JPH0350745B2 - - Google Patents
Info
- Publication number
- JPH0350745B2 JPH0350745B2 JP57161094A JP16109482A JPH0350745B2 JP H0350745 B2 JPH0350745 B2 JP H0350745B2 JP 57161094 A JP57161094 A JP 57161094A JP 16109482 A JP16109482 A JP 16109482A JP H0350745 B2 JPH0350745 B2 JP H0350745B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- hydroxy
- carbon atoms
- phenyl
- propoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims 44
- 125000000217 alkyl group Chemical group 0.000 claims 32
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 18
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 17
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 12
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 229910052757 nitrogen Inorganic materials 0.000 claims 9
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 8
- 229910052801 chlorine Inorganic materials 0.000 claims 8
- 125000001309 chloro group Chemical group Cl* 0.000 claims 8
- 229910052731 fluorine Inorganic materials 0.000 claims 8
- 125000001153 fluoro group Chemical group F* 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 6
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 4
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 4
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 4
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 4
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 125000005359 phenoxyalkyl group Chemical group 0.000 claims 4
- 125000003884 phenylalkyl group Chemical group 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- PVOAHINGSUIXLS-UHFFFAOYSA-N 1-Methylpiperazine Chemical compound CN1CCNCC1 PVOAHINGSUIXLS-UHFFFAOYSA-N 0.000 claims 2
- -1 diisopropylamino group Chemical group 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3137178.7 | 1981-08-18 | ||
| DE3137178 | 1981-09-18 | ||
| DE3226863.7 | 1982-07-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5877847A JPS5877847A (ja) | 1983-05-11 |
| JPH0350745B2 true JPH0350745B2 (enrdf_load_stackoverflow) | 1991-08-02 |
Family
ID=6142051
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57161094A Granted JPS5877847A (ja) | 1981-08-18 | 1982-09-17 | ２―ヒドロキシ―β―フェニル―プロピオフェノンのアミノプロパノール誘導体、その製法及びそれを含有する心膊障害及び冠動脈性心臓疾患の治療薬 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS5877847A (enrdf_load_stackoverflow) |
| ZA (1) | ZA826832B (enrdf_load_stackoverflow) |
-
1982
- 1982-09-17 JP JP57161094A patent/JPS5877847A/ja active Granted
- 1982-09-17 ZA ZA826832A patent/ZA826832B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5877847A (ja) | 1983-05-11 |
| ZA826832B (en) | 1983-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US3152173A (en) | Basically substituted diphenyl-methane derivatives and process for preparing them | |
| FI77224C (fi) | Foerfarande foer framstaellning av nya, terapeutiskt anvaendbara aminopropanolderivat av 2-hydroxi- -fenylpropiofenoner. | |
| PL113879B1 (en) | Process for preparing novel racemic or optically active1-aryloxy-2-hydroxy-3-alkylenaminopropanes | |
| IE60028B1 (en) | New diphenylpropylamine derivatives, processes for their preparation and their pharmaceutical use | |
| US5296596A (en) | Hexahydroazepine derivatives, a process for their preparation | |
| US4540697A (en) | Aminopropanol derivatives of 2-hydroxy-β-phenyl-propiophenones, pharmaceutical compositions and use | |
| US5747508A (en) | Amidinohydrazones of ketones derived from benzo B!furan, methods for their production, and pharmaceuticals containing these compounds | |
| JPH0350745B2 (enrdf_load_stackoverflow) | ||
| IL32481A (en) | Diphenylmethoxyethylamino derivatives,their preparation and pharmaceutical compositions containing them | |
| CA1233465A (en) | Aminopropanol derivatives of substituted 2-hydroxy- propiophenones, their preparation, and therapeutic agents containing these compounds | |
| EP0346367A1 (de) | Aryl- und aryloxy-substituierte tert.-alkylenamine, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung | |
| HU212415B (en) | Process for producing new cyclic oxym derivatives and pharmaceutical compositions containing them as active components | |
| EP0037062B1 (de) | Substituierte 3-Aryl-2-cycloalken-1-one, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel | |
| EP0352639B1 (de) | p-Hydroxiphenon-Derivate und deren Anwendung | |
| CS207621B2 (en) | Method of making the derivatives of the alpha-methyl-beta-aminopropiophenon | |
| US4612320A (en) | Aminopropanol derivatives of 1-(2-hydroxyphenyl)-3-phenylpropanols and therapeutic agents containing these compounds | |
| SU663305A3 (ru) | Способ получени производных м-диоксан-5-метиламина | |
| US4201790A (en) | Benzophenone derivatives | |
| NO167975B (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive aminopropanolderivater av 3-(3-hydroksyfenyl)-1-propanonforbindelser. | |
| EP0043971B1 (de) | Indanon-oxyalkyl-piperazinderivate, ihre Herstellung und diese enthaltende pharmazeutische Zubereitungen | |
| DE3328376A1 (de) | Aminopropanolderivate von 2-hydroxy-ss-phenyl-propiophenonen, verfahren zu ihrer herstellung und diese enthaltende arzneimittel | |
| DK144299B (da) | Analogifremgangsmaade til fremstilling af 1-fenyl2-amino-1,3-propandiol-n-alkyl-derivater eller fysiologisk acceptable salte deraf | |
| DE4112353A1 (de) | 1,3,4-trisubstituierte piperidin-derivate, ihre herstellung und verwendung | |
| NO167974B (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive aminopropanolderivater av 3-(2-hydroksyfenyl)-1-propanonforbindelser. | |
| CS236500B2 (en) | Method of aminopropanol derivatives production |