JPH0229312B2 - - Google Patents
Info
- Publication number
- JPH0229312B2 JPH0229312B2 JP58030017A JP3001783A JPH0229312B2 JP H0229312 B2 JPH0229312 B2 JP H0229312B2 JP 58030017 A JP58030017 A JP 58030017A JP 3001783 A JP3001783 A JP 3001783A JP H0229312 B2 JPH0229312 B2 JP H0229312B2
- Authority
- JP
- Japan
- Prior art keywords
- enzyme
- immobilized
- polymer particles
- glycidyl
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002245 particle Substances 0.000 claims description 64
- 229920000642 polymer Polymers 0.000 claims description 56
- 102000004190 Enzymes Human genes 0.000 claims description 45
- 108090000790 Enzymes Proteins 0.000 claims description 45
- 108010093096 Immobilized Enzymes Proteins 0.000 claims description 45
- 239000000178 monomer Substances 0.000 claims description 37
- 125000003055 glycidyl group Chemical group C(C1CO1)* 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 19
- 239000000839 emulsion Substances 0.000 claims description 15
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims description 14
- 238000004132 cross linking Methods 0.000 claims description 12
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims description 10
- VOZRXNHHFUQHIL-UHFFFAOYSA-N glycidyl methacrylate Chemical compound CC(=C)C(=O)OCC1CO1 VOZRXNHHFUQHIL-UHFFFAOYSA-N 0.000 claims description 7
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 claims description 6
- RRHGJUQNOFWUDK-UHFFFAOYSA-N Isoprene Chemical compound CC(=C)C=C RRHGJUQNOFWUDK-UHFFFAOYSA-N 0.000 claims description 6
- -1 acrylic ester Chemical class 0.000 claims description 6
- 229920002873 Polyethylenimine Polymers 0.000 claims description 5
- 125000006850 spacer group Chemical group 0.000 claims description 5
- JLBJTVDPSNHSKJ-UHFFFAOYSA-N 4-Methylstyrene Chemical compound CC1=CC=C(C=C)C=C1 JLBJTVDPSNHSKJ-UHFFFAOYSA-N 0.000 claims description 3
- GYCMBHHDWRMZGG-UHFFFAOYSA-N Methylacrylonitrile Chemical compound CC(=C)C#N GYCMBHHDWRMZGG-UHFFFAOYSA-N 0.000 claims description 3
- 108090001109 Thermolysin Proteins 0.000 claims description 3
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims description 3
- UIWXSTHGICQLQT-UHFFFAOYSA-N ethenyl propanoate Chemical compound CCC(=O)OC=C UIWXSTHGICQLQT-UHFFFAOYSA-N 0.000 claims description 3
- RPQRDASANLAFCM-UHFFFAOYSA-N oxiran-2-ylmethyl prop-2-enoate Chemical compound C=CC(=O)OCC1CO1 RPQRDASANLAFCM-UHFFFAOYSA-N 0.000 claims description 3
- 229920000193 polymethacrylate Polymers 0.000 claims description 3
- HJWLCRVIBGQPNF-UHFFFAOYSA-N prop-2-enylbenzene Chemical compound C=CCC1=CC=CC=C1 HJWLCRVIBGQPNF-UHFFFAOYSA-N 0.000 claims description 3
- 150000004985 diamines Chemical class 0.000 claims description 2
- 229920000058 polyacrylate Polymers 0.000 claims description 2
- 150000005846 sugar alcohols Polymers 0.000 claims description 2
- 108091005804 Peptidases Proteins 0.000 claims 2
- 102000035195 Peptidases Human genes 0.000 claims 2
- 125000005397 methacrylic acid ester group Chemical group 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 description 42
- 238000006243 chemical reaction Methods 0.000 description 17
- 239000006185 dispersion Substances 0.000 description 16
- 230000000694 effects Effects 0.000 description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 239000000758 substrate Substances 0.000 description 12
- 239000007864 aqueous solution Substances 0.000 description 11
- 238000007334 copolymerization reaction Methods 0.000 description 11
- 238000000034 method Methods 0.000 description 10
- 108090000631 Trypsin Proteins 0.000 description 9
- 102000004142 Trypsin Human genes 0.000 description 9
- 239000012588 trypsin Substances 0.000 description 9
- 238000006116 polymerization reaction Methods 0.000 description 8
- 239000005515 coenzyme Substances 0.000 description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 6
- 230000001070 adhesive effect Effects 0.000 description 6
- 239000012153 distilled water Substances 0.000 description 6
- 239000000853 adhesive Substances 0.000 description 5
- 125000003277 amino group Chemical group 0.000 description 5
- 239000000872 buffer Substances 0.000 description 5
- 239000007853 buffer solution Substances 0.000 description 5
- 239000003995 emulsifying agent Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 description 4
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 4
- 108090000637 alpha-Amylases Proteins 0.000 description 4
- 102000004139 alpha-Amylases Human genes 0.000 description 4
- 229940024171 alpha-amylase Drugs 0.000 description 4
- 238000006911 enzymatic reaction Methods 0.000 description 4
- 125000000524 functional group Chemical group 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- FDLQZKYLHJJBHD-UHFFFAOYSA-N [3-(aminomethyl)phenyl]methanamine Chemical compound NCC1=CC=CC(CN)=C1 FDLQZKYLHJJBHD-UHFFFAOYSA-N 0.000 description 3
- 238000005119 centrifugation Methods 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000002255 enzymatic effect Effects 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- JHPBZFOKBAGZBL-UHFFFAOYSA-N (3-hydroxy-2,2,4-trimethylpentyl) 2-methylprop-2-enoate Chemical compound CC(C)C(O)C(C)(C)COC(=O)C(C)=C JHPBZFOKBAGZBL-UHFFFAOYSA-N 0.000 description 2
- XFCMNSHQOZQILR-UHFFFAOYSA-N 2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOC(=O)C(C)=C XFCMNSHQOZQILR-UHFFFAOYSA-N 0.000 description 2
- INQDDHNZXOAFFD-UHFFFAOYSA-N 2-[2-(2-prop-2-enoyloxyethoxy)ethoxy]ethyl prop-2-enoate Chemical compound C=CC(=O)OCCOCCOCCOC(=O)C=C INQDDHNZXOAFFD-UHFFFAOYSA-N 0.000 description 2
- LTHJXDSHSVNJKG-UHFFFAOYSA-N 2-[2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCOCCOC(=O)C(C)=C LTHJXDSHSVNJKG-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 102100026189 Beta-galactosidase Human genes 0.000 description 2
- 108010036781 Fumarate Hydratase Proteins 0.000 description 2
- 102100036160 Fumarate hydratase, mitochondrial Human genes 0.000 description 2
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 2
- 102000004316 Oxidoreductases Human genes 0.000 description 2
- 108090000854 Oxidoreductases Proteins 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 108090000340 Transaminases Proteins 0.000 description 2
- 102000003929 Transaminases Human genes 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 102000005421 acetyltransferase Human genes 0.000 description 2
- 108020002494 acetyltransferase Proteins 0.000 description 2
- 125000003172 aldehyde group Chemical group 0.000 description 2
