological producing gamma-glutamyl-transpeptidase
CA1177423A (en) Enzymatic deesterification of cephalosporin methyl ester
US4141790A (en) Process for the preparation of 7-amino-cephem compounds using mold fungi
Fukagawa et al. DEACETYLATION OF PS-5, A NEW β-LACTAM COMPOUND I. MICROBIAL DEACETYLATION OF PS-5
JPS60149399A (ja) アスパラギン酸アミノトランスフエラ−ゼアイソザイムの測定法
JPH01199576A (ja) α−アミノアジピニルモノアミノ化合物の加水分解性を有するγ−グルタミルトランスペプチダーゼ
US4207395A (en) Process for deacylating N-acyl-6-substituted-2-[2-aminoethylthio]-1-carbadethiapen-2-em-3-carboxylic acids
KUBO et al. STUDIES ON THE BIOSYNTHESIS OF CARBAPENEM ANTIBIOTICS II. ISOLATION AND FUNCTIONS OF A SPECIFIC ACYLASE INVOLVED IN THE DEPANTOTHENYLATION OF THE OA-6129 COMPOUNDS
JP2712331B2 (ja) アシルアミノ酸ラセマーゼ、その製造法および用途
FUKAGAWA et al. STUDIES ON THE BIOSYNTHESIS OF CARBAPENEM ANTIBIOTICS I. BIOSYNTHETIC SIGNIFICANCE OF THE OA-6129 GROUP OF CARBAPENEM COMPOUNDS AS THE DIRECT PRECURSORS FOR PS-5, EPITHIENAMYCINS A AND C AND MM 17880
JP3093039B2 (ja) 新規エステル分解酵素ａおよびその製造方法
OGAWARA et al. A NEW 5'-NUCLEOTIDASE INHIBITOR, NUCLEOTICIDIN I. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL PROPERTIES
JPH0669380B2 (ja) バリエナミンおよびバリダミンの製造法
SERIZAWA et al. Enzymatic conversion of cephamycin C by D-amino acid oxidase from Trigonopsis variabilis
US4264734A (en) Process for producing antibiotic desacetyl 890A10
JPH04365473A (ja) クリプトコッカス・ラウレンティｄｓｍ２７６２
KR100328111B1 (ko) 데카르바밀라제의 제조방법
SERIZAWA et al. Stereo-specific synthesis of 3-trifluoromethylcephalosporin derivative by microbial acylase
Sugie et al. A new peptidase specific to D-amino acid peptides from a Nocardia sp.
EP0102529A2 (en) Process for preparation of aspartylphenylalanine alkyl esters
JPS6248379A (ja) セフアロスポリンｃアシラ−ゼの製造法