JPH0345047B2 - - Google Patents
Info
- Publication number
- JPH0345047B2 JPH0345047B2 JP11947382A JP11947382A JPH0345047B2 JP H0345047 B2 JPH0345047 B2 JP H0345047B2 JP 11947382 A JP11947382 A JP 11947382A JP 11947382 A JP11947382 A JP 11947382A JP H0345047 B2 JPH0345047 B2 JP H0345047B2
- Authority
- JP
- Japan
- Prior art keywords
- piperazinyl
- benzodioxepine
- acetyl
- hydroxyethyl
- benzodioxole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 14
- 239000004480 active ingredient Substances 0.000 claims description 9
- 125000002947 alkylene group Chemical group 0.000 claims description 5
- 125000005843 halogen group Chemical group 0.000 claims description 5
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
- 229940030600 antihypertensive agent Drugs 0.000 claims description 3
- 239000002220 antihypertensive agent Substances 0.000 claims description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
- 125000002252 acyl group Chemical group 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- -1 lithium aluminum hydride Chemical compound 0.000 description 63
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 42
- 150000001875 compounds Chemical class 0.000 description 35
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 29
- 238000006243 chemical reaction Methods 0.000 description 23
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 15
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 11
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 11
- 239000002904 solvent Substances 0.000 description 11
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 10
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 239000007788 liquid Substances 0.000 description 7
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000000704 physical effect Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 5
- 150000001412 amines Chemical class 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 4
- 239000013078 crystal Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 125000002490 anilino group Chemical class [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 3
- 239000002585 base Substances 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical compound C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 description 3
- 150000004885 piperazines Chemical class 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000006188 syrup Substances 0.000 description 3
- 235000020357 syrup Nutrition 0.000 description 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 3
- FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical compound C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 description 2
- DPZDJGRIQFGMEL-UHFFFAOYSA-N 1-(1,3-benzodioxol-5-yl)-3-(4-phenylpiperazin-1-yl)propan-1-one Chemical compound C=1C=C2OCOC2=CC=1C(=O)CCN(CC1)CCN1C1=CC=CC=C1 DPZDJGRIQFGMEL-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000007059 acute toxicity Effects 0.000 description 2
- 231100000403 acute toxicity Toxicity 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 230000003276 anti-hypertensive effect Effects 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 239000012280 lithium aluminium hydride Substances 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 239000003921 oil Substances 0.000 description 2
- 235000019198 oils Nutrition 0.000 description 2
- 238000007911 parenteral administration Methods 0.000 description 2
- 239000002504 physiological saline solution Substances 0.000 description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
- 239000012279 sodium borohydride Substances 0.000 description 2
- 229910000033 sodium borohydride Inorganic materials 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical class O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 2
- 238000011699 spontaneously hypertensive rat Methods 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- XGNXYCFREOZBOL-UHFFFAOYSA-N 1,3-benzodioxol-5-amine Chemical compound NC1=CC=C2OCOC2=C1 XGNXYCFREOZBOL-UHFFFAOYSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- JFFKDARGDHJTFW-UHFFFAOYSA-N 1-(1,3-benzodioxol-5-yl)-2-[4-(3-chlorophenyl)piperazin-1-yl]ethanol Chemical compound C=1C=C2OCOC2=CC=1C(O)CN(CC1)CCN1C1=CC=CC(Cl)=C1 JFFKDARGDHJTFW-UHFFFAOYSA-N 0.000 description 1
- FZRBMONDBFWRJN-UHFFFAOYSA-N 1-(1,3-benzodioxol-5-yl)-2-[4-(4-methylphenyl)piperazin-1-yl]ethanol Chemical compound C1=CC(C)=CC=C1N1CCN(CC(O)C=2C=C3OCOC3=CC=2)CC1 FZRBMONDBFWRJN-UHFFFAOYSA-N 0.000 description 1
- APHZIYWNAGUXGJ-UHFFFAOYSA-N 1-(1,3-benzodioxol-5-yl)-3-(4-phenylpiperazin-1-yl)propan-1-ol Chemical compound C=1C=C2OCOC2=CC=1C(O)CCN(CC1)CCN1C1=CC=CC=C1 APHZIYWNAGUXGJ-UHFFFAOYSA-N 0.000 description 1
- LVAXXJRNMOQLBL-UHFFFAOYSA-N 1-(1,3-benzodioxol-5-yl)-3-chloropropan-1-one Chemical compound ClCCC(=O)C1=CC=C2OCOC2=C1 LVAXXJRNMOQLBL-UHFFFAOYSA-N 0.000 description 1
- GJPBJWUWULDAFD-UHFFFAOYSA-N 1-(1,3-benzodioxol-5-yl)-4-(4-phenylpiperazin-1-yl)butan-1-ol;dihydrochloride Chemical compound Cl.Cl.C=1C=C2OCOC2=CC=1C(O)CCCN(CC1)CCN1C1=CC=CC=C1 GJPBJWUWULDAFD-UHFFFAOYSA-N 0.000 description 1
- QPLFQOXJGCNJOW-UHFFFAOYSA-N 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[4-(2-fluorophenyl)piperazin-1-yl]ethanol Chemical compound C=1C=C2OCCOC2=CC=1C(O)CN(CC1)CCN1C1=CC=CC=C1F QPLFQOXJGCNJOW-UHFFFAOYSA-N 0.000 description 1
- OOWJDFCJKAOKCG-UHFFFAOYSA-N 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[4-(4-methylphenyl)piperazin-1-yl]ethanone Chemical compound C1=CC(C)=CC=C1N1CCN(CC(=O)C=2C=C3OCCOC3=CC=2)CC1 OOWJDFCJKAOKCG-UHFFFAOYSA-N 0.000 description 1
- WGZPUGWFQANLQG-UHFFFAOYSA-N 1-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethanol Chemical compound C=1C=C2OCCOC2=CC=1C(O)CN(CC1)CCN1C1=CC=CC(C(F)(F)F)=C1 WGZPUGWFQANLQG-UHFFFAOYSA-N 0.000 description 1
- RXTKQQNKQBMXDP-UHFFFAOYSA-N 1-(2h-1,5-benzodioxepin-7-yl)-2-[4-(2-chlorophenyl)piperazin-1-yl]ethanone Chemical compound ClC1=CC=CC=C1N1CCN(CC(=O)C=2C=C3OC=CCOC3=CC=2)CC1 RXTKQQNKQBMXDP-UHFFFAOYSA-N 0.000 description 1
- ZTPLGULUBXUNGT-UHFFFAOYSA-N 1-(2h-1,5-benzodioxepin-7-yl)-2-[4-(4-methylphenyl)piperazin-1-yl]ethanol Chemical compound C1=CC(C)=CC=C1N1CCN(CC(O)C=2C=C3OC=CCOC3=CC=2)CC1 ZTPLGULUBXUNGT-UHFFFAOYSA-N 0.000 description 1
- BDBQGGBDMXIVKW-UHFFFAOYSA-N 1-(3,3-dimethyl-2,4-dihydro-1,5-benzodioxepin-7-yl)-2-(4-pyridin-2-ylpiperazin-1-yl)ethanol Chemical compound C1=C2OCC(C)(C)COC2=CC=C1C(O)CN(CC1)CCN1C1=CC=CC=N1 BDBQGGBDMXIVKW-UHFFFAOYSA-N 0.000 description 1
- HIXDQWDOVZUNNA-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(OC)C(OC)=C1 HIXDQWDOVZUNNA-UHFFFAOYSA-N 0.000 description 1
- LBLYYCQCTBFVLH-UHFFFAOYSA-N 2-Methylbenzenesulfonic acid Chemical compound CC1=CC=CC=C1S(O)(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 238000005727 Friedel-Crafts reaction Methods 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 description 1
- 239000012346 acetyl chloride Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001266 acyl halides Chemical class 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 150000001350 alkyl halides Chemical class 0.000 description 1
