JPH01212361A - Automatic chemical analyzer - Google Patents

Abstract

PURPOSE:To simplify the retrieval of a sample to be reexamined, by retrieving a part necessary for reexamination on the basis of a measuring elapse from a sample to be measured to display the same in a map form. CONSTITUTION:The concn. of the specific component in a reaction liquid containing a sample is measured and, if necessary, the re-measurement of a desired sample is performed. At this time, when abnormal data is detected on the way of the transfer of the sample by a pressure sensor, said data is immediately sent to a reexamination map preparing part 23. The measured result of a desired item transferred to the reaction line part of a measuring part 22 is similarly sent to the preparing part 23. This preparing part 23 retrieves a sample judged to be abnormal on the basis of a present pattern from various data inputted with the elapse of time to display the same on the map of a display part 25 by a mark. Therefore, a reexamination map is displayed on the display part 25 and an operator observes said map to make it possible to simply confirm a pattern necessary for reexamination.

Description

[Detailed Description of the Invention] [Object of the Invention] (Industrial Application Field) The present invention measures the concentration of a specific component in a reaction solution containing a sample, and re-measures a desired sample as necessary. Regarding automatic chemical analysis equipment.

(Prior art) Automated chemical analysis using human serum, etc. as a sample, adding desired reagents to it, and measuring the concentration of specific components in the reaction solution for diagnosis. The device is known.

FIG. 4 shows an example of the configuration of such an analyzer, and the analyzer is roughly divided into a sample supply section 11, a dilution line section 12, and a reaction line section 13. For example, as shown in FIG. 6, the sample supply unit 11 includes a plurality of sample tubes 14 (14a, 14b) that are used as vacuum blood collection tubes and are filled with samples such as serum collected directly from a patient.
, 14C2, . . . ) are arranged, and are sequentially transported in a predetermined direction indicated by an arrow. A barcode label 16 indicating a sample ID is provided on the surface of each sample tube 14, and a plurality of these sample tubes 14, for example, five, are placed together in a sample rack 15.
A sample ID system is adopted in which the samples are stored and handled in the storage section 15a. According to this, advantages such as prevention of specimen (sample) handling errors and rationalization of measurements can be obtained. A sample ID reader 17 for reading the barcode of each sample is provided at an intermediate position on the sample transfer path of the sample supply section 11. The barcode is read through the side opening '15 of the sample rack 15.
This is done via b.

A desired sample is aspirated from each sample tube 14 on the sample rack 15 transferred to the end of the sample supply section 11 by a sample dispensing nozzle 18a that can be moved back and forth, and is transferred to the dilution tube 19 on the dilution line section 12 ( 19a, 19
b, 19c, -). The dilution line section 12 moves each dilution tube 19 at regular intervals using a belt drive mechanism or the like, and dilutes the sample in the dilution tube 19 to a desired ratio using a dilution mechanism (not shown).

A reaction line section 13 is provided adjacent to the dilution line section 12, and a desired sample is aspirated from the dilution tube 19 transferred to a desired position by a sample dispensing nozzle 18b that can be moved back and forth and onto the reaction line section 13. is dispensed into the reaction cell.

FIG. 5 shows an example of the configuration of the reaction line section 13.
A plurality of reaction cells 2 (2a, 2
b, 2c, -) are arranged so as to be stored in the cell cassettes 3, and these cell cassettes 3 are sequentially moved in the direction of arrow Z by a drive source (not shown). The cell cassette 3 can be moved at a constant cycle time through the stop period to sequentially move each reaction cell to the light in each cycle.

A sample dispensing mechanism 4 is disposed at the P1 position on the outer periphery of the thermostatic chamber 1, and has the sample dispensing nozzle 18b, which moves back and forth as necessary to transfer the sample from the dilution tube 19 to the reaction cell. 2, sample dispensing is performed. A reagent dispensing mechanism 6 is arranged at the P2 position, and a desired reagent tube is housed in this mechanism 6, and a plurality of nozzles 7 (7a, 7b, 7c, . . . ) are used to dispense a corresponding reaction as necessary. A desired reagent is dispensed into the cell 2. A stirring mechanism 8 is arranged at the P3 position, and a stirrer 9 stirs the reaction cell 2 at the opposite position. All of these dispensing and stirring operations are performed while the cell cassette 3 is stopped.