- 108010005774 beta-Galactosidase Proteins 0.000 description 2
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 2
- 239000001639 calcium acetate Substances 0.000 description 2
- 235000011092 calcium acetate Nutrition 0.000 description 2
- 229960005147 calcium acetate Drugs 0.000 description 2
- 239000000969 carrier Substances 0.000 description 2
- 239000005018 casein Substances 0.000 description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 2
- 235000021240 caseins Nutrition 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 230000009849 deactivation Effects 0.000 description 2
- 230000003100 immobilizing effect Effects 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 239000003973 paint Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000012264 purified product Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- RRONHWAVOYADJL-HNNXBMFYSA-N (2s)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoic acid Chemical compound C([C@@H](C(=O)O)NC(=O)OCC=1C=CC=CC=1)C1=CC=CC=C1 RRONHWAVOYADJL-HNNXBMFYSA-N 0.000 description 1
- VDYWHVQKENANGY-UHFFFAOYSA-N 1,3-Butyleneglycol dimethacrylate Chemical compound CC(=C)C(=O)OC(C)CCOC(=O)C(C)=C VDYWHVQKENANGY-UHFFFAOYSA-N 0.000 description 1
- ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- JFZBUNLOTDDXNY-UHFFFAOYSA-N 2-[2-(2-methylprop-2-enoyloxy)propoxy]propyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCC(C)OCC(C)OC(=O)C(C)=C JFZBUNLOTDDXNY-UHFFFAOYSA-N 0.000 description 1
- HWSSEYVMGDIFMH-UHFFFAOYSA-N 2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCOCCOCCOC(=O)C(C)=C HWSSEYVMGDIFMH-UHFFFAOYSA-N 0.000 description 1
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 1
- 108020001657 6-phosphogluconate dehydrogenase Proteins 0.000 description 1
- 102000004567 6-phosphogluconate dehydrogenase Human genes 0.000 description 1
- ULGJWNIHLSLQPZ-UHFFFAOYSA-N 7-[(6,8-dichloro-1,2,3,4-tetrahydroacridin-9-yl)amino]-n-[2-(1h-indol-3-yl)ethyl]heptanamide Chemical compound C1CCCC2=NC3=CC(Cl)=CC(Cl)=C3C(NCCCCCCC(=O)NCCC=3C4=CC=CC=C4NC=3)=C21 ULGJWNIHLSLQPZ-UHFFFAOYSA-N 0.000 description 1
- 108010022752 Acetylcholinesterase Proteins 0.000 description 1
- 102000012440 Acetylcholinesterase Human genes 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 108010041525 Alanine racemase Proteins 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 102000004452 Arginase Human genes 0.000 description 1
- 108700024123 Arginases Proteins 0.000 description 1
- 108010024976 Asparaginase Proteins 0.000 description 1
- 102000015790 Asparaginase Human genes 0.000 description 1
- 108010005694 Aspartate 4-decarboxylase Proteins 0.000 description 1
- 108010003415 Aspartate Aminotransferases Proteins 0.000 description 1
- 102000004625 Aspartate Aminotransferases Human genes 0.000 description 1
- 108700016171 Aspartate ammonia-lyases Proteins 0.000 description 1
- 108010070255 Aspartate-ammonia ligase Proteins 0.000 description 1
- 102100035882 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 108090000746 Chymosin Proteins 0.000 description 1
- 108090000317 Chymotrypsin Proteins 0.000 description 1
- 108010036824 Citrate (pro-3S)-lyase Proteins 0.000 description 1
- RGJOEKWQDUBAIZ-IBOSZNHHSA-N CoASH Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)O[C@H]1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-IBOSZNHHSA-N 0.000 description 1
- 102000004420 Creatine Kinase Human genes 0.000 description 1
- 108010042126 Creatine kinase Proteins 0.000 description 1
- 102000000634 Cytochrome c oxidase subunit IV Human genes 0.000 description 1
- 108090000365 Cytochrome-c oxidases Proteins 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- 108010088842 Fibrinolysin Proteins 0.000 description 1
- 102000003793 Fructokinases Human genes 0.000 description 1
- 108090000156 Fructokinases Proteins 0.000 description 1
- 108010015776 Glucose oxidase Proteins 0.000 description 1
- 239000004366 Glucose oxidase Substances 0.000 description 1
- 108010070600 Glucose-6-phosphate isomerase Proteins 0.000 description 1
- 102000005731 Glucose-6-phosphate isomerase Human genes 0.000 description 1
- 102000008214 Glutamate decarboxylase Human genes 0.000 description 1
- 108091022930 Glutamate decarboxylase Proteins 0.000 description 1
- 102000016901 Glutamate dehydrogenase Human genes 0.000 description 1
- 108700023156 Glutamate dehydrogenases Proteins 0.000 description 1
- 108700016167 Glutamate racemases Proteins 0.000 description 1
- 108010036164 Glutathione synthase Proteins 0.000 description 1
- 102100034294 Glutathione synthetase Human genes 0.000 description 1
- 108010011689 Glycine transaminase Proteins 0.000 description 1
- 102000005548 Hexokinase Human genes 0.000 description 1
- 108700040460 Hexokinases Proteins 0.000 description 1
- 108010030471 Histamine N-methyltransferase Proteins 0.000 description 1
- 102000030789 Histidine Ammonia-Lyase Human genes 0.000 description 1
- 108700006308 Histidine ammonia-lyases Proteins 0.000 description 1
- 102000004195 Isomerases Human genes 0.000 description 1
- 108090000769 Isomerases Proteins 0.000 description 1
- 102000001399 Kallikrein Human genes 0.000 description 1
- 108060005987 Kallikrein Proteins 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 1
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 1
- 108010059881 Lactase Proteins 0.000 description 1
- 108010022065 Lactate racemase Proteins 0.000 description 1
- 108010004098 Leucyl aminopeptidase Proteins 0.000 description 1
- 102000002704 Leucyl aminopeptidase Human genes 0.000 description 1
- 108090000364 Ligases Proteins 0.000 description 1
- 102000003960 Ligases Human genes 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 102000004317 Lyases Human genes 0.000 description 1
- 108090000856 Lyases Proteins 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- 102000013460 Malate Dehydrogenase Human genes 0.000 description 1
- 108010026217 Malate Dehydrogenase Proteins 0.000 description 1
- 108020004687 Malate Synthase Proteins 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 108030007269 Methionine racemases Proteins 0.000 description 1
- XJLXINKUBYWONI-NNYOXOHSSA-O NADP(+) Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-NNYOXOHSSA-O 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 108010073038 Penicillin Amidase Proteins 0.000 description 1
- 108010087702 Penicillinase Proteins 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 108700023158 Phenylalanine ammonia-lyases Proteins 0.000 description 1
