JPH0363025B2 - - Google Patents
Info
- Publication number
- JPH0363025B2 JPH0363025B2 JP15214286A JP15214286A JPH0363025B2 JP H0363025 B2 JPH0363025 B2 JP H0363025B2 JP 15214286 A JP15214286 A JP 15214286A JP 15214286 A JP15214286 A JP 15214286A JP H0363025 B2 JPH0363025 B2 JP H0363025B2
- Authority
- JP
- Japan
- Prior art keywords
- standard solution
- sample
- dilution
- diluted
- concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000012086 standard solution Substances 0.000 claims description 53
- 239000012895 dilution Substances 0.000 claims description 49
- 238000010790 dilution Methods 0.000 claims description 49
- 239000000523 sample Substances 0.000 claims description 44
- 238000012742 biochemical analysis Methods 0.000 claims description 19
- 238000004458 analytical method Methods 0.000 claims description 18
- 238000004364 calculation method Methods 0.000 claims description 16
- 238000001514 detection method Methods 0.000 claims description 14
- 239000012470 diluted sample Substances 0.000 claims description 11
- 238000012937 correction Methods 0.000 claims description 8
- 238000012360 testing method Methods 0.000 claims description 5
- 238000005070 sampling Methods 0.000 description 8
- 238000004140 cleaning Methods 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 238000005259 measurement Methods 0.000 description 4
- 238000007599 discharging Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000003113 dilution method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Landscapes
- Automatic Analysis And Handling Materials Therefor (AREA)
Description
【発明の詳細な説明】
(イ) 産業上の利用分野
この発明は、生化学自動分析装置に関する。さ
らに詳しくは、生体試料を一定倍率で希釈した後
その所定量を繰返し生化学分析部へ供給して多項
目分析を行なうよう構成された多項目生化学分析
装置に関する。[Detailed Description of the Invention] (a) Field of Industrial Application This invention relates to an automatic biochemical analyzer. More specifically, the present invention relates to a multi-item biochemical analyzer configured to dilute a biological sample at a constant ratio and then repeatedly supply a predetermined amount of the diluted sample to a biochemical analysis section to perform multi-item analysis.
(ロ) 従来の技術
近年、臨床化学検査に用いる生化学自動分析装
置としては、検体の微量化のニーズに応じて検体
を希釈した後この希釈液をサンプリングして生化
学分析部へ供給して分析する装置が増えており、
ことに多項目分析を行なう装置においては比較的
多量の検体を要するため、かかる希釈方式の装置
が用いられている。(b) Conventional technology In recent years, automatic biochemical analyzers used in clinical chemistry tests have been designed to dilute a specimen in response to the need to reduce the amount of the specimen, then sample this diluted liquid and supply it to the biochemical analysis department. The number of analytical devices is increasing,
In particular, since a relatively large amount of specimen is required in an apparatus that performs multi-item analysis, such a dilution type apparatus is used.
このような希釈方式の多項目生化学自動分析装
置においては、通常、複数の試料容器を配列した
試料ライン及びこれに対応して複数の希釈容器を
配列した希釈ラインが備えられ、試料容器内の試
料（検体）は、適当な移動希釈分注器によつて希
釈容器内へ所定倍率（通常５〜20倍）で希釈分注
され次いでこの希釈試料が各項目測定毎に繰返し
生化学分析部へ供給されて分析に供される。そし
て、較正用の標準液としては、希釈試料に対応す
る既知濃度の希釈標準液が予め調製して用いら
れ、この希釈標準液を上記分注器で直接生化学分
析部へ供給した際の検知出力とその標準液濃度に
基づいて、各項目についての試料中の濃度が算出
されており、この較正は所定の分析サイクル毎に
更新されている。 Such a dilution type multi-item automatic biochemical analyzer is usually equipped with a sample line in which a plurality of sample containers are arranged and a corresponding dilution line in which a plurality of dilution containers are arranged. The sample (specimen) is diluted and dispensed into a dilution container at a predetermined magnification (usually 5 to 20 times) using an appropriate mobile dilution dispenser, and then this diluted sample is repeatedly sent to the biochemical analysis department for each item measurement. supplied for analysis. As the standard solution for calibration, a diluted standard solution with a known concentration corresponding to the diluted sample is prepared in advance and used, and detection is performed when this diluted standard solution is directly supplied to the biochemical analysis department using the above-mentioned dispenser. The concentration of each item in the sample is calculated based on the output and its standard solution concentration, and this calibration is updated every predetermined analysis cycle.