- 230000002152 alkylating effect Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 150000008064 anhydrides Chemical class 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000004531 blood pressure lowering effect Effects 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000007809 chemical reaction catalyst Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- MVEAAGBEUOMFRX-UHFFFAOYSA-N ethyl acetate;hydrochloride Chemical compound Cl.CCOC(C)=O MVEAAGBEUOMFRX-UHFFFAOYSA-N 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 239000012433 hydrogen halide Substances 0.000 description 1
- 229910000039 hydrogen halide Inorganic materials 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 239000002655 kraft paper Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229940098779 methanesulfonic acid Drugs 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- PMZCNFYSDCOWEK-UHFFFAOYSA-N n-(1,3-benzodioxol-5-yl)-3-chloropropanamide Chemical compound ClCCC(=O)NC1=CC=C2OCOC2=C1 PMZCNFYSDCOWEK-UHFFFAOYSA-N 0.000 description 1
- CDYDSQYZJFYXKA-UHFFFAOYSA-N n-[3-(4-phenylpiperazin-1-yl)propyl]-1,3-benzodioxol-5-amine;trihydrochloride Chemical compound Cl.Cl.Cl.C=1C=C2OCOC2=CC=1NCCCN(CC1)CCN1C1=CC=CC=C1 CDYDSQYZJFYXKA-UHFFFAOYSA-N 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
æ¬çºæã¯ã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³é¡ãŸãã¯
ãã®é žä»å å¡©ãæå¹æåãšããè¡å§éäžå€ã«é¢ã
ãã äžèšã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³é¡ã¯ãäžèšäž
è¬åŒ()ã§è¡šããããã äžè¬åŒ () åŒäžãïœã¯ïŒãïŒã®æŽæ°ã瀺ããã¯âïŒCH2ïŒn
âïŒïœã¯ïŒãïŒã®æŽæ°ã瀺ãïŒåã¯
ãã®é žä»å å¡©ãæå¹æåãšããè¡å§éäžå€ã«é¢ã
ãã äžèšã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³é¡ã¯ãäžèšäž
è¬åŒ()ã§è¡šããããã äžè¬åŒ () åŒäžãïœã¯ïŒãïŒã®æŽæ°ã瀺ããã¯âïŒCH2ïŒn
âïŒïœã¯ïŒãïŒã®æŽæ°ã瀺ãïŒåã¯
ãåŒãïŒR1ã¯æ°ŽçŽ åååã¯ççŽ æ°
ïŒãïŒã®ã¢ã«ãã«åºãR2ã¯C1ãC5ã®ã¢ã«ãã«åº
ã瀺ãïŒãã¯âCHïŒCHïŒâã
ã瀺ãïŒãã¯âCHïŒCHïŒâã
ãåŒãåã¯
ãåŒãïŒR3ã¯æ°ŽçŽ ååãC1ãC5ã®ã¢ã«
ãã«åºåã¯ã¢ã·ã«åºã瀺ãïŒãã¯ããªãžã«åºãŸ
ãã¯ããšãã«åºã瀺ããããšãã«åºã¯ããã²ã³
åºãC1ãC5ã®ã¢ã«ãã«åºãC1ãC5ã®ã¢ã«ã³ãã·
ã«åºããã³ããªãã«ãªãã¡ãã«åºããéžã°ããïŒ
皮以äžã®åºãæããŠããŠãããã æ¬çºæååç©ã®è£œé æ³ã説æããã  äžè¬åŒ()ã«ãããŠãã
ãã¯ããšãã«åºã瀺ããããšãã«åºã¯ããã²ã³
åºãC1ãC5ã®ã¢ã«ãã«åºãC1ãC5ã®ã¢ã«ã³ãã·
ã«åºããã³ããªãã«ãªãã¡ãã«åºããéžã°ããïŒ
皮以äžã®åºãæããŠããŠãããã æ¬çºæååç©ã®è£œé æ³ã説æããã  äžè¬åŒ()ã«ãããŠãã
ãåŒãã§ãã
ååç©ã§ããå ŽåïŒ
æ¬çºæååç©ã¯äžèšäžè¬åŒ()
ïŒäžèšäžè¬åŒ()äžããïœã¯äžè¬åŒ()ã«ã
ããïŒïœãšå矩ã§ãããã¯ããã²ã³åºã瀺
ããïŒã§è¡šããããÏâããã²ãã¢ã«ã«ãã€ã«
ã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³é¡ãšäžèšäžè¬åŒ
ïŒïŒ ïŒäžèšäžè¬åŒäžïŒ²ã¯äžè¬åŒ()ã«ããããšå
矩ã§ãããïŒã§è¡šããããããã©ãžã³é¡ãšã®å
å¿ã«ããåŸãããã  äžè¬åŒ()ã«ãããŠããâCHïŒOHïŒã§ã
ãå ŽåïŒ æ¬çºæååç©ã¯äžèšäžè¬åŒ() ïŒåŒäžãïœãåã³ïŒ²ã¯äžè¬åŒ()ã«ããããš
å矩ã§ããïŒã§ç€ºããÏâããã²ãã¢ã«ã«ãã€
ã«ã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³é¡ïŒäžè¬åŒ()
ã§ç€ºãããååç©ãšäžè¬åŒ()ã§ç€ºãããåå
ç©ãšã®åå¿ã«ããåŸãããïŒã®ã«ã«ããã«åºã®
éå ã«ãã€ãŠåŸãããã ãŸããäžè¬åŒ()ã§ç€ºãããÏâããã²ãã¢
ã«ã«ãã€ã«ã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³é¡ã®é
å ã«ãã€ãŠåŸãããäžèšäžè¬åŒ() ïŒäžèšäžè¬åŒäžïœã¯äžè¬åŒ()ã«ããããšå矩
ã§ãããã¯ããã²ã³åºã瀺ãïŒãšããã©ãžã³
é¡()ãšã®åå¿ã«ãã€ãŠãåŸãããã  äžè¬åŒ()ã«ãããŠããâNHCH2âã§ã
ãååç©ã§ããå ŽåïŒ æ¬çºæååç©ã¯ãäžèšäžè¬åŒ() ïŒåŒäžããïœã¯äžè¬åŒ()ã«ããããšå矩ã§
ãããã¯ããã²ã³åºã瀺ãïŒã§ç€ºãããÏâ
ããã²ãã¢ã«ã«ãã€ã«ã¢ã«ãã¬ã³ãžãªãã·ã¢ã
ãªã³é¡ãšãäžè¬åŒ()ã§ç€ºãããããã©ãžã³é¡
ãšãåå¿ããã次ãã§åŸãããÏâããã©ãžã
ã«ã¢ã«ã«ãã€ã«ã¢ã«ãã¬ã³ãžãªãã·ã¢ããªã³
ïŒäžè¬åŒ()ã§ç€ºãããïŒã®ã«ã«ããã«åºã®é
å ã«ãã€ãŠåŸãããã ïŒåŒäžãïœããã¯äžè¬åŒ()ã«ããããšå
矩ïŒãã®ããã«ããŠåŸãããåå¿çæç©ã®â
NHâåºããã¢ã«ãã«ååã¯ã¢ã·ã«åããããš
ã«ãã€ãŠå¯Ÿå¿ããã¢ããªã³èªå°äœãåŸãããšã
ã§ããã äžèšã®ïŒ¡ãã®æ¹æ³ã«ãããŠãæ¬çºæã«ä¿ãå
åç©ã¯ã次ã®ããã«ããŠè£œé ãããã Ïâããã²ãã¢ã«ã«ãã€ã«ã¢ã«ãã¬ã³ãžãªãã·
ãã³ãŒã³é¡()åã¯Ïâããã²ãã¢ã«ã«ãã€ã«ã¢
ã«ãã¬ã³ãžãªãã·ã¢ããªã³é¡()ãšããã©ãžã³é¡
ãšã¯ïŒïŒïŒã§åå¿ããããéåžžããã©ãžã³é¡ãé
å°ã«äœ¿çšããæ¹ãåå¿ãåæ»ã«é²è¡ãããåŸã€ãŠ
ããã©ãžã³é¡ã¯Ïâããã²ãã¢ã«ã«ãã€ã«ã¢ã«ã
ã¬ã³ãžãªãã·ãã³ãŒã³é¡åã¯Ïâããã²ãã¢ã«ã«
ãã€ã«ã¢ã«ãã¬ã³ãžãªãã·ã¢ããªã³é¡ïŒã¢ã«ã«å¯Ÿ
ããŠïŒã10ã¢ã«äœ¿çšãããã åå¿ã¯ç¡æº¶åªã§ãååé²è¡ããããåå¿ãåæ»
ã«é²ããããã«ãäžæŽ»æ§æº¶åªãçšããŠãããã溶
åªãšããŠã¯æ°Žããžãªããµã³ãããã©ããããã©
ã³ããžã¡ãã«ãã«ã ã¢ããããžã¡ãã«ã¹ã«ããã·
ããäœçŽã¢ã«ã³ãŒã«ãŸãã¯ãããã®äºçš®ä»¥äžã®æº¶
åªã®æ··åç©ãçšããããã åå¿æž©åºŠã¯ç¹ã«éå®ãããªããé垞宀枩ãã
150âã§ããã åå¿æéã¯åå¿æž©åºŠåã³åæã®åå¿æ§ã溶åªã®
çš®é¡ã«ããç°ãªããéåžž10åãã50æéã®ç¯å²ã§
ããã ãŸãåå¿ã«ããçããããã²ã³åæ°ŽçŽ ãæéã
ãŠåå¿ãä¿é²ãããããã«ãå¡©åºé¡ãæ·»å ããŠã
ãããå¡©åºé¡ãšããŠã¯ãæ°Žé žåã«ãªãŠã ãçé žã«
ãªãŠã ãæ°Žé žåãããªãŠã ãçé žæ°ŽçŽ ãããªãŠ
ã ãçé žãããªãŠã çã®ç¡æ©å¡©é¡ãããªãžã³ãã
ãªãšãã«ã¢ãã³çã®ç¬¬äžçŽææ©ã¢ãã³é¡çã§ã
ãããã®äœ¿çšéã¯ããã©ãžã³é¡ïŒã¢ã«ã«å¯Ÿãéåžž
ïŒãïŒã¢ã«ã§ããã æãŸããé žä»å å¡©ãåŸãããã«ã¯ãåå¿çµäºåŸ
éå°ã®ã¢ãã³é¡åã³æº¶åªãèžçãããã¯æ°ŽæŽã«ã
ãé€ããå Žåã«ãã€ãŠã¯æ°Žé žåãããªãŠã ããã
ã¯æ°Žé žåã«ãªãŠã çã®åŒ·å¡©åºæ°Žæº¶æ¶²ãå ããéé¢
ã®Ïâããã©ãžãã«ã¢ã«ã«ãã€ã«ã¢ã«ãã¬ã³ãžãª
ãã·ãã³ãŒã³é¡ãšãããã®åŸé ¢é žãšãã«ããšãŒã
ã«ãã¯ãããã«ã ããã³ãŒã³ããã«ãšã³çã®æº¶åª
ã§æ¬ååç©ãæœåºãããããã«æãŸããé žãå ã
ãŠäžåãããšç®çãšããé žä»å å¡©ãåŸãããã åŸãããÏâããã©ãžãã«ã¢ã«ã«ãã€ã«ã¢ã«ã
ã¬ã³ãžãªãã·ãã³ãŒã³é¡()ãããã¯ãã®é žä»å
å¡©ãäœçŽã¢ã«ã³ãŒã«æãã¯ãšãŒãã«ãããã©ãã
ããã©ã³ãªã©ã®ãšãŒãã«ç³»æº¶åªã«æº¶è§£ãã次ãã§
æ°ŽçŽ åããŠçŽ å¡©ãäœçšããããšãäžè¬åŒ() ïŒåŒäžããïœãã¯äžè¬åŒ()ã«ããããšå
矩ïŒã§ç€ºãããÏâããã©ãžãã«âαâãããã
ã·ã¢ã«ãã«ã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³é¡ãåŸã
ãããé žä»å å¡©ã®å Žåã¯ããã®ãŸãŸãããã¯éé¢
ã®Ïâããã©ãžãã«ã¢ã«ã«ãã€ã«ã¢ã«ãã¬ã³ãžãª
ãã·ãã³ãŒã³é¡ãšããæ°ŽçŽ åããŠçŽ å¡©ãåå¿ãã
ããšã«ãã€ãŠåŸããããåå¿çµäºåŸãåå¿æ¶²ã¯ã
ã®ãŸãŸããããã¯æ¿çž®ããé ¢é žãšãã«ããšãŒã
ã«ãã¯ãããã«ã ããã³ãŒã³çã§æœåºããããã®
ãŸãŸéé¢ã®ã¢ãã³ãšããŠåŸãããããã«æãŸãã
é žãå ããŠäžåãããšé žä»å å¡©ãåŸãããã äžè¬åŒ () ïŒåŒäžããïœãã¯äžè¬åŒ()ã«ããããšå
矩ïŒã§ç€ºãããååç©ã¯ãÏâããã©ãžãã«ã¢ã«
ã«ãã€ã«ã¢ã«ãã¬ã³ãžãªãã·ã¢ããªã³()åã¯ã
ã®é žä»å å¡©ããšãŒãã«ãããã©ããããã©ã³ãªã©
ã®ãšãŒãã«ç³»æº¶åªã«æº¶è§£ãã次ãã§é žä»å å¡©ã®å Ž
åã¯ãéé¢ã®Ïâããã©ãžãã«ã¢ã«ã«ãã€ã«ã¢ã«
ãã¬ã³ãžãªãã·ã¢ããªã³é¡ãšããäžèšæº¶æ¶²ãæ°ŽçŽ
åã¢ã«ãããŠã ãªããŠã ã§åŠçããããåå¿çµäº
åŸãåå¿æ··åç©ãåžžæ³åŠçã«ãã€ãŠçæããæ°Žé ž
åã¢ã«ãããŠã ãæ°Žé žåãªããŠã ãå»ãã次ã
ã§åå¿æ¶²ã¯ãã®ãŸãŸããããã¯æ¿çž®ããé ¢é žãšã
ã«ããšãŒãã«ãã¯ãããã«ã ããã³ãŒã³çã§æœåº
ãããç®çãšããååç©()ãéé¢ã®ã¢ãã³ãšã
ãŠåŸãããããæãŸããé žãå ããŠäžåãããšé ž
ä»å å¡©ãåŸãããã ããã«ãåŸãããã¢ããªã³èªå°äœ()ããã¢ã«
ãã«ãã©ã€ããã¢ã·ã«ãã©ã€ãåã¯ç¡æ°Žã¢ã«ã«ã³
é žãšãçé žã«ãªãŠã ãªã©ã®ç¡æ©å¡©åºåã¯ããªãšã
ã«ã¢ãã³ãããªãžã³ãªã©ã®ææ©å¡©åºã®ååšäžã«å
å¿ãããããšã«ãããçžå¿ããã¢ããªã³èªå°äœã
åŸãããšãã§ããã ãŸãÏâããã²ãã¢ã«ã«ãã€ã«ã¢ã«ãã¬ã³ãžãª
ãã·ãã³ãŒã³é¡()ã®äžã§ïœãïŒä»¥äžã®ååç©ã¯
Ïâããã²ãã¢ã«ã«ãã€ã«ã¯ããªã()ãšäžèšåŒ
ïŒXIïŒ ïŒäžèšåŒäžïŒžã¯äžè¬åŒ()ã«ããããšå矩ã§ã
ããïŒã§è¡šããããã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³
é¡ãšã®ããªãŒãã«ã¯ã©ããåå¿ã«ãã€ãŠåŸãã
ããïŒãªãŒã¬ãã㯠ã·ã³ã»ã·ã¹ ã³ã¬ã¯ãã€ã
ããªãŠãŒã ïŒïŒOrg.Syn.Coll.Vol ã109é ïŒ
äžè¬åŒ()ã®ã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³é¡ã«ã
ããŠïŒžãCH2ã®å Žåãããªãã¡ïŒïŒïŒâãã³ãŸãž
ãªããœãŒã«ãšÏâããã²ãã¢ã«ã«ãã€ã«ã¯ããªã
ãšã®åå¿ã«ãããŠã¯ãïŒïŒïŒâãã³ãŸãžãªããœãŒ
ã«ã¯ããªãŒãã«ã¯ã©ããåå¿è§ŠåªãšããŠäœ¿çšãã
ãç¡æ°Žå¡©åã¢ã«ãããŠã ã®äœçšã«ãã€ãŠå解ãæ
ãã®ã§äœæž©ã§åå¿ãè¡ãããšã奜ãŸãããåå¿æž©
床ã¯äžè¬ã«â30âã40âã§ãããããã®å Žåã¯â
20âãïŒâã§ååã«åå¿ãé²è¡ããã äžè¬åŒ()ã«ãããŠïœãïŒã®å Žåãããªãã¡ã
ãã²ãã¢ã»ãã«ã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³é¡
ã¯ãäžè¬åŒ()ã®ã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³é¡
ãšã¢ã»ãã«ã¯ãã©ã€ããåå¿ãããåŸãããã¢ã»
ãã«ã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³é¡ãããã²ã³å
åãšåå¿ãããããšã«ãã€ãŠè£œé ããããïŒOrg.
