JPH0330566B2 - - Google Patents
Info
- Publication number
- JPH0330566B2 JPH0330566B2 JP56104246A JP10424681A JPH0330566B2 JP H0330566 B2 JPH0330566 B2 JP H0330566B2 JP 56104246 A JP56104246 A JP 56104246A JP 10424681 A JP10424681 A JP 10424681A JP H0330566 B2 JPH0330566 B2 JP H0330566B2
- Authority
- JP
- Japan
- Prior art keywords
- acid
- stratum corneum
- softening
- basic amino
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001413 amino acids Chemical class 0.000 claims description 19
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 10
- 239000002537 cosmetic Substances 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 8
- VLHZUYUOEGBBJB-UHFFFAOYSA-N hydroxy stearic acid Natural products OCCCCCCCCCCCCCCCCCC(O)=O VLHZUYUOEGBBJB-UHFFFAOYSA-N 0.000 claims description 5
- 239000004310 lactic acid Substances 0.000 claims description 5
- 235000014655 lactic acid Nutrition 0.000 claims description 5
- 210000000434 stratum corneum Anatomy 0.000 description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- 230000000694 effects Effects 0.000 description 13
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
- 210000003491 skin Anatomy 0.000 description 11
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 7
- 239000004472 Lysine Substances 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 7
- 230000003020 moisturizing effect Effects 0.000 description 7
- 239000012071 phase Substances 0.000 description 7
- 239000007864 aqueous solution Substances 0.000 description 6
- 239000012153 distilled water Substances 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 239000003205 fragrance Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- 230000002335 preservative effect Effects 0.000 description 4
- 239000004475 Arginine Substances 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 3
- 238000004945 emulsification Methods 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- -1 triethanolamine Chemical compound 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 235000013871 bee wax Nutrition 0.000 description 2
- 239000012166 beeswax Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 229940035044 sorbitan monolaurate Drugs 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
- FSBIGDSBMBYOPN-VKHMYHEASA-N L-canavanine Chemical compound OC(=O)[C@@H](N)CCONC(N)=N FSBIGDSBMBYOPN-VKHMYHEASA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- FSBIGDSBMBYOPN-UHFFFAOYSA-N O-guanidino-DL-homoserine Natural products OC(=O)C(N)CCON=C(N)N FSBIGDSBMBYOPN-UHFFFAOYSA-N 0.000 description 1
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 1
- 229940063655 aluminum stearate Drugs 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 229960003104 ornithine Drugs 0.000 description 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229960005078 sorbitan sesquioleate Drugs 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Description
【発明の詳細な説明】
本発明は、分子中に水酸基とカルボキシル基を
もつオキシ酸と、塩基性アミノ酸を含む皮膚柔軟
化粧料に関する。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a skin softening cosmetic containing an oxyacid having a hydroxyl group and a carboxyl group in its molecule and a basic amino acid.
皮膚の最外層である角質層は、冬期、低温、低
湿など厳しい気象条件下で、しばしば乾燥したり
ざらつく。このようなことは、また洗剤、溶剤の
過度の使用においてもみられる。この皮膚の変化
は角質層中のNMF（天然保湿因子：ナチユラル
モイスチユアライジング・フアクター）とよばれ
る吸湿性の水溶性成分が失なわれ、角質層中の水
分が減少し角質層の柔軟性がなくなるためである
と考えられている。それゆえ、従来の皮膚を柔軟
にするための化粧料には、角質層に水分をできる
だけ多く与え、なおかつ、それを長時間保持させ
ることを考慮し、さまざまな保湿剤が配合されて
きた。また、α−オキシ酸の角質柔軟作用を利用
したものも提案されている。（特公昭55−19291号
公報）しかし保湿剤の皮膚への適用は、その効果
が一過性であり、氷続しない。また、α−オキシ
酸の適用は正常な皮膚生理を阻害するような低い
PH領域（PH２〜４）でしか、その効果が発現され
ないなど欠点が多い。 The outermost layer of the skin, the stratum corneum, often becomes dry and rough during harsh weather conditions such as winter, low temperature, and low humidity. This can also occur with excessive use of detergents and solvents. This change in the skin occurs due to the loss of a hygroscopic water-soluble component called NMF (natural moisturizing factor) in the stratum corneum, resulting in a decrease in moisture in the stratum corneum and the flexibility of the stratum corneum. It is thought that this is due to the disappearance of Therefore, conventional cosmetics for softening the skin have been formulated with various moisturizing agents in order to provide as much moisture as possible to the stratum corneum and retain it for a long time. Furthermore, products utilizing the keratin softening effect of α-oxyacid have also been proposed. (Japanese Patent Publication No. 55-19291) However, when a moisturizer is applied to the skin, its effect is temporary and does not last. In addition, the application of α-oxyacids may be too low to inhibit normal skin physiology.
