ES2016957B3 - Procedimiento para la obtencion de n,n'-diarilreas. - Google Patents
Procedimiento para la obtencion de n,n'-diarilreas.Info
- Publication number
- ES2016957B3 ES2016957B3 ES87114817T ES87114817T ES2016957B3 ES 2016957 B3 ES2016957 B3 ES 2016957B3 ES 87114817 T ES87114817 T ES 87114817T ES 87114817 T ES87114817 T ES 87114817T ES 2016957 B3 ES2016957 B3 ES 2016957B3
- Authority
- ES
- Spain
- Prior art keywords
- diarilreas
- procedure
- obtaining
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
- C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
- C07C273/1827—X being H
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19863636190 DE3636190A1 (de) | 1986-10-24 | 1986-10-24 | Verfahren zur herstellung von n,n-diaryl-harnstoffen |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2016957B3 true ES2016957B3 (es) | 1990-12-16 |
Family
ID=6312378
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES87114817T Expired - Lifetime ES2016957B3 (es) | 1986-10-24 | 1987-10-10 | Procedimiento para la obtencion de n,n'-diarilreas. |
Country Status (7)
Country | Link |
---|---|
US (1) | US4820871A (es) |
EP (1) | EP0264752B1 (es) |
JP (1) | JPS63122660A (es) |
CA (1) | CA1295340C (es) |
DE (2) | DE3636190A1 (es) |
DK (1) | DK555687A (es) |
ES (1) | ES2016957B3 (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5248755A (en) * | 1989-07-28 | 1993-09-28 | Chemie Linz Gesellschaft M.B.H. | Process for the preparation of asymmetrically substituted ureas, carbamates or thiocarbamates |
EP0410168B1 (de) * | 1989-07-28 | 1994-12-14 | Chemie Linz GmbH | Verfahren zur Herstellung unsymmetrisch substituierter Harnstoffe |
US5220061A (en) * | 1992-02-07 | 1993-06-15 | Arco Chemical Technology, L.P. | Selective process for the preparation of diphenylmethane bis-(dialkyl ureas |
JP3372436B2 (ja) * | 1996-11-28 | 2003-02-04 | オークマ株式会社 | インバータの制御装置 |
US6344476B1 (en) | 1997-05-23 | 2002-02-05 | Bayer Corporation | Inhibition of p38 kinase activity by aryl ureas |
US7517880B2 (en) * | 1997-12-22 | 2009-04-14 | Bayer Pharmaceuticals Corporation | Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas |
US7329670B1 (en) * | 1997-12-22 | 2008-02-12 | Bayer Pharmaceuticals Corporation | Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas |
US20080300281A1 (en) * | 1997-12-22 | 2008-12-04 | Jacques Dumas | Inhibition of p38 Kinase Activity Using Aryl and Heteroaryl Substituted Heterocyclic Ureas |
US20080269265A1 (en) * | 1998-12-22 | 2008-10-30 | Scott Miller | Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas |
US7928239B2 (en) | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
US8124630B2 (en) * | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
RU2319693C9 (ru) * | 1999-01-13 | 2008-08-20 | Байер Копэрейшн | Производные мочевины (варианты), фармацевтическая композиция (варианты) и способ лечения заболевания, связанного с ростом раковых клеток (варианты) |
WO2000041698A1 (en) * | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXY ARYL SUBSTITUTED DIPHENYL UREAS AS p38 KINASE INHIBITORS |
WO2000042012A1 (en) | 1999-01-13 | 2000-07-20 | Bayer Corporation | φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS |
MXPA02002578A (es) * | 1999-09-08 | 2002-10-23 | Guilford Pharm Inc | Compuestos de union a ciclofilina no peptidicos, y su uso. |
US7235576B1 (en) | 2001-01-12 | 2007-06-26 | Bayer Pharmaceuticals Corporation | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
MXPA03006666A (es) | 2001-01-25 | 2004-05-31 | Guilford Pharm Inc | Compuestos de union de ciclofilina carbociclicos trisubstituidos y su uso. |