Syn.Coll.Vol ã480é ïŒ æ¬çºæã«ä¿ãäžèšäžè¬åŒ()ã§ç€ºãããååç©
ã®å ·äœäŸã以äžã«ç€ºãã ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªã
ãœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªã
ãœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªã
ãœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªãã«ãªãã¡ãã«ããš
ãã«ïŒâïŒâããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã« ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããµã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããµã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããµã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªã
ãµã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªã
ãµã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªã
ãµã³ ïŒâãïŒâãïŒâïŒïŒâããªãã«ãªãã¡ãã«ããš
ãã«ïŒâïŒâããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããµã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããµã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããµã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªããµã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªã
ã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªã
ã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªã
ã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãã«ãªãã¡ãã«ããš
ãã«ïŒâïŒâããã©ãžãã«ãã¢ã»ãã«âïŒïŒïŒâ
ãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªãã«ãªãã¡ãã«ããš
ãã«ïŒâïŒâããã©ãžãã«ãâïŒâããããã·ãšã
ã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãž
ãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãž
ãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãž
ãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸ
ãžãªããœãŒã« ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããµã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ãâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâããªãã«ãªãã¡ãã«ããš
ãã«ïŒâïŒâããã©ãžãã«ãâïŒâããããã·ãšã
ã«ãâïŒïŒïŒâãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãž
ãªããµã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãž
ãªããµã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãž
ãªããµã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸ
ãžãªããµã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãžãª
ãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãã«ãªãã¡ãã«ããš
ãã«ïŒâïŒâããã©ãžãã«ãâïŒâããããã·ãšã
ã«ãâïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãž
ãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãž
ãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãž
ãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸ
ãžãªãã»ã㳠以äžã®äŸç€ºã¯ãäžè¬åŒ()ã«ãããŠãïœãïŒã
ãâïŒCH2ïŒnâïŒïœã¯ïŒãïŒïŒãã
ããïŒïœãšå矩ã§ãããã¯ããã²ã³åºã瀺
ããïŒã§è¡šããããÏâããã²ãã¢ã«ã«ãã€ã«
ã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³é¡ãšäžèšäžè¬åŒ
ïŒïŒ ïŒäžèšäžè¬åŒäžïŒ²ã¯äžè¬åŒ()ã«ããããšå
矩ã§ãããïŒã§è¡šããããããã©ãžã³é¡ãšã®å
å¿ã«ããåŸãããã  äžè¬åŒ()ã«ãããŠããâCHïŒOHïŒã§ã
ãå ŽåïŒ æ¬çºæååç©ã¯äžèšäžè¬åŒ() ïŒåŒäžãïœãåã³ïŒ²ã¯äžè¬åŒ()ã«ããããš
å矩ã§ããïŒã§ç€ºããÏâããã²ãã¢ã«ã«ãã€
ã«ã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³é¡ïŒäžè¬åŒ()
ã§ç€ºãããååç©ãšäžè¬åŒ()ã§ç€ºãããåå
ç©ãšã®åå¿ã«ããåŸãããïŒã®ã«ã«ããã«åºã®
éå ã«ãã€ãŠåŸãããã ãŸããäžè¬åŒ()ã§ç€ºãããÏâããã²ãã¢
ã«ã«ãã€ã«ã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³é¡ã®é
å ã«ãã€ãŠåŸãããäžèšäžè¬åŒ() ïŒäžèšäžè¬åŒäžïœã¯äžè¬åŒ()ã«ããããšå矩
ã§ãããã¯ããã²ã³åºã瀺ãïŒãšããã©ãžã³
é¡()ãšã®åå¿ã«ãã€ãŠãåŸãããã  äžè¬åŒ()ã«ãããŠããâNHCH2âã§ã
ãååç©ã§ããå ŽåïŒ æ¬çºæååç©ã¯ãäžèšäžè¬åŒ() ïŒåŒäžããïœã¯äžè¬åŒ()ã«ããããšå矩ã§
ãããã¯ããã²ã³åºã瀺ãïŒã§ç€ºãããÏâ
ããã²ãã¢ã«ã«ãã€ã«ã¢ã«ãã¬ã³ãžãªãã·ã¢ã
ãªã³é¡ãšãäžè¬åŒ()ã§ç€ºãããããã©ãžã³é¡
ãšãåå¿ããã次ãã§åŸãããÏâããã©ãžã
ã«ã¢ã«ã«ãã€ã«ã¢ã«ãã¬ã³ãžãªãã·ã¢ããªã³
ïŒäžè¬åŒ()ã§ç€ºãããïŒã®ã«ã«ããã«åºã®é
å ã«ãã€ãŠåŸãããã ïŒåŒäžãïœããã¯äžè¬åŒ()ã«ããããšå
矩ïŒãã®ããã«ããŠåŸãããåå¿çæç©ã®â
NHâåºããã¢ã«ãã«ååã¯ã¢ã·ã«åããããš
ã«ãã€ãŠå¯Ÿå¿ããã¢ããªã³èªå°äœãåŸãããšã
ã§ããã äžèšã®ïŒ¡ãã®æ¹æ³ã«ãããŠãæ¬çºæã«ä¿ãå
åç©ã¯ã次ã®ããã«ããŠè£œé ãããã Ïâããã²ãã¢ã«ã«ãã€ã«ã¢ã«ãã¬ã³ãžãªãã·
ãã³ãŒã³é¡()åã¯Ïâããã²ãã¢ã«ã«ãã€ã«ã¢
ã«ãã¬ã³ãžãªãã·ã¢ããªã³é¡()ãšããã©ãžã³é¡
ãšã¯ïŒïŒïŒã§åå¿ããããéåžžããã©ãžã³é¡ãé
å°ã«äœ¿çšããæ¹ãåå¿ãåæ»ã«é²è¡ãããåŸã€ãŠ
ããã©ãžã³é¡ã¯Ïâããã²ãã¢ã«ã«ãã€ã«ã¢ã«ã
ã¬ã³ãžãªãã·ãã³ãŒã³é¡åã¯Ïâããã²ãã¢ã«ã«
ãã€ã«ã¢ã«ãã¬ã³ãžãªãã·ã¢ããªã³é¡ïŒã¢ã«ã«å¯Ÿ
ããŠïŒã10ã¢ã«äœ¿çšãããã åå¿ã¯ç¡æº¶åªã§ãååé²è¡ããããåå¿ãåæ»
ã«é²ããããã«ãäžæŽ»æ§æº¶åªãçšããŠãããã溶
åªãšããŠã¯æ°Žããžãªããµã³ãããã©ããããã©
ã³ããžã¡ãã«ãã«ã ã¢ããããžã¡ãã«ã¹ã«ããã·
ããäœçŽã¢ã«ã³ãŒã«ãŸãã¯ãããã®äºçš®ä»¥äžã®æº¶
åªã®æ··åç©ãçšããããã åå¿æž©åºŠã¯ç¹ã«éå®ãããªããé垞宀枩ãã
150âã§ããã åå¿æéã¯åå¿æž©åºŠåã³åæã®åå¿æ§ã溶åªã®
çš®é¡ã«ããç°ãªããéåžž10åãã50æéã®ç¯å²ã§
ããã ãŸãåå¿ã«ããçããããã²ã³åæ°ŽçŽ ãæéã
ãŠåå¿ãä¿é²ãããããã«ãå¡©åºé¡ãæ·»å ããŠã
ãããå¡©åºé¡ãšããŠã¯ãæ°Žé žåã«ãªãŠã ãçé žã«
ãªãŠã ãæ°Žé žåãããªãŠã ãçé žæ°ŽçŽ ãããªãŠ
ã ãçé žãããªãŠã çã®ç¡æ©å¡©é¡ãããªãžã³ãã
ãªãšãã«ã¢ãã³çã®ç¬¬äžçŽææ©ã¢ãã³é¡çã§ã
ãããã®äœ¿çšéã¯ããã©ãžã³é¡ïŒã¢ã«ã«å¯Ÿãéåžž
ïŒãïŒã¢ã«ã§ããã æãŸããé žä»å å¡©ãåŸãããã«ã¯ãåå¿çµäºåŸ
éå°ã®ã¢ãã³é¡åã³æº¶åªãèžçãããã¯æ°ŽæŽã«ã
ãé€ããå Žåã«ãã€ãŠã¯æ°Žé žåãããªãŠã ããã
ã¯æ°Žé žåã«ãªãŠã çã®åŒ·å¡©åºæ°Žæº¶æ¶²ãå ããéé¢
ã®Ïâããã©ãžãã«ã¢ã«ã«ãã€ã«ã¢ã«ãã¬ã³ãžãª
ãã·ãã³ãŒã³é¡ãšãããã®åŸé ¢é žãšãã«ããšãŒã
ã«ãã¯ãããã«ã ããã³ãŒã³ããã«ãšã³çã®æº¶åª
ã§æ¬ååç©ãæœåºãããããã«æãŸããé žãå ã
ãŠäžåãããšç®çãšããé žä»å å¡©ãåŸãããã åŸãããÏâããã©ãžãã«ã¢ã«ã«ãã€ã«ã¢ã«ã
ã¬ã³ãžãªãã·ãã³ãŒã³é¡()ãããã¯ãã®é žä»å
å¡©ãäœçŽã¢ã«ã³ãŒã«æãã¯ãšãŒãã«ãããã©ãã
ããã©ã³ãªã©ã®ãšãŒãã«ç³»æº¶åªã«æº¶è§£ãã次ãã§
æ°ŽçŽ åããŠçŽ å¡©ãäœçšããããšãäžè¬åŒ() ïŒåŒäžããïœãã¯äžè¬åŒ()ã«ããããšå
矩ïŒã§ç€ºãããÏâããã©ãžãã«âαâãããã
ã·ã¢ã«ãã«ã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³é¡ãåŸã
ãããé žä»å å¡©ã®å Žåã¯ããã®ãŸãŸãããã¯éé¢
ã®Ïâããã©ãžãã«ã¢ã«ã«ãã€ã«ã¢ã«ãã¬ã³ãžãª
ãã·ãã³ãŒã³é¡ãšããæ°ŽçŽ åããŠçŽ å¡©ãåå¿ãã
ããšã«ãã€ãŠåŸããããåå¿çµäºåŸãåå¿æ¶²ã¯ã
ã®ãŸãŸããããã¯æ¿çž®ããé ¢é žãšãã«ããšãŒã
ã«ãã¯ãããã«ã ããã³ãŒã³çã§æœåºããããã®
ãŸãŸéé¢ã®ã¢ãã³ãšããŠåŸãããããã«æãŸãã
é žãå ããŠäžåãããšé žä»å å¡©ãåŸãããã äžè¬åŒ () ïŒåŒäžããïœãã¯äžè¬åŒ()ã«ããããšå
矩ïŒã§ç€ºãããååç©ã¯ãÏâããã©ãžãã«ã¢ã«
ã«ãã€ã«ã¢ã«ãã¬ã³ãžãªãã·ã¢ããªã³()åã¯ã
ã®é žä»å å¡©ããšãŒãã«ãããã©ããããã©ã³ãªã©
ã®ãšãŒãã«ç³»æº¶åªã«æº¶è§£ãã次ãã§é žä»å å¡©ã®å Ž
åã¯ãéé¢ã®Ïâããã©ãžãã«ã¢ã«ã«ãã€ã«ã¢ã«
ãã¬ã³ãžãªãã·ã¢ããªã³é¡ãšããäžèšæº¶æ¶²ãæ°ŽçŽ
åã¢ã«ãããŠã ãªããŠã ã§åŠçããããåå¿çµäº
åŸãåå¿æ··åç©ãåžžæ³åŠçã«ãã€ãŠçæããæ°Žé ž
åã¢ã«ãããŠã ãæ°Žé žåãªããŠã ãå»ãã次ã
ã§åå¿æ¶²ã¯ãã®ãŸãŸããããã¯æ¿çž®ããé ¢é žãšã
ã«ããšãŒãã«ãã¯ãããã«ã ããã³ãŒã³çã§æœåº
ãããç®çãšããååç©()ãéé¢ã®ã¢ãã³ãšã