It has many drawbacks, such as its effects are only expressed in the PH range (PH 2 to 4).
この欠点を補うために、水酸化ナトリウムや水
酸化カリウムなどの強アルカリやトリエタノール
アミンなどのオキシ類を添加して中性PH領域で実
施した例もみられるが、これらの強アルカリは、
多量に配合すると安定性が悪いものもみられ、皮
膚のPH域に合わせるのにも困難を伴ない、一定の
品質が得られ難い。また、アミン類については、
文献等にみられるように、長期連用した場合、体
質によつてはアレルギーの認められることが知ら
れているので、他の中和剤を用いた方が好まし
い。 In order to compensate for this drawback, there are examples of adding strong alkalis such as sodium hydroxide or potassium hydroxide, or oxy compounds such as triethanolamine, in a neutral pH range, but these strong alkalis
When blended in large amounts, some products have poor stability, and it is difficult to match the pH range of the skin, making it difficult to obtain a constant quality. Regarding amines,
As seen in the literature, it is known that long-term use may cause allergies depending on the constitution, so it is preferable to use other neutralizing agents.
本発明者らは、これらの欠点を解決するため、
鋭意研究を重ねた結果特定のオキシ酸と、生体構
成成分で、NMF中の遊離アミノ酸として存在し
皮膚科学的に安全性が立証されている塩基性アミ
ノ酸を配合することにより、皮膚のPHである弱酸
性（PH4.5〜７）で従来の化粧料に比して皮膚科
学的に極めて安全で、角層の保質性、柔軟性に秀
れ、著しく長時間柔軟効果を持続させることがで
きる化粧料を見い出し完成するに至つた。 In order to solve these drawbacks, the present inventors
As a result of intensive research, we have successfully improved the pH of the skin by combining specific oxyacids and basic amino acids, which are biological constituents and exist as free amino acids in NMF, and whose safety has been proven dermatologically. Weakly acidic (PH4.5-7), it is dermatologically safer than conventional cosmetics, has excellent stratum corneum preservation and flexibility, and can maintain its softening effect for an extremely long time. He discovered and perfected a cosmetic product.
即ち、本発明は、乳酸、オキシカプリン酸、オ
キシステアリン酸及びクエン酸から選ばれた一種
または二種以上のオキシ酸と、塩基性アミノ酸
を、配合モル比１：0.5〜0.5：１で１〜10％配合
したことを特徴とする、PHが4.5〜7.0の皮膚柔軟
化粧料を提供するものである。 That is, in the present invention, one or more oxyacids selected from lactic acid, oxycapric acid, oxystearic acid, and citric acid and a basic amino acid are mixed at a molar ratio of 1:0.5 to 0.5:1. The present invention provides a skin softening cosmetic with a PH of 4.5 to 7.0, which is characterized by containing 10%.
本発明によれば、オキシ酸に塩基性アミノ酸を
組合せることによつてオキシ酸単独よりも吸湿性
が著しく向上し角層に付与される水分量が増し、
その結果、皮膚の角層を柔軟にして、角質細胞の
正常な代謝を助けるという効果を発揮することが
できる。 According to the present invention, by combining a basic amino acid with an oxyacid, the hygroscopicity is significantly improved compared to the oxyacid alone, and the amount of moisture imparted to the stratum corneum is increased.
As a result, it can have the effect of softening the stratum corneum of the skin and supporting normal metabolism of the stratum corneum.
