JPH0352478B2 - - Google Patents

Info

Publication number
JPH0352478B2
JPH0352478B2 JP58112956A JP11295683A JPH0352478B2 JP H0352478 B2 JPH0352478 B2 JP H0352478B2 JP 58112956 A JP58112956 A JP 58112956A JP 11295683 A JP11295683 A JP 11295683A JP H0352478 B2 JPH0352478 B2 JP H0352478B2
Authority
JP
Japan
Prior art keywords
isoglutamine
alanyl
mdp
effect
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP58112956A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5931745A (ja
Inventor
Furegeru Marutein
Kuroidoro Miran
Korinsukii Iri
Maseku Kareru
Seifueruto Yarosurafu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SUHOFUA SUHOENE HODONIKI PURO ZUDORABOTONIKO BUIROBU
Original Assignee
SUHOFUA SUHOENE HODONIKI PURO ZUDORABOTONIKO BUIROBU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SUHOFUA SUHOENE HODONIKI PURO ZUDORABOTONIKO BUIROBU filed Critical SUHOFUA SUHOENE HODONIKI PURO ZUDORABOTONIKO BUIROBU
Publication of JPS5931745A publication Critical patent/JPS5931745A/ja
Publication of JPH0352478B2 publication Critical patent/JPH0352478B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP58112956A 1982-06-29 1983-06-24 Ｌ―アラニル―ｄ―イソグルタミンアダマンチルアミド及びその製造方法 Granted JPS5931745A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CS824908A CS231221B1 (en) 1982-06-29 1982-06-29 L-alanyl-d-isoglutamine adamantylamide
CS4908-82 1982-06-29

Publications (2)

Publication Number Publication Date
JPS5931745A JPS5931745A (ja) 1984-02-20
JPH0352478B2 true JPH0352478B2 (enExample) 1991-08-12

Family

ID=5392849

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58112956A Granted JPS5931745A (ja) 1982-06-29 1983-06-24 Ｌ―アラニル―ｄ―イソグルタミンアダマンチルアミド及びその製造方法

Country Status (9)

Country Link
US (1) US4515715A (enExample)
EP (1) EP0098520B1 (enExample)
JP (1) JPS5931745A (enExample)
AT (1) ATE17652T1 (enExample)
CS (1) CS231221B1 (enExample)
DD (1) DD217210A1 (enExample)
DE (1) DE3362009D1 (enExample)
HU (1) HU194911B (enExample)
MX (1) MX156864A (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS231221B1 (en) * 1982-06-29 1984-10-15 Martin Flegel L-alanyl-d-isoglutamine adamantylamide
FR2572399B1 (fr) * 1984-10-31 1987-01-16 Panmedica Sa Nouveaux derives de l'adamantanamine, leurs procedes de preparation et medicaments les contenant
YU30589A (en) * 1989-02-09 1991-10-31 Imunoloski Z Zagreb New adamantyl containing tripeptides and it's hydrochloride and process for preparing and use
IT1264129B1 (it) * 1993-04-09 1996-09-16 Codev S A Peptidi ad attivita' immunomodulatoria derivati da frammenti di leucochinina
AU4251300A (en) 1999-05-07 2000-11-21 University Of Virginia Patent Foundation Biological production of stable glutamine, poly-glutamine derivatives in transgenic organisms and their use for therapeutic purposes
WO2005016959A1 (en) * 2003-08-13 2005-02-24 Pepharm R & D Limited Biologically active peptides comprising phenylalanyl-glutamate (fe) and phenylalanyl-glutamyl-glutamate (fee)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2482957A2 (fr) * 1979-06-29 1981-11-27 Rhone Poulenc Ind Nouveaux dipeptides, leur preparation et les medicaments qui les contiennent
US4273704A (en) * 1979-12-03 1981-06-16 G. D. Searle & Co. N-Adamantane-substituted tetrapeptide amides
CS231221B1 (en) * 1982-06-29 1984-10-15 Martin Flegel L-alanyl-d-isoglutamine adamantylamide

Also Published As

Publication number Publication date
CS490882A1 (en) 1984-02-13
EP0098520B1 (de) 1986-01-29
US4515715A (en) 1985-05-07
ATE17652T1 (de) 1986-02-15
DD217210A1 (de) 1985-01-09
MX156864A (es) 1988-10-07
JPS5931745A (ja) 1984-02-20
HU194911B (en) 1988-03-28
EP0098520A1 (de) 1984-01-18
DE3362009D1 (en) 1986-03-13
CS231221B1 (en) 1984-10-15

Similar Documents

Publication Publication Date Title
FI64164B (fi) Foerfarande foer framstaellning av 2-(2-acylamino-2-desoxi-(d)-glukosyl-3-0)-alkankarboxylsyrapeptid-derivat
CA2854725C (en) Methods for preparation of glycosphingolipids and uses thereof
RU2060996C1 (ru) Производные аденозина
JPH02200691A (ja) リゾスフィンゴ脂質誘導体
JPS638119B2 (enExample)
JPH0352478B2 (enExample)
AU596800B2 (en) Improvements in or relating to organic compounds
EP0100104B1 (en) Muramyldipeptide derivatives
Kafarski et al. N-(Phosphonoacetyl) amino phosphonates. Phosphonate analogs of N-(phosphonoacetyl)-L-aspartic acid (PALA)
WO2003106481A1 (en) A process of producing ala-glu dipeptide
US4472379A (en) Nitrosourea derivatives
TW202136227A (zh) 合成方法及中間體
US4165312A (en) Phosphorylated nonapeptides, processes for the preparation thereof and pharmaceutical compositions containing them
US6518254B1 (en) Ribonucleoside-TRIBOSE
JPS5973551A (ja) ペプチド及びプソイドペプチド誘導体、その製造法及びこれを含有し選択的阿片剤δ受体「きつ」抗性製薬組成物
PT97281A (pt) Processo para a preparacao de novos derivados contendo fosforo
CA1206958A (en) L-alanyl-d-isoglutamine adamantylamide
JPS5951935B2 (ja) 新規なペプチドおよびその製造法
US3341510A (en) L-alanyl-l-phenylalanyl-l-isoleucyl-glycyl-l-leucyl-l-methioninamide and a protectedderivative thereof
CN103242432A (zh) 通过氢亚磷酸二酯中间体合成磷氨米酮的方法
JP2640980B2 (ja) Ｎ▲上６▼，ｎ▲上６▼―ジ置換―アデノシン―３’，５’―環状リン酸及びその製法
JPH0414120B2 (enExample)
EP0355899A2 (en) Nucleotide derivatives
Nagasawa et al. Latentiated forms of the transport‐inhibitory α‐amino acid adamantanine
Watanabe et al. Nucleosides. LXXX. Synthetic Studies of Nucleoside Antibiotics. 10. Synthesis of 1-[2, 3, 4-Trideoxy-4-(sarcosyl-D-seryl) amino-β-D-erythrohex-2-enopyranosyluronic acid] cytosine, the Nucleoside of Blasticidin S Bearing the Dipeptide of Gougerotin