(ハ) 発明が解決しようとする問題点
しかしながら、上記希釈方式の分析装置におい
ては、移動希釈分注器という機械的な希釈分注手
段を用いているため、希釈倍率の機械的誤差こと
に系統的誤差が生じ易く、一定の希釈倍率に対応
して調製した前記希釈標準液をベースとして分析
演算を行なつた際に、無視し得ない誤差を生じる
という問題点があつた。ことに微量試料（例えば
10μ程度）を対象して分析を行なつた場合、例
えば20倍希釈に設定すると濃度として±１〜２％
程度の誤差を生じる不都合がある。(C) Problems to be Solved by the Invention However, since the above-mentioned dilution type analyzer uses a mechanical dilution dispensing means called a mobile dilution dispenser, it is systematically subject to mechanical errors in the dilution ratio. There is a problem in that a non-ignorable error is likely to occur when analytical calculations are performed based on the diluted standard solution prepared in accordance with a fixed dilution ratio. Especially for trace samples (e.g.
For example, if you set a 20-fold dilution, the concentration will be ±1 to 2%.
There is an inconvenience that a degree of error may occur.
従つて、未希釈の標準液を試料容器に導入し、
試料と同条件で分注器による希釈操作を介して分
析部へ供給して較正を行なうのが理想的である
が、この場合には較正時毎に試料容器への標準液
の導入、セツトや制御モードの設定等の操作を要
し煩雑であるという問題点があつた。 Therefore, introduce the undiluted standard solution into the sample container,
Ideally, calibration should be performed by supplying the sample to the analysis section through a dilution operation using a pipettor under the same conditions as the sample, but in this case, the standard solution must be introduced into the sample container, set, and There was a problem in that it required complicated operations such as setting the control mode.
この発明は、かかる状況に鑑みなされたもので
あり、ことに簡便な操作で較正の適正化を行ない
うる希釈方式の多項目生化学自動分析装置を提供
しようとするものである。 The present invention has been made in view of this situation, and it is an object of the present invention to provide a multi-item biochemical automatic analyzer using a dilution method, which allows optimization of calibration with a particularly simple operation.
(ニ) 問題点を解決しようとする手段
かくしてこの発明によれば(a)複数の試料容器を
配列した試料ライン及びこれに対応して複数の希
釈容器を配列した希釈ラインと(b)既知濃度の希釈
標準液を貯留する標準液貯槽と(c)多項目分析を行
なう生化学分析部と(d)上記試料容器内の試料を吸
引し希釈容器内へ所定倍率で希釈分注し次いでこ
の希釈試料の所定量を吸引し生化学分析部へ繰返
し分別供給すると共に、所定の分析サイクル毎に
上記標準液貯槽中の希釈標準液を吸引して生化学
分析部へ直接供給しうる移動希釈分注手段と(e)希
釈標準液の濃度及び生化学分析部への供給時の検
知出力に基づいて各試料中の被検成分の濃度を算
出する演算部とを備え、
上記試料容器内に試料の代わりに未希釈標準液
を導入し移動希釈分注手段による希釈分注操作を
介して生化学分析部へ供給した際の検知出力Ａに
より、算出演算のベースとなる希釈標準液の濃度
を各項目について下式：（）
Ｃ＝C0・Ａ／Ｂ …（）
〔式中、Ｃは補正された希釈標準液の演算用濃
度、C0は実際の希釈標準液の濃度、Ｂは希釈標
準液の検知出力を示す〕
に基づいて補正する補正演算部を具備したことを
特徴とする生化学自動分析装置が提供される。(d) Means for solving the problem According to the present invention, (a) a sample line in which a plurality of sample containers are arranged, a dilution line in which a plurality of dilution containers are arranged correspondingly, and (b) a known concentration. (c) a biochemical analysis section that performs multi-item analysis; and (d) aspirating the sample in the sample container, diluting it at a predetermined ratio into the dilution container, and then dispensing the diluted standard solution. A mobile dilution dispenser that