次に本発明の構成について述べる。本発明に用
いられるオキシ酸は、乳酸、オキシカプリン酸、
オキシステアリン酸及びクエン酸から選ばれた一
種または二種以上のオキシ酸である。 Next, the configuration of the present invention will be described. The oxyacids used in the present invention include lactic acid, oxycapric acid,
One or more oxyacids selected from oxystearic acid and citric acid.
本発明で用いられる塩基性アミノ酸は、たとえ
ば、リジン、アルギニン、ヒスチジン、オルニチ
ン、カナバニン等である。 The basic amino acids used in the present invention include, for example, lysine, arginine, histidine, ornithine, and canavanine.
オキシ酸と塩基性アミノ酸との割合はモル比で
１：0.5〜0.5：１であるが、好ましくは１：0.7〜
0.7：１のように等量に近い比が望ましい。化粧
料中に含まれるオキシ酸と塩基性アミノ酸の混合
物の濃度は重量で0.1〜20％であるが、好ましく
は１〜10％である。 The molar ratio of oxyacid to basic amino acid is 1:0.5 to 0.5:1, preferably 1:0.7 to 0.5:1.
A ratio close to equivalence, such as 0.7:1, is desirable. The concentration of the mixture of oxyacid and basic amino acid contained in the cosmetic is 0.1 to 20% by weight, preferably 1 to 10%.
本発明において、オキシ酸と塩基性アミノ酸は
塩として配合してもかまわない。 In the present invention, the oxyacid and the basic amino acid may be blended as a salt.
本発明の皮膚柔軟化粧料は、以上の必須成分の
他に、界面活性剤、油分、保湿剤、水等化粧料と
して一般に用いられる基剤が必要に応じて配合さ
れる。 In addition to the above-mentioned essential ingredients, the skin softening cosmetic composition of the present invention may optionally contain bases commonly used in cosmetic compositions, such as surfactants, oils, humectants, and water.
次に、実施例により本発明をさらに詳細に説明
する。なお、配合量は特に記載のあるものを除き
重量％である。 Next, the present invention will be explained in more detail with reference to Examples. In addition, the blending amounts are weight % unless otherwise specified.
実施例 １
α−オキシカプリル酸 0.15M 24ｇ
リジン 0.15M 21.9ｇ
水 954.1ｇ
比較例 １
α−オキシカプリル酸 0.15M 24.0ｇ
水 976.0ｇ
製造方法
α−オキシカプリル酸24ｇとリジン21.9ｇを水
に溶かし、全体が1000ｇになるように水を加え
る。Example 1 α-oxycaprylic acid 0.15M 24g Lysine 0.15M 21.9g Water 954.1g Comparative Example 1 α-oxycaprylic acid 0.15M 24.0g Water 976.0g Production method Dissolve 24g α-oxycaprylic acid and 21.9g lysine in water. , Add water so that the total amount is 1000g.
オキシカルボン酸と塩基性アミノ酸を配合した
水溶液（実施例１）とオキシカルボン酸のみを含
む水溶液（比較例１）のPH、角層に対する保湿
性、柔軟効果を比較した。 An aqueous solution containing oxycarboxylic acid and a basic amino acid (Example 1) and an aqueous solution containing only oxycarboxylic acid (Comparative Example 1) were compared in terms of pH, moisturizing properties for the stratum corneum, and softening effects.
保湿性の測定は、一定重量の角層を試験水溶液
に充分浸漬した後、測定湿度中に放置して行い、
定重量に達した時の、角層100mg中の水分量（mg）
を吸湿量として表わした。 Moisture retention is measured by thoroughly immersing a certain weight of the stratum corneum in the test aqueous solution and then leaving it in the measuring humidity.
Water content (mg) in 100mg of stratum corneum when constant weight is reached
is expressed as the amount of moisture absorbed.
又、柔軟効果の測定は、20mm×５mmの角層片に
試験水溶液2μを塗布し、東洋製機製の動的粘
弾性測定装置を用い弾性率を測定した。 The softening effect was measured by applying 2μ of the test aqueous solution to a 20 mm x 5 mm piece of the stratum corneum, and measuring the elastic modulus using a dynamic viscoelasticity measuring device manufactured by Toyo Seiki.