- 108010064785 Phospholipases Proteins 0.000 description 1
- 102000015439 Phospholipases Human genes 0.000 description 1
- 108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 1
- 102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 1
- 108010059820 Polygalacturonase Proteins 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 102000055027 Protein Methyltransferases Human genes 0.000 description 1
- 102000013009 Pyruvate Kinase Human genes 0.000 description 1
- 108020005115 Pyruvate Kinase Proteins 0.000 description 1
- 108010031852 Pyruvate Synthase Proteins 0.000 description 1
- 102000006382 Ribonucleases Human genes 0.000 description 1
- 108010083644 Ribonucleases Proteins 0.000 description 1
- 239000002262 Schiff base Substances 0.000 description 1
- 150000004753 Schiff bases Chemical class 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 1
- 108090000190 Thrombin Proteins 0.000 description 1
- 102000004357 Transferases Human genes 0.000 description 1
- 108090000992 Transferases Proteins 0.000 description 1
- DAKWPKUUDNSNPN-UHFFFAOYSA-N Trimethylolpropane triacrylate Chemical compound C=CC(=O)OCC(CC)(COC(=O)C=C)COC(=O)C=C DAKWPKUUDNSNPN-UHFFFAOYSA-N 0.000 description 1
- OKKRPWIIYQTPQF-UHFFFAOYSA-N Trimethylolpropane trimethacrylate Chemical compound CC(=C)C(=O)OCC(CC)(COC(=O)C(C)=C)COC(=O)C(C)=C OKKRPWIIYQTPQF-UHFFFAOYSA-N 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 108010092464 Urate Oxidase Proteins 0.000 description 1
- 108010046334 Urease Proteins 0.000 description 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
- 102100033220 Xanthine oxidase Human genes 0.000 description 1
- 108010093894 Xanthine oxidase Proteins 0.000 description 1
- 108700040099 Xylose isomerases Proteins 0.000 description 1
- 229940022698 acetylcholinesterase Drugs 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 125000005907 alkyl ester group Chemical group 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 108010003977 aminoacylase I Proteins 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 229960003272 asparaginase Drugs 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-M asparaginate Chemical compound [O-]C(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-M 0.000 description 1
- 229940009098 aspartate Drugs 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 108010051210 beta-Fructofuranosidase Proteins 0.000 description 1
- 150000001718 carbodiimides Chemical class 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000011545 carbonate/bicarbonate buffer Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229960002376 chymotrypsin Drugs 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 description 1
- 239000005516 coenzyme A Substances 0.000 description 1
- 235000017471 coenzyme Q10 Nutrition 0.000 description 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 1
- 229940093530 coenzyme a Drugs 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 description 1
- 239000012954 diazonium Substances 0.000 description 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-O diazynium Chemical compound [NH+]#N IJGRMHOSHXDMSA-UHFFFAOYSA-O 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
- 235000019797 dipotassium phosphate Nutrition 0.000 description 1
- 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 1
- 108010093305 exopolygalacturonase Proteins 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 230000009477 glass transition Effects 0.000 description 1
- 229940116332 glucose oxidase Drugs 0.000 description 1
- 235000019420 glucose oxidase Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000009931 harmful effect Effects 0.000 description 1
- 108010030923 hesperidinase Proteins 0.000 description 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 239000001573 invertase Substances 0.000 description 1
- 235000011073 invertase Nutrition 0.000 description 1
- 229940116108 lactase Drugs 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- KUGLDBMQKZTXPW-JEDNCBNOSA-N methyl (2s)-2-amino-3-methylbutanoate;hydrochloride Chemical compound Cl.COC(=O)[C@@H](N)C(C)C KUGLDBMQKZTXPW-JEDNCBNOSA-N 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- 108010001078 naringinase Proteins 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 108010028584 nucleotidase Proteins 0.000 description 1
- 229940055729 papain Drugs 0.000 description 1
- 235000019834 papain Nutrition 0.000 description 1
- 229950009506 penicillinase Drugs 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 229940012957 plasmin Drugs 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 239000003505 polymerization initiator Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000005373 porous glass Substances 0.000 description 1
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000005185 salting out Methods 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229960001322 trypsin Drugs 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
Landscapes
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Description
ãçºæã®è©³çŽ°ãªèª¬æã
æ¬çºæã¯åºå®åé
µçŽ ã«é¢ãã詳ããã¯ãã°ãªã·
ãžã«åºãå€æ°æããªããå®å®ãªæ°Žåæ£æ§ãæãã
埮现ãªæ°Žäžæº¶æ§æ°Žåæ£åé«ååéåäœç²åãæ äœ
ãšãããã®ã°ãªã·ãžã«åºã«é µçŽ ãé«å¯åºŠã«åºå®å
ãããé«æŽ»æ§ã§å®å®ãªåºå®åé µçŽ ã«é¢ããã
ãžã«åºãå€æ°æããªããå®å®ãªæ°Žåæ£æ§ãæãã
埮现ãªæ°Žäžæº¶æ§æ°Žåæ£åé«ååéåäœç²åãæ äœ
ãšãããã®ã°ãªã·ãžã«åºã«é µçŽ ãé«å¯åºŠã«åºå®å
ãããé«æŽ»æ§ã§å®å®ãªåºå®åé µçŽ ã«é¢ããã
äžè¬ã«åå¿æ§å®èœåºãæããæ°Žåæ£åé«ååé
åäœç²åã¯ããã®éåäœã®æããç¹æ§ã«å ããŠã
ãããæããåå¿æ§å®èœåºã«ãã€ãŠãéåäœãå€
æ§ããåã¯æ¶æ©å€ãšããŠæ©èœãããããšãã§ãã
ã®ã§ãäŸãã°ãæ°Žåæ£åç²çå€ãæ¥çå€ã«ããã
ç²çæ¥çç¹æ§ãæ¹åããããã®é«ååæ¶æ©æ§å å¡«
æãšããŠããŸããæ°Žåæ£åå¡æã«ãããå¡è匷å
ã®ããã®é«ååæ¶æ©æ§å å¡«æçã«çšããããšãã§
ããã
åäœç²åã¯ããã®éåäœã®æããç¹æ§ã«å ããŠã
ãããæããåå¿æ§å®èœåºã«ãã€ãŠãéåäœãå€
æ§ããåã¯æ¶æ©å€ãšããŠæ©èœãããããšãã§ãã
ã®ã§ãäŸãã°ãæ°Žåæ£åç²çå€ãæ¥çå€ã«ããã
ç²çæ¥çç¹æ§ãæ¹åããããã®é«ååæ¶æ©æ§å å¡«
æãšããŠããŸããæ°Žåæ£åå¡æã«ãããå¡è匷å
ã®ããã®é«ååæ¶æ©æ§å å¡«æçã«çšããããšãã§
ããã
ãŸããæ¢ã«æ°Žäžæº¶æ§ã®æ
äœã«é
µçŽ ãè£é
µçŽ ãåº
å®åããŠãé µçŽ åå¿ã«çšããæ¹æ³ãç¥ãããŠãã
ããåŸæ¥ã¯ãããæ äœãšããŠãã»ã«ããŒã¹ããã
ã¹ãã©ã³ãã¢ã¬ããŒã¹çã®å€ç³é¡ã®èªå°äœãããª
ã¢ã¯ãªã«ã¢ããã²ã«ãå€åæ§ã¬ã©ã¹çã®åŸïŒmmä¹
è³æ°mmã®ç²åãçšããããŠããã«ãããããã®ã
ããªç²åã«é µçŽ ãåºå®åãããåºå®åé µçŽ ã¯ãé
åžžãã«ã©ã ã«å å¡«ãããåºå®ãããŠãåºè³ªæº¶æ¶²ãš
æ¥è§Šãããã®ã§ãåºè³ªãé«ååéã®å Žåãåºå®å
é µçŽ è¡šé¢ã«æ¡æ£ãé£ããåå¿ã«é·æéãèŠãããš
å ±ã«ãåå¿åçãäœããšããåé¡ãããããã®ã
ããåå¿æ§å®èœåºãæããæ°Žåæ£åé«ååéåäœ
ç²åã«é µçŽ ãåºå®åããæ°Žæ§ã®åå¿ç³»ã«ãããŠé