ãŠåŸãããããæãŸããé žãå ããŠäžåãããšé ž
ä»å å¡©ãåŸãããã ããã«ãåŸãããã¢ããªã³èªå°äœ()ããã¢ã«
ãã«ãã©ã€ããã¢ã·ã«ãã©ã€ãåã¯ç¡æ°Žã¢ã«ã«ã³
é žãšãçé žã«ãªãŠã ãªã©ã®ç¡æ©å¡©åºåã¯ããªãšã
ã«ã¢ãã³ãããªãžã³ãªã©ã®ææ©å¡©åºã®ååšäžã«å
å¿ãããããšã«ãããçžå¿ããã¢ããªã³èªå°äœã
åŸãããšãã§ããã ãŸãÏâããã²ãã¢ã«ã«ãã€ã«ã¢ã«ãã¬ã³ãžãª
ãã·ãã³ãŒã³é¡()ã®äžã§ïœãïŒä»¥äžã®ååç©ã¯
Ïâããã²ãã¢ã«ã«ãã€ã«ã¯ããªã()ãšäžèšåŒ
ïŒXIïŒ ïŒäžèšåŒäžïŒžã¯äžè¬åŒ()ã«ããããšå矩ã§ã
ããïŒã§è¡šããããã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³
é¡ãšã®ããªãŒãã«ã¯ã©ããåå¿ã«ãã€ãŠåŸãã
ããïŒãªãŒã¬ãã㯠ã·ã³ã»ã·ã¹ ã³ã¬ã¯ãã€ã
ããªãŠãŒã ïŒïŒOrg.Syn.Coll.Vol ã109é ïŒ
äžè¬åŒ()ã®ã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³é¡ã«ã
ããŠïŒžãCH2ã®å Žåãããªãã¡ïŒïŒïŒâãã³ãŸãž
ãªããœãŒã«ãšÏâããã²ãã¢ã«ã«ãã€ã«ã¯ããªã
ãšã®åå¿ã«ãããŠã¯ãïŒïŒïŒâãã³ãŸãžãªããœãŒ
ã«ã¯ããªãŒãã«ã¯ã©ããåå¿è§ŠåªãšããŠäœ¿çšãã
ãç¡æ°Žå¡©åã¢ã«ãããŠã ã®äœçšã«ãã€ãŠå解ãæ
ãã®ã§äœæž©ã§åå¿ãè¡ãããšã奜ãŸãããåå¿æž©
床ã¯äžè¬ã«â30âã40âã§ãããããã®å Žåã¯â
20âãïŒâã§ååã«åå¿ãé²è¡ããã äžè¬åŒ()ã«ãããŠïœãïŒã®å Žåãããªãã¡ã
ãã²ãã¢ã»ãã«ã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³é¡
ã¯ãäžè¬åŒ()ã®ã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³é¡
ãšã¢ã»ãã«ã¯ãã©ã€ããåå¿ãããåŸãããã¢ã»
ãã«ã¢ã«ãã¬ã³ãžãªãã·ãã³ãŒã³é¡ãããã²ã³å
åãšåå¿ãããããšã«ãã€ãŠè£œé ããããïŒOrg.
Syn.Coll.Vol ã480é ïŒ æ¬çºæã«ä¿ãäžèšäžè¬åŒ()ã§ç€ºãããååç©
ã®å ·äœäŸã以äžã«ç€ºãã ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªã
ãœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªã
ãœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªã
ãœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªãã«ãªãã¡ãã«ããš
ãã«ïŒâïŒâããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã« ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããµã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããµã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããµã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªã
ãµã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªã
ãµã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªã
ãµã³ ïŒâãïŒâãïŒâïŒïŒâããªãã«ãªãã¡ãã«ããš
ãã«ïŒâïŒâããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããµã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããµã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããµã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªããµã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªã
ã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªã
ã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªã
ã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãã«ãªãã¡ãã«ããš
ãã«ïŒâïŒâããã©ãžãã«ãã¢ã»ãã«âïŒïŒïŒâ
ãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãª
ãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãã¢ã»ãã«ãâïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªãã«ãªãã¡ãã«ããš
ãã«ïŒâïŒâããã©ãžãã«ãâïŒâããããã·ãšã
ã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãž
ãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãž
ãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãž
ãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸ
ãžãªããœãŒã« ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããµã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ãâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâããªãã«ãªãã¡ãã«ããš
ãã«ïŒâïŒâããã©ãžãã«ãâïŒâããããã·ãšã
ã«ãâïŒïŒïŒâãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãž
ãªããµã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãž
ãªããµã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãž
ãªããµã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸ
ãžãªããµã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãžãª
ãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãã«ãªãã¡ãã«ããš
ãã«ïŒâïŒâããã©ãžãã«ãâïŒâããããã·ãšã
ã«ãâïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãž
ãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãž
ãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãž
ãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸ
ãžãªãã»ã㳠以äžã®äŸç€ºã¯ãäžè¬åŒ()ã«ãããŠãïœãïŒã
ãâïŒCH2ïŒnâïŒïœã¯ïŒãïŒïŒãã
ãåŒã
åã¯âCHïŒOHïŒâã®å Žåã§ããããäŸç€ºããå
åç©ã®ããããã«å¯Ÿå¿ããïœãïŒããïŒãŸã§ã®å
åç©ããã¹ãŠæ¬çºæã«ãããŠçšããããååç©ãš
ããŠäŸç€ºãããã 次ã«ãäžè¬åŒ()ã«ãããŠããâCH2C
ïŒOH3ïŒ2CH2âã§ïœãïŒã®å Žåã®ååç©ãäŸç€ºã
ãã ïŒâïŒïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«âïŒïŒïŒâãã³ãŸ
ãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«âïŒïŒ
ïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«âïŒïŒ
ïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«âïŒïŒ
ïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãã«ãªãã¡ãã«ããš
ãã«ïŒâïŒâããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâ
ãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«âïŒïŒïŒâã
ã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«âïŒïŒïŒâã
ã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«âïŒïŒïŒâã
ã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«âïŒïŒïŒâ
ãã³ãŸãžãªãã»ãã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ãšãã«ãâïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãã«ãªãã¡ãã«ããš
ãã«ïŒâïŒâããã©ãžãã«ãâïŒâããããã·ãšã
ã«ãâïŒïŒïŒâãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªã
ã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãžã¡ãã«
âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãžã¡ãã«
âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãžã¡ãã«
âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãžã¡ã
ã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ åæ§ã«ããŠãïœãïŒãïŒåã³ïŒåã¯ïŒºãâ
CH2CHïŒCH3ïŒCH2âã§ããååç©ããæ¬çºæã«
ãããŠçšããããååç©ãšããŠäŸç€ºãããã 次ã«ãäžè¬åŒ()ã«ãããŠããâCH2âãïœ
ãïŒãã
åç©ã®ããããã«å¯Ÿå¿ããïœãïŒããïŒãŸã§ã®å
åç©ããã¹ãŠæ¬çºæã«ãããŠçšããããååç©ãš
ããŠäŸç€ºãããã 次ã«ãäžè¬åŒ()ã«ãããŠããâCH2C
ïŒOH3ïŒ2CH2âã§ïœãïŒã®å Žåã®ååç©ãäŸç€ºã
ãã ïŒâïŒïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«âïŒïŒïŒâãã³ãŸ
ãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«âïŒïŒ
ïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«âïŒïŒ
ïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«âïŒïŒ
ïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãã«ãªãã¡ãã«ããš
ãã«ïŒâïŒâããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâ
ãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«âïŒïŒïŒâã
ã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«âïŒïŒïŒâã
ã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«âïŒïŒïŒâã
