JPH03133920A - Hair tonic - Google Patents

Abstract

PURPOSE:To obtain a hair tonic, containing a ginkgo extract and nucleic acids as essential ingredients and capable of accelerating and normalizing hair and scalp function and exhibiting excellent hair tonic and hair growing effects. CONSTITUTION:The objective hair tonic obtained by including 0.0001-10wt.% ginkgo extract and 0.0001-5wt.% nucleic acids, blending the prepared mixture with a normal base used in products for hair and preparing the hair tonic according to a conventional method. The ginkgo extract is obtained by dipping a raw material such as leaf, flower, branch or fruit of a ginkgo in a solvent such as ethyl alcohol, extracting the raw material at ambient temperature or while heating the solvent and filtering the resultant extract. Adenylic acid derivatives, adenine, guanine and derivatives thereof, etc., are cited as the nucleic acids. The hair tonic can be prepared in the form of milky lotion, cream, lotion, etc., and further hair tonic, hair liquid, hair lotion, hair cream, hair rinse, shampoo, hair set lotion, hair spray, etc., as a dosage form.

Description

[Detailed description of the invention] [Industrial application field] The present invention contains a ginkgo biloba extract and nucleic acids,
This invention relates to a hair nourishment that enhances and normalizes scalp function and has excellent hair nourishing and hair growth effects.

[Prior Art] Various hair nourishing agents have been used to prevent and treat physiological symptoms such as baldness, thinning hair, dandruff, and seborrhea.

These hair care products contain various drugs that have various effects such as promoting blood circulation in the scalp, suppressing lipid secretion, and activating hair matrix cells, but so far, these drugs have not been shown to have sufficient effects. I couldn't say yes.

Recently, plant extracts such as crude drugs have been attracting attention as hair nourishing agents in terms of effectiveness and safety. Among these crude drug extracts, ginkgo biloba extract has been proposed as an excellent hair nourishing agent.

However, although this ginkgo biloba extract has a superior hair-nourishing effect compared to conventional extracts, it has not yet achieved a satisfactory hair-nourishing effect.

[Problems to be Solved by the Invention] Therefore, it has been desired to develop a hair nourishment that is safer and has excellent hair growth and hair growth effects.

[Means for Solving the Problems] In view of the actual situation of refusal, the present inventors conducted intensive research and found that the hair nourishing and hair growth effects of ginkgo biloba extract are synergistically enhanced by combination with nucleic acids. Therefore, it was discovered that a hair nourishment containing these two components is extremely effective and excellent, and the present invention was completed.

That is, the present invention provides a hair nourishment characterized by containing a ginkgo biloba extract and nucleic acids as essential components.

The ginkgo biloba extract used as an essential component in the present invention is Ginkgo biloba (Ginkg).

It is extracted from the leaves, flowers, fruits, etc. of biloba L.). The extraction method is not particularly limited, and for example, water, methyl alcohol,
Primary alcohols such as ethyl alcohol, liquid polyhydric alcohols such as propylene glycol and 1゜3-butylene glycol, lower alkyl esters such as ethyl acetate, hydrocarbons such as benzene and hexane, ethyl ether,
A method using a known solvent such as acetone is adopted, and these solvents can be used alone or in combination of two or more. Among these, preferred extraction solvents include aqueous solutions of organic solvents that are miscible with water, particularly aqueous solutions of ethyl alcohol, methyl alcohol, acetone, and the like.

Ginkgo biloba extract is obtained by immersing raw materials such as ginkgo leaves, flowers, branches, fruits, etc. in the above extraction solvent, extracting this at room temperature or with heating, and filtering.The resulting extract is used as is. However, if necessary, it may be further concentrated. Moreover, these extracts can also be purified and used.

The content of ginkgo biloba extract in the hair nourishment of the present invention is preferably 0.0001 to 10% by weight as dry solid content (
(hereinafter simply referred to as "r%"), more preferably 0.0
It is 1 to 5%. When using an extract, the concentration of the extract is not limited in any way as long as the content of dry solids, which are solutes, is within the above range.