é¢ã®é µçŽ ãšåæ§ã®æåãå¯èœã«ããŠãåå¿æ§ã«ã
ãããåºå®åé µçŽ ãåŸãããšãææ¡ãããŠããã
å®åããŠãé µçŽ åå¿ã«çšããæ¹æ³ãç¥ãããŠãã
ããåŸæ¥ã¯ãããæ äœãšããŠãã»ã«ããŒã¹ããã
ã¹ãã©ã³ãã¢ã¬ããŒã¹çã®å€ç³é¡ã®èªå°äœãããª
ã¢ã¯ãªã«ã¢ããã²ã«ãå€åæ§ã¬ã©ã¹çã®åŸïŒmmä¹
è³æ°mmã®ç²åãçšããããŠããã«ãããããã®ã
ããªç²åã«é µçŽ ãåºå®åãããåºå®åé µçŽ ã¯ãé
åžžãã«ã©ã ã«å å¡«ãããåºå®ãããŠãåºè³ªæº¶æ¶²ãš
æ¥è§Šãããã®ã§ãåºè³ªãé«ååéã®å Žåãåºå®å
é µçŽ è¡šé¢ã«æ¡æ£ãé£ããåå¿ã«é·æéãèŠãããš
å ±ã«ãåå¿åçãäœããšããåé¡ãããããã®ã
ããåå¿æ§å®èœåºãæããæ°Žåæ£åé«ååéåäœ
ç²åã«é µçŽ ãåºå®åããæ°Žæ§ã®åå¿ç³»ã«ãããŠé
é¢ã®é µçŽ ãšåæ§ã®æåãå¯èœã«ããŠãåå¿æ§ã«ã
ãããåºå®åé µçŽ ãåŸãããšãææ¡ãããŠããã
ããããäžè¬ã«åå¿æ§å®èœåºãç¹ã«ã°ãªã·ãžã«
åºãå€æ°æããæ°Žåæ£åé«ååéåäœç²åã補é
ããããšã¯ãã°ãªã·ãžã«åºãæããåéäœãå€é
ã«å«æããåéäœçµæãä¹³åå ±éåãããéã®é
åå®å®æ§ãæªãã容æã«åéãèµ·ããçã®ãã
ã«ãåŸæ¥ãããã補é ããããšã¯å°é£ã§ãããšã
ããŠããã
åºãå€æ°æããæ°Žåæ£åé«ååéåäœç²åã補é
ããããšã¯ãã°ãªã·ãžã«åºãæããåéäœãå€é
ã«å«æããåéäœçµæãä¹³åå ±éåãããéã®é
åå®å®æ§ãæªãã容æã«åéãèµ·ããçã®ãã
ã«ãåŸæ¥ãããã補é ããããšã¯å°é£ã§ãããšã
ããŠããã
æ¬çºæè
ãã¯ãäžèšããçš®ã
ã®åé¡ã解決ãã
ããã«éæç 究ããçµæãäºæããªãããšã«ãã°
ãªã·ãžã«åºãæããåéäœãã¢ã¯ãªããããªã«å
ã¯ã¡ã¿ã¯ãªããããªã«ãšå€å®èœæ§å éšæ¶æ©çšåé
äœãšå ±ã«ä¹³åå ±éåããããšã«ãããåéäœçµæ
ã«ãããã°ãªã·ãžã«åºå«æåéäœã10ééïŒ ä»¥äž
ãšããŠããå®å®ã«ããããå ±éåãããããšãã§
ãããšå ±ã«ããã®ããã«ããŠåŸãããæ°Žåæ£åé«
ååéåäœç²åã¯é«å¯åºŠã«ã°ãªã·ãžã«åºãæãã
äžã€ããã®æ°Žåæ£æ¶²ã¯æ©æ¢°çå®å®æ§ã«ããããã
ãšãèŠåºããæŽã«ããããæ°Žåæ£åé«ååéåäœ
ç²åã«ãããæããã°ãªã·ãžã«åºãä»ããŠãå ±æ
çµåã«ãã€ãŠé µçŽ ãåºå®åããããšã«ãã€ãŠãå
å¿ç³»ã«ãããŠåæ£æ§ã«ããããããããé«æŽ»æ§ã§
å®å®ãªåºå®åé µçŽ ãåŸãããšãã§ããããšãèŠåº
ããŠãæ¬çºæã«è³ã€ããã®ã§ããã
ããã«éæç 究ããçµæãäºæããªãããšã«ãã°
ãªã·ãžã«åºãæããåéäœãã¢ã¯ãªããããªã«å
ã¯ã¡ã¿ã¯ãªããããªã«ãšå€å®èœæ§å éšæ¶æ©çšåé
äœãšå ±ã«ä¹³åå ±éåããããšã«ãããåéäœçµæ
ã«ãããã°ãªã·ãžã«åºå«æåéäœã10ééïŒ ä»¥äž
ãšããŠããå®å®ã«ããããå ±éåãããããšãã§
ãããšå ±ã«ããã®ããã«ããŠåŸãããæ°Žåæ£åé«
ååéåäœç²åã¯é«å¯åºŠã«ã°ãªã·ãžã«åºãæãã
äžã€ããã®æ°Žåæ£æ¶²ã¯æ©æ¢°çå®å®æ§ã«ããããã
ãšãèŠåºããæŽã«ããããæ°Žåæ£åé«ååéåäœ
ç²åã«ãããæããã°ãªã·ãžã«åºãä»ããŠãå ±æ
çµåã«ãã€ãŠé µçŽ ãåºå®åããããšã«ãã€ãŠãå
å¿ç³»ã«ãããŠåæ£æ§ã«ããããããããé«æŽ»æ§ã§
å®å®ãªåºå®åé µçŽ ãåŸãããšãã§ããããšãèŠåº
ããŠãæ¬çºæã«è³ã€ããã®ã§ããã
æ¬çºæã«ããåºå®åé
µçŽ ã¯ã(a)ã°ãªã·ãžã«ã¢ã¯
ãªã¬ãŒãåã³ïŒåã¯ã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒã10
ã60ééïŒ ã(b)ãã®åéäœãšå ±éåãåŸã第ïŒã®
ã©ãžã«ã«éåæ§åéäœãšããŠã®ã¢ã¯ãªã«é žãšã¹ã
ã«ãã¡ã¿ã¯ãªã«é žãšã¹ãã«ãé ¢é žããã«ãããã
ãªã³é žããã«ãã¹ãã¬ã³ãã¡ãã«ã¹ãã¬ã³ããã
ã«ãã«ãšã³ããã¿ãžãšã³ãã€ãœãã¬ã³åã¯ããã
ã®æ··åç©10ã88ééïŒ ã(c)å€å®èœæ§å éšæ¶æ©çšå
éäœïŒã30ééïŒ ãåã³(d)第ïŒã®ã©ãžã«ã«éåæ§
åéäœãšããŠã®ã¢ã¯ãªããããªã«åã¯ã¡ã¿ã¯ãªã
ãããªã«ïŒã60ééïŒ ãšãããªãåéäœçµæãä¹³
åå ±éåãããŠãªãå¹³åç²åŸ0.03ã2ÎŒïœã®æ°Žåæ£
åé«ååéåäœç²åã®ã°ãªã·ãžã«åºãä»ããŠé µçŽ
ãåºå®åãããŠããããšãç¹åŸŽãšããã
ãªã¬ãŒãåã³ïŒåã¯ã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒã10
ã60ééïŒ ã(b)ãã®åéäœãšå ±éåãåŸã第ïŒã®
ã©ãžã«ã«éåæ§åéäœãšããŠã®ã¢ã¯ãªã«é žãšã¹ã
ã«ãã¡ã¿ã¯ãªã«é žãšã¹ãã«ãé ¢é žããã«ãããã
ãªã³é žããã«ãã¹ãã¬ã³ãã¡ãã«ã¹ãã¬ã³ããã
ã«ãã«ãšã³ããã¿ãžãšã³ãã€ãœãã¬ã³åã¯ããã
ã®æ··åç©10ã88ééïŒ ã(c)å€å®èœæ§å éšæ¶æ©çšå
éäœïŒã30ééïŒ ãåã³(d)第ïŒã®ã©ãžã«ã«éåæ§
åéäœãšããŠã®ã¢ã¯ãªããããªã«åã¯ã¡ã¿ã¯ãªã
ãããªã«ïŒã60ééïŒ ãšãããªãåéäœçµæãä¹³
åå ±éåãããŠãªãå¹³åç²åŸ0.03ã2ÎŒïœã®æ°Žåæ£
åé«ååéåäœç²åã®ã°ãªã·ãžã«åºãä»ããŠé µçŽ
ãåºå®åãããŠããããšãç¹åŸŽãšããã
æ¬çºæã«ããã°ãäžèšã®ãããªåéäœçµæãçš
ããããšã«ãããã°ãªã·ãžã«ã¢ã¯ãªã¬ãŒãåã³ïŒ
åã¯ã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒãïŒä»¥äžãã°ãªã·ãž
ã«ïŒã¡ã¿ïŒã¢ã¯ãªã¬ãŒããšç§°ãããïŒãåéäœçµ
æã®10ééïŒ ä»¥äžãšããŠããå®å®ã«ä¹³åå ±éåã
ããããšãã§ããããããŠãåŸãããæ°Žåæ£åé«
ååéåäœç²åã¯é«å¯åºŠã«ã°ãªã·ãžã«åºãæãã
ãšå ±ã«åŒ·åºŠã«ããããããããç²åçžäºã«ç²çæ§
ããããããŸããã°ãªã·ãžã«åºãé«å¯åºŠã«æããª
ãããæ©æ¢°çå®å®æ§ã«ããããã®ã§ããã
ããããšã«ãããã°ãªã·ãžã«ã¢ã¯ãªã¬ãŒãåã³ïŒ
åã¯ã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒãïŒä»¥äžãã°ãªã·ãž
ã«ïŒã¡ã¿ïŒã¢ã¯ãªã¬ãŒããšç§°ãããïŒãåéäœçµ
æã®10ééïŒ ä»¥äžãšããŠããå®å®ã«ä¹³åå ±éåã
ããããšãã§ããããããŠãåŸãããæ°Žåæ£åé«
ååéåäœç²åã¯é«å¯åºŠã«ã°ãªã·ãžã«åºãæãã
ãšå ±ã«åŒ·åºŠã«ããããããããç²åçžäºã«ç²çæ§
ããããããŸããã°ãªã·ãžã«åºãé«å¯åºŠã«æããª
ãããæ©æ¢°çå®å®æ§ã«ããããã®ã§ããã
ç¹ã«å¥œãŸããåéäœçµæã¯ãã°ãªã·ãžã«ïŒã¡
ã¿ïŒã¢ã¯ãªã¬ãŒã15ã45ééïŒ ããã®åéäœãšå ±
éåãåŸã第ïŒã®ã©ãžã«ã«éåæ§åéäœ20ã78é
éïŒ ãå€å®èœæ§å éšæ¶æ©çšåéäœïŒã20ééïŒ ã
åã³ã¢ã¯ãªããããªã«åã¯ã¡ã¿ã¯ãªããããªã«
ïŒä»¥äžãïŒã¡ã¿ïŒã¢ã¯ãªããããªã«ãšç§°ãããïŒïŒ
ã40ééïŒ ãšãããªãã
ã¿ïŒã¢ã¯ãªã¬ãŒã15ã45ééïŒ ããã®åéäœãšå ±
éåãåŸã第ïŒã®ã©ãžã«ã«éåæ§åéäœ20ã78é
éïŒ ãå€å®èœæ§å éšæ¶æ©çšåéäœïŒã20ééïŒ ã
åã³ã¢ã¯ãªããããªã«åã¯ã¡ã¿ã¯ãªããããªã«
ïŒä»¥äžãïŒã¡ã¿ïŒã¢ã¯ãªããããªã«ãšç§°ãããïŒïŒ
ã40ééïŒ ãšãããªãã
æ¬çºæã«ãããŠãã°ãªã·ãžã«ïŒã¡ã¿ïŒã¢ã¯ãªã¬
ãŒããšå ±éåããã第ïŒã®ã©ãžã«ã«éåæ§åéäœ
ãšããŠã¯ãïŒã¡ã¿ïŒã¢ã¯ãªããããªã«ãé€ããŠã
ããããšå ±éåæ§ãæããéãã¯ç¹ã«å¶éããã
ãã®ã§ã¯ãªããã奜ãŸããã¯ãé ¢é žããã«ããã
ããªã³é žããã«ãã¢ã¯ãªã«é žãšã¹ãã«ãã¡ã¿ã¯ãª
ã«é žãšã¹ãã«ãã¹ãã¬ã³ãã¡ãã«ã¹ãã¬ã³ããã
ã«ãã«ãšã³ããã¿ãžãšã³ãã€ãœãã¬ã³çã®ïŒçš®å
ã¯ïŒçš®ä»¥äžãçšãããããç¹ã«ãã¢ã¯ãªã«é žåã³
ã¡ã¿ã¯ãªã«é žã®ççŽ æ°ïŒãïŒã®ã¢ã«ãã«ãšã¹ãã«
ãã¹ãã¬ã³ã奜ãŸããçšãããããå°ãåŸããã
éåäœç²åãããã®çšéã«å¿ããæèŠã®ã¬ã©ã¹è»¢
移ç¹ãæããããã«ãããããéžã°ããã®ã¯åœç¶
ã§ããã
ãŒããšå ±éåããã第ïŒã®ã©ãžã«ã«éåæ§åéäœ
ãšããŠã¯ãïŒã¡ã¿ïŒã¢ã¯ãªããããªã«ãé€ããŠã
ããããšå ±éåæ§ãæããéãã¯ç¹ã«å¶éããã
ãã®ã§ã¯ãªããã奜ãŸããã¯ãé ¢é žããã«ããã
ããªã³é žããã«ãã¢ã¯ãªã«é žãšã¹ãã«ãã¡ã¿ã¯ãª
ã«é žãšã¹ãã«ãã¹ãã¬ã³ãã¡ãã«ã¹ãã¬ã³ããã
ã«ãã«ãšã³ããã¿ãžãšã³ãã€ãœãã¬ã³çã®ïŒçš®å
ã¯ïŒçš®ä»¥äžãçšãããããç¹ã«ãã¢ã¯ãªã«é žåã³
ã¡ã¿ã¯ãªã«é žã®ççŽ æ°ïŒãïŒã®ã¢ã«ãã«ãšã¹ãã«
ãã¹ãã¬ã³ã奜ãŸããçšãããããå°ãåŸããã
éåäœç²åãããã®çšéã«å¿ããæèŠã®ã¬ã©ã¹è»¢
移ç¹ãæããããã«ãããããéžã°ããã®ã¯åœç¶
ã§ããã
ãŸããå
éšæ¶æ©çšå€å®èœæ§åéäœãšããŠã¯ãå€
䟡ã¢ã«ã³ãŒã«ã®ããªã¢ã¯ãªã¬ãŒãåã¯ããªã¡ã¿ã¯
ãªã¬ãŒãïŒä»¥äžãããªïŒã¡ã¿ïŒã¢ã¯ãªã¬ãŒããšç§°
ãããïŒã奜ãŸãããå ·äœçã«ã¯ããšãã¬ã³ã°ãª
ã³ãŒã«ãžã¡ã¿ã¯ãªã¬ãŒãããžãšãã¬ã³ã°ãªã³ãŒã«
ãžã¡ã¿ã¯ãªã¬ãŒããããªãšãã¬ã³ã°ãªã³ãŒã«ãžã¡
ã¿ã¯ãªã¬ãŒãããžãããã¬ã³ã°ãªã³ãŒã«ãžã¡ã¿ã¯
ãªã¬ãŒããïŒïŒïŒâããã¬ã³ã°ãªã³ãŒã«ãžã¡ã¿ã¯
ãªã¬ãŒããããªãšãã¬ã³ã°ãªã³ãŒã«ãžã¢ã¯ãªã¬ãŒ
ããããªã¡ãããŒã«ãããã³ããªã¡ã¿ã¯ãªã¬ãŒ
ããããªã¡ãããŒã«ãããã³ããªã¢ã¯ãªã¬ãŒãã
ããã©ã¡ãããŒã«ã¡ã¿ã³ããã©ã¢ã¯ãªã¬ãŒãçã
çšããããããžããã«ãã³ãŒã³ã奜ãŸããçšãã
ããã
䟡ã¢ã«ã³ãŒã«ã®ããªã¢ã¯ãªã¬ãŒãåã¯ããªã¡ã¿ã¯
ãªã¬ãŒãïŒä»¥äžãããªïŒã¡ã¿ïŒã¢ã¯ãªã¬ãŒããšç§°
ãããïŒã奜ãŸãããå ·äœçã«ã¯ããšãã¬ã³ã°ãª
ã³ãŒã«ãžã¡ã¿ã¯ãªã¬ãŒãããžãšãã¬ã³ã°ãªã³ãŒã«
ãžã¡ã¿ã¯ãªã¬ãŒããããªãšãã¬ã³ã°ãªã³ãŒã«ãžã¡
ã¿ã¯ãªã¬ãŒãããžãããã¬ã³ã°ãªã³ãŒã«ãžã¡ã¿ã¯
ãªã¬ãŒããïŒïŒïŒâããã¬ã³ã°ãªã³ãŒã«ãžã¡ã¿ã¯
ãªã¬ãŒããããªãšãã¬ã³ã°ãªã³ãŒã«ãžã¢ã¯ãªã¬ãŒ
ããããªã¡ãããŒã«ãããã³ããªã¡ã¿ã¯ãªã¬ãŒ
ããããªã¡ãããŒã«ãããã³ããªã¢ã¯ãªã¬ãŒãã
ããã©ã¡ãããŒã«ã¡ã¿ã³ããã©ã¢ã¯ãªã¬ãŒãçã
çšããããããžããã«ãã³ãŒã³ã奜ãŸããçšãã
ããã
æŽã«ãæ¬çºæã«ãããŠã¯ãæ°Žåæ£åé«ååéå
äœç²åãåŸãããã®ç¬¬ïŒã®ã©ãžã«ã«éåæ§åéäœ
æåãšããŠãïŒã¡ã¿ïŒã¢ã¯ãªããããªã«ãå«æã
ãããšãå¿ é ã§ãããã°ãªã·ãžã«ïŒã¡ã¿ïŒã¢ã¯ãª
ã¬ãŒããšããã«å ±éåæ§ãæãã第ïŒã®ã©ãžã«ã«
éåæ§åéäœã®ã¿ãä¹³åå ±éåããããšãéåã
äžå®å®ã§ãã€ãŠãå®å®ãªæ°Žåæ£åé«ååéåäœç²
åãåŸãããšãå°é£ã§ãããããããªãããæ¬çº