ã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãã¢ã»ãã«ãâïŒïŒïŒâãžã¡ãã«âïŒïŒïŒâ
ãã³ãŸãžãªãã»ãã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ãšãã«ãâïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâ
ãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãã«ãªãã¡ãã«ããš
ãã«ïŒâïŒâããã©ãžãã«ãâïŒâããããã·ãšã
ã«ãâïŒïŒïŒâãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªã
ã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒ
âãžã¡ãã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãžã¡ãã«
âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãžã¡ãã«
âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãžã¡ãã«
âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãâïŒâããããã·ãšãã«ãâïŒïŒïŒâãžã¡ã
ã«âïŒïŒïŒâãã³ãŸãžãªãã»ãã³ åæ§ã«ããŠãïœãïŒãïŒåã³ïŒåã¯ïŒºãâ
CH2CHïŒCH3ïŒCH2âã§ããååç©ããæ¬çºæã«
ãããŠçšããããååç©ãšããŠäŸç€ºãããã 次ã«ãäžè¬åŒ()ã«ãããŠããâCH2âãïœ
ãïŒãã
ãåŒãã§ããå Žåã®ååç©
ãäŸç€ºããã
âãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ãšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãªãã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãª
ãã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãª
ãã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãª
ãã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãªã
ã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãªã
ã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãªã
ã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâããªãã«ãªãã¡ãã«ããš
ãã«ïŒâïŒâããã©ãžãã«ããšãã«ãâïŒïŒïŒâã¡
ãã¬ã³ãžãªãã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãª
ãã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãª
ãã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãª
ãã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãªãã·ã¢ããª
㳠âãïŒâãïŒâïŒïŒâããªã«ïŒâããã©ãžãã«ã
ãšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãªãã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãªãã·ã¢ããª
㳠âãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãªãã·ã¢ã
ãªã³ ããã«ãåæ§ã«ããŠïŒºãïŒâCH2ïŒnâïŒïœã¯ïŒå
ã¯ïŒïŒã§ãã€ãŠãïœãïŒãïŒåã³ïŒåã¯ïŒ¹ã
ãšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãªãã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãª
ãã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãª
ãã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâãã«ãªãããšãã«ïŒâïŒâ
ããã©ãžãã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãª
ãã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãªã
ã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãªã
ã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãªã
ã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâããªãã«ãªãã¡ãã«ããš
ãã«ïŒâïŒâããã©ãžãã«ããšãã«ãâïŒïŒïŒâã¡
ãã¬ã³ãžãªãã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãª
ãã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãª
ãã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãª
ãã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãªãã·ã¢ããª
㳠âãïŒâãïŒâïŒïŒâããªã«ïŒâããã©ãžãã«ã
ãšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãªãã·ã¢ããªã³ âãïŒâãïŒâïŒïŒâããªã«ïŒâïŒâããã©ãžã
ã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãªãã·ã¢ããª
㳠âãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ããšãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãªãã·ã¢ã
ãªã³ ããã«ãåæ§ã«ããŠïŒºãïŒâCH2ïŒnâïŒïœã¯ïŒå
ã¯ïŒïŒã§ãã€ãŠãïœãïŒãïŒåã³ïŒåã¯ïŒ¹ã
ãåŒãïŒR3ã¯ã¡ãã«åºåã¯ã¢ã»ãã«åºïŒ
ã§ããååç©ããæ¬çºæã«ãããååç©ãšããŠäŸ
瀺ãããã 次ã«ãäžèšååç©ã®ãã¡ã奜ãŸããååç©ã次
ã«æããã ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâããããã·ãšãã«ãâïŒïŒïŒâã
ã³ãŸãžãªããœãŒã« ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ããã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ããã«ãâïŒïŒïŒâãã³ãŸãžãª
ããµã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ããã«ãâïŒïŒïŒâãã³ãŸãžãª
ãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãâïŒâããããã·ããã«ãâïŒïŒïŒâãã³ãŸ
ãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãâïŒâããããã·ããã«ãâïŒïŒïŒâãã³ãŸ
ãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãâïŒâããããã·ããã«ãâïŒïŒïŒâãã³ãŸ
ãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ããã«ãâïŒïŒïŒ
âãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ããã«ãâïŒïŒïŒ
âãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ããã«ãâïŒïŒïŒ
âãã³ãŸãžãªãã»ãã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ãã³ãã«ãâïŒïŒïŒâãã³ãŸãž
ãªããœãŒã« ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ãã³ãã«ãâïŒïŒïŒâãã³ãŸãž
ãªããµã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ãã³ãã«ãâïŒïŒïŒâãã³ãŸãž
ãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãã³ãã«ãâïŒïŒ
ïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ãããªã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã« ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ãããªã«ïŒâïŒïŒïŒâãã³ãŸãžãªããµã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ãããªã«ãâïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ããããªã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ããããªã«ãâïŒïŒïŒâãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ããããªã«ãâïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ããããªã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ããããªã«ãâïŒïŒïŒâãã³ãŸãžãª
ããµã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ããããªã«ãâïŒïŒïŒâãã³ãŸãžãª
ãã»ãã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ãã¬ãªã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã« ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ãã¬ãªã«ãâïŒïŒïŒâãã³ãŸãžãªããµã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ãã¬ãªã«ãâïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ããã¬ãªã«ãâïŒïŒïŒâãã³ãŸãžãªã
ãµã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ããã¬ãªã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ããã¬ãªã«ãâïŒïŒïŒâãã³ãŸãžãª
ããµã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ããã¬ãªã«ãâïŒïŒïŒâãã³ãŸãžãª
ãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ããã¬ãªã«ãâïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ããã¬ãªã«ãâïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒâãã³ãŸãžãªãã»ã㳠âãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâã
ãã©ãžãã«ããšãã«ãââã¢ã»ãã«âïŒïŒïŒâ
ã¡ãã¬ã³ãžãªãã·ã¢ããªã³ ãŸãäžèšã®çš®ã ã®ååç©ã®é žä»å å¡©ãæ¬çºæã«
ä¿ãè¬å€ã®æå¹æåãšããŠçšãããããä»å å¡©ãš
ããŠçšããããé žãšããŠã¯ãå¡©åæ°ŽçŽ é žãã·ãŠãŠ
