JPH0372046B2 - - Google Patents
Info
- Publication number
- JPH0372046B2 JPH0372046B2 JP58206226A JP20622683A JPH0372046B2 JP H0372046 B2 JPH0372046 B2 JP H0372046B2 JP 58206226 A JP58206226 A JP 58206226A JP 20622683 A JP20622683 A JP 20622683A JP H0372046 B2 JPH0372046 B2 JP H0372046B2
- Authority
- JP
- Japan
- Prior art keywords
- interferon
- long
- oil
- acting
- collagen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000014150 Interferons Human genes 0.000 claims description 43
- 108010050904 Interferons Proteins 0.000 claims description 43
- 229940079322 interferon Drugs 0.000 claims description 43
- 238000002360 preparation method Methods 0.000 claims description 29
- 108010035532 Collagen Proteins 0.000 claims description 12
- 102000008186 Collagen Human genes 0.000 claims description 12
- 229920001436 collagen Polymers 0.000 claims description 12
- 230000005923 long-lasting effect Effects 0.000 claims description 5
- 239000008188 pellet Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- -1 spheres Substances 0.000 claims description 4
- 239000012155 injection solvent Substances 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 description 9
- 238000002347 injection Methods 0.000 description 8
- 239000007924 injection Substances 0.000 description 8
- 239000003921 oil Substances 0.000 description 8
- 235000019198 oils Nutrition 0.000 description 8
- 239000008280 blood Substances 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 239000000725 suspension Substances 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 108010045569 atelocollagen Proteins 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000008159 sesame oil Substances 0.000 description 4
- 235000011803 sesame oil Nutrition 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 238000000748 compression moulding Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 229920001223 polyethylene glycol Polymers 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 102000006992 Interferon-alpha Human genes 0.000 description 2
- 108010047761 Interferon-alpha Proteins 0.000 description 2
- 241000283977 Oryctolagus Species 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 240000001090 Papaver somniferum Species 0.000 description 2
- 235000008753 Papaver somniferum Nutrition 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- FOCVUCIESVLUNU-UHFFFAOYSA-N Thiotepa Chemical compound C1CN1P(N1CC1)(=S)N1CC1 FOCVUCIESVLUNU-UHFFFAOYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 210000004102 animal cell Anatomy 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 239000010419 fine particle Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 230000009422 growth inhibiting effect Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000012053 oil suspension Substances 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 229960001196 thiotepa Drugs 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58206226A JPS6097918A (ja) | 1983-11-01 | 1983-11-01 | インタ−フエロン持続性製剤 |
| DE8484112313T DE3484584D1 (de) | 1983-10-14 | 1984-10-12 | Injektionen mit verzoegerter abgabe. |
| EP19840112313 EP0140255B1 (fr) | 1983-10-14 | 1984-10-12 | Injections à libération prolongée |
| EP19840112310 EP0139286B1 (fr) | 1983-10-14 | 1984-10-12 | Préparation à libération prolongée de longue durée |
| DE8484112310T DE3484951D1 (de) | 1983-10-14 | 1984-10-12 | Verlaengerte praeparate mit verzoegerter abgabe. |
| DE19843486029 DE3486029T2 (de) | 1983-10-14 | 1984-10-12 | Ifn-praeparat mit verzoegerter abgabe fuer parentale verabreichung. |
| EP19840112312 EP0138216B1 (fr) | 1983-10-14 | 1984-10-12 | Préparation IFN à libération prolongée pour administration par voie parentérale |
