JPH0256635B2 - - Google Patents

Info

Publication number
JPH0256635B2
JPH0256635B2 JP56148903A JP14890381A JPH0256635B2 JP H0256635 B2 JPH0256635 B2 JP H0256635B2 JP 56148903 A JP56148903 A JP 56148903A JP 14890381 A JP14890381 A JP 14890381A JP H0256635 B2 JPH0256635 B2 JP H0256635B2
Authority
JP
Japan
Prior art keywords
reaction chamber
reagents
sample
matrix
chamber
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP56148903A
Other languages
English (en)
Japanese (ja)
Other versions
JPS57110962A (en
Inventor
Ii Futsudo Reroi
Daburyuu Funkapiraa Maikeru
Jei Doraiaa Uiriamu
Emu Hyuuitsuku Rodonii
Daburyuu Sutaaku Anton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KARIFUORUNIA INST OBU TEKUNOROJII
Original Assignee
KARIFUORUNIA INST OBU TEKUNOROJII
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by KARIFUORUNIA INST OBU TEKUNOROJII filed Critical KARIFUORUNIA INST OBU TEKUNOROJII
Publication of JPS57110962A publication Critical patent/JPS57110962A/ja
Publication of JPH0256635B2 publication Critical patent/JPH0256635B2/ja
Granted legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J4/00—Feed or outlet devices; Feed or outlet control devices
    • B01J4/02—Feed or outlet devices; Feed or outlet control devices for feeding measured, i.e. prescribed quantities of reagents
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K7/00—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves
    • F16K7/12—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm
    • F16K7/14—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm arranged to be deformed against a flat seat
    • F16K7/17—Diaphragm valves or cut-off apparatus, e.g. with a member deformed, but not moved bodily, to close the passage ; Pinch valves with flat, dished, or bowl-shaped diaphragm arranged to be deformed against a flat seat the diaphragm being actuated by fluid pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00283—Reactor vessels with top opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00286—Reactor vessels with top and bottom openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00389—Feeding through valves
    • B01J2219/00396—Membrane valves
    • B01J2219/00398—Membrane valves in multiple arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00418—Means for dispensing and evacuation of reagents using pressure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00423—Means for dispensing and evacuation of reagents using filtration, e.g. through porous frits
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00495—Means for heating or cooling the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00695—Synthesis control routines, e.g. using computer programs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1079—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Mechanical Engineering (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Fluid Mechanics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP14890381A 1980-09-23 1981-09-22 Improved apparatus and method for sequentially executing chemical processes Granted JPS57110962A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19010080A 1980-09-23 1980-09-23

Publications (2)

Publication Number Publication Date
JPS57110962A JPS57110962A (en) 1982-07-10
JPH0256635B2 true JPH0256635B2 (esLanguage) 1990-11-30

Family

ID=22700018

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14890381A Granted JPS57110962A (en) 1980-09-23 1981-09-22 Improved apparatus and method for sequentially executing chemical processes

Country Status (6)

Country Link
JP (1) JPS57110962A (esLanguage)
CA (1) CA1163425A (esLanguage)
DE (1) DE3137875C2 (esLanguage)
FR (1) FR2490505B1 (esLanguage)
GB (3) GB2084899B (esLanguage)
SE (3) SE466223B (esLanguage)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2544720B1 (fr) * 1983-04-19 1987-11-27 California Inst Of Techn Installation perfectionnee et procede pour la synthese de composes chimiques, en particulier d'oligonucleotides
GB2143240B (en) * 1983-07-13 1988-01-13 Nippon Zeon Co Apparatus for synthesizing polynucleotide
JPS60105691A (ja) * 1983-11-14 1985-06-11 Nippon Zeon Co Ltd ポリヌクレオチド合成装置
CA1218930A (en) * 1984-02-22 1987-03-10 Allelix Biopharmaceuticals Inc. Device for performing quantitative chemical and immunochemical assays
US4668476A (en) * 1984-03-23 1987-05-26 Applied Biosystems, Inc. Automated polypeptide synthesis apparatus
DE3508162C1 (de) * 1985-03-07 1986-06-19 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Leitungssystem fuer Laboratoriumszwecke
DE3750624T2 (de) * 1986-08-15 1995-02-16 Beckmann Research Inst Of The Durchlaufreaktor für Peptidsequenatoren.
US4773446A (en) * 1986-08-27 1988-09-27 Porton Instruments, Inc. Valve block assembly
DE3637869A1 (de) * 1986-11-06 1988-05-19 Draegerwerk Ag Mehrfachhalterung fuer pruefroehrchen
US5188963A (en) * 1989-11-17 1993-02-23 Gene Tec Corporation Device for processing biological specimens for analysis of nucleic acids
EP0388224A3 (en) * 1989-03-17 1991-05-22 Seiko Instruments Inc. Method and apparatus for effecting chemical treatment
JPH02307059A (ja) * 1989-05-23 1990-12-20 Seiko Instr Inc 反応容器
US5605839A (en) * 1990-04-11 1997-02-25 Ludwig Institute For Cancer Research Methods and apparatus for use in sequential chemical reactions
DE9109797U1 (de) * 1991-08-07 1991-09-26 Wissenschaftliche Gerätebau Dr.-Ing. Herbert Knauer GmbH, 1000 Berlin Gerät zur Durchführung von chemischen Prozessen an einer Probe eines chemischen Materials
IT1255014B (it) * 1992-03-27 1995-10-13 Instrumentation Lab Spa Dispositivi di movimentazione ed intercettazione di fluidi
US5203368A (en) * 1992-07-29 1993-04-20 Protein Technologies Inc. Matrix of valves
US5641459A (en) * 1995-08-17 1997-06-24 Pharmacia Biotech Ab Machine for synthesizing oligonucleotides
DE19652823A1 (de) * 1996-12-18 1998-03-26 Guenter Prof Dr Fuhr Strukturierter Polytetrafluorethylen-Spacer
GB2409411A (en) * 2003-12-22 2005-06-29 William Thomas Dennis Bates Blood collection system
CN103974762A (zh) * 2011-09-30 2014-08-06 通用电气健康护理有限公司 用于多步放射化学的反应器