Further, a measurement system 10 for measuring the concentration of a specific component in a reaction solution of a sample and a reagent in a reaction cell by, for example, a colorimetric method is disposed at a position in the middle of the thermostatic chamber 1. It consists of a lamp provided on the inner circumference side, a detector provided on the outer circumference side, etc. At the moment when each reaction cell crosses the optical path from the lamp to the detector during rotational movement, the absorbance within this reaction cell is measured by the detector to obtain photometric data. In this way, the desired items [total protein (TP), uric acid (CIA), triglyceride (TG), etc.] for each sample are measured, and the measurement results are sent to the output section 20.
will be printed out on a data sheet.

When performing such chemical analysis, it is desirable to perform accurate measurements on all samples, but in reality, inaccurate measurements may occur due to various reasons. For example, if the amount of sample dispensed is less than the desired amount, or if the sample is not sufficiently diluted and the viscosity of the sample is too high, accurate measurement will not be possible. Therefore, these samples will need to be measured again, necessitating so-called re-examination.

(Problem to be Solved by the Invention) In conventional automatic chemical analyzers, searching for samples to be retested is done by checking the data sheet obtained in the output section, which is time consuming and labor intensive. The problem is that it becomes a hassle.

The present invention was made in response to the above circumstances.
It is an object of the present invention to provide an automatic chemical analyzer that can easily search for samples to be retested.

[Structure of the Invention] (Means for Solving the Problems) In order to achieve the above object, the present invention searches for samples that require re-inspection based on the measurement progress from among the samples to be measured, and maps them on the display section. The present invention is equipped with a re-examination map creation section that displays the map in the form of a re-examination map.

(Function) The sample to be measured is transferred through the measurement path and the measurement result is finally output, but in the course of a series of measurements, samples that cannot be measured or samples with abnormal measurement results are found and may need to be retested. memorized as a target. These samples that were subject to re-inspection are then displayed on the display in the form of a map reflecting the layout of the measurement path. Therefore, the operator can easily confirm which samples require retesting by observing the display section.

(Embodiment) FIG. 1 is a block diagram showing an embodiment of the automatic chemical analyzer of the present invention, in which the measurement item selection section 21 consists of a keyboard etc. arranged in the console section of the instrument, and can be used to operate desired key switches. The desired measurement item (T
R, UA, TG, etc.) is selected and the necessary information is input. The measuring section 22 is a block for actually analyzing the target sample, and is configured as shown in FIG. 4. In particular, the desired item is measured in the reaction line section 13 as shown in FIG. The measurement results are sent to the output section 20 and printed out on a data sheet.

Further, this measurement result is sent to a re-examination map creation section 23, which will be described later. The measurement section 22 operates not only to send measurement result data to the retest map creation section 23, but also to detect abnormal data in the course of measurement and send these data to the retest map creation section 23 each time. These abnormal data are data that mean that it has become impossible to measure the sample during sample transfer. For example, the sample dispensing nozzles 18a and 18b in FIG. When there is a problem such as dry suction, clogging, etc., it sends detection data of these phenomena. Detection of such data can be carried out, for example, by using the nozzle pipe 2 as shown in FIG.
This can be easily achieved by providing a pressure sensor 28 in the middle of the pressure sensor 7.

