JPH028270B2 - - Google Patents
Info
- Publication number
- JPH028270B2 JPH028270B2 JP15059078A JP15059078A JPH028270B2 JP H028270 B2 JPH028270 B2 JP H028270B2 JP 15059078 A JP15059078 A JP 15059078A JP 15059078 A JP15059078 A JP 15059078A JP H028270 B2 JPH028270 B2 JP H028270B2
- Authority
- JP
- Japan
- Prior art keywords
- area
- cell
- image
- electronic device
- image detector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 claims description 71
- 238000006243 chemical reaction Methods 0.000 claims description 63
- 239000002245 particle Substances 0.000 claims description 56
- 239000003153 chemical reaction reagent Substances 0.000 claims description 24
- 238000003384 imaging method Methods 0.000 claims description 22
- 239000000427 antigen Substances 0.000 claims description 18
- 102000036639 antigens Human genes 0.000 claims description 18
- 108091007433 antigens Proteins 0.000 claims description 18
- 239000013060 biological fluid Substances 0.000 claims description 18
- 238000012360 testing method Methods 0.000 claims description 18
- 239000000523 sample Substances 0.000 claims description 17
- 230000003287 optical effect Effects 0.000 claims description 12
- 239000004816 latex Substances 0.000 claims description 11
- 229920000126 latex Polymers 0.000 claims description 11
- 239000012491 analyte Substances 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 7
- 239000003610 charcoal Substances 0.000 claims description 6
- 230000008105 immune reaction Effects 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 238000011534 incubation Methods 0.000 claims description 4
- 239000012780 transparent material Substances 0.000 claims description 4
- 239000013068 control sample Substances 0.000 claims description 3
- 238000012258 culturing Methods 0.000 claims 3
- 239000012925 reference material Substances 0.000 claims 2
- 230000001678 irradiating effect Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 84
- 238000003018 immunoassay Methods 0.000 description 15
- 239000000306 component Substances 0.000 description 14
- 230000002776 aggregation Effects 0.000 description 11
- 238000004220 aggregation Methods 0.000 description 9
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 230000028993 immune response Effects 0.000 description 9
- 238000003127 radioimmunoassay Methods 0.000 description 9
- 239000003814 drug Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 238000005259 measurement Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 230000004520 agglutination Effects 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 239000000725 suspension Substances 0.000 description 5
- 238000003556 assay Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 239000012530 fluid Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000000376 reactant Substances 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 208000006379 syphilis Diseases 0.000 description 4
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 239000011324 bead Substances 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 230000005499 meniscus Effects 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 230000009257 reactivity Effects 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 238000009827 uniform distribution Methods 0.000 description 3
- 239000005995 Aluminium silicate Substances 0.000 description 2
- 102000011022 Chorionic Gonadotropin Human genes 0.000 description 2
- 108010062540 Chorionic Gonadotropin Proteins 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 238000005054 agglomeration Methods 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000036046 immunoreaction Effects 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000012634 optical imaging Methods 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000002285 radioactive effect Effects 0.000 description 2
- 239000012429 reaction media Substances 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000009920 chelation Effects 0.000 description 1
- 229940015047 chorionic gonadotropin Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 229940084986 human chorionic gonadotropin Drugs 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000000984 immunochemical effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 238000009828 non-uniform distribution Methods 0.000 description 1
- 230000005693 optoelectronics Effects 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000013074 reference sample Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Investigating Or Analysing Materials By Optical Means (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15059078A JPS5580054A (en) | 1978-12-07 | 1978-12-07 | Qualitative and quantitative determination method of and apparatus for immunity reaction |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15059078A JPS5580054A (en) | 1978-12-07 | 1978-12-07 | Qualitative and quantitative determination method of and apparatus for immunity reaction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5580054A JPS5580054A (en) | 1980-06-16 |
| JPH028270B2 true JPH028270B2 (en, 2012) | 1990-02-23 |
Family
ID=15500202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15059078A Granted JPS5580054A (en) | 1978-12-07 | 1978-12-07 | Qualitative and quantitative determination method of and apparatus for immunity reaction |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5580054A (en, 2012) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61213769A (ja) * | 1985-03-20 | 1986-09-22 | Toyobo Co Ltd | 診断用試薬キツト |
| JPS6239770A (ja) * | 1985-08-15 | 1987-02-20 | Toyobo Co Ltd | 診断用試薬キツト |
| JP2000304689A (ja) | 1999-04-21 | 2000-11-02 | Hiroyuki Ogawa | 投影観察方法、微生物検査方法および投影検出装置 |
| JP2001299383A (ja) * | 2000-04-21 | 2001-10-30 | Hiroyuki Ogawa | 微生物検査方法 |
| JP5189201B2 (ja) | 2008-04-02 | 2013-04-24 | アボット ポイント オブ ケア インコーポレイテッド | 全血を含む生体体液のイムノアッセイを実施するためのリガンドアッセイにおける結合標識と遊離標識との仮想分離 |
-
1978
- 1978-12-07 JP JP15059078A patent/JPS5580054A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5580054A (en) | 1980-06-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4197088A (en) | Method for qualitative and quantitative determination of immunological reactions | |
| US4400353A (en) | Electro-optical system for use in evaluating immunological reactions | |
| US4411518A (en) | Apparatus for use in qualitative determination of immunological reactions | |
| US4240751A (en) | Method and apparatus for specific binding substances | |
| JP2656564B2 (ja) | 免疫分析方法 | |
| CA2177362C (en) | Sensor device for sandwich assay | |
| US4521521A (en) | Particle reagent size distribution measurements for immunoassay | |
| US4250394A (en) | Apparatus for determining immunochemical substances | |
| US4639419A (en) | Immunological color change test involving two differently colored reagent spots | |
| JPH07505473A (ja) | 自動連続ランダム・アクセス分析システムおよびその構成要素 | |
| US20070054405A1 (en) | Patient sample classification based upon low angle light scattering | |
| KR20040071750A (ko) | 래터럴 플로우식 분석 시험을 하기 위한 판독 장치, 방법및 시스템 | |
| JPH08501146A (ja) | 消失性波光学的バイオセンサ分析における測定精度の向上方法 | |
| JP3693680B2 (ja) | 磁性粒子を使用するアッセイ | |
| JP3062347B2 (ja) | 分析装置 | |
| US4213764A (en) | Method for determining immunochemical substances | |
| JPS6365369A (ja) | 抗原−抗体反応の測定法 | |
| EP0254430B1 (en) | Light-scattering immunoassay system | |
| JP3283078B2 (ja) | 免疫学的測定装置 | |
| US4605305A (en) | Laser nephelometer for sensing antigens and antibodies characterized in having measuring cell comprised of capiliary tube with the diameter of laser beam | |
| JPH028270B2 (en, 2012) | ||
| DE69329147T2 (de) | Analysenküvette mit einer niedrigen doppelbrechung | |
| JPH03110473A (ja) | 血液型自動判定方法及びその装置 | |
| JPS61202142A (ja) | 吸光度を用いた分析方法および分析装置 | |
| JPS59100863A (ja) | 診断用試験スライドおよびその製造方法 |