åæ°ŽçŽ é žãç¡«é žããªã³é žãç¡é žçã®ç¡æ©é žãé ¢
é žãã³ãã¯é žãã¢ãžãã³é žãããããªã³é žãé ç³
é žãããã«é žããã¬ã€ã³é žãã·ãŠãŠé žãã¯ãšã³
é žãå®æ¯éŠé žããã«ãšã³ã¹ã«ãã³é žãã¡ã¿ã³ã¹ã«
ãã³é žçã®ææ©é žãæããããã æ¬çºæã®è¡å§éäžå€ã¯ãããªãæ¹æ³ã§ãæäžã§
ãããã奜é©ã«ã¯ä»¥äžã®ãããªæ¹æ³ãå®æœãã
ãã ããªãã¡ç®äžæ³šå°ãéèå 泚å°ãçè泚å°ãè ¹
è å 泚å°çã®éçµå£æäžããŸãçµå£æäžãå¯èœã§
ããã æäžéã¯æ£è ã®å¹Žä»€ãå¥åº·ç¶æ ãäœéãåæåŠ
çããããªãã°ãã®çš®é¡ãåŠçœ®é »åºŠãææã®å¹æ
ã®æ§è³ªçã«ãã決å®ãããã äžè¬çã«æå¹æåã®ïŒæ¥æäžéã¯0.1ã100mgïŒ
KgäœéãéåžžïŒã30mgïŒKgäœéã§ãããïŒåãã
ãã¯ãã以äžæäžãããã çµå£æäžããå Žåã¯é å€ãã«ãã»ã«å€ãç²å€ã
液å€ããšãªãã·ã«å€çã®åœ¢äœã§ããŸãéçµå£æäž
ã®å Žåã¯æ¶²äœãããã¯æžæ¿çã®æ®ºèãã液ç¶ã®åœ¢
äœã§çšãããããäžè¿°ã®æ§ãªåœ¢äœã§çšããããå Ž
åãåºäœãããã¯æ¶²äœã®æ¯æ§ã®ãªã補å€çæ äœã
çµæã«å«ãŸãåŸãã åºäœæ äœã®äŸãšããŠã¯éåžžã®ãŒã©ãã³ã¿ã€ãã®
ã«ãã»ã«ãçšããããããŸãæå¹æåãè£å©è¬ãš
ãšãã«ãããã¯ãããªãã«é å€åãç²æ«å è£ ãã
ãã ãããã®ã«ãã»ã«ãé å€ãç²æ«ã¯äžè¬çã«ïŒã
95ïŒ ã奜ãŸããã¯25ã90ïŒ ééã®æå¹æåãå«
ãã ããªãã¡ãããã®æäžåœ¢åŒã§ã¯ïŒã500mgã奜
ãŸããã¯25ã250mgã®æå¹æåãå«æããã®ãã
ãã 液ç¶æ äœãšããŠã¯æ°Žãããã¯ç³æ²¹ãããŒãã
æ²¹ã倧è±æ²¹ãããã©ã«æ²¹ããŽãæ²¹çã®åæ€ç©èµ·å
ã®ããŸãã¯åæã®æ²¹çãçšããããã ãŸããäžè¬ã«ççé£å¡©æ°Žãããã¹ãããŒã¹ãã
ãã¯é¡äŒŒã®ã·ãšç³æº¶æ¶²ããšãã¬ã³ã°ãªã³ãŒã«ãã
ããã¬ã³ã°ãªã³ãŒã«ãããªãšãã¬ã³ã°ãªã³ãŒã«ç
ã®ã°ãªã³ãŒã«é¡ã液ç¶æ äœãšããŠå¥œãŸããããšã
ã«ççé£å¡©æ°Žãçšãã泚å°æ¶²ã®å Žåã«ã¯éåžž0.5
ã20ïŒ ã奜ãŸããã¯ïŒã10ïŒ ééã®æå¹æåãå«
ãããã«ããã çµå£æäžã®æ¶²å€ã®å Žåã0.5ã10ïŒ ééã®æå¹
æåãå«ãæžæ¿æ¶²ãããã¯ã·ããããããã ãã®å Žåã®æ äœãšããŠã¯éŠæãã·ãããã補å€
åŠçãã»ã«äœçã®æ°Žæ§è³Šåœ¢å€ãçšããã å®æœäŸ ïŒ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ããããªãã«ïŒâïŒïŒïŒâãã³ãŸãžãªããœãŒã« ïŒâïŒïŒâã¯ããããããªãã«ïŒâïŒïŒïŒâãã³
ãŸãžãªããœãŒã«ïŒïŒïœïŒããã³ïŒ®âããšãã«ãã
ã©ãžã³ïŒ2.4ïœïŒãDMFïŒ20mlïŒã«æº¶è§£ããããª
ãšãã«ã¢ãã³ïŒ1.7ïœïŒãå ãã宀枩äž10æéæ¹
æãããåå¿çµäºåŸãæ°Žäžã«æ³šããé ¢é žãšãã«ã§
æœåºãããæœåºæ¶²ãç¡æ°Žç¡«é žãœãŒãã§ä¹Ÿç¥åŸã溶
åªãçå»ããæ®æž£ãã¡ã¿ããŒã«ããçµæ¶åããã
åŸãããçµæ¶ããšã¿ããŒã«ããåçµæ¶ããïŒâ
ãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒããã
ãªãã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã«ãåŸã
ïŒ4.0ïœã84ïŒ åçïŒãäžèšååç©ã®ç©æ§ã¯è¡šïŒã®
No.47ã®æ¬ã«èšèŒãããŠãããšããã§ããã ãªããå¡©é žå¡©ãåŸãå Žåã¯ãæœåºæ¶²ãæ¿çž®åŸã
æ®æž£ãé ¢é žãšãã«ã«æº¶è§£ããŠ20ïŒ å¡©é žïŒãšã¿ããŒ
ã«ãå ããçããæ²æ®¿ãåãããšã¿ããŒã«ãã
åçµæ¶ããããšã«ãã€ãŠåŸãããã å®æœäŸ ïŒ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ãããªã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã«ïŒå¡©
é žå¡© ïŒâïŒïŒâã¯ãããããªã«ïŒâïŒïŒïŒâãã³ãŸãž
ãªããœãŒã«ïŒ4.0ïœïŒããã³ïŒ®âããšãã«ããã©
ãžã³ïŒ3.0ïœïŒãDMFïŒ25mlïŒã«æº¶è§£ããããªãš
ãã«ã¢ãã³ïŒ2.2ïœïŒãå ãã80âã§40æéå ç±
æ¹æãããåå¿çµäºåŸãæ°Žäžã«æ³šããé ¢é žãšãã«
ã§æœåºãããæœåºæ¶²ãç¡æ°Žç¡«é žãœãŒãã§ä¹Ÿç¥åŸã
溶åªãçå»ãããæ®æž£ãé ¢é žãšãã«ã«æº¶è§£ãã20
ïŒ å¡©é žïŒãšã¿ããŒã«ïŒ6.5mlïŒãå ãçæããçµ
æ¶ãåãããšã¿ããŒã«ããåçµæ¶ããŠïŒâãïŒ
âïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒãããªã«ã
âïŒïŒïŒâãã³ãŸãžãªããµã³ïŒå¡©é žå¡©ãåŸã
ïŒ5.1ïœã68ïŒ åçïŒãäžèšååç©ã®ç©æ§ã¯è¡šïŒã®
No.57ã«èšèŒãããŠãããšããã§ããã å®æœäŸ ïŒ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ãããã«ãâïŒïŒïŒâãã³ãŸ
ãžãªããœãŒã« å®æœäŸïŒã§åŸãããïŒâãïŒâïŒïŒâããšãã«â
ïŒâããã©ãžãã«ïŒããããªãã«ãâïŒïŒïŒâã
ã³ãŸãžãªããµã³ïŒ4.0ïœïŒãã¡ã¿ããŒã«ïŒ50mlïŒ
ã«æžæ¿ããæ°ŽçŽ åç¡ŒçŽ ãããªãŠã ïŒ0.5ïœïŒãå
ãã宀枩äž10æéåå¿ãããåå¿çµäºåŸãåå¿æ¶²
ãæžå§äžçå»ããé ¢é žãšãã«ã§æœåºãããæœåºæ¶²
ã飜åé£å¡©æ°Žã§æŽæµåŸãç¡æ°Žç¡«é žãœãŒãã§ä¹Ÿç¥
ãã溶åªãçå»åŸãã¡ã¿ããŒã«ããçµæ¶åããã
ãšã«ãã€ãŠïŒâãïŒâïŒïŒâããšãã«âïŒâããã©
ãžãã«ïŒâïŒâããããã·ãããã«ãâïŒïŒïŒâã
ã³ãŸãžãªããœãŒã«ãåŸãïŒ3.6ïœã75ïŒ åçïŒãæ¬
ååç©ã®ç©æ§ã¯è¡šâïŒã®No.ïŒã®æ¬ã«ç€ºãããŠãã
ãšããã§ããã å®æœäŸ ïŒ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ããã«ãâïŒïŒïŒâãã³ãŸãž
ãªããœãŒã«ïŒå¡©é žå¡© å®æœäŸïŒã§åŸãããïŒâãïŒâïŒïŒâããšãã«â
ïŒâããã©ãžãã«ïŒãããªã«ãâïŒïŒïŒâãã³ãŸ
ãžãªããœãŒã«å¡©é žå¡©ïŒ3.8ïœïŒãã¡ã¿ããŒã«ïŒ50
mlïŒã«æžæ¿ã2NâNaOHïŒ4.5mlïŒãå ããæ°ŽçŽ
åç¡ŒçŽ ãããªãŠã ïŒ0.5ïœïŒãå ãã宀枩äž10æ
éæ¹æãããåå¿çµäºåŸã溶åªãçå»ããé ¢é žãš
ãã«ã§æœåºãã飜åé£å¡©æ°Žã§æŽæµããç¡æ°Žç¡«é žãœ
ãŒãã§ä¹Ÿç¥åŸ20ïŒ å¡©é žïŒãšã¿ããŒã«ïŒ4.9mlïŒã
å ããæåºããçµæ¶ãåãããšã¿ããŒã«ã§åçµ
æ¶ããããšã«ãã€ãŠãïŒâãïŒâïŒïŒâããšãã«â
ïŒâããã©ãžãã«ïŒâïŒâããããã·ããã«ãâ
ïŒïŒïŒâãã³ãŸãžãªããœãŒã«ïŒå¡©é žå¡©ãåŸã
ïŒ3.5ïœã62ïŒ åçïŒãæ¬ååç©ã®ç©æ§ã¯è¡šïŒã®No.
19ã®æ¬ã«ç€ºãããŠãããšããã§ããã å®æœäŸ ïŒ ïŒ®âãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ãããã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãªãã·ã¢ããª
ã³ïŒå¡©é žå¡© âïŒïŒâã¯ããããããªãã«ïŒâïŒïŒïŒâã¡ã
ã¬ã³ãžãªãã·ã¢ããªã³2.0ïœãïŒïŒ®âãžã¡ãã«
ãã«ã ã¢ãã20mlã«æº¶è§£ããâããšãã«ããã©
ãžã³1.6ïœãšããªãšãã«ã¢ãã³ïŒmlãå ããçªçŽ
é°å²æ°äžã80âã§20æéæ¹æãããåå¿æ¶²ãæžå§
çå»ããæ®æž£ã«é ¢é žãšãã«ãš2Nâæ°Žé žåãããª
ãŠã 氎溶液ãå ããæ°Žå±€åé¢ããæŽã«æ°ŽæŽãïŒå
è¡ãªãé ¢é žãšãã«å±€ãç¡æ°Žç¡«é žãããªãŠã ã§ä¹Ÿç¥
åŸãé ¢é žãšãã«ãæžå§çå»ãããåºåœ¢ã®æ®æž£ããš
ã¿ããŒã«ããåçµæ¶ããâãïŒâïŒïŒâããšãã«
âïŒâããã©ãžãã«ïŒããããªãã«ãâïŒïŒïŒâ
ã¡ãã¬ã³ãžãªãã·ã¢ããªã³3.4ïœãåŸããïŒåç90
ïŒ ïŒæ¬¡ã«ããªããŠã ã¢ã«ãããŠã ãã€ãã©ã€ã
0.6ïœãšããã©ãã€ãããã©ã³20mlã®æžæ¿æ¶²ã«æ¹
æäžãããã©ãã€ãããã©ã³20mlã«æº¶è§£ããã
âãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒãã
ããªãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãªãã·ã¢ããªã³
ïŒïœã滎äžããã滎äžçµäºåŸãïŒæéå ç±éæµã
ããå·åŸãåžžæ³éããåŠçãè¡ãªããæåºããã
æ°Žé žåã¢ã«ãããŠã ãå¥ãã液ãæžå§çå»ã
ããæ®æž£ãã·ãªã«ã²ã«ã¯ããã粟補ããåŸããã
ã·ããããé ¢é žãšãã«ã«æº¶è§£åŸãæ°·å·æ¹æäž20ïŒ
å¡©åæ°ŽçŽ âé ¢é žãšãã«ãå ããŠæåºçµæ¶ãå
ãããšã¿ããŒã«ããåçµæ¶ããâãïŒâïŒïŒâã
ãšãã«âïŒâããã©ãžãã«ïŒãããã«ãâïŒïŒïŒ
âã¡ãã¬ã³ãžãªãã·ã¢ããªã³ïŒå¡©é žå¡©1.9ïœãåŸ
ãïŒåç74.8ïŒ ïŒæ¬ååç©ã®ç©æ§ã¯è¡šïŒã®No.79ã®
æ¬ã«ç€ºãããŠããéãã§ããã åæ§ã®æ¹æ³ã«ãã€ãŠãä»ã®ååç©ã補é ããã
ãã®ç©æ§ã¯ãè¡šïŒã«èšèŒãããŠããéãã§ããã
瀺ãããã 次ã«ãäžèšååç©ã®ãã¡ã奜ãŸããååç©ã次
ã«æããã ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ãšãã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâããããã·ãšãã«ãâïŒïŒïŒâã
ã³ãŸãžãªããœãŒã« ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ããã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ããã«ãâïŒïŒïŒâãã³ãŸãžãª
ããµã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ããã«ãâïŒïŒïŒâãã³ãŸãžãª
ãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãâïŒâããããã·ããã«ãâïŒïŒïŒâãã³ãŸ
ãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãâïŒâããããã·ããã«ãâïŒïŒïŒâãã³ãŸ
ãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ãâïŒâããããã·ããã«ãâïŒïŒïŒâãã³ãŸ
ãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ããã«ãâïŒïŒïŒ
âãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ããã«ãâïŒïŒïŒ
âãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ããã«ãâïŒïŒïŒ