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3077766A (en) 1960-07-08 1963-02-19 Phillips Petroleum Co Shut off valve for chromatographic system
DE1227855B (de) * 1960-07-12 1966-11-03 Ichthyol Ges Verfahren zur Herstellung von Enzymkoerpern fuer die Durchfuehrung enzymatischer Reaktionen
US3717436A (en) 1971-01-25 1973-02-20 Beckman Ind Inc Process for the sequential degradation of peptide chains
BE786213A (fr) * 1971-07-13 1973-01-15 Technicon Instr Procede et appareil pour l'analyse d'echantillons, notamment desang
US3725010A (en) 1971-08-23 1973-04-03 Beckman Instruments Inc Apparatus for automatically performing chemical processes
BE795316A (fr) * 1972-02-11 1973-05-29 Nat Patent Dev Corp Systeme catalytique presentant une activite enzymatique durable et de stabilite augmentee
GB1427192A (en) * 1972-05-26 1976-03-10 Kannegiesser M Apparatus for manufacturing mouldings from expandable synthetic plastics more particularly polyurethane
JPS5117438B2 (esLanguage) * 1972-05-26 1976-06-02
DE2308088C2 (de) * 1973-02-19 1983-03-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Verfahren zur automatisierten Bestimmung der Aminosäuresequenz und Vorrichtung zu ihrer Durchführung
US3892531A (en) * 1973-07-05 1975-07-01 Beckman Instruments Inc Apparatus for sequencing peptides and proteins
US3959307A (en) 1974-02-15 1976-05-25 Wittmann Brigitte Method to determine automatically the sequence of amino acids
US3951167A (en) 1974-12-05 1976-04-20 E. I. Du Pont De Nemours And Company Fluid handling assembly
US4065412A (en) * 1976-05-07 1977-12-27 Durrum Instrument Corporation Peptide or protein sequencing method and apparatus
US4119120A (en) 1976-11-29 1978-10-10 Beckman Instruments, Inc. Fluid switch
US4252769A (en) * 1979-12-26 1981-02-24 California Institute Of Technology Apparatus for the performance of chemical processes

Also Published As

Publication number Publication date
DE3137875A1 (de) 1982-05-06
GB8333306D0 (en) 1984-01-18
GB2146741B (en) 1985-11-20
GB8333305D0 (en) 1984-01-18
SE8802124D0 (sv) 1988-06-07
SE501968C2 (sv) 1995-07-03
SE8802125D0 (sv) 1988-06-07
SE466223B (sv) 1992-01-13
FR2490505B1 (fr) 1986-01-03
GB2146550A (en) 1985-04-24
DE3137875C2 (de) 1995-11-02
FR2490505A1 (fr) 1982-03-26
SE8802125A0 (sv) 1988-06-07
GB2084899A (en) 1982-04-21
GB2146741A (en) 1985-04-24
SE8105597L (sv) 1982-05-06
GB2146550B (en) 1985-11-13
GB2084899B (en) 1985-05-30
SE8802124L (esLanguage) 1988-06-07
JPS57110962A (en) 1982-07-10
CA1163425A (en) 1984-03-13

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