JPH0260678B2 - - Google Patents

Info

Publication number
JPH0260678B2
JPH0260678B2 JP53053312A JP5331278A JPH0260678B2 JP H0260678 B2 JPH0260678 B2 JP H0260678B2 JP 53053312 A JP53053312 A JP 53053312A JP 5331278 A JP5331278 A JP 5331278A JP H0260678 B2 JPH0260678 B2 JP H0260678B2
Authority
JP
Japan
Prior art keywords
thienamycin
reaction
methyl
formula
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP53053312A
Other languages
English (en)
Japanese (ja)
Other versions
JPS53137993A (en
Inventor
Jii Kurisutensen Baaton
Jee Reenza Uiriamu
Jee Uirudongaa Kenesu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPS53137993A publication Critical patent/JPS53137993A/ja
Publication of JPH0260678B2 publication Critical patent/JPH0260678B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72—Hydrazones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP5331278A 1977-05-05 1978-05-06 Nnalkyllnniminomethyl derivative of thienamycine Granted JPS53137993A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79397577A 1977-05-05 1977-05-05

Publications (2)

Publication Number Publication Date
JPS53137993A JPS53137993A (en) 1978-12-01
JPH0260678B2 true JPH0260678B2 (cs) 1990-12-17

Family

ID=25161306

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5331278A Granted JPS53137993A (en) 1977-05-05 1978-05-06 Nnalkyllnniminomethyl derivative of thienamycine

Country Status (13)

Country Link
JP (1) JPS53137993A (cs)
BE (1) BE866661A (cs)
CH (1) CH637962A5 (cs)
DE (1) DE2819453A1 (cs)
DK (1) DK170778A (cs)
ES (1) ES469426A1 (cs)
FR (1) FR2389626B1 (cs)
GB (1) GB1604275A (cs)
IE (1) IE46873B1 (cs)
IT (1) IT1104190B (cs)
LU (1) LU79598A1 (cs)
NL (1) NL7804229A (cs)
SE (1) SE436569B (cs)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT73791B (en) * 1980-10-17 1983-10-14 Merck & Co Inc Process for preparing 2-carbamimidoyl-6-substituted-1- -carbadethiapen-2-em-3-carboxylic acids

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics
IL50911A (en) * 1975-11-21 1981-01-30 Merck & Co Inc Substituted n-methylene derivatives of thienamycin

Also Published As

Publication number Publication date
GB1604275A (en) 1981-12-09
SE436569B (sv) 1985-01-07
IT1104190B (it) 1985-10-21
CH637962A5 (en) 1983-08-31
BE866661A (fr) 1978-11-03
IE780849L (en) 1978-11-05
NL7804229A (nl) 1978-11-07
DE2819453A1 (de) 1978-11-09
DE2819453C2 (cs) 1993-02-25
FR2389626A1 (cs) 1978-12-01
ES469426A1 (es) 1980-02-01
LU79598A1 (fr) 1979-02-02
SE7804447L (sv) 1978-11-06
DK170778A (da) 1979-01-15
FR2389626B1 (cs) 1980-06-20
IE46873B1 (en) 1983-10-19
IT7849176A0 (it) 1978-05-03
JPS53137993A (en) 1978-12-01

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