can aspirate a predetermined amount of sample and repeatedly separate and supply it to the biochemical analysis department, as well as aspirate the diluted standard solution in the standard solution storage tank and supply it directly to the biochemical analysis department every predetermined analysis cycle. and (e) a calculation section that calculates the concentration of the test component in each sample based on the concentration of the diluted standard solution and the detection output at the time of supply to the biochemical analysis section. Instead, by introducing the undiluted standard solution and supplying it to the biochemical analysis department through the dilution dispensing operation using the mobile dilution dispensing means, the concentration of the diluted standard solution, which is the basis for calculation, can be determined for each item. The following formula: () C= C0・A/B...() [In the formula, C is the concentration for calculation of the corrected diluted standard solution, C0 is the actual concentration of the diluted standard solution, and B is the diluted standard solution. An automatic biochemical analyzer is provided, characterized in that it includes a correction calculation section that performs correction based on the detection output of .
(ホ) 作 用
この発明の装置においては、上記式（）に基
づいて、所定分析サイクル毎に較正に供される希
釈標準液の算出演算用の濃度が補正される。即
ち、未希釈標準液を希釈分注操作を介して分析部
へ供給した際の出力と予め希釈調製された標準液
を供給した際の出力との相違は、希釈分注手段の
希釈操作による設定希釈倍率と実際の希釈倍率と
の差異に対応するため、前者の検知出力Ａを後者
の検知出力Ｂで除した係数を希釈標準液の設定濃
度C0に乗ずることにより算出演算に用いる希釈
標準液濃度値を適正化することができ、希釈分注
操作による誤差を解消することができる。さら
に、かかる適正化のための操作は、較正毎に行な
う必要はなく、長期間（例えば、１ケ月程度）毎
で充分であり、操作上の煩雑さを招くこともな
い。(E) Effect In the apparatus of the present invention, the concentration for calculation of the diluted standard solution used for calibration is corrected every predetermined analysis cycle based on the above formula (). In other words, the difference between the output when an undiluted standard solution is supplied to the analysis section through the dilution dispensing operation and the output when a pre-diluted standard solution is supplied is due to the setting by the dilution operation of the dilution dispensing means. In order to accommodate the difference between the dilution ratio and the actual dilution ratio, the diluted standard solution used for calculation is multiplied by the coefficient obtained by dividing the former detection output A by the latter detection output B by the set concentration C 0 of the diluted standard solution. The concentration value can be optimized, and errors caused by dilution and dispensing operations can be eliminated. Furthermore, it is not necessary to carry out such an operation for optimization every time the calibration is performed, and it is sufficient to carry out every long period of time (for example, about one month) without causing any operational complexity.