æã«åŸã€ãŠãã°ãªã·ãžã«ïŒã¡ã¿ïŒã¢ã¯ãªã¬ãŒããš
第ïŒã®ã©ãžã«ã«éåæ§åéäœãšïŒã¡ã¿ïŒã¢ã¯ãªã
ãããªã«ãšå€å®èœæ§å éšæ¶æ©çšåéäœãšãä¹³åå ±
éåãããããšã«ãããéåã®å®å®æ§ã確ä¿ãã
ãããã®ãããªçµæãåŸãããçç±ã¯å¿ ãããæ
ããã§ã¯ãªãããïŒã¡ã¿ïŒã¢ã¯ãªããããªã«ãšå
éšæ¶æ©çšåéäœãšãäžèšçµæç¯å²ã«ãããŠã°ãªã·
ãžã«ïŒã¡ã¿ïŒã¢ã¯ãªã¬ãŒãã«æå¹ã«å ±éåããã
ããæ°Žäžæº¶åããŠãéåãå®å®åããã®ã§ãã
ããåŸã€ãŠãïŒã¡ã¿ïŒã¢ã¯ãªããããªã«ãšå€å®èœ
æ§å éšæ¶æ©çšåéäœã®éãäžèšç¯å²ãããå°ãªã
ãšããåã¯å€ããããšãã¯ãéåã®å®å®æ§ãæãª
ããããŸããåŸãããéåäœç²åæ°Žåæ£æ¶²ãæ©æ¢°
çå®å®æ§ã«å£ãã
äœç²åãåŸãããã®ç¬¬ïŒã®ã©ãžã«ã«éåæ§åéäœ
æåãšããŠãïŒã¡ã¿ïŒã¢ã¯ãªããããªã«ãå«æã
ãããšãå¿ é ã§ãããã°ãªã·ãžã«ïŒã¡ã¿ïŒã¢ã¯ãª
ã¬ãŒããšããã«å ±éåæ§ãæãã第ïŒã®ã©ãžã«ã«
éåæ§åéäœã®ã¿ãä¹³åå ±éåããããšãéåã
äžå®å®ã§ãã€ãŠãå®å®ãªæ°Žåæ£åé«ååéåäœç²
åãåŸãããšãå°é£ã§ãããããããªãããæ¬çº
æã«åŸã€ãŠãã°ãªã·ãžã«ïŒã¡ã¿ïŒã¢ã¯ãªã¬ãŒããš
第ïŒã®ã©ãžã«ã«éåæ§åéäœãšïŒã¡ã¿ïŒã¢ã¯ãªã
ãããªã«ãšå€å®èœæ§å éšæ¶æ©çšåéäœãšãä¹³åå ±
éåãããããšã«ãããéåã®å®å®æ§ã確ä¿ãã
ãããã®ãããªçµæãåŸãããçç±ã¯å¿ ãããæ
ããã§ã¯ãªãããïŒã¡ã¿ïŒã¢ã¯ãªããããªã«ãšå
éšæ¶æ©çšåéäœãšãäžèšçµæç¯å²ã«ãããŠã°ãªã·
ãžã«ïŒã¡ã¿ïŒã¢ã¯ãªã¬ãŒãã«æå¹ã«å ±éåããã
ããæ°Žäžæº¶åããŠãéåãå®å®åããã®ã§ãã
ããåŸã€ãŠãïŒã¡ã¿ïŒã¢ã¯ãªããããªã«ãšå€å®èœ
æ§å éšæ¶æ©çšåéäœã®éãäžèšç¯å²ãããå°ãªã
ãšããåã¯å€ããããšãã¯ãéåã®å®å®æ§ãæãª
ããããŸããåŸãããéåäœç²åæ°Žåæ£æ¶²ãæ©æ¢°
çå®å®æ§ã«å£ãã
äžèšåéäœçµæã®ä¹³åå
±éååå¿ã«ãããŠã¯ã
PHãïŒä»è¿ã«ä¿ã€ããšãæãŸãããåå¿æã®PHã
é žæ§åã¯ã¢ã«ã«ãªæ§ã«åã€ãŠãããšãã°ãªã·ãžã«
åºãéè£ãããšå ±ã«ã氎溶æ§éåäœãçããåŸå
ã倧ããããã§ããããŸããã°ãªã·ãžã«åºã®éè£
ã«ãã€ãŠãåŸãããéåäœç²åãå€ãã®ã°ãªã·ãž
ã«åºãæãããæ¶æ©æ§èœãããã«åºå®åãåŸãé µ
çŽ éãååã§ãªããªãããã§ããã
PHãïŒä»è¿ã«ä¿ã€ããšãæãŸãããåå¿æã®PHã
é žæ§åã¯ã¢ã«ã«ãªæ§ã«åã€ãŠãããšãã°ãªã·ãžã«
åºãéè£ãããšå ±ã«ã氎溶æ§éåäœãçããåŸå
ã倧ããããã§ããããŸããã°ãªã·ãžã«åºã®éè£
ã«ãã€ãŠãåŸãããéåäœç²åãå€ãã®ã°ãªã·ãž
ã«åºãæãããæ¶æ©æ§èœãããã«åºå®åãåŸãé µ
çŽ éãååã§ãªããªãããã§ããã
äžèšã®ãããªåéäœçµæã¯ãæ°Žåªäœäžã«ãŠåŸæ¥
ããç¥ãããŠããéåžžã®æ¹æ³ã«ãŠä¹³åå ±éåãã
ãããšãã§ããããæ¬çºæã«ããæ°Žåæ£åé«åå
éåäœç²åãæ°Žåæ£åç²çå€ãæ¥çå€ãå¡æçã«
ãããé«ååç²çå€ããåºå®åé µçŽ ã®ããã®æ äœ
ãšããŠçšããå Žåãä¹³åå€ãæ··åšãããšãäŸã
ã°ãæ¥çå€ãå¡èã®èæ°Žæ§ãå£åãããæãã¯é µ
çŽ ã®åºå®åã®éã«é µçŽ ã倱掻ããçã®æ害ãªåœ±é¿
ãçŸããããšãããã®ã§ãä¹³åå ±éåã«éããŠã¯
ä¹³åå€ãçšããªãã®ã奜ãŸãããæ¬çºæã«ããäž
èšåéäœçµæã«ããã°ãç¹ã«ä¹³åå€ãèŠããããŠ
å®å®ã«å ±éåãããããšãã§ãããããããåŸã
ããæ°Žåæ£åé«ååéåäœç²åã®çšéããä¹³åå€
ã«ãã€ãŠæ害ãªåœ±é¿ãæããªããã°ãäžèšçµæã®
åéäœãå ±éåãããã«éããŠãä¹³åå€ãå¿ èŠã«
å¿ããŠçšããŠãããã
ããç¥ãããŠããéåžžã®æ¹æ³ã«ãŠä¹³åå ±éåãã
ãããšãã§ããããæ¬çºæã«ããæ°Žåæ£åé«åå
éåäœç²åãæ°Žåæ£åç²çå€ãæ¥çå€ãå¡æçã«
ãããé«ååç²çå€ããåºå®åé µçŽ ã®ããã®æ äœ
ãšããŠçšããå Žåãä¹³åå€ãæ··åšãããšãäŸã
ã°ãæ¥çå€ãå¡èã®èæ°Žæ§ãå£åãããæãã¯é µ
çŽ ã®åºå®åã®éã«é µçŽ ã倱掻ããçã®æ害ãªåœ±é¿
ãçŸããããšãããã®ã§ãä¹³åå ±éåã«éããŠã¯
ä¹³åå€ãçšããªãã®ã奜ãŸãããæ¬çºæã«ããäž
èšåéäœçµæã«ããã°ãç¹ã«ä¹³åå€ãèŠããããŠ
å®å®ã«å ±éåãããããšãã§ãããããããåŸã
ããæ°Žåæ£åé«ååéåäœç²åã®çšéããä¹³åå€
ã«ãã€ãŠæ害ãªåœ±é¿ãæããªããã°ãäžèšçµæã®
åéäœãå ±éåãããã«éããŠãä¹³åå€ãå¿ èŠã«
å¿ããŠçšããŠãããã
åèšã®ãããªåéäœçµæã®ä¹³åå
±éåã«ãã€ãŠ
åŸãããæ°Žåæ£åé«ååéåäœç²åã®å¹³åç²åŸã¯
0.03ÎŒã2ÎŒãéåžžã0.07ÎŒä¹è³1ÎŒã§ããããã®ç¯å²
ã®ç²åŸã¯ãåŸãããåºå®åé µçŽ ãæ°Žäžã«åæ£ãã
ãã®ã容æã§ããã®ã§å¥œãŸããã
åŸãããæ°Žåæ£åé«ååéåäœç²åã®å¹³åç²åŸã¯
0.03ÎŒã2ÎŒãéåžžã0.07ÎŒä¹è³1ÎŒã§ããããã®ç¯å²
ã®ç²åŸã¯ãåŸãããåºå®åé µçŽ ãæ°Žäžã«åæ£ãã
ãã®ã容æã§ããã®ã§å¥œãŸããã
次ã«ãæ¬çºæã«ããåºå®åé
µçŽ ã®è£œé ã«ã€ããŠ
説æãããå°ãæ¬çºæã«ãããŠé µçŽ ã®ä»£ããã«è£
é µçŽ ãåºå®åãåŸãããšã¯æããã§ãããæ¬çºæ
ã«ãããŠã¯ãé µçŽ ã«ã¯è£é µçŽ ãå«ãŸãããã®ãšã
ãã
説æãããå°ãæ¬çºæã«ãããŠé µçŽ ã®ä»£ããã«è£
é µçŽ ãåºå®åãåŸãããšã¯æããã§ãããæ¬çºæ
ã«ãããŠã¯ãé µçŽ ã«ã¯è£é µçŽ ãå«ãŸãããã®ãšã
ãã
æ¬çºæã«ããåºå®åé
µçŽ ã¯ãäžã«èª¬æãããã
ãªæ°Žåæ£åé«ååéåäœç²åã«ããã®æããã°ãª
ã·ãžã«åºãä»ããŠé µçŽ ãåºå®åãããŠããã
ãªæ°Žåæ£åé«ååéåäœç²åã«ããã®æããã°ãª
ã·ãžã«åºãä»ããŠé µçŽ ãåºå®åãããŠããã
æ°Žåæ£åé«ååéåäœç²åã®æããã°ãªã·ãžã«
åºãä»ããŠé µçŽ ãå ±æçµåã«ãŠåºå®åããæ¹æ³ã¯
ç¹ã«å¶éããããåŸæ¥ããç¥ãããŠããæ¹æ³ãé©
å®ã«æ¡çšãããã
åºãä»ããŠé µçŽ ãå ±æçµåã«ãŠåºå®åããæ¹æ³ã¯
ç¹ã«å¶éããããåŸæ¥ããç¥ãããŠããæ¹æ³ãé©
å®ã«æ¡çšãããã
äŸãã°ãäžã€ã®æ¹æ³ãšããŠãã°ãªã·ãžã«åºã«çŽ
æ¥ã«é µçŽ ãåºå®åããå Žåã¯ãéåäœç²åã®æã
ãã°ãªã·ãžã«åºã«PHãïŒãïŒä»è¿ã§é µçŽ ãåå¿ã
ããã°ããããã®éãããç¥ãããŠããããã«ã
é µçŽ ã倱掻ããªãããã«ãäœæž©ã§æ°åæéåå¿ã
ããã®ãæãŸããããŸããå¥ã®æ¹æ³ãšããŠãéå
äœç²åã®æããã°ãªã·ãžã«åºã«ããªãšãã¬ã³ã€ã
ã³ãïœâãã·ãªã¬ã³ãžã¢ãã³ã®ããã«ååå ã«ã¢
ããåºãïŒä»¥äžæããããªã¢ãã³ãã¹ããŒãµåºãš
ããŠåå¿ãããæ°ãã«åœ¢æãããã¢ããåºæ«ç«¯ã«
é µçŽ ãçµåãããããšãã§ãããå³ã¡ãäŸãã°ã
PHïŒã13ã枩床20ã40âã®ç¯å²ã§ãžã¢ãã³ãéå
äœç²åã«åå¿ãããã°ãããããããŠéåäœç²å
ã«å°å ¥ãããã¢ããåºã«é µçŽ ãåºå®åããã®ã§ã
ãããã®ã¢ããåºã«é µçŽ ãå ±æçµåã«ãŠåºå®åã
ãã«ã¯ãåŸæ¥ããç¥ãããŠããéåžžã®æ¹æ³ã«ãã
ããšãã§ããäŸãã°ããžã¢ãŸããŠã æ³ãã«ã«ããž
ã€ããæ³ãããªã·ã¢ããŒãæ³ããžã¢ã«ãããæ³ç
ãæ¡çšããããšãã§ããã
æ¥ã«é µçŽ ãåºå®åããå Žåã¯ãéåäœç²åã®æã
ãã°ãªã·ãžã«åºã«PHãïŒãïŒä»è¿ã§é µçŽ ãåå¿ã
ããã°ããããã®éãããç¥ãããŠããããã«ã
é µçŽ ã倱掻ããªãããã«ãäœæž©ã§æ°åæéåå¿ã
ããã®ãæãŸããããŸããå¥ã®æ¹æ³ãšããŠãéå
äœç²åã®æããã°ãªã·ãžã«åºã«ããªãšãã¬ã³ã€ã
ã³ãïœâãã·ãªã¬ã³ãžã¢ãã³ã®ããã«ååå ã«ã¢
ããåºãïŒä»¥äžæããããªã¢ãã³ãã¹ããŒãµåºãš
ããŠåå¿ãããæ°ãã«åœ¢æãããã¢ããåºæ«ç«¯ã«
é µçŽ ãçµåãããããšãã§ãããå³ã¡ãäŸãã°ã
PHïŒã13ã枩床20ã40âã®ç¯å²ã§ãžã¢ãã³ãéå
äœç²åã«åå¿ãããã°ãããããããŠéåäœç²å
ã«å°å ¥ãããã¢ããåºã«é µçŽ ãåºå®åããã®ã§ã
ãããã®ã¢ããåºã«é µçŽ ãå ±æçµåã«ãŠåºå®åã
ãã«ã¯ãåŸæ¥ããç¥ãããŠããéåžžã®æ¹æ³ã«ãã
ããšãã§ããäŸãã°ããžã¢ãŸããŠã æ³ãã«ã«ããž
ã€ããæ³ãããªã·ã¢ããŒãæ³ããžã¢ã«ãããæ³ç
ãæ¡çšããããšãã§ããã
以äžã®ããã«ããŠãé
µçŽ ãéåäœç²åã«å
±æçµ
åãããåŸãçšããåå¿è©Šè¬ãåºå®åãããŠããª
ãé µçŽ ãé å¿åé¢ãèåé¢çã®é©å®ã®æ段ã«ãã€
ãŠé€å»ããã°ãæ¬çºæã®åºå®åé µçŽ ãåŸãã
åãããåŸãçšããåå¿è©Šè¬ãåºå®åãããŠããª
ãé µçŽ ãé å¿åé¢ãèåé¢çã®é©å®ã®æ段ã«ãã€
ãŠé€å»ããã°ãæ¬çºæã®åºå®åé µçŽ ãåŸãã
æ¬çºæã«ããåºå®åé
µçŽ ã¯æ°Žåæ£æ¶²ãšããŠçšã
ãããåºè³ªãšæ¥è§Šããããåºå®åé µçŽ ã®äœ¿çšé
ã¯ãåºå®åé µçŽ ã®ç²åŸãé µçŽ ã®åºå®åéãå¿ èŠãš
ããåå¿é床ãåºè³ªæ¿åºŠçã«ããé©å®ã«æ±ºå®ãã
ãã
ãããåºè³ªãšæ¥è§Šããããåºå®åé µçŽ ã®äœ¿çšé
ã¯ãåºå®åé µçŽ ã®ç²åŸãé µçŽ ã®åºå®åéãå¿ èŠãš
ããåå¿é床ãåºè³ªæ¿åºŠçã«ããé©å®ã«æ±ºå®ãã
ãã
æ¬çºæã«ãããŠåºå®åãããé
µçŽ ã¯èäœå
é
µçŽ
ã§ããããèäœå€é µçŽ ã§ãããããŸããé µçŽ ã¯å¿
ãããé«åºŠã«ç²Ÿè£œãããŠããå¿ èŠã¯ãªããæœåºæ¶²
ãéšå粟補åãçšãããããæŽã«ãæ¬çºæã«åŸã€
ãŠãåäžã®é µçŽ ãåºå®åããŠãããããè€æ°ã®é µ
çŽ ãåæã«åºå®åããŠãããã
ã§ããããèäœå€é µçŽ ã§ãããããŸããé µçŽ ã¯å¿
ãããé«åºŠã«ç²Ÿè£œãããŠããå¿ èŠã¯ãªããæœåºæ¶²
ãéšå粟補åãçšãããããæŽã«ãæ¬çºæã«åŸã€
ãŠãåäžã®é µçŽ ãåºå®åããŠãããããè€æ°ã®é µ
çŽ ãåæã«åºå®åããŠãããã
æ¬çºæã«ãããŠé
µçŽ ã¯ç¹ã«å¶éããããçš®ã
ã®
é µçŽ ãçšãããããå ·äœäŸãšããŠãã¢ããé žãªã
ã·ããŒãŒãã«ã¿ã©ãŒãŒãããµã³ãã³ãªãã·ããŒ
ãŒãã°ã«ã³ãŒã¹ãªãã·ããŒãŒãã°ã«ã³ãŒã¹âïŒâ
ãªã³é žããããã²ããŒãŒãã°ã«ã¿ãã³é žãããã
ã²ããŒãŒãããã¯ãã ãªãã·ããŒãŒãããã·ã
ãŒãŒãä¹³é žããããã²ããŒãŒããã«ãªãã·ããŒ
ãŒãïŒâãã¹ãã°ã«ã³ã³é žããããã²ããŒãŒããª
ã³ãŽé žããããã²ããŒãŒã®ãããªé žåéå é µçŽ ã
ã¢ã¹ãã©ã®ã³é žã¢ã»ãã«ãã©ã³ã¹ããšã©ãŒãŒãã¢
ã¹ãã©ã®ã³é žã¢ãããã©ã³ã¹ããšã©ãŒãŒãã°ãªã·
ã³ã¢ãããã©ã³ã¹ããšã©ãŒãŒãã°ã«ã¿ãã³é žâãª
ãã¶ãé ¢é žã¢ãããã©ã³ã¹ããšã©ãŒãŒãã°ã«ã¿ã
ã³é žâãã«ãã³é žã¢ãããã©ã³ã¹ããšã©ãŒãŒãã¯
