JPH03176414A - Cosmetic for skin, scalp and hair containing agent for inhibiting proliferation of dandruff bacteria and composed of component extracted from plant - Google Patents

Abstract

PURPOSE:To obtain a dandruff-preventing skin agent for external use or cosmetic for skin, scalp and hair by compounding a water-soluble component extracted from Japanese and Chinese crude herb drugs as an agent for inhibiting proliferation of dandruff bacteria. CONSTITUTION:The objective cosmetic can be produced by compounding a skin agent for external use for the treatment of skin, hair, scalp, etc., or a cosmetic with 0.1-5% of a dandruff bacteria inhibiting agent containing a water- soluble component extracted from UKON (rhizome of Curcuma longa), SHAJIN (root of Adenophora stricta) and/or AMACHAZURU (Gynostemma pentaphyllum). The dandruff bacteria is Pityrosporum ovale which is a yeast constantly existing on the scalp. The dandruff bacteria inhibiting agent is also effective in pharmaceutically treating seborrheic eczema of scalp, preventing alopecia and promoting the blood flow of peripheral vessel.

Description

Detailed Description of the Invention "Industrial Application Field" The PO growth inhibitor made of an extract of a specified plant according to the present invention is formulated into a dosage form (formulation) for external application or rubbing. , pharmaceuticals, quasi-drugs.

Can be used as cosmetics.

Its effects can prevent, prevent, and improve the onset of dandruff caused by PO and the accompanying itching. Furthermore, the Po growth inhibitor obtained according to the present invention has a strong antioxidant effect on fats and oils, and is effective, for example, in preventing rancidity of the fat and oil base used in the formulation.

``Conventional technology'' Various causes have been known to cause dandruff and itching on the skin and scalp, but one of them is 5. It is said that the prevalence of dandruff and itching is particularly high in the period from the infancy stage to adulthood, and symptoms associated with dandruff and itching are known to increase in such cases.

Therefore, recently, drugs that inhibit or inhibit the growth of dandruff are considered to be useful for effective prevention and prevention, and when developing drugs to prevent dandruff, PO
There is a need for something that has a growth inhibiting effect on.

In other words, research on the sebum secretion ability from a biochemical perspective shows that dandruff or the itching that accompanies dandruff is caused by triglycerides in sebum being released into the follicular canal.
As a result of the invasion, lipase production is increased, which increases the production of glycerol and MM fatty acids, and the excess free fatty acids produced at this time have particularly strong saturation-forming and inflammation-inducing effects. That's true.

Originally, PO is lipid-dependent and lipophilic, so as sebum increases and accumulates in the hair follicle canal, PO also gradually increases.

Furthermore, in addition to this, neutrophil chemotactic ability and complement activation factors by PO, and the destruction of hair follicle epithelium by protease, lipase, hyaluronidase, etc., which are products of the bacteria,
The induction of inflammation is also being considered as a new hypothesis.

In addition to the above factors, the disease develops due to a complex interrelationship of internal and external factors such as genetic factors, age, dietary factors, gastrointestinal disorders, stress, irregular menstruation, mechanical stimulation, and cosmetics. However, in any case, in the mechanism of occurrence of dandruff and itching, preventing the inhabitation (invasion and growth) of PO in the lesions is the best way to prevent and treat dandruff and itching. It is considered to be very important.

Furthermore, dandruff consists of secretions from sebaceous glands, secretions from sweat glands, peelings from the epidermal layer, etc. 1 It usually occurs due to increased secretion of sebaceous glands, etc., and is also promoted by the proliferation of bacteria on the skin, especially PO. That is what is said.

Therefore, scalp and hair cosmetics containing antibacterial agents and bactericidal agents that have a growth-inhibiting effect on PO have traditionally been used to treat dandruff,
It has been used to prevent itching, and a typical example is in hair shampoo. Zinc pyrithione can be used.

Recently, extracts from various naturally occurring plants that have a growth inhibiting effect on dandruff bacteria have been actively applied to the skin and scalp.

``Problem to be solved by the invention'' Zinc pyrithione, which is often used as an anti-itch agent, hardly dissolves in water or ethanol.
It has problems such as the formation of precipitates and lees, and is therefore unsuitable for use in formulations that are emulsified or dispersed, and not in formulations that are not in a dispersion system.

In addition, the recent trend toward natural products has led to an increasing use of plant extracts in hair cosmetics.

However, the amount of water-soluble plant Sodeyama extract that has a PO growth inhibiting effect was extremely small.