(ヘ) 実施例
第１図は、この発明の生化学自動分析装置の一
実施例を示す構成説明図であり、第２図はその一
部を示す平面構成説明図である。図において生化
学自動分析装置１は、複数の試料容器２１を配列
した試料ライン２及び複数の希釈容器３１を配列
した希釈ライン３を有するサンプリングテーブル
４と、既知濃度の被検成分を各々含有する希釈標
準液の貯槽５と、多項目分析を行なう生化学分析
部６と、試料のサンプリング、希釈、移送等を行
なう回転移動式希釈分注器７と、制御部９と、表
示部１０とから基本構成されてなる。なお、８は
洗浄液貯槽である。生化学分析部６は、反応キユ
ベツト６１を連続的に配列したターンテーブル６
２と、この透明の反応キユベツト６１内に所定項
目測定用の一種又は二種の試薬を（例えば、
GOT，CPK，ALP，BUN等の光学測定用試薬）
を選択して分注する反応試薬分注器６３と、光
源、分光手段及び受光器を備え反応キユベツト内
の反応液の所定波長における吸光度を検知する検
出器６４から構成されてなる。そして、希釈分注
器７は、第２図に示すように試料ライン上の試料
吸引位置ｂ、希釈ライン上の希釈試料吐出・吸引
位置ａ、希釈標準液吸引位置ｃ、ノズル７１の洗
浄位置ｄ及び反応キユベツトへの吐出位置ｅの間
を移動し、ノズルを上下させて吸引、吐出動作を
行なう。具体的には、試料容器内の試料の吸引
（位置ｂ）→希釈容器内への試料の希釈吐出（位
置ａ）→ノズルの洗浄（位置ｄ）→希釈容器内の
希釈試料の一部の吸引（位置ａ）→反応キユベツ
トへの希釈試料の吐出（位置ｅ）からなる試料サ
ンプリング操作と、希釈標準液の吸引（位置ｃ）
→反応キユベツトへの希釈標準液の吐出（位置
ｅ）からなる標準液サンプリング操作を行なう。
標準液サンプリング操作は、ターンテーブル分析
毎に行なわれる。その既知濃度値と検知出力との
比率に基づいて試料中の所定項目の濃度が演算さ
れ［例えば、濃度＝試料の出力×（希釈標準液の
出力×希釈倍率／希釈標準液の出力］、表示部１
０で表示される。(F) Embodiment FIG. 1 is an explanatory diagram showing the configuration of an embodiment of the automatic biochemical analyzer of the present invention, and FIG. 2 is a plan explanatory diagram showing a part of the configuration. In the figure, an automatic biochemical analyzer 1 includes a sampling table 4 having a sample line 2 in which a plurality of sample containers 21 are arranged, a dilution line 3 in which a plurality of dilution containers 31 are arranged, each containing a known concentration of a test component. A storage tank 5 for a diluted standard solution, a biochemical analysis section 6 that performs multi-item analysis, a rotationally movable dilution dispenser 7 that performs sample sampling, dilution, transfer, etc., a control section 9, and a display section 10. It basically consists of: Note that 8 is a cleaning liquid storage tank. The biochemical analysis section 6 includes a turntable 6 on which reaction cuvettes 61 are continuously arranged.
2, and one or two types of reagents for measuring a predetermined item (for example,
Reagents for optical measurement of GOT, CPK, ALP, BUN, etc.)
The reaction reagent dispenser 63 selects and dispenses a reaction reagent, and a detector 64 includes a light source, a spectroscopic means, and a light receiver and detects the absorbance at a predetermined wavelength of the reaction solution in the reaction cuvette. As shown in FIG. 2, the dilution dispenser 7 has a sample suction position b on the sample line, a diluted sample discharge/suction position a on the dilution line, a diluted standard solution suction position c, and a cleaning position d of the nozzle 71. and the discharge position e to the reaction cuvette, and the nozzle is moved up and down to perform suction and discharge operations. Specifically, the steps are aspirating the sample in the sample container (position b) → discharging the diluted sample into the dilution container (position a) → cleaning the nozzle (position d) → suctioning a part of the diluted sample in the dilution container (Position a) → Sample sampling operation consisting of discharging the diluted sample into the reaction cuvette (Position e) and aspirating the diluted standard solution (Position c)
→ Perform the standard solution sampling operation consisting of discharging the diluted standard solution into the reaction cuvette (position e).
A standard solution sampling operation is performed for each turntable analysis. The concentration of a predetermined item in the sample is calculated based on the ratio between the known concentration value and the detection output [For example, concentration = sample output x (output of diluted standard solution x dilution ratio / output of diluted standard solution]) and displayed. Part 1
Displayed as 0.