ã¬ã¢ãã³ãã¹ããããŒãŒããã¹ã¿ãã³ã¡ãã«ãã©
ã³ã¹ããšã©ãŒãŒããã«ãã³é žãããŒãŒããã©ã¯ã
ãããŒãŒããããœãããŒãŒãÎŽâãªãžã³ã¢ã»ãã«
ãã©ã³ã¹ããšã©ãŒãŒããã€ã·ã³ã¢ãããããããŒ
ãŒã®ãããªè»¢ç§»é µçŽ ãã¢ã¹ãã©ã®ããŒãŒãã¢ã»ã
ã«ã³ãªã³ãšã¹ãã©ãŒãŒãã¢ããã¢ã·ã©ãŒãŒãã¢ã
ã©ãŒãŒãã¢ã«ã®ããŒãŒãâã¢ã«ã®ãã³ãã€ãã
ãŒãŒãã€ã³ãã«ã¿ãŒãŒããŠã¬ã¢ãŒãŒããŠãªã«ãŒ
ãŒããŠããããŒãŒããšã¹ãã©ãŒãŒãβâã¬ã©ã¯ã
ã·ããŒãŒãã«ãªã¯ã¬ã€ã³ããã¢ããªãã·ã³ãããª
ãã·ã³ãããã³ãã³ãããªã³ã®ããŒãŒããã¯ã¬ãª
ãããŒãŒãããã€ã³ããã€ãŠããããŒãŒããã©ã¹
ãã³ããã¯ãããŒãŒããã¹ããªãžããŒãŒãããã·
ã³ããµãŒã¢ãªã·ã³ãããã·ãªããŒãŒãããã·ãªã³
ã¢ãããŒãŒããã¹ããªããŒãŒããã¹ãã¢ã¿ãŒãŒã
ã©ã¯ã¿ãŒãŒããªããŒãŒããªããã¯ã¬ã¢ãŒãŒãã¬ã³
ãã³ã®ãããªå æ°Žåè§£é µçŽ ãã¢ã¹ãã©ã®ã³é žãã«
ã«ããã·ã©ãŒãŒãã¢ã¹ãã«ã¿ãŒãŒãã¯ãšã³é žãªã¢
ãŒãŒãã°ã«ã¿ãã³é žãã«ã«ããã·ã©ãŒãŒããã¹ã
ãžã³ã¢ã³ã¢ãã¢ãªã¢ãŒãŒãããšãã«ã¢ã©ãã³ã¢ã³
ã¢ãã¢ãªã¢ãŒãŒãããã©ãŒãŒããããŒã«é žããã©
ã¿ãŒãŒããªã³ãŽé žã·ã³ãã¿ãŒãŒã®ãããªãªã¢ãŒ
ãŒãã¢ã©ãã³ã©ã»ããŒãŒãã°ã«ã³ãŒã¹ã€ãœã¡ã©ãŒ
ãŒãã°ã«ã³ãŒã¹ãã¹ããšãŒãã€ãœã¡ã©ãŒãŒãã°ã«
ã¿ãã³é žã©ã»ããŒãŒãä¹³é žã©ã»ããŒãŒãã¡ããªã
ã³ã©ã»ããŒãŒã®ãããªç°æ§åé µçŽ ãã¢ã¹ãã©ã®ã³
ã·ã³ã¿ãŒãŒãã°ã«ã¿ããªã³ã·ã³ã¿ãŒãŒããã«ãã³
é žã·ã³ã¿ãŒãŒã®ãããªãªã¬ãŒãŒçãæããããšã
ã§ããã
é µçŽ ãçšãããããå ·äœäŸãšããŠãã¢ããé žãªã
ã·ããŒãŒãã«ã¿ã©ãŒãŒãããµã³ãã³ãªãã·ããŒ
ãŒãã°ã«ã³ãŒã¹ãªãã·ããŒãŒãã°ã«ã³ãŒã¹âïŒâ
ãªã³é žããããã²ããŒãŒãã°ã«ã¿ãã³é žãããã
ã²ããŒãŒãããã¯ãã ãªãã·ããŒãŒãããã·ã
ãŒãŒãä¹³é žããããã²ããŒãŒããã«ãªãã·ããŒ
ãŒãïŒâãã¹ãã°ã«ã³ã³é žããããã²ããŒãŒããª
ã³ãŽé žããããã²ããŒãŒã®ãããªé žåéå é µçŽ ã
ã¢ã¹ãã©ã®ã³é žã¢ã»ãã«ãã©ã³ã¹ããšã©ãŒãŒãã¢
ã¹ãã©ã®ã³é žã¢ãããã©ã³ã¹ããšã©ãŒãŒãã°ãªã·
ã³ã¢ãããã©ã³ã¹ããšã©ãŒãŒãã°ã«ã¿ãã³é žâãª
ãã¶ãé ¢é žã¢ãããã©ã³ã¹ããšã©ãŒãŒãã°ã«ã¿ã
ã³é žâãã«ãã³é žã¢ãããã©ã³ã¹ããšã©ãŒãŒãã¯
ã¬ã¢ãã³ãã¹ããããŒãŒããã¹ã¿ãã³ã¡ãã«ãã©
ã³ã¹ããšã©ãŒãŒããã«ãã³é žãããŒãŒããã©ã¯ã
ãããŒãŒããããœãããŒãŒãÎŽâãªãžã³ã¢ã»ãã«
ãã©ã³ã¹ããšã©ãŒãŒããã€ã·ã³ã¢ãããããããŒ
ãŒã®ãããªè»¢ç§»é µçŽ ãã¢ã¹ãã©ã®ããŒãŒãã¢ã»ã
ã«ã³ãªã³ãšã¹ãã©ãŒãŒãã¢ããã¢ã·ã©ãŒãŒãã¢ã
ã©ãŒãŒãã¢ã«ã®ããŒãŒãâã¢ã«ã®ãã³ãã€ãã
ãŒãŒãã€ã³ãã«ã¿ãŒãŒããŠã¬ã¢ãŒãŒããŠãªã«ãŒ
ãŒããŠããããŒãŒããšã¹ãã©ãŒãŒãβâã¬ã©ã¯ã
ã·ããŒãŒãã«ãªã¯ã¬ã€ã³ããã¢ããªãã·ã³ãããª
ãã·ã³ãããã³ãã³ãããªã³ã®ããŒãŒããã¯ã¬ãª
ãããŒãŒãããã€ã³ããã€ãŠããããŒãŒããã©ã¹
ãã³ããã¯ãããŒãŒããã¹ããªãžããŒãŒãããã·
ã³ããµãŒã¢ãªã·ã³ãããã·ãªããŒãŒãããã·ãªã³
ã¢ãããŒãŒããã¹ããªããŒãŒããã¹ãã¢ã¿ãŒãŒã
ã©ã¯ã¿ãŒãŒããªããŒãŒããªããã¯ã¬ã¢ãŒãŒãã¬ã³
ãã³ã®ãããªå æ°Žåè§£é µçŽ ãã¢ã¹ãã©ã®ã³é žãã«
ã«ããã·ã©ãŒãŒãã¢ã¹ãã«ã¿ãŒãŒãã¯ãšã³é žãªã¢
ãŒãŒãã°ã«ã¿ãã³é žãã«ã«ããã·ã©ãŒãŒããã¹ã
ãžã³ã¢ã³ã¢ãã¢ãªã¢ãŒãŒãããšãã«ã¢ã©ãã³ã¢ã³
ã¢ãã¢ãªã¢ãŒãŒãããã©ãŒãŒããããŒã«é žããã©
ã¿ãŒãŒããªã³ãŽé žã·ã³ãã¿ãŒãŒã®ãããªãªã¢ãŒ
ãŒãã¢ã©ãã³ã©ã»ããŒãŒãã°ã«ã³ãŒã¹ã€ãœã¡ã©ãŒ
ãŒãã°ã«ã³ãŒã¹ãã¹ããšãŒãã€ãœã¡ã©ãŒãŒãã°ã«
ã¿ãã³é žã©ã»ããŒãŒãä¹³é žã©ã»ããŒãŒãã¡ããªã
ã³ã©ã»ããŒãŒã®ãããªç°æ§åé µçŽ ãã¢ã¹ãã©ã®ã³
ã·ã³ã¿ãŒãŒãã°ã«ã¿ããªã³ã·ã³ã¿ãŒãŒããã«ãã³
é žã·ã³ã¿ãŒãŒã®ãããªãªã¬ãŒãŒçãæããããšã
ã§ããã
ãŸããè£é
µçŽ ãšããŠãäŸãã°ãNADã
NADPãATPãADPãAMPãFADãè£é µçŽ ã
è£é µçŽ çãæããããšãã§ãããå°ããã®å Ž
åãè£é µçŽ ã«äºãã¹ããŒãµåºãçµåãããè£é µçŽ
ã奜ãŸããçšããããšãã§ããå ·äœäŸãšããŠãäŸ
ãã°ïŒ®âãïŒïŒâã¢ããããã·ã«ïŒã«ã«ãã¢ã€ã«
ã¡ãã«ãâNADãN6âã¹ã¯ã·ãã«âNADãN6
âãïŒïŒâã¢ããããã·ã«ïŒã«ã«ãã¢ã€ã«ã¡ãã«ã
âNADPçãæããããšãã§ããã
NADPãATPãADPãAMPãFADãè£é µçŽ ã
è£é µçŽ çãæããããšãã§ãããå°ããã®å Ž
åãè£é µçŽ ã«äºãã¹ããŒãµåºãçµåãããè£é µçŽ
ã奜ãŸããçšããããšãã§ããå ·äœäŸãšããŠãäŸ
ãã°ïŒ®âãïŒïŒâã¢ããããã·ã«ïŒã«ã«ãã¢ã€ã«
ã¡ãã«ãâNADãN6âã¹ã¯ã·ãã«âNADãN6
âãïŒïŒâã¢ããããã·ã«ïŒã«ã«ãã¢ã€ã«ã¡ãã«ã
âNADPçãæããããšãã§ããã
æ¬çºæã«ããåºå®åé
µçŽ ã¯ãã°ãªã·ãžã«åºãé«
å¯åºŠã«æããæ°Žåæ£åé«ååéåäœç²åäžã«ãã®
ã°ãªã·ãžã«åºãä»ããŠå ±æçµåã«ãŠåºå®åãããŠ
ãããåŸã€ãŠãé µçŽ ããŸããé«å¯åºŠã«åºå®åãã
ãŠãããããéåžžã«é µçŽ 掻æ§ã®é«ãåºå®åé µçŽ ã
åŸãããããããã®åºå®åé µçŽ ã¯é µçŽ ã®å€±æŽ»ãå°
ãªããé·æã®äœ¿çšã«ãã€ãŠãé«ãé µçŽ æŽ»æ§ãç¶æ
ãããæŽã«ãåŸæ¥ã®ã»ã«ããŒã¹èªå°äœç²åçãæ
äœãšããå Žåãšç°ãªãããããèªäœãéé¢ã®é µçŽ
ãè£é µçŽ ãšåæ§ã«åå¿ç³»å ãèªç±ã«ç§»åã§ããã
ããåºè³ªã®æ¡æ£ãåå¿ã«æ®ã©åœ±é¿ãäžãããåŸã€
ãŠãé«ååéã®åºè³ªã®å Žåã«ãéé¢ã®é µçŽ åå¿ç³»
ãšåæ§ã®é«ãåå¿é床ã§é µçŽ åå¿ãè¡ãªãããã
ãšãã§ããã
å¯åºŠã«æããæ°Žåæ£åé«ååéåäœç²åäžã«ãã®
ã°ãªã·ãžã«åºãä»ããŠå ±æçµåã«ãŠåºå®åãããŠ
ãããåŸã€ãŠãé µçŽ ããŸããé«å¯åºŠã«åºå®åãã
ãŠãããããéåžžã«é µçŽ 掻æ§ã®é«ãåºå®åé µçŽ ã
åŸãããããããã®åºå®åé µçŽ ã¯é µçŽ ã®å€±æŽ»ãå°
ãªããé·æã®äœ¿çšã«ãã€ãŠãé«ãé µçŽ æŽ»æ§ãç¶æ
ãããæŽã«ãåŸæ¥ã®ã»ã«ããŒã¹èªå°äœç²åçãæ
äœãšããå Žåãšç°ãªãããããèªäœãéé¢ã®é µçŽ
ãè£é µçŽ ãšåæ§ã«åå¿ç³»å ãèªç±ã«ç§»åã§ããã
ããåºè³ªã®æ¡æ£ãåå¿ã«æ®ã©åœ±é¿ãäžãããåŸã€
ãŠãé«ååéã®åºè³ªã®å Žåã«ãéé¢ã®é µçŽ åå¿ç³»
ãšåæ§ã®é«ãåå¿é床ã§é µçŽ åå¿ãè¡ãªãããã
ãšãã§ããã
ãŸããæ¬çºæã«ããåºå®åé
µçŽ ã¯æ°Žäžæº¶æ§ã®æ
äœã«åºå®åãããŠãããããé µçŽ åå¿åŸã«ã¯é å¿
åé¢ãå¡©æãåéå€ãçšããåéæ²æ®¿ãå€åæ§è
ã«ããèåé¢çã«ãã€ãŠå®¹æã«ååã§ããããã
ãŠãé·æéã«ããã€ãŠé«ãé µçŽ æŽ»æ§ãä¿æããã€
ã€ãç¹°è¿ããŠäœ¿çšããããšãã§ããã
äœã«åºå®åãããŠãããããé µçŽ åå¿åŸã«ã¯é å¿
åé¢ãå¡©æãåéå€ãçšããåéæ²æ®¿ãå€åæ§è
ã«ããèåé¢çã«ãã€ãŠå®¹æã«ååã§ããããã
ãŠãé·æéã«ããã€ãŠé«ãé µçŽ æŽ»æ§ãä¿æããã€
ã€ãç¹°è¿ããŠäœ¿çšããããšãã§ããã
以äžã«å®æœäŸãæããŠæ¬çºæã説æããããæ¬
çºæã¯ãããå®æœäŸã«ããéå®ããããã®ã§ã¯ãª
ãã
çºæã¯ãããå®æœäŸã«ããéå®ããããã®ã§ã¯ãª
ãã
å®æœäŸ ïŒ
(1) æ°Žåæ£åé«ååéåäœç²åã®èª¿è£œ
ã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒã18ïœãã¡ãã«ã¡ã¿
ã¯ãªã¬ãŒã26ïœãããã©ãšãã¬ã³ã°ãªã³ãŒã«ãž
ã¡ã¿ã¯ãªã¬ãŒãïŒïœåã³ã¢ã¯ãªããããªã«12ïœ
ãèžçæ°Ž300ïœã«å ããéç¡«é žã«ãªãŠã 0.3ïœã
æ°Ž40mlã«æº¶è§£ããéåéå§å€æ°Žæº¶æ¶²ã70âã®æž©
床ã§çªçŽ æ°æµäžã«å ããPHã7.0ã«ç¶æãã€ã€
200rpmã§æ¹æããŠïŒæééåãããæŽã«ãæž©
床ã80âã«é«ããŠïŒæééåãããŠãåºåœ¢åçŽ
15ïŒ ãå¹³åç²åŸ0.4ÎŒã®éåäœç²åã®æ°Žåæ£æ¶²ã
åŸããéåã¯éåžžã«å®å®ã«è¡ãªãããŠãåéç©
ã¯0.03ïŒ ã§ãã€ãããã®éåäœç²åãé å¿åé¢
ããèžçæ°Ž340mlã«ååæ£ãããŠãéåäœç²å
ã®æ°Žåæ£æ¶²ãåŸãã
ã¯ãªã¬ãŒã26ïœãããã©ãšãã¬ã³ã°ãªã³ãŒã«ãž
ã¡ã¿ã¯ãªã¬ãŒãïŒïœåã³ã¢ã¯ãªããããªã«12ïœ
ãèžçæ°Ž300ïœã«å ããéç¡«é žã«ãªãŠã 0.3ïœã
æ°Ž40mlã«æº¶è§£ããéåéå§å€æ°Žæº¶æ¶²ã70âã®æž©
床ã§çªçŽ æ°æµäžã«å ããPHã7.0ã«ç¶æãã€ã€
200rpmã§æ¹æããŠïŒæééåãããæŽã«ãæž©
床ã80âã«é«ããŠïŒæééåãããŠãåºåœ¢åçŽ
15ïŒ ãå¹³åç²åŸ0.4ÎŒã®éåäœç²åã®æ°Žåæ£æ¶²ã
åŸããéåã¯éåžžã«å®å®ã«è¡ãªãããŠãåéç©
ã¯0.03ïŒ ã§ãã€ãããã®éåäœç²åãé å¿åé¢
ããèžçæ°Ž340mlã«ååæ£ãããŠãéåäœç²å
ã®æ°Žåæ£æ¶²ãåŸãã
(2) åºå®åé
µçŽ ã®èª¿è£œ
ããªãã·ã³150mgã0.05Mçé
žå¡©âéçé
žå¡©
ç·©è¡æ¶²ïŒPH8.0ïŒ10mlã«æº¶è§£ããé µçŽ æ°Žæº¶æ¶²ã
äžèšéåäœç²åæ°Žåæ£æ¶²30mlã«å ãã10âã§48
æéåå¿ããããåå¿çµäºåŸãé å¿åé¢ããæ²
éããéåäœç²åã0.2Mããªã¹å¡©é žç·©è¡æ¶²
ïŒPH8.0ïŒã§æŽæ»ããŠãæªåºå®ã®ããªãã·ã³ãé€
å»ãããšå ±ã«ãæªåå¿ã®ã°ãªã·ãžã«åºãããã
ã¯ãããåã³ã0.1Mã®ããªã¹å¡©é žç·©è¡æ¶²ïŒPH
8.0ïŒã«åæ£ãããŠãåºå®åé µçŽ ãåŸãã
ç·©è¡æ¶²ïŒPH8.0ïŒ10mlã«æº¶è§£ããé µçŽ æ°Žæº¶æ¶²ã
äžèšéåäœç²åæ°Žåæ£æ¶²30mlã«å ãã10âã§48
æéåå¿ããããåå¿çµäºåŸãé å¿åé¢ããæ²
éããéåäœç²åã0.2Mããªã¹å¡©é žç·©è¡æ¶²
ïŒPH8.0ïŒã§æŽæ»ããŠãæªåºå®ã®ããªãã·ã³ãé€
å»ãããšå ±ã«ãæªåå¿ã®ã°ãªã·ãžã«åºãããã
ã¯ãããåã³ã0.1Mã®ããªã¹å¡©é žç·©è¡æ¶²ïŒPH
8.0ïŒã«åæ£ãããŠãåºå®åé µçŽ ãåŸãã
ãã®åºå®åé
µçŽ ã®ããªãã·ã³åºå®åéã¯ãé
åäœç²åïŒïœåœã20mgã§ããããŸããïŒïŒ ã«ãŒ
ã€ã³æ°Žæº¶æ¶²ãåºè³ªãšããŠæž¬å®ãã掻æ§åçã¯60
ïŒ ã§ãã€ãã
åäœç²åïŒïœåœã20mgã§ããããŸããïŒïŒ ã«ãŒ
ã€ã³æ°Žæº¶æ¶²ãåºè³ªãšããŠæž¬å®ãã掻æ§åçã¯60
ïŒ ã§ãã€ãã