âãã³ãŸãžãªãã»ãã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ãã³ãã«ãâïŒïŒïŒâãã³ãŸãž
ãªããœãŒã« ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ãã³ãã«ãâïŒïŒïŒâãã³ãŸãž
ãªããµã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ãã³ãã«ãâïŒïŒïŒâãã³ãŸãž
ãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ãâïŒâããããã·ãã³ãã«ãâïŒïŒ
ïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ãããªã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã« ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ãããªã«ïŒâïŒïŒïŒâãã³ãŸãžãªããµã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ãããªã«ãâïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ããããªã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã« ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ããããªã«ãâïŒïŒïŒâãã³ãŸãžãªããµã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ããããªã«ãâïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ããããªã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ããããªã«ãâïŒïŒïŒâãã³ãŸãžãª
ããµã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ããããªã«ãâïŒïŒïŒâãã³ãŸãžãª
ãã»ãã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ãã¬ãªã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã« ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ãã¬ãªã«ãâïŒïŒïŒâãã³ãŸãžãªããµã³ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ãã¬ãªã«ãâïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¯ããããšãã«ïŒâïŒâã
ãã©ãžãã«ããã¬ãªã«ãâïŒïŒïŒâãã³ãŸãžãªã
ãµã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ããã¬ãªã«ãâïŒïŒïŒâãã³ãŸãžãª
ããœãŒã« ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ããã¬ãªã«ãâïŒïŒïŒâãã³ãŸãžãª
ããµã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ããã¬ãªã«ãâïŒïŒïŒâãã³ãŸãžãª
ãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâããªãžã«ïŒâïŒâããã©ãž
ãã«ããã¬ãªã«ãâïŒïŒïŒâãã³ãŸãžãªãã»ãã³ ïŒâãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâ
ããã©ãžãã«ããã¬ãªã«ãâïŒïŒïŒâãžã¡ãã«â
ïŒïŒïŒâãã³ãŸãžãªãã»ã㳠âãïŒâãïŒâïŒïŒâã¡ããã·ããšãã«ïŒâïŒâã
ãã©ãžãã«ããšãã«ãââã¢ã»ãã«âïŒïŒïŒâ
ã¡ãã¬ã³ãžãªãã·ã¢ããªã³ ãŸãäžèšã®çš®ã ã®ååç©ã®é žä»å å¡©ãæ¬çºæã«
ä¿ãè¬å€ã®æå¹æåãšããŠçšãããããä»å å¡©ãš
ããŠçšããããé žãšããŠã¯ãå¡©åæ°ŽçŽ é žãã·ãŠãŠ
åæ°ŽçŽ é žãç¡«é žããªã³é žãç¡é žçã®ç¡æ©é žãé ¢
é žãã³ãã¯é žãã¢ãžãã³é žãããããªã³é žãé ç³
é žãããã«é žããã¬ã€ã³é žãã·ãŠãŠé žãã¯ãšã³
é žãå®æ¯éŠé žããã«ãšã³ã¹ã«ãã³é žãã¡ã¿ã³ã¹ã«
ãã³é žçã®ææ©é žãæããããã æ¬çºæã®è¡å§éäžå€ã¯ãããªãæ¹æ³ã§ãæäžã§
ãããã奜é©ã«ã¯ä»¥äžã®ãããªæ¹æ³ãå®æœãã
ãã ããªãã¡ç®äžæ³šå°ãéèå 泚å°ãçè泚å°ãè ¹
è å 泚å°çã®éçµå£æäžããŸãçµå£æäžãå¯èœã§
ããã æäžéã¯æ£è ã®å¹Žä»€ãå¥åº·ç¶æ ãäœéãåæåŠ
çããããªãã°ãã®çš®é¡ãåŠçœ®é »åºŠãææã®å¹æ
ã®æ§è³ªçã«ãã決å®ãããã äžè¬çã«æå¹æåã®ïŒæ¥æäžéã¯0.1ã100mgïŒ
KgäœéãéåžžïŒã30mgïŒKgäœéã§ãããïŒåãã
ãã¯ãã以äžæäžãããã çµå£æäžããå Žåã¯é å€ãã«ãã»ã«å€ãç²å€ã
液å€ããšãªãã·ã«å€çã®åœ¢äœã§ããŸãéçµå£æäž
ã®å Žåã¯æ¶²äœãããã¯æžæ¿çã®æ®ºèãã液ç¶ã®åœ¢
äœã§çšãããããäžè¿°ã®æ§ãªåœ¢äœã§çšããããå Ž
åãåºäœãããã¯æ¶²äœã®æ¯æ§ã®ãªã補å€çæ äœã
çµæã«å«ãŸãåŸãã åºäœæ äœã®äŸãšããŠã¯éåžžã®ãŒã©ãã³ã¿ã€ãã®
ã«ãã»ã«ãçšããããããŸãæå¹æåãè£å©è¬ãš
ãšãã«ãããã¯ãããªãã«é å€åãç²æ«å è£ ãã
ãã ãããã®ã«ãã»ã«ãé å€ãç²æ«ã¯äžè¬çã«ïŒã
95ïŒ ã奜ãŸããã¯25ã90ïŒ ééã®æå¹æåãå«
ãã ããªãã¡ãããã®æäžåœ¢åŒã§ã¯ïŒã500mgã奜
ãŸããã¯25ã250mgã®æå¹æåãå«æããã®ãã
ãã 液ç¶æ äœãšããŠã¯æ°Žãããã¯ç³æ²¹ãããŒãã
æ²¹ã倧è±æ²¹ãããã©ã«æ²¹ããŽãæ²¹çã®åæ€ç©èµ·å
ã®ããŸãã¯åæã®æ²¹çãçšããããã ãŸããäžè¬ã«ççé£å¡©æ°Žãããã¹ãããŒã¹ãã
ãã¯é¡äŒŒã®ã·ãšç³æº¶æ¶²ããšãã¬ã³ã°ãªã³ãŒã«ãã
ããã¬ã³ã°ãªã³ãŒã«ãããªãšãã¬ã³ã°ãªã³ãŒã«ç
ã®ã°ãªã³ãŒã«é¡ã液ç¶æ äœãšããŠå¥œãŸããããšã
ã«ççé£å¡©æ°Žãçšãã泚å°æ¶²ã®å Žåã«ã¯éåžž0.5
ã20ïŒ ã奜ãŸããã¯ïŒã10ïŒ ééã®æå¹æåãå«
ãããã«ããã çµå£æäžã®æ¶²å€ã®å Žåã0.5ã10ïŒ ééã®æå¹
æåãå«ãæžæ¿æ¶²ãããã¯ã·ããããããã ãã®å Žåã®æ äœãšããŠã¯éŠæãã·ãããã補å€
åŠçãã»ã«äœçã®æ°Žæ§è³Šåœ¢å€ãçšããã å®æœäŸ ïŒ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ããããªãã«ïŒâïŒïŒïŒâãã³ãŸãžãªããœãŒã« ïŒâïŒïŒâã¯ããããããªãã«ïŒâïŒïŒïŒâãã³
ãŸãžãªããœãŒã«ïŒïŒïœïŒããã³ïŒ®âããšãã«ãã
ã©ãžã³ïŒ2.4ïœïŒãDMFïŒ20mlïŒã«æº¶è§£ããããª
ãšãã«ã¢ãã³ïŒ1.7ïœïŒãå ãã宀枩äž10æéæ¹
æãããåå¿çµäºåŸãæ°Žäžã«æ³šããé ¢é žãšãã«ã§
æœåºãããæœåºæ¶²ãç¡æ°Žç¡«é žãœãŒãã§ä¹Ÿç¥åŸã溶
åªãçå»ããæ®æž£ãã¡ã¿ããŒã«ããçµæ¶åããã
åŸãããçµæ¶ããšã¿ããŒã«ããåçµæ¶ããïŒâ
ãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒããã
ãªãã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã«ãåŸã
ïŒ4.0ïœã84ïŒ åçïŒãäžèšååç©ã®ç©æ§ã¯è¡šïŒã®
No.47ã®æ¬ã«èšèŒãããŠãããšããã§ããã ãªããå¡©é žå¡©ãåŸãå Žåã¯ãæœåºæ¶²ãæ¿çž®åŸã
æ®æž£ãé ¢é žãšãã«ã«æº¶è§£ããŠ20ïŒ å¡©é žïŒãšã¿ããŒ
ã«ãå ããçããæ²æ®¿ãåãããšã¿ããŒã«ãã
åçµæ¶ããããšã«ãã€ãŠåŸãããã å®æœäŸ ïŒ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ãããªã«ãâïŒïŒïŒâãã³ãŸãžãªããœãŒã«ïŒå¡©
é žå¡© ïŒâïŒïŒâã¯ãããããªã«ïŒâïŒïŒïŒâãã³ãŸãž
ãªããœãŒã«ïŒ4.0ïœïŒããã³ïŒ®âããšãã«ããã©
ãžã³ïŒ3.0ïœïŒãDMFïŒ25mlïŒã«æº¶è§£ããããªãš
ãã«ã¢ãã³ïŒ2.2ïœïŒãå ãã80âã§40æéå ç±
æ¹æãããåå¿çµäºåŸãæ°Žäžã«æ³šããé ¢é žãšãã«
ã§æœåºãããæœåºæ¶²ãç¡æ°Žç¡«é žãœãŒãã§ä¹Ÿç¥åŸã
溶åªãçå»ãããæ®æž£ãé ¢é žãšãã«ã«æº¶è§£ãã20
ïŒ å¡©é žïŒãšã¿ããŒã«ïŒ6.5mlïŒãå ãçæããçµ
æ¶ãåãããšã¿ããŒã«ããåçµæ¶ããŠïŒâãïŒ
âïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒãããªã«ã
âïŒïŒïŒâãã³ãŸãžãªããµã³ïŒå¡©é žå¡©ãåŸã
ïŒ5.1ïœã68ïŒ åçïŒãäžèšååç©ã®ç©æ§ã¯è¡šïŒã®
No.57ã«èšèŒãããŠãããšããã§ããã å®æœäŸ ïŒ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ãããã«ãâïŒïŒïŒâãã³ãŸ
ãžãªããœãŒã« å®æœäŸïŒã§åŸãããïŒâãïŒâïŒïŒâããšãã«â
ïŒâããã©ãžãã«ïŒããããªãã«ãâïŒïŒïŒâã
ã³ãŸãžãªããµã³ïŒ4.0ïœïŒãã¡ã¿ããŒã«ïŒ50mlïŒ
ã«æžæ¿ããæ°ŽçŽ åç¡ŒçŽ ãããªãŠã ïŒ0.5ïœïŒãå
ãã宀枩äž10æéåå¿ãããåå¿çµäºåŸãåå¿æ¶²
ãæžå§äžçå»ããé ¢é žãšãã«ã§æœåºãããæœåºæ¶²
ã飜åé£å¡©æ°Žã§æŽæµåŸãç¡æ°Žç¡«é žãœãŒãã§ä¹Ÿç¥
ãã溶åªãçå»åŸãã¡ã¿ããŒã«ããçµæ¶åããã
ãšã«ãã€ãŠïŒâãïŒâïŒïŒâããšãã«âïŒâããã©
ãžãã«ïŒâïŒâããããã·ãããã«ãâïŒïŒïŒâã
ã³ãŸãžãªããœãŒã«ãåŸãïŒ3.6ïœã75ïŒ åçïŒãæ¬
ååç©ã®ç©æ§ã¯è¡šâïŒã®No.ïŒã®æ¬ã«ç€ºãããŠãã
ãšããã§ããã å®æœäŸ ïŒ ïŒâãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
âïŒâããããã·ããã«ãâïŒïŒïŒâãã³ãŸãž
ãªããœãŒã«ïŒå¡©é žå¡© å®æœäŸïŒã§åŸãããïŒâãïŒâïŒïŒâããšãã«â
ïŒâããã©ãžãã«ïŒãããªã«ãâïŒïŒïŒâãã³ãŸ
ãžãªããœãŒã«å¡©é žå¡©ïŒ3.8ïœïŒãã¡ã¿ããŒã«ïŒ50
mlïŒã«æžæ¿ã2NâNaOHïŒ4.5mlïŒãå ããæ°ŽçŽ
åç¡ŒçŽ ãããªãŠã ïŒ0.5ïœïŒãå ãã宀枩äž10æ
éæ¹æãããåå¿çµäºåŸã溶åªãçå»ããé ¢é žãš
ãã«ã§æœåºãã飜åé£å¡©æ°Žã§æŽæµããç¡æ°Žç¡«é žãœ
ãŒãã§ä¹Ÿç¥åŸ20ïŒ å¡©é žïŒãšã¿ããŒã«ïŒ4.9mlïŒã
å ããæåºããçµæ¶ãåãããšã¿ããŒã«ã§åçµ
æ¶ããããšã«ãã€ãŠãïŒâãïŒâïŒïŒâããšãã«â
ïŒâããã©ãžãã«ïŒâïŒâããããã·ããã«ãâ
ïŒïŒïŒâãã³ãŸãžãªããœãŒã«ïŒå¡©é žå¡©ãåŸã
ïŒ3.5ïœã62ïŒ åçïŒãæ¬ååç©ã®ç©æ§ã¯è¡šïŒã®No.