一方、制御部９は、サンプリングテーブル、希
釈分注器、生化学分析部等の駆動を予め定められ
たプログラムに従つてマイクロコンピユータで制
御すると共に、上記所定項目の濃度を算出する演
算部を有し、さらに補正演算部を備えている。補
正演算部は試料の代わりに未希釈標準液を用いて
前記試料サンプリング操作を行なつた際に得られ
る検知出力により、試料中の濃度の算出演算ベー
スに用いる希釈標準液の濃度を下式（）：
Ｃ＝C0・Ａ／Ｂ
［式中、Ｃは補正された希釈標準液の演算用濃
度、C0は実際の希釈標準液の濃度、Ａは未希釈
標準液の検知出力、Ｂは希釈標準液の検知出力を
示す］
に基づいて補正を行なう。なお、上記各数値は、
複数回測定による平均値を採用するのが好まし
く、通常、３回の平均値を用いるのが最適であ
る。これらの補正演算及び平均値モードの採用
は、キーボード等による外部入力により行なわれ
る。 On the other hand, the control section 9 controls the driving of the sampling table, dilution dispenser, biochemical analysis section, etc. using a microcomputer according to a predetermined program, and also has a calculation section that calculates the concentration of the above-mentioned predetermined items. Furthermore, it is equipped with a correction calculation section. The correction calculation unit uses the detection output obtained when performing the sample sampling operation using the undiluted standard solution instead of the sample to calculate the concentration of the diluted standard solution used as the calculation base for the concentration in the sample using the following formula ( ): C= C0・A/B [In the formula, C is the calculated concentration of the corrected diluted standard solution, C0 is the actual concentration of the diluted standard solution, A is the detection output of the undiluted standard solution, and B is the detection output of the undiluted standard solution. Indicates the detection output of the diluted standard solution]. In addition, each of the above numerical values is
It is preferable to use the average value obtained from multiple measurements, and it is usually optimal to use the average value from three measurements. These correction calculations and adoption of the average value mode are performed by external input using a keyboard or the like.
かかる生化学自動分析装置１において、各試料
ライン２に血清等の試料が導入された試料容器２
１が順次配例され、かつ希釈ライン３に空の希釈
容器３１を配列した状態で、希釈分注器７は位置
ｃにおいて希釈標準液（未希釈標準液の20倍希釈
液）を吸引し位置ｅでキユベツト６１内へ分注
し、これにより分析部６で得られる検知出力が外
部入力される希釈標準液の濃度と共に演算部内に
記憶される。これは各項目について行なわれる。
次いでノズル洗浄の後、位置ｂにおいて試料の吸
引、位置ａにおける希釈分注（設定希釈倍数は上
記と同じで20倍）、続いてノズル洗浄後の位置ａ
における希釈吸引及び位置ｅにおける希釈試料の
吐出（分注）が行なわれ、これが繰返されて多項
目に対応する数の希釈試料がキユベツト６１に連
続的に導入され、分析部６で前記希釈標準液の濃
度及び出力に基づいて各項目についての濃度が算
出される。所定数の試料について分析を行なつた
後、再び希釈標準液による較正が行なわれ、この
較正も所定分析サイクル毎に行なわれるが、さら
に所定の較正回数毎に前記式（）による希釈標
準液の濃度値の補正が各項目について行なわれ、
希釈分注操作による希釈誤差が是正されることと
なる。かかる補正は、通常の病院のルーチン検査
においては１カ月に一度程度で充分であり、これ
により正確度の高い多項目分析を簡便に行なうこ
とができることとなる。 In such an automatic biochemical analyzer 1, each sample line 2 includes a sample container 2 into which a sample such as serum is introduced.
1 are sequentially arranged and the empty dilution containers 31 are arranged in the dilution line 3, the dilution dispenser 7 aspirates the diluted standard solution (a 20-fold diluted solution of the undiluted standard solution) at the position c. The sample is dispensed into the cuvette 61 in step e, and the detection output obtained by the analysis section 6 is stored in the calculation section together with the concentration of the diluted standard solution inputted from the outside. This is done for each item.