If the content of ginkgo biloba extract is less than 0.0001%, sufficient hair-nourishing effect may not be obtained;
No further increase in effect was observed even if the mixture was added in excess of
Problems with the product may occur, such as coloring and odor, and depending on the dosage form, precipitation.

On the other hand, the nucleic acids that are other essential components of the present invention include deoxyribonucleic acid and its salts, adenosine diphosphoric acid, adenosine diphosphoric acid, adenosine-phosphate, adenosine,
Examples include adenylic acid derivatives such as cyclic adenosine-phosphate and salts thereof, ribonucleic acid and salts thereof, adenine, guanine, cytosine, thymine, xanthine and derivatives thereof, guanosine and derivatives and salts thereof.

Among these, preferred are adenylic acid derivatives and their salts, adenine, guanine and their derivatives.

These can be used alone or in combination of two or more.

The content of these nucleic acids in the hair growth medium of the present invention is generally 0.
．． 0001-5%, preferably 0.001-3%.

If the content of nucleic acids is less than 0.0001%, a sufficient effect may not be obtained, and even if the content exceeds 5%, the effect remains almost constant and no increase is observed.

The hair nourishing composition of the present invention can be manufactured by iA by blending the ginkgo biloba extract and nucleic acids, which are essential ingredients, into various types of base materials commonly known as hair products, according to a conventional method.

Examples of the forms of hair nourishing agents include milky lotion, cream,
Examples include lotions, and dosage forms include hair tonics, hair liquids, hair lotions, hair creams, hair rinses, shampoos, hair setting lotions, hair sprays, hair packs, and the like.

In addition, the ingredients that make up the hair nourishment base include purified water, lower alcohol base, polyhydric alcohols, oils and fats, surfactants, beauty ingredients, ultraviolet absorbers, thickeners, pigments, preservatives,
Examples include those used in ordinary cosmetics such as fragrances, and these can be appropriately selected and used.

[Example] Next, the present invention will be further explained with reference to production examples and examples.

However, the present invention is not limited in any way by these Examples.

Production Example 1 1.0 kg of dried pulverized Ginkgo biloba leaves was defatted using 87x of an ethyl acetate-benzene mixture (1:1), and then air-dried to remove the solvent. Then 70V/V
% ethanol 8? Extraction was carried out by heating with X for 5 hours. After that, the remaining residue was extracted again with 70V/V% ethanol 8 yen 2 for 3 hours under heating, and the resulting extract was combined with the previous extract at 50°C.
The mixture was concentrated to dryness to obtain 196 g of crude crystals. Add 95V/V% ethanol 271 to the obtained crude crystals, perform stirring extraction, filter out insoluble materials, and further add 25% aqueous ammonia to the extract to adjust the pH to 9.0 and precipitate. After removing the precipitate, 20g of activated carbon was added, stirred at 50"C for 30 minutes, and the reviving carbon was filtered off. The treated solution was heated at 50°C.
The mixture was concentrated to dryness at a temperature below 50% C. to obtain 12 g of powder.

Production Example 2 1.0 kg of dried green ginkgo leaves was extracted with a 57K water-acetone mixture (1:1) at 60°C for 6 hours. Add hexane to the obtained extract (in 27,
After removing the hexane-soluble portion, 200 g of ammonium sulfate was added to the hexane-insoluble portion, and extraction was performed using 1.0 Yχ of methyl ethyl ketone. After further concentrating the obtained extract, 70V
/V% ethanol 27χ was added to dilute the mixture to obtain a ginkgo biloba extract.

Example 1 Samples with the formulations shown in Table 1 were prepared, and the hair growth effect was evaluated by the following test method. In addition, the compounding amounts in the table are weight %.

(Margins below) Hair growth effect test method: Groups of 10 male C3H/HeNCrj mice (8 weeks old) were tested using the method of Ogawa et al. (8th Dermatology Society: 96 (3),
195-197.1986).