柔軟効果は、ブランクとして測定した角層の弾
性率(E)に対する、試験水溶液塗布後ｔ時間の弾性
率（Et）の比Ｅ／Etで表わした。 The softening effect was expressed as the ratio E/Et of the elastic modulus (Et) at time t after application of the test aqueous solution to the elastic modulus (E) of the stratum corneum measured as a blank.
結果を表１、図１，２に示す。 The results are shown in Table 1 and Figures 1 and 2.
表１、実施例１と比較例１のPH
PH
実施例１ 6.58
比較１ 2.40
表１から明きらかなように、実施例１は比較例１
に比べて、PHは、中性付近である。このことは、
塩基性アミノ酸添加によつて皮フ生理学上安全性
が高まつたことを示している。また、実施例１と
比較例２の各水溶液を角層に塗布した後の角層の
吸湿量は、第１図からみても明らかなように、塩
基性アミノ酸添加によつて、大きく向上した。一
方、角層に対する柔軟効果も、塩基性アミノ酸の
添加により、著しく、増加することが第２図より
明きらかである。Table 1, PH of Example 1 and Comparative Example 1 PH Example 1 6.58 Comparison 1 2.40 As is clear from Table 1, Example 1 is the same as Comparative Example 1.
Compared to , the pH is near neutral. This means that
This indicates that the addition of basic amino acids has increased the physiological safety of the skin. Further, as is clear from FIG. 1, the amount of moisture absorbed by the stratum corneum after each of the aqueous solutions of Example 1 and Comparative Example 2 was applied to the stratum corneum was greatly improved by the addition of the basic amino acid. On the other hand, it is clear from FIG. 2 that the softening effect on the stratum corneum is also significantly increased by the addition of basic amino acids.
実施例 ２
柔軟化粧水
クエン酸 2.8
リジン 2.2
グリセリン 3.0
プロピレングリコール 4.0
ジプロピレングリコール 4.0
ポリオキシエチレン（20モル）ソルビタンモノ
ラウリン酸エステル 1.5
エチルアルコール 10.0
蒸留水 72.3
香料 0.1
防腐剤 0.1
（製造方法）
蒸留水にクエン酸、リジン、グリセリン、プロ
ピレングリコール、ジプロピレングリコールを加
え、室温にて溶解する（水部）。エチルアルコー
ルにポリオキシエチレンソルビタンモノラウリン
酸エステル香料、防腐剤を加え、室温にて溶解す
る（アルコール部）。水部にアルコール部を加え
柔軟化粧水を得る。Example 2 Soft lotion Citric acid 2.8 Lysine 2.2 Glycerin 3.0 Propylene glycol 4.0 Dipropylene glycol 4.0 Polyoxyethylene (20 mol) Sorbitan monolaurate 1.5 Ethyl alcohol 10.0 Distilled water 72.3 Fragrance 0.1 Preservative 0.1 (Production method) In distilled water Add citric acid, lysine, glycerin, propylene glycol, and dipropylene glycol and dissolve at room temperature (water part). Add polyoxyethylene sorbitan monolaurate fragrance and preservative to ethyl alcohol and dissolve at room temperature (alcohol part). An alcohol part is added to the water part to obtain a softening lotion.
得られた柔軟化粧水は、角層に対して優れた保
湿効果、柔軟効果を示した。 The obtained softening lotion exhibited excellent moisturizing and softening effects on the stratum corneum.