US7371763B2 (en) * | 2001-04-20 | 2008-05-13 | Bayer Pharmaceuticals Corporation | Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas |
RS52500B (en) * | 2001-12-03 | 2013-04-30 | Bayer Healthcare Llc | Aryl of urea compounds in combination with other cytostatic or cytotoxic agents for the treatment of human cancers |
US20080108672A1 (en) * | 2002-01-11 | 2008-05-08 | Bernd Riedl | Omega-Carboxyaryl Substituted Diphenyl Ureas As Raf Kinase Inhibitors |
AU2003209119A1 (en) | 2002-02-11 | 2003-09-04 | Bayer Pharmaceuticals Corporation | Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors |
US20040023961A1 (en) * | 2002-02-11 | 2004-02-05 | Bayer Corporation | Aryl ureas with raf kinase and angiogenisis inhibiting activity |
CN1318404C (zh) | 2002-02-11 | 2007-05-30 | 拜耳制药公司 | 作为激酶抑制剂的芳基脲类化合物 |
PT1478358E (pt) * | 2002-02-11 | 2013-09-11 | Bayer Healthcare Llc | Tosilato de sorafenib para o tratamento de doenças caracterizadas por angiogénese anormal |
US7557129B2 (en) * | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
PL1626714T3 (pl) * | 2003-05-20 | 2007-12-31 | Bayer Healthcare Llc | Diarylowe pochodne mocznika do schorzeń, w których pośredniczy PDGFR |
CN1856469B (zh) * | 2003-07-23 | 2013-03-06 | 拜耳医药保健有限责任公司 | 用于治疗和预防疾病和疾病症状的氟代ω-羧芳基二苯基脲 |
CN101010315A (zh) * | 2004-04-30 | 2007-08-01 | 拜耳制药公司 | 用于治疗癌症的取代的吡唑基脲衍生物 |
CN102924336A (zh) * | 2012-09-28 | 2013-02-13 | 黎明化工研究设计院有限责任公司 | 一种制备n-甲基-n’,n’-二苯基脲的方法 |
CN103232371B (zh) * | 2013-04-26 | 2014-11-26 | 黎明化工研究设计院有限责任公司 | 一种制备n-甲基-n’,n’-二苯基脲的方法 |
WO2020117408A1 (en) * | 2018-12-07 | 2020-06-11 | Dow Global Technologies Llc | Method for converting monoisocyanates to ureas |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2683727A (en) * | 1954-07-13 | Secondary aromatic amines | ||
CH513134A (de) * | 1968-06-10 | 1971-09-30 | Bayer Ag | Verfahren zur Herstellung von N-Arylharnstoffen |
JPS5419937A (en) * | 1977-07-12 | 1979-02-15 | Showa Denko Kk | Preparation of urea substitution product |
DE2928485A1 (de) * | 1979-07-14 | 1981-01-29 | Bayer Ag | Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen |
BR8106184A (pt) * | 1980-01-25 | 1981-11-24 | Reanal Finomvegyszergyar | Processo para preparacao de derivados de n-aril-n'-(mono-ou dissubstituido)-ureia |
IT1137177B (it) * | 1981-06-02 | 1986-09-03 | Anic Spa | Processo per la preparazione di uree asimmetriche a partire da uretani ed ammine |
US4473579A (en) * | 1982-01-26 | 1984-09-25 | American Cyanamid Company | Antiatherosclerotic tetrasubstituted ureas and thioureas |
-
1986
- 1986-10-24 DE DE19863636190 patent/DE3636190A1/de not_active Withdrawn
-
1987
- 1987-10-07 US US07/105,856 patent/US4820871A/en not_active Expired - Fee Related
- 1987-10-10 ES ES87114817T patent/ES2016957B3/es not_active Expired - Lifetime
- 1987-10-10 EP EP87114817A patent/EP0264752B1/de not_active Expired - Lifetime
- 1987-10-10 DE DE8787114817T patent/DE3764602D1/de not_active Expired - Lifetime
- 1987-10-21 JP JP62264043A patent/JPS63122660A/ja active Granted
- 1987-10-22 CA CA000549951A patent/CA1295340C/en not_active Expired - Lifetime
- 1987-10-23 DK DK555687A patent/DK555687A/da not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DK555687D0 (da) | 1987-10-23 |
DE3636190A1 (de) | 1988-04-28 |
DK555687A (da) | 1988-04-25 |
JPH0360817B2 (es) | 1991-09-17 |
EP0264752A1 (de) | 1988-04-27 |
EP0264752B1 (de) | 1990-08-29 |
DE3764602D1 (de) | 1990-10-04 |
JPS63122660A (ja) | 1988-05-26 |
CA1295340C (en) | 1992-02-04 |
US4820871A (en) | 1989-04-11 |
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