19ã®æ¬ã«ç€ºãããŠãããšããã§ããã å®æœäŸ ïŒ ïŒ®âãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒ
ãããã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãªãã·ã¢ããª
ã³ïŒå¡©é žå¡© âïŒïŒâã¯ããããããªãã«ïŒâïŒïŒïŒâã¡ã
ã¬ã³ãžãªãã·ã¢ããªã³2.0ïœãïŒïŒ®âãžã¡ãã«
ãã«ã ã¢ãã20mlã«æº¶è§£ããâããšãã«ããã©
ãžã³1.6ïœãšããªãšãã«ã¢ãã³ïŒmlãå ããçªçŽ
é°å²æ°äžã80âã§20æéæ¹æãããåå¿æ¶²ãæžå§
çå»ããæ®æž£ã«é ¢é žãšãã«ãš2Nâæ°Žé žåãããª
ãŠã 氎溶液ãå ããæ°Žå±€åé¢ããæŽã«æ°ŽæŽãïŒå
è¡ãªãé ¢é žãšãã«å±€ãç¡æ°Žç¡«é žãããªãŠã ã§ä¹Ÿç¥
åŸãé ¢é žãšãã«ãæžå§çå»ãããåºåœ¢ã®æ®æž£ããš
ã¿ããŒã«ããåçµæ¶ããâãïŒâïŒïŒâããšãã«
âïŒâããã©ãžãã«ïŒããããªãã«ãâïŒïŒïŒâ
ã¡ãã¬ã³ãžãªãã·ã¢ããªã³3.4ïœãåŸããïŒåç90
ïŒ ïŒæ¬¡ã«ããªããŠã ã¢ã«ãããŠã ãã€ãã©ã€ã
0.6ïœãšããã©ãã€ãããã©ã³20mlã®æžæ¿æ¶²ã«æ¹
æäžãããã©ãã€ãããã©ã³20mlã«æº¶è§£ããã
âãïŒâïŒïŒâããšãã«âïŒâããã©ãžãã«ïŒãã
ããªãã«ãâïŒïŒïŒâã¡ãã¬ã³ãžãªãã·ã¢ããªã³
ïŒïœã滎äžããã滎äžçµäºåŸãïŒæéå ç±éæµã
ããå·åŸãåžžæ³éããåŠçãè¡ãªããæåºããã
æ°Žé žåã¢ã«ãããŠã ãå¥ãã液ãæžå§çå»ã
ããæ®æž£ãã·ãªã«ã²ã«ã¯ããã粟補ããåŸããã
ã·ããããé ¢é žãšãã«ã«æº¶è§£åŸãæ°·å·æ¹æäž20ïŒ
å¡©åæ°ŽçŽ âé ¢é žãšãã«ãå ããŠæåºçµæ¶ãå
ãããšã¿ããŒã«ããåçµæ¶ããâãïŒâïŒïŒâã
ãšãã«âïŒâããã©ãžãã«ïŒãããã«ãâïŒïŒïŒ
âã¡ãã¬ã³ãžãªãã·ã¢ããªã³ïŒå¡©é žå¡©1.9ïœãåŸ
ãïŒåç74.8ïŒ ïŒæ¬ååç©ã®ç©æ§ã¯è¡šïŒã®No.79ã®
æ¬ã«ç€ºãããŠããéãã§ããã åæ§ã®æ¹æ³ã«ãã€ãŠãä»ã®ååç©ã補é ããã
ãã®ç©æ§ã¯ãè¡šïŒã«èšèŒãããŠããéãã§ããã
ãè¡šã
ãè¡šã
ãè¡šã
ãè¡šã
ãè¡šã
ãè¡šã
ãè¡šã
è©ŠéšäŸ
æ¬çºæã«ä¿ãè¬å€ã®è¡å§éäžäœçšã以äžã®æ¹æ³
ã§æ€èšãããããªãã¡ãåç©ã¯èªç¶çºçé«è¡å§ã©
ããïŒSHRïŒïŒ300ã370ïœãïŒãïŒæ什ïŒãçš
ãããšãŒãã«éº»é äžã«å°Ÿåèããæ¿å ¥ããã«ããŒ
ãã«ã«ãããç¡éº»é äžã§èŠ³è¡çã«è¡å§ããã³å¿æ
æ°ã枬å®ããè¬ç©æäžåã®å¹³åè¡å§ããã³å¿ææ°
ãæ±ããåŸãïŒæéããšã«è¬ç©ãïŒãïŒã10mgïŒ
Kgãçµå£æäžããéå§äœçšãå€å®ããæäžåå€ã
ãã®éäžçã§è¡šããããçµæãè¡šïŒã«ç€ºãã ãŸããæ¥æ§æ¯æ§å€ïŒLD50ïŒã¯ããŠã¹ãçšãã
ãªãããã€ãŒã«ã ãŠã€ã«ã³ã¯ãœã³ïŒLitchfield
âWilcoxonïŒæ³ã«ããç®åºãããã®çµæãè¡šïŒ
ã«ç€ºãã æ¬çºæã«ä¿ãè¬å€ã¯è¡šïŒã«ç€ºãåŠãçãããïŒ
mgïŒKgçµå£æäžã§ååãªè¡å§éäžäœçšã瀺ããè¬
å¹ã®çºçŸãéããäœçšãæç¶çã§ãããåãæ¥æ§
æ¯æ§ã匱ããè¬å¹ã®çºçŸéãèæ ®ããã°éåžžã«å®
å šæ§ã®é«ãè¬ç©ã§ãããšæšæž¬ãããã
ã§æ€èšãããããªãã¡ãåç©ã¯èªç¶çºçé«è¡å§ã©
ããïŒSHRïŒïŒ300ã370ïœãïŒãïŒæ什ïŒãçš
ãããšãŒãã«éº»é äžã«å°Ÿåèããæ¿å ¥ããã«ããŒ
ãã«ã«ãããç¡éº»é äžã§èŠ³è¡çã«è¡å§ããã³å¿æ
æ°ã枬å®ããè¬ç©æäžåã®å¹³åè¡å§ããã³å¿ææ°
ãæ±ããåŸãïŒæéããšã«è¬ç©ãïŒãïŒã10mgïŒ
Kgãçµå£æäžããéå§äœçšãå€å®ããæäžåå€ã
ãã®éäžçã§è¡šããããçµæãè¡šïŒã«ç€ºãã ãŸããæ¥æ§æ¯æ§å€ïŒLD50ïŒã¯ããŠã¹ãçšãã
ãªãããã€ãŒã«ã ãŠã€ã«ã³ã¯ãœã³ïŒLitchfield
âWilcoxonïŒæ³ã«ããç®åºãããã®çµæãè¡šïŒ
ã«ç€ºãã æ¬çºæã«ä¿ãè¬å€ã¯è¡šïŒã«ç€ºãåŠãçãããïŒ
mgïŒKgçµå£æäžã§ååãªè¡å§éäžäœçšã瀺ããè¬
å¹ã®çºçŸãéããäœçšãæç¶çã§ãããåãæ¥æ§
æ¯æ§ã匱ããè¬å¹ã®çºçŸéãèæ ®ããã°éåžžã«å®
å šæ§ã®é«ãè¬ç©ã§ãããšæšæž¬ãããã
ãè¡šã
ãè¡šã
ïŒ ååç©ã®æ§é ã¯è¡šïŒã®å¯Ÿå¿ãã
No.ã®æ¬ã®ååç©ãšåäžã§ã
ãã
No.ã®æ¬ã®ååç©ãšåäžã§ã
ãã
ãè¡šã
ïŒ ååç©ã®æ§é ã¯è¡šïŒã®å¯Ÿå¿ãã
No.ã®æ¬ã®ååç©ãšåäžã§ããã
No.ã®æ¬ã®ååç©ãšåäžã§ããã
Claims (1)
- ãç¹èš±è«æ±ã®ç¯å²ã ïŒ äžè¬åŒ() ãåŒäžãïœã¯ïŒãïŒã®æŽæ°ã瀺ããã¯âïŒCH2ïŒ
nâïŒïœã¯ïŒãïŒã®æŽæ°ã瀺ãïŒåã¯
ãåŒãïŒR1ã¯æ°ŽçŽ åååã¯ççŽ æ° ïŒãïŒã®ã¢ã«ãã«åºãR2ã¯C1ãC5ã®ã¢ã«ãã«åº
ã瀺ãïŒãã¯âCHïŒOHïŒâããåŒãå㯠ãåŒãïŒR3ã¯æ°ŽçŽ ååãC1ãC5ã®ã¢ã« ãã«åºåã¯ã¢ã·ã«åºã瀺ãïŒãã¯ããªãžã«åºãŸ
ãã¯ããã²ã³åºãC1ãC5ã®ã¢ã«ãã«åºãC1ãC5
ã®ã¢ã«ã³ãã·ã«åºããã³ããªãã«ãªãã¡ãã«åºã
ãéžã°ããïŒçš®ä»¥äžã®åºãæããŠããŠãããããš
ãã«åºã瀺ãããã§è¡šããããã¢ã«ãã¬ã³ãžãªã
ã·ãã³ãŒã³é¡ãŸãã¯ãã®é žä»å å¡©ãæå¹æåãšã
ãè¡å§éäžå€ã
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11947382A JPS5910517A (ja) | 1982-07-09 | 1982-07-09 | è¡å§éäžå€ |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11947382A JPS5910517A (ja) | 1982-07-09 | 1982-07-09 | è¡å§éäžå€ |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5910517A JPS5910517A (ja) | 1984-01-20 |
JPH0345047B2 true JPH0345047B2 (ja) | 1991-07-09 |
Family
ID=14762176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11947382A Granted JPS5910517A (ja) | 1982-07-09 | 1982-07-09 | è¡å§éäžå€ |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5910517A (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS636394U (ja) * | 1986-06-26 | 1988-01-16 | ||
JP2712222B2 (ja) * | 1988-01-29 | 1998-02-10 | äžè±ååŠæ ªåŒäŒç€Ÿ | æäžå®è¬ |
MX9201991A (es) * | 1991-05-02 | 1992-11-01 | Jonh Wyeth & Brother Limited | Derivados de piperazina y procedimiento para su preparacion. |
CN109384707B (zh) * | 2018-10-16 | 2021-12-17 | åäžçå·¥å€§åŠ | è¯å¹¶èïŒèªïŒç¯è¡çç©åå ¶çšé |
-
1982
- 1982-07-09 JP JP11947382A patent/JPS5910517A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
JPS5910517A (ja) | 1984-01-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0154969B1 (en) | Piperazine derivatives and their acid addition salts | |
EP0061149B1 (en) | Alkylenedioxybenzene derivatives and acid addition salts thereof and a process for their preparation | |
US4558129A (en) | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | |
EP0054304B1 (en) | Alkylenedioxybenzene derivatives, acid addition salts thereof and a method for their preparation | |
JPS6340784B2 (ja) | ||
JPH0819064B2 (ja) | ã€ã³ãã³ã®æ°èªå°äœããããã®è£œé æ³åã³è¬å€ãšããŠã®äœ¿çš | |
JPH0345042B2 (ja) | ||
JPS6227062B2 (ja) | ||
JPH0345047B2 (ja) | ||
JPS6120536B2 (ja) | ||
EP0161498B1 (en) | Phenylpiperazine derivatives and their acid addition salts | |
JPS647995B2 (ja) | ||
JPS645035B2 (ja) | ||
JPH0351711B2 (ja) | ||
JPS645036B2 (ja) | ||
JPH0352459B2 (ja) | ||
JPH0345070B2 (ja) | ||
JPH0345045B2 (ja) | ||
JPS645037B2 (ja) | ||
JPH0345046B2 (ja) | ||
JPH0582388B2 (ja) | ||
JPH0123469B2 (ja) | ||
JPS6121463B2 (ja) | ||
JPH0249303B2 (ja) | ||
JPS6237627B2 (ja) |