å°ã掻æ§åçãšã¯ãåºå®åãããé
µçŽ ã®æŽ»æ§
ã®çè«éã«å¯Ÿããå®éã®æŽ»æ§ã®å²åãšããŠå®çŸ©
ããããããã§ã¯ãïŒïŒ ã«ãŒã€ã³æ°Žæº¶æ¶²ãåºè³ª
ãšããŠãé µçŽ ã35âã§10åéåå¿ãããåŸãïŒ
ïŒ ããªã¯ãã«é ¢é žã«ããé«ååéã¿ã³ãã¯è³ªã
æ²æ®¿ãããéé¢ã®éã¿ã³ãã¯æ§å解質éã
280nmã®åžå 床ããæ±ãããã®åžå 床ãïŒåé
ã«1.0å¢å ããã掻æ§ãïŒåäœãšããŠãé µçŽ åº
å®åéãšåã掻æ§ãæããéé¢ã®é µçŽ éã§é€ã
ãŠæ±ããã
ã®çè«éã«å¯Ÿããå®éã®æŽ»æ§ã®å²åãšããŠå®çŸ©
ããããããã§ã¯ãïŒïŒ ã«ãŒã€ã³æ°Žæº¶æ¶²ãåºè³ª
ãšããŠãé µçŽ ã35âã§10åéåå¿ãããåŸãïŒ
ïŒ ããªã¯ãã«é ¢é žã«ããé«ååéã¿ã³ãã¯è³ªã
æ²æ®¿ãããéé¢ã®éã¿ã³ãã¯æ§å解質éã
280nmã®åžå 床ããæ±ãããã®åžå 床ãïŒåé
ã«1.0å¢å ããã掻æ§ãïŒåäœãšããŠãé µçŽ åº
å®åéãšåã掻æ§ãæããéé¢ã®é µçŽ éã§é€ã
ãŠæ±ããã
ãŸããåå¿åŸã®äžèšåºå®åé
µçŽ ãé å¿åé¢
ããç·©è¡æ¶²ã§æŽæ»ããŠåã³åºè³ªãšåå¿ãããæ
äœãïŒåç¹°è¿ãããšããåºå®åé µçŽ ã¯æåã®æŽ»
æ§ã®85ïŒ ãä¿æããŠããã
ããç·©è¡æ¶²ã§æŽæ»ããŠåã³åºè³ªãšåå¿ãããæ
äœãïŒåç¹°è¿ãããšããåºå®åé µçŽ ã¯æåã®æŽ»
æ§ã®85ïŒ ãä¿æããŠããã
æ¯èŒäŸ ïŒ
å€å®èœæ§å
éšæ¶æ©çšåéäœãçšããªãã»ãã¯ã
ã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒã18ïœãã¡ãã«ã¡ã¿ã¯ãª
ã¬ãŒã30ïœåã³ã¢ã¯ãªããããªã«12ïœãå®æœäŸïŒ
ãšåãæ¡ä»¶äžã§ä¹³åå ±éåããããšãããåéç©
ã1.5ïŒ ãçããŠãåºåœ¢åçŽ13ïŒ ãå¹³åç²åŸ0.5ÎŒ
ã®éåäœç²åã®æ°Žåæ£æ¶²ãåŸãã
ã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒã18ïœãã¡ãã«ã¡ã¿ã¯ãª
ã¬ãŒã30ïœåã³ã¢ã¯ãªããããªã«12ïœãå®æœäŸïŒ
ãšåãæ¡ä»¶äžã§ä¹³åå ±éåããããšãããåéç©
ã1.5ïŒ ãçããŠãåºåœ¢åçŽ13ïŒ ãå¹³åç²åŸ0.5ÎŒ
ã®éåäœç²åã®æ°Žåæ£æ¶²ãåŸãã
ãã®éåäœç²åã«å®æœäŸïŒãšåæ§ã®æ¹æ³ã«ãã
ããªãã·ã³ãåºå®åãããšãããããªãã·ã³ã®åº
å®åéã¯éåäœç²åïŒïœåœã10mgã§ããã掻æ§å
çã¯å®æœäŸïŒãšåãæ¡ä»¶äžã§60ïŒ ã§ãã€ãããŸ
ãããã®åå¿åŸã«é å¿åé¢ããŠæ²éããéåäœç²
åãç·©è¡æ¶²ã§æŽæ»ããåŸãåã³åºè³ªãšåå¿ããã
æäœãïŒåç¹°è¿ãããšãããã®æŽ»æ§ã¯æåã®54ïŒ
ã«ãŸã§äœäžããã
ããªãã·ã³ãåºå®åãããšãããããªãã·ã³ã®åº
å®åéã¯éåäœç²åïŒïœåœã10mgã§ããã掻æ§å
çã¯å®æœäŸïŒãšåãæ¡ä»¶äžã§60ïŒ ã§ãã€ãããŸ
ãããã®åå¿åŸã«é å¿åé¢ããŠæ²éããéåäœç²
åãç·©è¡æ¶²ã§æŽæ»ããåŸãåã³åºè³ªãšåå¿ããã
æäœãïŒåç¹°è¿ãããšãããã®æŽ»æ§ã¯æåã®54ïŒ
ã«ãŸã§äœäžããã
æ¯èŒäŸ ïŒ
ã¢ã¯ãªããããªã«ãçšããããšãªããã°ãªã·ãž
ã«ã¡ã¿ã¯ãªã¬ãŒã18ïœãã¡ãã«ã¡ã¿ã¯ãªã¬ãŒã38
ïœåã³ããã©ãšãã¬ã³ã°ãªã³ãŒã«ãžã¡ã¿ã¯ãªã¬ãŒ
ãïŒïœãå®æœäŸïŒãšåãæ¡ä»¶äžã«ä¹³åå ±éåãã
ãããšãè©Šã¿ãããã»ãŒå šäœãåéããéåãå®
å®ã«è¡ãªãããšãã§ããªãã€ãã
ã«ã¡ã¿ã¯ãªã¬ãŒã18ïœãã¡ãã«ã¡ã¿ã¯ãªã¬ãŒã38
ïœåã³ããã©ãšãã¬ã³ã°ãªã³ãŒã«ãžã¡ã¿ã¯ãªã¬ãŒ
ãïŒïœãå®æœäŸïŒãšåãæ¡ä»¶äžã«ä¹³åå ±éåãã
ãããšãè©Šã¿ãããã»ãŒå šäœãåéããéåãå®
å®ã«è¡ãªãããšãã§ããªãã€ãã
å®æœäŸ ïŒ
(1) æ°Žåæ£åé«ååéåäœç²åã®èª¿è£œ
ã°ãªã·ãžã«ã¡ã¿ã¯ãªã¬ãŒã18ïœãã¹ãã¬ã³15
ïœãã¡ãã«ã¡ã¿ã¯ãªã¬ãŒã13ïœããžããã«ãã³
ãŒã³ïŒïœåã³ã¢ã¯ãªããããªã«12ïœãèžçæ°Ž
300mlã«å ããå®æœäŸïŒãšåãæ¡ä»¶äžã§ä¹³åå ±
éåããŠãåºåœ¢å15ïŒ ãå¹³åç²åŸ0.38ÎŒã®éå
äœç²åã®æ°Žåæ£æ¶²ãåŸããéåã¯éåžžã«å®å®ã«
è¡ãªãããŠãåéç©ã¯0.04ïŒ ã§ãã€ãããã®é
åäœç²åãé å¿åé¢ããæ²éããéåäœç²åã
èžçæ°Žã§æŽæ»ããæäœãïŒåç¹°è¿ããåŸãåã³
èžçæ°Žã«åæ£ãããã
ïœãã¡ãã«ã¡ã¿ã¯ãªã¬ãŒã13ïœããžããã«ãã³
ãŒã³ïŒïœåã³ã¢ã¯ãªããããªã«12ïœãèžçæ°Ž
300mlã«å ããå®æœäŸïŒãšåãæ¡ä»¶äžã§ä¹³åå ±
éåããŠãåºåœ¢å15ïŒ ãå¹³åç²åŸ0.38ÎŒã®éå
äœç²åã®æ°Žåæ£æ¶²ãåŸããéåã¯éåžžã«å®å®ã«
è¡ãªãããŠãåéç©ã¯0.04ïŒ ã§ãã€ãããã®é
åäœç²åãé å¿åé¢ããæ²éããéåäœç²åã
èžçæ°Žã§æŽæ»ããæäœãïŒåç¹°è¿ããåŸãåã³
èžçæ°Žã«åæ£ãããã
(2) åºå®åé
µçŽ ã®èª¿è£œ
ãã®åæ£æ¶²30mlãïœâãã·ãªã¬ã³ãžã¢ãã³ã®
10ééïŒ æ°Žæº¶æ¶²30mlã«åæ£ããã40âã®æž©åºŠã§
24æéåå¿ãããã次ã«ãæ®åããïœâãã·ãª
ã¬ã³ãžã¢ãã³ãé€ãããã«0.1Mãªã³é žäºã«ãª
ãŠã åã³0.1Mãªã³é žäºæ°ŽçŽ ã«ãªãŠã ãã調補
ããç·©è¡æ¶²ïŒPH6.0ïŒã§ïŒåæŽæ»ããåãç·©è¡
液30mlã«ååæ£ãããã
10ééïŒ æ°Žæº¶æ¶²30mlã«åæ£ããã40âã®æž©åºŠã§
24æéåå¿ãããã次ã«ãæ®åããïœâãã·ãª
ã¬ã³ãžã¢ãã³ãé€ãããã«0.1Mãªã³é žäºã«ãª
ãŠã åã³0.1Mãªã³é žäºæ°ŽçŽ ã«ãªãŠã ãã調補
ããç·©è¡æ¶²ïŒPH6.0ïŒã§ïŒåæŽæ»ããåãç·©è¡
液30mlã«ååæ£ãããã
ãã®åæ£æ¶²ã«ïŒâã·ã¯ãããã·ã«âïŒâïŒïŒ
âã¢ã«ããªããšãã«ïŒã«ã«ããžã€ããâã¡ãâ
ïœâãã«ãšã³ã¹ã«ãããŒã0.5ïœãå ããæ¹æ
ãã€ã€ãPHã5.0ã«èª¿æŽããã次ã«ãαâã¢ã
ã©ãŒãŒ500mgãæ°Ž30mlã«æº¶è§£ãããPHã5.0ã«èª¿
æŽããé µçŽ æ°Žæº¶æ¶²ãäžèšéåäœç²ååæ£æ¶²ã«å
ããæ¹æäžãPHã5.0ã«èª¿æŽãã€ã€ãïŒâã§24
æéåå¿ãããŠãαâã¢ãã©ãŒãŒãéåäœç²å
ã«åºå®åãããåå¿åŸãé å¿åé¢ã«ããæ²éã
ãéåäœç²åãç·©è¡æ¶²ã«ãŠæŽæ»ããŠãæªåºå®ã®
αâã¢ãã©ãŒãŒãé€å»ããåã³ç·©è¡æ¶²ã«åæ£ã
ããŠãåºå®åé µçŽ ãåŸãã
âã¢ã«ããªããšãã«ïŒã«ã«ããžã€ããâã¡ãâ
ïœâãã«ãšã³ã¹ã«ãããŒã0.5ïœãå ããæ¹æ
ãã€ã€ãPHã5.0ã«èª¿æŽããã次ã«ãαâã¢ã
ã©ãŒãŒ500mgãæ°Ž30mlã«æº¶è§£ãããPHã5.0ã«èª¿
æŽããé µçŽ æ°Žæº¶æ¶²ãäžèšéåäœç²ååæ£æ¶²ã«å
ããæ¹æäžãPHã5.0ã«èª¿æŽãã€ã€ãïŒâã§24
æéåå¿ãããŠãαâã¢ãã©ãŒãŒãéåäœç²å
ã«åºå®åãããåå¿åŸãé å¿åé¢ã«ããæ²éã
ãéåäœç²åãç·©è¡æ¶²ã«ãŠæŽæ»ããŠãæªåºå®ã®
αâã¢ãã©ãŒãŒãé€å»ããåã³ç·©è¡æ¶²ã«åæ£ã
ããŠãåºå®åé µçŽ ãåŸãã
ãã®åºå®åé
µçŽ ã®Î±âã¢ãã©ãŒãŒåºå®åé
ã¯ãéåäœç²åïŒïœåœã52mgã§ããã掻æ§åç
ã¯35ïŒ ã§ãã€ãã掻æ§åçã¯ãããã§ã¯ãïŒïŒ
ãã³ãã³æ°Žæº¶æ¶²ãåºè³ªãšããŠãåºå®åé µçŽ ã35
âã§30åéåå¿ããããšãŠçŽ ãã³ãã³åå¿ãã
ãã³ãã³ã®å解éãæ±ããããšã«ãããåºå®å
é µçŽ ã®æŽ»æ§ãå³ã¡ããã³ãã³å解é床ïŒmgïŒ
åïŒãåŸããããšçãã掻æ§ãæããéé¢ã®é µ
çŽ éãé µçŽ åºå®åéã§é€ããŠæ±ããã
ã¯ãéåäœç²åïŒïœåœã52mgã§ããã掻æ§åç
ã¯35ïŒ ã§ãã€ãã掻æ§åçã¯ãããã§ã¯ãïŒïŒ
ãã³ãã³æ°Žæº¶æ¶²ãåºè³ªãšããŠãåºå®åé µçŽ ã35
âã§30åéåå¿ããããšãŠçŽ ãã³ãã³åå¿ãã
ãã³ãã³ã®å解éãæ±ããããšã«ãããåºå®å
é µçŽ ã®æŽ»æ§ãå³ã¡ããã³ãã³å解é床ïŒmgïŒ
åïŒãåŸããããšçãã掻æ§ãæããéé¢ã®é µ
çŽ éãé µçŽ åºå®åéã§é€ããŠæ±ããã
å®æœäŸ ïŒ
å®æœäŸïŒã§åŸãéåäœç²åæ°Žåæ£æ¶²30mlã«ããª
ãšãã¬ã³ã€ãã³ïŒæ¥æ¬è§ŠåªååŠå·¥æ¥(æ ª)補â
1000ïŒã®ïŒééïŒ æ°Žæº¶æ¶²100mlãå ãã40âã§24
æéåå¿ãããããã®åŸãé å¿åé¢ãæ°ŽæŽããæŽ
ã«é å¿åé¢ãã0.1Mããªã¹ç·©è¡æ¶²ïŒPH6.5ïŒã§æŽ
æ»ããé å¿åé¢ããããããæŽã«æ°ŽæŽããèžçæ°Ž
ã«åæ£ãããŠãéåäœç²ååæ£æ¶²30mlãšããã
ãšãã¬ã³ã€ãã³ïŒæ¥æ¬è§ŠåªååŠå·¥æ¥(æ ª)補â
1000ïŒã®ïŒééïŒ æ°Žæº¶æ¶²100mlãå ãã40âã§24
æéåå¿ãããããã®åŸãé å¿åé¢ãæ°ŽæŽããæŽ
ã«é å¿åé¢ãã0.1Mããªã¹ç·©è¡æ¶²ïŒPH6.5ïŒã§æŽ
æ»ããé å¿åé¢ããããããæŽã«æ°ŽæŽããèžçæ°Ž
ã«åæ£ãããŠãéåäœç²ååæ£æ¶²30mlãšããã
ãã®åæ£æ¶²ã«ïŒééïŒ
ã°ã«ã¿ã«ã¢ã«ããã氎溶
液60mlãå ãã宀枩ã§ïŒæéåå¿ãããåŸãæ°ŽæŽ
ããããã®ããã«ããŠãéåäœç²åã«çµåããã
ããªãšãã¬ã³ã€ãã³ã®ã¢ããåºãšã·ããå¡©åºã圢
æãããŠãéåäœç²åã«ã¢ã«ãããåºãå°å ¥ãã
ããã«ããªãã·ã³150mgãå®æœäŸïŒãšåæ§ã«ããŠ
åå¿ãããŠåºå®åããããã®åŸãæªåå¿ã®ããªã
ã·ã³ãé€å»ãããšå ±ã«ãæªåå¿ã®ã¢ã«ãããåºã
ãããã¯ããåã³ã0.01Mããªã¹å¡©é žç·©è¡æ¶²ã«å
æ£ãããŠãåºå®åé µçŽ ãåŸãã
液60mlãå ãã宀枩ã§ïŒæéåå¿ãããåŸãæ°ŽæŽ
ããããã®ããã«ããŠãéåäœç²åã«çµåããã
ããªãšãã¬ã³ã€ãã³ã®ã¢ããåºãšã·ããå¡©åºã圢
æãããŠãéåäœç²åã«ã¢ã«ãããåºãå°å ¥ãã
ããã«ããªãã·ã³150mgãå®æœäŸïŒãšåæ§ã«ããŠ
åå¿ãããŠåºå®åããããã®åŸãæªåå¿ã®ããªã
ã·ã³ãé€å»ãããšå ±ã«ãæªåå¿ã®ã¢ã«ãããåºã
ãããã¯ããåã³ã0.01Mããªã¹å¡©é žç·©è¡æ¶²ã«å
æ£ãããŠãåºå®åé µçŽ ãåŸãã
ãã®åºå®åé
µçŽ ã«ãããããªãã·ã³ã®åºå®åé
ã¯éåäœç²åïŒïœåœã25mgã§ããããŸããå®æœäŸ
ïŒãšåæ§ã«ããŠæ±ãã掻æ§åçã¯68ïŒ ã§ãã€ãã
ã¯éåäœç²åïŒïœåœã25mgã§ããããŸããå®æœäŸ
ïŒãšåæ§ã«ããŠæ±ãã掻æ§åçã¯68ïŒ ã§ãã€ãã
å®æœäŸ ïŒ
å®æœäŸïŒã§åŸãããªãšãã¬ã³ã€ãã³ãã¹ããŒãµ
åºãšããŠçµåããã°ã«ã¿ã«ã¢ã«ãããåŠçããé
åäœç²åæ°Žåæ£æ¶²ãçšããŠåºå®åé µçŽ ã調補ã
ããå³ã¡ããžã¡ãã«ã¹ã«ããã·ãïŒmlãšé ¢é žã«ã«
ã·ãŠã 20mmolãå«ã氎溶液ïŒmlã«ãµãŒã¢ãªã·ã³
45mgã溶解ãããã®æ°Žæº¶æ¶²ã«äžèšéåäœç²ååæ£
液30mlïŒåºåœ¢å4.5ïœïŒãå ããŠãïŒâã§äžå€æ¹
æããã次ã«ãéåäœç²åãé å¿åé¢ãããžã¡ã
ã«ã¹ã«ããã·ãïŒmlãšé ¢é žã«ã«ã·ãŠã 20mmolã
å«ã氎溶液ã§ååã«æŽæ»ããåŸãåã氎溶液ã«å
åæ£ãããŠãåºå®åé µçŽ ãåŸãã
åºãšããŠçµåããã°ã«ã¿ã«ã¢ã«ãããåŠçããé