実施例 ３
Ｗ／Ｏ型乳液
マイクロクリスタリンワツクス 1.0
ミツロウ 2.0
ラノリン 2.0
流動パラフイン 30.0
ソルビタンセスキオレイン酸エステル 4.0
ポリオキシエチレンソルビタンモノオレイン酸
エステル（20E.O.） 1.0
ステアリン酸アルミニウム 0.2
乳酸 1.7
アルギニン 2.6
蒸留水 55.4
香料 0.4
防腐剤 0.4
（製造方法）
蒸留水に乳酸、アルギニンを加え加熱して70℃
に保つ（水相）。他の成分を混合し加熱溶解して
70℃に保つ（油相）。油相を撹拌しながら、これ
に水相を徐々に加えホモミキサーで均一に乳化す
る。乳化後撹拌しながら30℃まで冷却する。Example 3 W/O type emulsion microcrystalline wax 1.0 Beeswax 2.0 Lanolin 2.0 Liquid paraffin 30.0 Sorbitan sesquioleate 4.0 Polyoxyethylene sorbitan monooleate (20E.O.) 1.0 Aluminum stearate 0.2 Lactic acid 1.7 Arginine 2.6 Distillation Water 55.4 Fragrance 0.4 Preservative 0.4 (Production method) Add lactic acid and arginine to distilled water and heat to 70℃.
(aqueous phase). Mix other ingredients and heat to dissolve
Keep at 70℃ (oil phase). While stirring the oil phase, gradually add the water phase to it and uniformly emulsify with a homomixer. After emulsification, cool to 30°C while stirring.
得られた乳液は、角層に対して優れた保湿効
果、柔軟効果を示した。 The obtained emulsion exhibited excellent moisturizing and softening effects on the stratum corneum.
実施例 ４
Ｏ／Ｗ型クリーム
ミツロウ 10.0
セチルアルコール 5.0
水添ラノリン 8.0
スクワラン 37.5
グリセリルモノステアリン酸エステル 2.0
ポリオキシエチレン（20モル）ソルビタンモノ
ラウリン酸エステル 2.0
プロピレングリコール 5.0
オキシステアリン酸 4.7
リジン 2.2
蒸留水 25.9
香料 0.5
防腐剤 0.5
（製造方法）
蒸留水にプロピレングリコール、オキシステア
リン酸、リジンを加え、加熱して70℃に保つ（水
相）。他の成分を混合し、加熱溶解して70℃に保
つ（油相）。水相に油相を加え予備乳化を行ない、
ホモミキサーで均一に乳化し、乳化後冷却しなが
らかきまぜる。Example 4 O/W type cream beeswax 10.0 Cetyl alcohol 5.0 Hydrogenated lanolin 8.0 Squalane 37.5 Glyceryl monostearate 2.0 Polyoxyethylene (20 mol) Sorbitan monolaurate 2.0 Propylene glycol 5.0 Oxystearic acid 4.7 Lysine 2.2 Distilled water 25.9 Fragrance 0.5 Preservative 0.5 (Production method) Add propylene glycol, oxystearic acid, and lysine to distilled water, heat and keep at 70℃ (water phase). Mix other ingredients, heat and dissolve and keep at 70℃ (oil phase). Add the oil phase to the water phase for preliminary emulsification.
Uniformly emulsify with a homomixer, and after emulsification, stir while cooling.
得られた乳液は角層に対して優れた保湿効果、
柔軟効果を示した。 The obtained emulsion has an excellent moisturizing effect on the stratum corneum,
It showed a softening effect.
第１図は、実施例１、比較例１及び蒸留水で処
理した角層の保湿性を示すグラフ。第２図は、実
施例１及び比較例１の角層に対する柔軟効果を示
すグラフ。
FIG. 1 is a graph showing the moisturizing properties of the stratum corneum treated with Example 1, Comparative Example 1, and distilled water. FIG. 2 is a graph showing the softening effect on the stratum corneum of Example 1 and Comparative Example 1.