Next, after nozzle cleaning, the sample is aspirated at position b, diluted and dispensed at position a (the set dilution factor is the same as above, 20 times), and then, after nozzle cleaning, the sample is aspirated at position a.
The diluted sample is suctioned at , and the diluted sample is discharged (dispensed) at position e. This is repeated, and a number of diluted samples corresponding to multiple items are continuously introduced into the cuvette 61 , and the analysis section 6 collects the diluted standard solution. The concentration for each item is calculated based on the concentration and output of. After analyzing a predetermined number of samples, calibration is performed again using the diluted standard solution, and this calibration is also performed at each predetermined analysis cycle. The density value is corrected for each item,
The dilution error caused by the dilution and dispensing operation will be corrected. It is sufficient to perform such correction once a month in routine examinations at a normal hospital, and this allows highly accurate multi-item analysis to be performed easily.
(ト) 発明の効果
この発明の生化学自動分析装置によれば、較正
毎に標準液の試料容器への導入することなく、正
確度の高い多項目分析を行なうことができる。従
つて、大量の試料の多項目生化学分析を行なうル
ーチン検査用の分析装置として極めて有用であ
る。(G) Effects of the Invention According to the automatic biochemical analyzer of the present invention, highly accurate multi-item analysis can be performed without introducing a standard solution into a sample container for each calibration. Therefore, it is extremely useful as an analyzer for routine testing that performs multi-item biochemical analysis of a large amount of samples.
第１図は、この発明の生化学自動分析装置の一
実施例を示す構成説明図、第２図は同じくその一
部を示す平面構成説明図である。
１…生化学自動分析装置、２…試料ライン、３
…希釈ライン、４…サンプリングテーブル、５…
標準液貯蔵、６…生化学分析部、７…回転移動式
希釈分注器、９…制御部、２１…試料容器、３１
…希釈容器。
FIG. 1 is a structural explanatory diagram showing one embodiment of an automatic biochemical analyzer of the present invention, and FIG. 2 is a planar structural explanatory diagram showing a part of the same. 1... Biochemical automatic analyzer, 2... Sample line, 3
...dilution line, 4...sampling table, 5...
Standard solution storage, 6...Biochemical analysis section, 7...Rotating and moving dilution dispenser, 9...Control unit, 21...Sample container, 31
...Dilution container.
Claims (1)
これに対応して複数の希釈容器を配列した希釈ラ
インと(b)既知濃度の希釈標準液を貯留する標準液
貯槽と(c)多項目分析を行なう生化学分析部と(d)上
記試料容器内の試料を吸引し希釈容器内へ所定倍
率で希釈分注し次いでこの希釈試料の所定量を吸
引し生化学分析部へ繰返し分別供給すると共に、
所定の分析サイクル毎に上記標準液貯槽中の希釈
標準液を吸引して生化学分析部へ直接供給しうる
移動希釈分注手段と(e)希釈標準液の濃度及び生化
学分析部への供給時の検知出力に基づいて各試料
中の被検成分の濃度を算出する演算部とを備え、 上記試料容器内に試料の代わりに未希釈標準液
を導入し移動希釈分注手段による希釈分注操作を
介して生化学分析部へ供給した際の検知出力Ａに
より、算出演算のベースとなる希釈標準液の濃度
を各項目について下式：（） Ｃ＝C0・Ａ／Ｂ …（） 〔式中、Ｃは補正された希釈標準液の演算用濃
度、C0は実際の希釈標準液の濃度、Ｂは希釈標
準液の検知出力を示す〕 に基づいて補正する補正演算部を具備したことを
特徴とする生化学自動分析装置。[Claims] 1. (a) A sample line in which a plurality of sample containers are arranged, a dilution line in which a plurality of dilution containers are correspondingly arranged, and (b) a standard solution storage tank in which a diluted standard solution of a known concentration is stored. and (c) a biochemical analysis department that performs multi-item analysis; and (d) aspirates the sample in the sample container, dilutes it at a predetermined ratio into a dilution container, and then aspirates a predetermined amount of this diluted sample for biochemical analysis. In addition to repeatedly separating and supplying