That is, a 2 x 4 cm area on the back of a mouse was pricked with hair, and from the next day samples ■ to ■ were applied once a day to the area where the skin color started to change from pink to gray (the area where hair regeneration started). The change in area ratio was determined. The area ratio was calculated according to the following formula (I) and was taken as the hair regeneration rate.

Area of hair regeneration area Hair regeneration rate = xlOO(X) Area of stinging hair area 9th day, 12th day, 15th day and 1st day after starting sample application
Table 2 shows the results of determining the average value of the hair regeneration rate in each group on the 9th day.

Results: Surface hair regeneration rate (%) Sample Day 9 Day 12 Day 15 Day 19 ■ 11.2 4g, 3 78.8
92.3 ■ 12.1 43.5
71.0 90.5 ■ 8.6
32.6 68.4 83.2 ■
22.2 69.3 92.7
98.2 ■ 23.9 65.1
89.4 Zo.

■ 3.5 28.9 60.
0 81.1 As shown in Table 2, the hair nourishing agent (■, ■) that combines ginkgo biloba extract and nucleic acids is different from the control (■).
Hair regeneration was clearly faster and had a remarkable hair regeneration promoting effect, not only when compared with the hair nourishing products (■, ■, ■) containing only ginkgo biloba extract or vitamins (■, ■, ■).

Example 2 Hair cream type hair nourishing agent = (Ingredients) (1) Beeswax (2) Liquid paraffin (wt%) 1.0 50°0 (3) Stearic acid 3.0 (4) Sorbitan sesquioleate 2.0 ( 5) Boxoxysorbitan monolaurate (20E, O) 1.5 (6) Ginkgo biloba extract (50% aqueous solution of the one obtained in Production Example 1) 1.0 (7) Sodium deoxyribonucleic acid 0.02 (8) Flavor
0.2(9) Methyl roseoxybenzoate
0.1 (10) Purified water Remaining amount (manufacturing method) A. Mix, heat, and dissolve (1) to (5) and (9).

B, (6), (7) and (10) are mixed and stirred.

B was added to C and A and emulsified, and after cooling, (8) was added to obtain a hair cream type hair nourishing agent.

Example 3 Hair lotion type hair tonic: (Ingredients) (% by weight) (1) Salicyl H0, 1 (2) Milk 1120.01 (3) Sodium lactate 0.05 (4) Ethyl alcohol 40.0 (5) Ginkgo biloba Extract (obtained in Production Example 1) 0.2 (6) Adenosine triphosphate 0.1 (7) Flavor 0.05 (8) Methyl roseoxybenzoate 0.1 (9) Purified water
Remaining amount (manufacturing method) Mix and dissolve A, (1), (4), (5), (7) and (8).

Mix and dissolve B, (2), (3), (6) and (9).

B was added to C and A and mixed and stirred to obtain a hair lotion type hair nourishing agent.

Example 4 Hair liquid type hair nourishing agent: (Ingredients) (% by weight) (1) Polyoxypropylene butyl ether phosphoric acid (35P, O) 9.0 (2)
Polyoxypropylene monobutyl ether (60P, 0) 10.0 (3) Triethanolamine 1.0 (4) Sodium hyaluronate 0.05 (5) Ginkgo biloba extract (70% ethyl alcohol of that obtained in Production Example 1) Solution) 0.1 (6) Adenine 0.01 (7) Ethyl alcohol 30.0 (8) Fragrance
0.2 (9) Methyl roseoxybenzoate 0.1 (10) Purified water
Remaining amount (manufacturing method) A: Mix and dissolve (3), (4) and (6) in (10).

B. Mix and dissolve (1), (2), (5) and (7) to (8).

B was added to C and A and mixed and dissolved to obtain a hair liquid type hair tonic.

[Effects of the Invention] As described above, the hair nourishment of the present invention has an effective hair regeneration promoting effect. In other words, the functions of the hair and scalp were enhanced and normalized, resulting in excellent hair growth and growth effects.

that's all

Claims (1)

[Claims] (1) A hair nourishing agent characterized by containing a ginkgo biloba extract and nucleic acids as essential components.