| US06/846,193 US4774091A (en) | 1983-10-14 | 1986-03-31 | Long-term sustained-release preparation |
| US06/855,387 US4855134A (en) | 1983-10-14 | 1986-04-24 | Sustained-release preparation |
| US07/187,443 US5021241A (en) | 1983-10-14 | 1988-04-28 | Long-term sustained-release preparation |
| US07/358,157 US5081156A (en) | 1983-10-14 | 1989-05-30 | Sustained-release preparation |
| US07/844,929 US5385738A (en) | 1983-10-14 | 1992-03-04 | Sustained-release injection |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP58206226A JPS6097918A (ja) | 1983-11-01 | 1983-11-01 | インタ−フエロン持続性製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6097918A JPS6097918A (ja) | 1985-05-31 |
| JPH0372046B2 true JPH0372046B2 (fr) | 1991-11-15 |
Family
ID=16519848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP58206226A Granted JPS6097918A (ja) | 1983-10-14 | 1983-11-01 | インタ−フエロン持続性製剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6097918A (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60174726A (ja) * | 1984-02-21 | 1985-09-09 | Nippon Shinyaku Co Ltd | 注射用医薬組成物 |
| JP2609851B2 (ja) * | 1986-09-04 | 1997-05-14 | 悦子 柿崎 | 徐放性注射剤 |
| US5023080A (en) * | 1988-06-17 | 1991-06-11 | Basic Bio Systems, Inc. | Time release protein |
| BR9205864A (pt) * | 1991-04-08 | 1994-06-28 | Sumitomo Pharma | Formulações sólidas porosas contendo substâncias proteináceas fisiologicamente ativas. |
| CA2217134A1 (fr) * | 1996-10-09 | 1998-04-09 | Sumitomo Pharmaceuticals Co., Ltd. | Formulation a liberation-retard |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57150609A (en) * | 1981-02-16 | 1982-09-17 | Ici Ltd | Pharmaceutical composition, heterogeneous copolymer comprising lactic acid and glycolic acid units and manufacture |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0120061A4 (fr) * | 1982-09-29 | 1986-08-21 | Theodore E Spielberg | Organismes vivants encapsules programmes genetiquement produisant des substances therapeutiques. |
-
1983
- 1983-11-01 JP JP58206226A patent/JPS6097918A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57150609A (en) * | 1981-02-16 | 1982-09-17 | Ici Ltd | Pharmaceutical composition, heterogeneous copolymer comprising lactic acid and glycolic acid units and manufacture |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6097918A (ja) | 1985-05-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5081156A (en) | Sustained-release preparation | |
| KR100236771B1 (ko) | 히아루론산을 이용한 약물의 서방성 미세입자 제형 | |
| EP0138216B1 (fr) | Préparation IFN à libération prolongée pour administration par voie parentérale | |
| CA2433037C (fr) | Preparation a liberation prolongee | |
| US5385738A (en) | Sustained-release injection | |
| JP4887542B2 (ja) | Ｐｅｇｔ／ｐｂｔブロックコポリマーを基にしたインターフェロンのための制御放出組成物 | |
| US20090142399A1 (en) | Dispersant agent for sustained-release preparations | |
| JP5160005B2 (ja) | 徐放性製剤 | |
| CN1339962A (zh) | 稳定的非水性单相粘性载体及采用该载体的制剂 | |
| JP2008528698A (ja) | 埋め込み可能なインターフェロン含有デバイス | |
| EP0140255A2 (fr) | Injections à libération prolongée | |
| KR20010012374A (ko) | 지속 효과를 갖는 서방성 겔 | |
| JP4683319B2 (ja) | 徐放性製剤用の分散剤 | |
| JPS62230729A (ja) | Ｃｓｆ徐放性製剤 | |
| US8987340B2 (en) | Sublimable sustained release delivery system and method of making same | |
| JPH1045616A (ja) | 注射用徐放性製剤 | |
| JPH0372046B2 (fr) | ||
| JPH0512328B2 (fr) | ||
| JPS58189118A (ja) | 経鼻投与製剤 | |
| WO1989003671A1 (fr) | Preparation a liberation entretenue | |
| JPS60126217A (ja) | 長期徐放性製剤 | |
| JPH01149732A (ja) | ソマトトロピン製剤 | |
| KR100329336B1 (ko) | 히아루론산을 이용한 단백질 약물의 서방성 미세 입자 제형 | |
| JPH05246879A (ja) | 長期徐放性製剤 | |
| JPS6084213A (ja) | 徐放性消炎鎮痛製剤 |