JPH0316923B2 - - Google Patents

Info

Publication number

JPH0316923B2

JPH0316923B2 JP57216871A JP21687182A JPH0316923B2 JP H0316923 B2 JPH0316923 B2 JP H0316923B2 JP 57216871 A JP57216871 A JP 57216871A JP 21687182 A JP21687182 A JP 21687182A JP H0316923 B2 JPH0316923 B2 JP H0316923B2

Authority

JP

Japan

Prior art keywords

atractylodine

tablets

results

choleretic

once

Prior art date

1982-12-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Lifetime

Links

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• 239000000731 choleretic agent Substances 0.000 claims description 5
• 239000004480 active ingredient Substances 0.000 claims description 3
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 9
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 8
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
• 230000001989 choleretic effect Effects 0.000 description 5
• 239000000203 mixture Substances 0.000 description 5
• 239000003814 drug Substances 0.000 description 4
• 229940079593 drug Drugs 0.000 description 4
• 239000008187 granular material Substances 0.000 description 4
• 235000019359 magnesium stearate Nutrition 0.000 description 4
• VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 4
• FKJIJBSJQSMPTI-CAOXKPNISA-M sodium;(4r)-4-[(5s,8r,9s,10s,13r,14s,17r)-10,13-dimethyl-3,7,12-trioxo-1,2,4,5,6,8,9,11,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]pentanoate Chemical compound [Na+].C1CC(=O)C[C@H]2CC(=O)[C@H]3[C@@H]4CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]4(C)C(=O)C[C@@H]3[C@]21C FKJIJBSJQSMPTI-CAOXKPNISA-M 0.000 description 4
• 208000024891 symptom Diseases 0.000 description 4
• 241000700159 Rattus Species 0.000 description 3
• 210000000941 bile Anatomy 0.000 description 3
• 239000002775 capsule Substances 0.000 description 3
• 239000013078 crystal Substances 0.000 description 3
• 238000004519 manufacturing process Methods 0.000 description 3
• 239000003960 organic solvent Substances 0.000 description 3
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
• 241001465754 Metazoa Species 0.000 description 2
• 241000699670 Mus sp. Species 0.000 description 2
• 239000004698 Polyethylene Substances 0.000 description 2
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
• 210000000013 bile duct Anatomy 0.000 description 2
• 238000004440 column chromatography Methods 0.000 description 2
• 230000034994 death Effects 0.000 description 2
• 231100000517 death Toxicity 0.000 description 2
• 238000009472 formulation Methods 0.000 description 2
• 238000010438 heat treatment Methods 0.000 description 2
• 239000008101 lactose Substances 0.000 description 2
• -1 polyethylene Polymers 0.000 description 2
• 229920000573 polyethylene Polymers 0.000 description 2
• 239000000843 powder Substances 0.000 description 2
• 239000000741 silica gel Substances 0.000 description 2
• 229910002027 silica gel Inorganic materials 0.000 description 2
• 239000007787 solid Substances 0.000 description 2
• 239000002904 solvent Substances 0.000 description 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
• 238000005303 weighing Methods 0.000 description 2
• 241000208838 Asteraceae Species 0.000 description 1
• 241000132011 Atractylodes lancea Species 0.000 description 1
• 241000700157 Rattus norvegicus Species 0.000 description 1
• 210000001015 abdomen Anatomy 0.000 description 1
• 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
• 231100000403 acute toxicity Toxicity 0.000 description 1
• 230000007059 acute toxicity Effects 0.000 description 1
• 238000011047 acute toxicity test Methods 0.000 description 1
• 239000002671 adjuvant Substances 0.000 description 1
• 238000009835 boiling Methods 0.000 description 1
• 239000001913 cellulose Substances 0.000 description 1
• 229920002678 cellulose Polymers 0.000 description 1
• 238000010586 diagram Methods 0.000 description 1
• 230000029087 digestion Effects 0.000 description 1
• 201000010099 disease Diseases 0.000 description 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
• 239000002934 diuretic Substances 0.000 description 1
• 230000001882 diuretic effect Effects 0.000 description 1
• 238000001035 drying Methods 0.000 description 1
• 210000001198 duodenum Anatomy 0.000 description 1
• 238000000921 elemental analysis Methods 0.000 description 1
• 238000000605 extraction Methods 0.000 description 1
• 239000000706 filtrate Substances 0.000 description 1
• 235000013305 food Nutrition 0.000 description 1
• 239000007902 hard capsule Substances 0.000 description 1
• 241000411851 herbal medicine Species 0.000 description 1
• 230000000968 intestinal effect Effects 0.000 description 1
• 238000002844 melting Methods 0.000 description 1
• 230000008018 melting Effects 0.000 description 1
• 239000002245 particle Substances 0.000 description 1
• 239000000546 pharmaceutical excipient Substances 0.000 description 1
• 229920001592 potato starch Polymers 0.000 description 1
• 238000002360 preparation method Methods 0.000 description 1
• 239000000047 product Substances 0.000 description 1
• 238000001953 recrystallisation Methods 0.000 description 1
• 238000010992 reflux Methods 0.000 description 1
• 235000013555 soy sauce Nutrition 0.000 description 1
• 230000006641 stabilisation Effects 0.000 description 1
• 238000011105 stabilization Methods 0.000 description 1
• 239000003826 tablet Substances 0.000 description 1
• 238000004809 thin layer chromatography Methods 0.000 description 1
• 231100000419 toxicity Toxicity 0.000 description 1
• 230000001988 toxicity Effects 0.000 description 1