JPH0360817B2 - - Google Patents

Info

Publication number
JPH0360817B2
JPH0360817B2 JP62264043A JP26404387A JPH0360817B2 JP H0360817 B2 JPH0360817 B2 JP H0360817B2 JP 62264043 A JP62264043 A JP 62264043A JP 26404387 A JP26404387 A JP 26404387A JP H0360817 B2 JPH0360817 B2 JP H0360817B2
Authority
JP
Japan
Prior art keywords
mol
formula
diarylamine
phenyl
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP62264043A
Other languages
English (en)
Japanese (ja)
Other versions
JPS63122660A (ja
Inventor
Kinasee Borufuramu
Furanke Yoahimu
Fuiige Herumuuto
Bedemaiyaa Karurufuriito
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of JPS63122660A publication Critical patent/JPS63122660A/ja
Publication of JPH0360817B2 publication Critical patent/JPH0360817B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP62264043A 1986-10-24 1987-10-21 Ｎ，ｎ−ジアリール−尿素の製造法 Granted JPS63122660A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3636190.9 1986-10-24
DE19863636190 DE3636190A1 (de) 1986-10-24 1986-10-24 Verfahren zur herstellung von n,n-diaryl-harnstoffen

Publications (2)

Publication Number Publication Date
JPS63122660A JPS63122660A (ja) 1988-05-26
JPH0360817B2 true JPH0360817B2 (en:Method) 1991-09-17

Family

ID=6312378

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62264043A Granted JPS63122660A (ja) 1986-10-24 1987-10-21 Ｎ，ｎ−ジアリール−尿素の製造法

Country Status (7)

Country Link
US (1) US4820871A (en:Method)
EP (1) EP0264752B1 (en:Method)
JP (1) JPS63122660A (en:Method)
CA (1) CA1295340C (en:Method)
DE (2) DE3636190A1 (en:Method)
DK (1) DK555687A (en:Method)
ES (1) ES2016957B3 (en:Method)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59007989D1 (de) * 1989-07-28 1995-01-26 Chemie Linz Gmbh Verfahren zur Herstellung unsymmetrisch substituierter Harnstoffe.
US5248755A (en) * 1989-07-28 1993-09-28 Chemie Linz Gesellschaft M.B.H. Process for the preparation of asymmetrically substituted ureas, carbamates or thiocarbamates
US5220061A (en) * 1992-02-07 1993-06-15 Arco Chemical Technology, L.P. Selective process for the preparation of diphenylmethane bis-(dialkyl ureas
JP3372436B2 (ja) * 1996-11-28 2003-02-04 オークマ株式会社 インバータの制御装置
US6344476B1 (en) 1997-05-23 2002-02-05 Bayer Corporation Inhibition of p38 kinase activity by aryl ureas
US7517880B2 (en) 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US20080300281A1 (en) * 1997-12-22 2008-12-04 Jacques Dumas Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas
US7329670B1 (en) * 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
US20080269265A1 (en) * 1998-12-22 2008-10-30 Scott Miller Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas
RU2319693C9 (ru) 1999-01-13 2008-08-20 Байер Копэрейшн Производные мочевины (варианты), фармацевтическая композиция (варианты) и способ лечения заболевания, связанного с ростом раковых клеток (варианты)
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
ATE538794T1 (de) * 1999-01-13 2012-01-15 Bayer Healthcare Llc Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer
US7928239B2 (en) 1999-01-13 2011-04-19 Bayer Healthcare Llc Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
EP1140840B1 (en) 1999-01-13 2006-03-22 Bayer Pharmaceuticals Corp. -g(v)-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
MXPA02002578A (es) * 1999-09-08 2002-10-23 Guilford Pharm Inc Compuestos de union a ciclofilina no peptidicos, y su uso.
US7235576B1 (en) 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP1360173A2 (en) 2001-01-25 2003-11-12 Guilford Pharmaceuticals Inc. Trisubstituted carbocyclic cyclophilin binding compounds and their use
US7371763B2 (en) * 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
ATE345130T1 (de) * 2001-12-03 2006-12-15 Bayer Pharmaceuticals Corp Arylharnstoff-verbindungen in kombination mit anderen zytostatisch oder zytotoxisch wirksamen stoffen zur behandlungen menschlicher krebserkrankungen
US20080108672A1 (en) * 2002-01-11 2008-05-08 Bernd Riedl Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors
US20030216396A1 (en) * 2002-02-11 2003-11-20 Bayer Corporation Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors
US7838541B2 (en) 2002-02-11 2010-11-23 Bayer Healthcare, Llc Aryl ureas with angiogenesis inhibiting activity
PT1580188E (pt) 2002-02-11 2012-01-25 Bayer Healthcare Llc Aril-ureias como inibidores de cinases
US20040023961A1 (en) * 2002-02-11 2004-02-05 Bayer Corporation Aryl ureas with raf kinase and angiogenisis inhibiting activity
UY28213A1 (es) 2003-02-28 2004-09-30 Bayer Pharmaceuticals Corp Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
WO2004113274A2 (en) * 2003-05-20 2004-12-29 Bayer Pharmaceuticals Corporation Diaryl ureas with kinase inhibiting activity
RS52625B (sr) * 2003-07-23 2013-06-28 Bayer Healthcare Llc Fluoro supstituisana omega-karboksiaril difenil urea za lečenje i prevenciju bolesti i stanja bolesti
ATE517885T1 (de) * 2004-04-30 2011-08-15 Bayer Healthcare Llc Substituierte pyrazolyl-harnstoff-derivate zur behandlung von krebs
CN102924336A (zh) * 2012-09-28 2013-02-13 黎明化工研究设计院有限责任公司 一种制备n-甲基-n’，n’-二苯基脲的方法
CN103232371B (zh) * 2013-04-26 2014-11-26 黎明化工研究设计院有限责任公司 一种制备n-甲基-n’，n’-二苯基脲的方法
US10927227B2 (en) * 2017-07-11 2021-02-23 Covestro Deutschland Ag Flexible foam with halogen-free flame retardant
KR102790008B1 (ko) * 2018-12-07 2025-04-07 다우 글로벌 테크놀로지스 엘엘씨 모노이소시아네이트를 요소로 전환하는 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2683727A (en) * 1954-07-13 Secondary aromatic amines
CH513134A (de) * 1968-06-10 1971-09-30 Bayer Ag Verfahren zur Herstellung von N-Arylharnstoffen
JPS5419937A (en) * 1977-07-12 1979-02-15 Showa Denko Kk Preparation of urea substitution product
DE2928485A1 (de) * 1979-07-14 1981-01-29 Bayer Ag Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen
CH649078A5 (de) * 1980-01-25 1985-04-30 Reanal Finomvegyszergyar Verfahren zur herstellung von n-mono- oder disubstituierten n-aryl-harnstoff-derivaten.
IT1137177B (it) * 1981-06-02 1986-09-03 Anic Spa Processo per la preparazione di uree asimmetriche a partire da uretani ed ammine
US4473579A (en) * 1982-01-26 1984-09-25 American Cyanamid Company Antiatherosclerotic tetrasubstituted ureas and thioureas

Also Published As

Publication number Publication date
CA1295340C (en) 1992-02-04
DE3636190A1 (de) 1988-04-28
EP0264752B1 (de) 1990-08-29
ES2016957B3 (es) 1990-12-16
DK555687D0 (da) 1987-10-23
EP0264752A1 (de) 1988-04-27
US4820871A (en) 1989-04-11
DK555687A (da) 1988-04-25
JPS63122660A (ja) 1988-05-26
DE3764602D1 (de) 1990-10-04

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