A mobile dilution and dispensing means capable of aspirating the diluted standard solution in the standard solution storage tank and directly supplying it to the biochemical analysis department every predetermined analysis cycle; and (e) determining the concentration of the diluted standard solution and supplying it to the biochemical analysis department. and an arithmetic unit that calculates the concentration of the test component in each sample based on the detection output at the time, and an undiluted standard solution is introduced into the sample container instead of the sample and diluted and dispensed by the mobile dilution and dispenser. Based on the detection output A when supplied to the biochemical analysis department through operation, the concentration of the diluted standard solution, which is the basis for calculation, is calculated for each item using the following formula: () C = C 0 · A / B ... () [ In the formula, C is the concentration for calculation of the corrected diluted standard solution, C0 is the actual concentration of the diluted standard solution, and B is the detection output of the diluted standard solution. Equipped with a correction calculation section that performs correction based on A biochemical automatic analyzer featuring:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15214286A JPS6324164A (en) | 1986-06-27 | 1986-06-27 | Automatic biochemical anlayzing instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15214286A JPS6324164A (en) | 1986-06-27 | 1986-06-27 | Automatic biochemical anlayzing instrument |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6324164A JPS6324164A (en) | 1988-02-01 |
| JPH0363025B2 true JPH0363025B2 (en) | 1991-09-27 |
Family
ID=15533952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15214286A Granted JPS6324164A (en) | 1986-06-27 | 1986-06-27 | Automatic biochemical anlayzing instrument |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6324164A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4528814B2 (en) | 2007-09-10 | 2010-08-25 | 株式会社日立ハイテクノロジーズ | Automatic analyzer and method of operating automatic analyzer |
| JP5054751B2 (en) * | 2009-11-02 | 2012-10-24 | 株式会社日立ハイテクノロジーズ | Automatic analyzer and method of operating automatic analyzer |
-
1986
- 1986-06-27 JP JP15214286A patent/JPS6324164A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6324164A (en) | 1988-02-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3990944B2 (en) | Automatic analyzer | |
| EP1087231B1 (en) | Automatic analysis apparatus | |
| WO2006132211A1 (en) | Automatic analyzing instrument | |
| JP2000105248A (en) | Method for handling organism sample and analyzer | |
| JPH11326332A (en) | Automatic analyzing device | |
| JPH11304797A (en) | Biochemical automatic analysis device | |
| JP2001083081A (en) | Method for preparing nonlinear calibration curve in automatic chemical analysis device | |
| JP5271929B2 (en) | Automatic analyzer | |
| JP2002196005A (en) | Automatic chemical analyzer having recalculating function | |
| JP2001272409A (en) | Analysis device of organism sample | |
| JPS6327661B2 (en) | ||
| JPH0363025B2 (en) | ||
| JP2001264344A (en) | Analyzing device | |
| EP3640647B1 (en) | Automated analysis device | |
| JP3109443U (en) | Automatic analyzer | |
| JPH09257804A (en) | Method and apparatus for automatically analyzing multiple items | |
| JPH047956B2 (en) | ||
| JP2508115B2 (en) | Automatic biochemical analyzer | |
| JPH01212361A (en) | Automatic chemical analyzer | |
| JP2001208762A (en) | Analysis method of bio-sample | |
| JP2533527B2 (en) | Automatic analyzer | |
| JP5192316B2 (en) | Automatic analyzer | |
| JPH04249744A (en) | Automatic apparatus for biochemical analysis | |
| JPS62217163A (en) | Automatic analyzing instrument | |
| EP3992634A1 (en) | Automatic analysis device |