åäœç²åæ°Žåæ£æ¶²ãçšããŠåºå®åé µçŽ ã調補ã
ããå³ã¡ããžã¡ãã«ã¹ã«ããã·ãïŒmlãšé ¢é žã«ã«
ã·ãŠã 20mmolãå«ã氎溶液ïŒmlã«ãµãŒã¢ãªã·ã³
45mgã溶解ãããã®æ°Žæº¶æ¶²ã«äžèšéåäœç²ååæ£
液30mlïŒåºåœ¢å4.5ïœïŒãå ããŠãïŒâã§äžå€æ¹
æããã次ã«ãéåäœç²åãé å¿åé¢ãããžã¡ã
ã«ã¹ã«ããã·ãïŒmlãšé ¢é žã«ã«ã·ãŠã 20mmolã
å«ã氎溶液ã§ååã«æŽæ»ããåŸãåã氎溶液ã«å
åæ£ãããŠãåºå®åé µçŽ ãåŸãã
âãã³ãžã«ãªãã·ã«ã«ããã«ââããšãã«
ã¢ã©ãã³1mmolãšïŒ¬âããªã³ã¡ãã«ãšã¹ãã«å¡©
é žå¡©0.1mmolãããªã¹å¡©é žç·©è¡æ¶²ïŒPH8.0ïŒ20ml
ã«å ããç¡«é žã¢ã³ã¢ããŠã ïŒïœãINã«æ§ãœãŒã
氎溶液ïŒmlãæ·»å ããããæ¹æãããããã«äžèš
åºå®åé µçŽ ã®åæ£æ¶²ïŒmlãæ·»å ãã40âã§äžå€é
ãšãããããã®ããã«ããŠæåºããçæç©ãâ
ãã³ãžã«ãªãã·ã«ã«ããã«ââããšãã«ã¢ã©ã
ã«ââããªã³ã¡ãã«ãšã¹ãã«ãé ¢é žãšãã«ã§æœ
åºããïŒééïŒ ã¢ã³ã¢ãã¢æ°Žã0.5Mã¯ãšã³é žã
æ°Žã®é åºã§æŽæ»ããæžå§ä¹Ÿç¥ããŠãèç¹107ã108
âã®ç²Ÿè£œç©ãåŸããåçã¯72ïŒ ã§ãã€ãã
ã¢ã©ãã³1mmolãšïŒ¬âããªã³ã¡ãã«ãšã¹ãã«å¡©
é žå¡©0.1mmolãããªã¹å¡©é žç·©è¡æ¶²ïŒPH8.0ïŒ20ml
ã«å ããç¡«é žã¢ã³ã¢ããŠã ïŒïœãINã«æ§ãœãŒã
氎溶液ïŒmlãæ·»å ããããæ¹æãããããã«äžèš
åºå®åé µçŽ ã®åæ£æ¶²ïŒmlãæ·»å ãã40âã§äžå€é
ãšãããããã®ããã«ããŠæåºããçæç©ãâ
ãã³ãžã«ãªãã·ã«ã«ããã«ââããšãã«ã¢ã©ã
ã«ââããªã³ã¡ãã«ãšã¹ãã«ãé ¢é žãšãã«ã§æœ
åºããïŒééïŒ ã¢ã³ã¢ãã¢æ°Žã0.5Mã¯ãšã³é žã
æ°Žã®é åºã§æŽæ»ããæžå§ä¹Ÿç¥ããŠãèç¹107ã108
âã®ç²Ÿè£œç©ãåŸããåçã¯72ïŒ ã§ãã€ãã
å°ãäžèšåºå®åé
µçŽ ãåé¢ããåã³åãåå¿ã«
䜿çšãããšããé«ã掻æ§ã瀺ããã
䜿çšãããšããé«ã掻æ§ã瀺ããã
Claims (1)
- ãç¹èš±è«æ±ã®ç¯å²ã ïŒ (a)ã°ãªã·ãžã«ã¢ã¯ãªã¬ãŒãåã³ïŒåã¯ã°ãªã·
ãžã«ã¡ã¿ã¯ãªã¬ãŒã10ã60ééïŒ ã(b)ãã®åéäœ
ãšå ±éåãåŸã第ïŒã®ã©ãžã«ã«éåæ§åéäœãšã
ãŠã®ã¢ã¯ãªã«é žãšã¹ãã«ãã¡ã¿ã¯ãªã«é žãšã¹ã
ã«ãé ¢é žããã«ãããããªã³é žããã«ãã¹ãã¬
ã³ãã¡ãã«ã¹ãã¬ã³ãããã«ãã«ãšã³ããã¿ãžãš
ã³ãã€ãœãã¬ã³åã¯ãããã®æ··åç©10ã88éé
ïŒ ã(c)å€å®èœæ§å éšæ¶æ©çšåéäœïŒã30ééïŒ ã
åã³(d)第ïŒã®ã©ãžã«ã«éåæ§åéäœãšããŠã®ã¢ã¯
ãªããããªã«åã¯ã¡ã¿ã¯ãªããããªã«ïŒã60éé
ïŒ ãšãããªãåéäœçµæãä¹³åå ±éåãããŠãªã
å¹³åç²åŸ0.03ã2ÎŒïœã®æ°Žåæ£åé«ååéåäœç²å
ã®ã°ãªã·ãžã«åºãä»ããŠé µçŽ ãåºå®åãããŠãã
ããšãç¹åŸŽãšããåºå®åé µçŽ ã ïŒ å€å®èœæ§å éšæ¶æ©çšåéäœãå€äŸ¡ã¢ã«ã³ãŒã«
ã®ããªã¢ã¯ãªã¬ãŒãåã¯ããªã¡ã¿ã¯ãªã¬ãŒãã§ã
ãããšãç¹åŸŽãšããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®
åºå®åé µçŽ ã ïŒ æ°Žåæ£åé«ååéåäœç²åã®ã°ãªã·ãžã«åºã«
ã¹ããŒãµåºãä»ããŠé µçŽ ãåºå®åãããŠããããš
ãç¹åŸŽãšããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®åºå®å
é µçŽ ã ïŒ ã¹ããŒãµåºããžã¢ãã³åã¯ããªãšãã¬ã³ã€ã
ã³ã§ããããšãç¹åŸŽãšããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé
èšèŒã®åºå®åé µçŽ ã ïŒ é µçŽ ãã¿ã³ãã¯åè§£é µçŽ ã§ããããšãç¹åŸŽãš
ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®åºå®åé µçŽ ã ïŒ ã¿ã³ãã¯åè§£é µçŽ ããµãŒã¢ãªã·ã³ã§ããããš
ãç¹åŸŽãšããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®åºå®å
é µçŽ ã
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3001783A JPS59154988A (ja) | 1983-02-23 | 1983-02-23 | åºå®åé µçŽ |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3001783A JPS59154988A (ja) | 1983-02-23 | 1983-02-23 | åºå®åé µçŽ |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS59154988A JPS59154988A (ja) | 1984-09-04 |
JPH0229312B2 true JPH0229312B2 (ja) | 1990-06-28 |
Family
ID=12292076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3001783A Granted JPS59154988A (ja) | 1983-02-23 | 1983-02-23 | åºå®åé µçŽ |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS59154988A (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08128432A (ja) * | 1994-10-28 | 1996-05-21 | Seru Japan Kk | ããè£ çœ® |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4331805A1 (de) * | 1993-09-18 | 1995-03-23 | Basf Ag | Matte, transparente Thermoplastharze |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5390991A (en) * | 1977-01-19 | 1978-08-10 | Ceskoslovenska Akademie Ved | Glycidyl esterrbased polar high polymer sorption agent for gas or liquid chromatography |
JPS57132884A (en) * | 1981-02-10 | 1982-08-17 | Japan Atom Energy Res Inst | Immobilizing method of enzyme |
JPS57150387A (en) * | 1981-03-12 | 1982-09-17 | Nitto Electric Ind Co Ltd | Immobilized coenzyme-apoenzyme |
JPS57153010A (en) * | 1981-02-21 | 1982-09-21 | Roehm Gmbh | Manufacture of pearly, bridged, hydrophilic and protein binding active carrier polymer |
JPS57163394A (en) * | 1981-03-12 | 1982-10-07 | Nitto Electric Ind Co Ltd | Immobilized coenzyme |
DE3130924A1 (de) * | 1981-08-05 | 1983-02-17 | Röhm GmbH, 6100 Darmstadt | Oberflaechenreiche systeme zur fixierung von nucleophile gruppen enthaltenden substraten |
-
1983
- 1983-02-23 JP JP3001783A patent/JPS59154988A/ja active Granted
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5390991A (en) * | 1977-01-19 | 1978-08-10 | Ceskoslovenska Akademie Ved | Glycidyl esterrbased polar high polymer sorption agent for gas or liquid chromatography |
JPS57132884A (en) * | 1981-02-10 | 1982-08-17 | Japan Atom Energy Res Inst | Immobilizing method of enzyme |
JPS57153010A (en) * | 1981-02-21 | 1982-09-21 | Roehm Gmbh | Manufacture of pearly, bridged, hydrophilic and protein binding active carrier polymer |
JPS57150387A (en) * | 1981-03-12 | 1982-09-17 | Nitto Electric Ind Co Ltd | Immobilized coenzyme-apoenzyme |
JPS57163394A (en) * | 1981-03-12 | 1982-10-07 | Nitto Electric Ind Co Ltd | Immobilized coenzyme |
DE3130924A1 (de) * | 1981-08-05 | 1983-02-17 | Röhm GmbH, 6100 Darmstadt | Oberflaechenreiche systeme zur fixierung von nucleophile gruppen enthaltenden substraten |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08128432A (ja) * | 1994-10-28 | 1996-05-21 | Seru Japan Kk | ããè£ çœ® |
Also Published As
Publication number | Publication date |
---|---|
JPS59154988A (ja) | 1984-09-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US4478976A (en) | Water-insoluble protein material, its preparation and its use | |
Nilsson et al. | The use of bead polymerization of acrylic monomers for immobilization of enzymes | |
US4525457A (en) | Method of immobilizing enzymatically active materials | |
US4931476A (en) | Crosslinked polymers and a process for their preparation | |
JPH0229312B2 (ja) | ||
JPS6153036B2 (ja) | ||
JPS5945357B2 (ja) | åºå®åé µçŽ | |
JPH0314428B2 (ja) | ||
JPH0314432B2 (ja) | ||
JPH03236777A (ja) | é µçŽ ã®åºå®åæ¹æ³ | |
JPS6012034B2 (ja) | åºå®åé µçŽ ã®è£œé æ¹æ³ | |
JPH0314430B2 (ja) | ||
JPH0314433B2 (ja) | ||
JPS6012033B2 (ja) | åºå®åé µçŽ | |
JPH0314431B2 (ja) | ||
JPH0314429B2 (ja) | ||
JPH0361421B2 (ja) | ||
US4783409A (en) | Immobilized enzyme having reversible solubility | |
JPS6012035B2 (ja) | åºå®åé µçŽ | |
JPS5944038B2 (ja) | åºå®åé µçŽ | |
JPS5945885A (ja) | åºå®åé µçŽ åã³ãã®è£œé æ¹æ³ | |
JPS5945884A (ja) | åºå®åé µçŽ åã³ãã®è£œé æ¹æ³ | |
JPS5945883A (ja) | åºå®åé µçŽ åã³ãã®è£œé æ¹æ³ | |
JPS58165790A (ja) | çç掻æ§ãæããããããŸã«çµæç© | |
JPS58152486A (ja) | é µçŽ åå¿æ¹æ³ |