Therefore, the present inventors took this opportunity to find water-soluble natural products from various plants that have the effect of inhibiting PO growth, and based on many plants, We conducted a search and evaluation of extracts that were randomly selected and characterized for their preventive effects on dandruff.

<Oral> Structure of the Invention The present invention provides a dandruff bacteria growth inhibitor using a water-soluble component obtained from at least one of turmeric, shajin, and Jiaogulan, and an anti-dandruff agent containing the same. This product relates to external preparations for skin, or cosmetics for the skin, scalp, and hair.

``Means to solve the problem'' The effects of plant-derived ingredients on PO have already been demonstrated in Kichi 113 [
(Document source: Cosmetic Journal, Vol. 22, Vol. 3, 1988) According to the report, from among the known plant extracts and grasses, there are many plants such as Aspergillus japonicus, Stonewort, Cucumber, and Chamomile. The extract has been confirmed to have a growth inhibiting effect on PO.

The present inventors extracted water-soluble components from many other plants, such as turmeric and Jiaogulan, and thereby obtained P.
They succeeded in selecting a dandruff fungus growth inhibitor that has an inhibitory effect on O dandruff growth.

“Vityrosvorum has an inhibitory effect on opal (
(a) Test method Test bacterial species, Vityrosvorum opal (IFo 0
656) was cultured on a polydextrose agar medium containing 5% Nikkor TMGO-5 (manufactured by Nikko Chemical Co., Ltd.), and 3 platinum loops were taken and placed in 5 mβ of physiological saline containing 0.7% Twin 80. Vityrosvorum was made into an opal suspension.

This Vityrosvorum opal suspension was added to a polydextrose plate medium (9%) containing 5% Nikkor TMGO-5.
Smear 20ul on 0ml.

After 30 minutes, place a disk for antibiotic titer measurement in the center of the medium, drop 30 μβ of the sample (each plant extract) there,
After culturing at 37°C for 48 hours, the diameter of the produced inhibition circle was measured.

(b) Results of Bokinu Table 1 below shows the results of the growth inhibition effect on PO.

In addition, PO growth inhibitors (
Extract) is the effect of those obtained in Production/Extraction Examples 1 to 3 described later.

In addition, in the final evaluation, when the disk diameter is 8 mm, the blocking circle diameter is 1 mm or less.

Although there were many cases, it was excluded here because it was considered to have no growth inhibiting effect.

That is, Table 1 shows the same growth-inhibiting effect on PO that extracts of chamomile, kujin, etc. have as shown in the above publication (Yoshimasa et al., Cosmetic Journal, Volume 22, Volume 3, 1988). We were able to single out turmeric, shajin, and Jiaogulan extracts as having moderate effects.

The extract obtained from the identified plants according to the present invention is P
As an O growth inhibitor, it can be effective by incorporating a small amount into a prescription, and can be used in shampoos, conditioners, hair tonics, hair creams, hair ticks, hair pomades, etc. for one hair and one scalp, and even cosmetics for the skin. It can be used by being incorporated into external skin preparations and cosmetics, which have various dosage forms such as water, cream, and emulsion.

(Approximate amount of compounding amount) All of the extracts and PO growth inhibitors according to the present invention can be used as a compounding agent to prevent dandruff and itching, and the upper and lower limits of the amount to be included in the prescription are not specified. ,
As for the usual blending amount, effects can be expected by containing it in the prescription at about 0.1 to 0.5%.

In addition, the PO growth inhibitor made from the plant extract according to the present invention can be used in all kinds of cosmetics, from solution-type products to creams, milky lotions, and even foundations, lipsticks, shampoos, conditioners, and other skin and skin products.・Can be added to the formulation of products for hair, etc.

For specific formulations, for example, see the following publications:
Prescription examples corresponding to various uses are shown, so if you use them according to the addition method, it will be better.

(Location of references in prescriptions) Science of fragrances and cosmetics; Back 1) Osamu et al. / IO 5, 1981: Published by Koyo Shoten (commentary on extracted super-thick plants) The plants used in the present invention are Since there are many herbal medicines, they are listed below using their Japanese names.

■ Turmeric/Kaikin It is the dried rhizome of turmeric, a member of the ginger family.

[Yes] Shajin/Yusan. Adenophra ginseng (Adenophra), a member of the Campanulaceae family.
triphylla A, DC, 5ubsup, a
perticaspanulataKitamural
It is the dried root of.