The re-examination map creation section 23 is comprised of a microprocessor, memory, etc., and searches for samples that require re-examination based on the data sent from the measuring section 22, creates a re-examination map, and displays it on the display section 25, which will be described later. It is for. Samples subject to re-examination include those for which abnormal data was detected during transportation as described above, as well as samples for which measurement results have been obtained after measurement has been completed and that are clearly abnormal and outside the logic check setting range. Those that show data can be listed. Data showing such abnormal results are caused by insufficient dilution. Based on the data sent to the re-examination map creation section 23 in this way, a pattern that is regarded as abnormal data is preset in the processor. The retest map creation unit 23 holds in its memory a map as shown in FIG. 2 that reflects the layout of the samples placed in the reaction line unit 13 in advance, and indicates that retesting is necessary based on the input data. It has a function that sequentially marks and displays samples that are considered as such on the map. Examples of means for displaying this mark include a method in which only the target sample is made to blink, and in the case of color display, a method in which the target sample is displayed in a different color from other samples. In FIG. 2, as an example, diagonally shaded samples indicate samples that require re-examination.

The display control section 24 converts the signal sent from the reexamination map creation section 23 into a display pattern, and causes the display section 25 to display samples that require reexamination in the form of a reexamination map. Display section 25
consists of a well-known CRT display or the like.

The control unit 26 is in charge of controlling the entire device, which is composed of a dedicated microprocessor.

Next, the operation of this embodiment will be explained.

When a desired sample is analyzed using the apparatus configured as shown in FIG. 4, if abnormal data is detected by the pressure sensor 28 or the like shown in FIG. 7 during sample transfer, this abnormal data is immediately sent to the retest map creation section. Sent to 23rd. On the other hand, the measurement results of the sample transferred to the reaction line section 13 and subjected to measurement of desired items as shown in FIG. 5 are similarly sent to the retest map creation section 23. The re-examination map creation section 23 searches for samples that can be regarded as abnormal data based on the preset patterns of the various data input over time in this way, and displays them on the map on the display section 25 as shown in FIG. Display the mark with .

As a result, the reexamination map is displayed on the display section 25, so that the operator can easily confirm patterns that require reexamination by observing the display section 25. Therefore, unlike in the past, the user no longer has to wait until the data sheet is completely printed out, so that re-examination operations can be started quickly.

FIG. 3 shows another embodiment of the present invention, in which the retest map is adapted to the case where the reaction line section 13 is constituted by a circular constant temperature bath 1.

In this case as well, the same effects as in the embodiment described above can be obtained.

In the explanation in the main text, we have given an example of how abnormal data is detected, but this is not the only example; by similarly installing optimal sensors at necessary positions on the sample transfer route, we can detect more causes of abnormalities. It can be dealt with.

[Effects of the Invention] As described above, according to the present invention, the retest map is displayed after searching for those that require retesting from among the samples to be measured. This allows you to easily check which samples require re-examination.

[Brief explanation of the drawing]

FIG. 1 is a block diagram showing an embodiment of the automatic chemical analyzer of the present invention, FIG. 2 is an example of a retest map displayed by the device of this embodiment, and FIG. 3 is a table of a retest map according to another embodiment of the present invention. As an example, FIG. 4 is a plan view showing the configuration of an automatic chemical analyzer,
FIG. 5 is a plan view showing the configuration of the reaction line section of the automatic chemical analyzer, FIG. 6 is a perspective view showing an example of a sample rack and sample tube used in the automatic chemical analyzer, and FIG. 7 is the device of this embodiment. FIG. 2 is a perspective view showing the main parts of a sample dispensing nozzle used in FIG. 11... Sample supply section, 12... Dilution line section,
13... Reaction line section, 20... Output section, 21...
・Measurement item selection section, 22...Measurement section, 23...Retest map creation section, 25...Display section. +8b Figure 5

Claims (1)

[Claims] In an automatic chemical analyzer that measures the concentration of a specific component in a reaction solution containing a sample and re-measures the desired sample as necessary, there is a display section that displays the measurement results of the sample, and a display section that displays the sample measurement results. 1. An automatic chemical analyzer comprising: a retest map creation unit that searches for items that require remeasurement from the list and displays them on the display unit in the form of a map.