Claims (1)
酸及びクエン酸から選ばれた一種または二種以上
のオキシ酸と、塩基性アミノ酸を、配合モル比
１：0.5〜0.5：１で１〜10％配合したことを特徴
とする、PHが4.5〜7.0の皮膚柔軟化粧料。1. One or more oxyacids selected from lactic acid, oxycapric acid, oxystearic acid, and citric acid and basic amino acids are blended in a molar ratio of 1:0.5 to 0.5:1 in an amount of 1 to 10%. A skin softening cosmetic with a pH of 4.5 to 7.0.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10424681A JPS588007A (en) | 1981-07-03 | 1981-07-03 | Cosmetic for making skin soft |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10424681A JPS588007A (en) | 1981-07-03 | 1981-07-03 | Cosmetic for making skin soft |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS588007A JPS588007A (en) | 1983-01-18 |
| JPH0330566B2 true JPH0330566B2 (en) | 1991-04-30 |
Family
ID=14375578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10424681A Granted JPS588007A (en) | 1981-07-03 | 1981-07-03 | Cosmetic for making skin soft |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS588007A (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5942250A (en) * | 1986-12-23 | 1999-08-24 | Tristrata Technology, Inc. | Compositions and methods for enhancing the topical effects of sunscreen agents |
| US5385938B1 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Method of using glycolic acid for treating wrinkles |
| US5834510A (en) * | 1986-12-23 | 1998-11-10 | Tristrata Technology, Inc. | Compositions comprising 2-hydroxycarboxylic acids and related compounds, and methods for alleviating signs of dermatological aging |
| AU618517B2 (en) * | 1986-12-23 | 1992-01-02 | Eugene J. Van Scott | Additives enhancing topical actions of therapeutic agents |
| US5389677B1 (en) * | 1986-12-23 | 1997-07-15 | Tristrata Inc | Method of treating wrinkles using glycalic acid |
| US5702688A (en) * | 1986-12-23 | 1997-12-30 | Tristrata Technology, Inc. | Amphoteric compositions and polymeric forms of alpha hydroxyacids, and their therapeutic use |
| WO1992018116A1 (en) * | 1991-04-10 | 1992-10-29 | Yu Ruey J | Compositions comprising 2-hydroxycarboxylic acids and related compounds, and methods for alleviating signs of dermatological aging |
| DE4341000A1 (en) * | 1993-12-02 | 1995-06-08 | Beiersdorf Ag | Use of L-arginine, L-ornithine or L-citrulline and topical preparations with these substances |
| TW300883B (en) * | 1994-07-26 | 1997-03-21 | Kao Corp | |
| DE19518815A1 (en) * | 1995-05-23 | 1996-11-28 | Beiersdorf Ag | Cosmetic or dermatological preparations containing alpha-hydroxy fatty acids |
| FR2737407B1 (en) * | 1995-07-31 | 1997-09-12 | Oreal | USE OF HYDROXYLATED CARBOXYLIC ACIDS FOR THE TREATMENT OF KERATINIC MATERIALS |
| JP3444329B2 (en) * | 1996-04-03 | 2003-09-08 | ポーラ化成工業株式会社 | Water-in-oil emulsion composition |
| FR2756489A1 (en) * | 1996-12-02 | 1998-06-05 | Eynard Michele | Treatment of hyperkeratoses |
| US6191167B1 (en) | 1997-12-29 | 2001-02-20 | Tristrata Technology, Inc. | Pharmaceutical compositions containing hydroxycarboxylic acid and/or ketocarboxylic acids and methods of using the same |
| JP2000327560A (en) * | 1999-05-18 | 2000-11-28 | Noevir Co Ltd | Bathing agent composition |
| JP4870257B2 (en) * | 2000-09-11 | 2012-02-08 | 株式会社コーセー | Cosmetics |
| JP2004244341A (en) * | 2003-02-12 | 2004-09-02 | Noevir Co Ltd | Weakly acidic external preparation for skin and weakly acidic skin cleanser |
| JP5006056B2 (en) * | 2007-01-22 | 2012-08-22 | 株式会社ナリス化粧品 | Toilet lotion |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5277011A (en) * | 1975-12-23 | 1977-06-29 | Ajinomoto Co Inc | Preparation of l-malate |
| JPS5519291A (en) * | 1978-07-24 | 1980-02-09 | Unilever Nv | Cosmetic composition |
-
1981
- 1981-07-03 JP JP10424681A patent/JPS588007A/en active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5277011A (en) * | 1975-12-23 | 1977-06-29 | Ajinomoto Co Inc | Preparation of l-malate |
| JPS5519291A (en) * | 1978-07-24 | 1980-02-09 | Unilever Nv | Cosmetic composition |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS588007A (en) | 1983-01-18 |
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