■ Amachazuru/sweet tea vine: Dried leaves, stems, roots, and whole plant of Amachazur, a member of the Cucurbitaceae family.

(Disclosure of basic manufacturability) [1] Any of the above @~@ #! ! Use the neck or Class IIi or higher as a raw material, add it to water (IR water), leave it for day and night, stir well, centrifuge and separate the aqueous layer,
PO growth inhibitor and eggplant.

In use, the aqueous layer portion (aqueous solution) may be used as it is, or may be used as a concentrated solution, paste, or even dry powder as appropriate.

Below, in the present invention, based on the specified plant,
An example of production/extraction of a solution-type PO growth inhibitor obtained by the simplest method is shown.

That is, the data of the PO growth inhibition test disclosed above (Table 1) discloses the effects of plant extracts obtained by the methods shown below.

('5J Preparation/Extraction Example 1) Add 1 Oe of water to 1 kg of turmeric, and at room temperature,
- After being stirred day and night, centrifugation is performed to obtain a solution of turmeric extract, which is used as a PO growth inhibitor.

(￥lJ production/extraction example 2) Add 10°C of water to Shajin Ikg and leave to stir at room temperature - day and night, then centrifuge and extract the Shajin extract. am is obtained and used as a PO inhibitor.

(Manufacture/Extraction Example 3) Add 10β of water to 1 kg of Amachazur and leave to stir at room temperature for days and nights. Centrifuge to obtain a solution of Amachazur extract, which inhibits PO growth. Agent and eggplant.

"Confirmation of anti-dandruff and anti-itch effect" (a) Test method In the test, the PO obtained in the above production/extraction example was added to the hair shampoo formulation as shown in the following table and Table 2. We made hair shampoos with and without growth inhibitors, and used them on 20 people, including those who tend to have dandruff on their hair, and those who suffer from dandruff and itchy hair for about two weeks. Compare the effects when used.

I decided to evaluate it.

The results were as shown in the following table and Tables 3 and 4.

That is, the numbers shown in Tables 3 and 4 are the results of the responses received regarding the effects of using each hair shampoo, expressed in terms of the number of people.

(b) Results As shown in Table 3, the extract according to the present invention: hair shampoo containing a PO growth inhibitor.

Even when compared to additive-free hair shampoo, it was estimated that it was clearly effective in suppressing dandruff.

Furthermore, as shown in Table 4, the hair shampoo containing the extracted extract 2PO growth inhibitor of the present invention was considered to have a soothing effect on itching compared to the hair shampoo containing no additives.

"Table 2" Hair Jump prescription "Table 3" Anti-dandruff effect (number of respondents) In addition, Tables 3 and 4 show the above-mentioned production/extraction examples of plant extracts (solutions): PO growth inhibitors , we have tried to show the effect of using it when added to hair shampoo. Both are easy and both are effective.

<C> Effects of the invention The present invention provides PO
The key point is that we have discovered and made available a growth inhibitor for this disease.

That is, by using the extract obtained from the plant according to the present invention in external preparations for the skin, scalp, and hair, or cosmetics, the expected effects are: (1) prevention of dandruff and itching on the skin and scalp; and.

It can be helpful in treatment.

■ Plant extract according to the present invention: According to the PO growth inhibitor, since it is water-soluble, it can be used, for example, in the formulation of water-soluble skin or hair cosmetics without using emulsifiers or dispersants. If necessary, known and commonly used ingredients such as surfactants, humectants, lower alcohols, thickeners, fragrances, antioxidants, chelating agents, pigments, and preservatives can be used in combination. There are no special contraindications for combination.

(2) The PO growth inhibitor according to the present invention can prevent not only dandruff and itching, but also seborrheic eczema on the head and hair loss, and has the effect of promoting blood flow in the peripheral blood vessels of the face and skin.

■ The PO growth inhibitor according to the present invention can be used in small amounts and at the same time, for formulations containing various lipids in the formulation.
It exerts an antioxidant effect on fats and oils.

That is, the PO growth inhibitor according to the present invention is characterized by having an antioxidant effect on sebum and fats and oils, suppressing the production of lipid peroxides, and also serving as a stabilizer.

Claims (1)

[Claims] (1) Skin that is expected to have an anti-dandruff effect and is formulated with a dandruff bacteria growth inhibitor containing a water-soluble component obtained from at least one of turmeric, shajin, and Jiaogulan as a plant extract material. External preparations or cosmetics for the skin, scalp, and hair.