JPH02240009A - Skin external application agent - Google Patents

Abstract

PURPOSE: To obtain a preparation for external use for skin, containing crude drug composed of a plant of the family Guttiferae or Oleaceae or its extract and useful for the prevention, care and treatment of acne or roughened skin. CONSTITUTION: This preparation contains a crude drug composed of a plant of the family Guttiferae or its extract or a plant of the family Oleaceae or its extract in an amount of 0.005-10wt.%, preferably 0.1-5wt.% on dry basis in the total preparation for external use for skin. Remarkable synergistic effect can be attained by using the above component in combination with 0.005-10wt.%, preferably 0.1-5wt.% of a crude drug composed of a plant of the family Paeoniaceae or its extract. The preparation is applied in an amount of 0.00001-0.02g/day, preferably 0.00002-0.01g/day in terms of the dried weight of the active component per 20cm<2> of the human skin.

Description

[Detailed Description of the Invention] [Industrial Application Field] The present invention relates to a novel, safe and effective skin preparation containing crude drugs, which is particularly effective in preventing, treating or treating acne or rough skin. .

[Prior art] Acne is a skin disease that mainly occurs during adolescence and is called acne vulgaris, which is clinically defined as ``chronic inflammatory changes that occur in the pores, mainly in the pilosebaceous system.'' ing.

The etiology of acne is currently not clear, and it is a skin disease in which various factors are intricately intertwined, but in general,
It is thought that excessive sebum secretion, hair follicle keratinization, or bacteria within the hair follicle play an important role.

At present, there are only a few external preparations that are effective in treating acne, and their effectiveness cannot be said to be sufficient, and no drug that exhibits satisfactory therapeutic effects has yet been obtained.

[Problems to be Solved by the Invention] The present inventors were researching compounds that are particularly effective for preventing, treating, or treating rough skin or acne among naturally derived substances with excellent safety, and found that It has been found that herbal medicines of plants of the family Hypericumaceae or extracts thereof are effective. Furthermore, the present inventors have also found that there is a significant synergistic effect when a herbal medicine from a plant belonging to the Botanaceae family or an extract thereof is used in combination with the herbal medicine from a plant belonging to the Hypericaceae family or its extract from a plant belonging to the Oleaceae family or from a plant belonging to the Oleaceae family. Heading (Means for Solving the Problems) Accordingly, the present invention relates to a skin preparation for external use, characterized by containing one or more crude drugs of Hypericulaceae plants or extracts thereof.

Furthermore, the present invention... The present invention relates to a skin preparation for external use, characterized by containing one or more crude drugs of Oleaceae plants or extracts thereof.

Furthermore, the present invention relates to a skin preparation for external use, which is characterized by containing at least one crude drug of a plant of the Hypericaceae family or an extract thereof, and one or more crude drug of a plant of the Butaceae family or an extract thereof.

Furthermore, the present invention relates to an external skin preparation characterized by containing one or more crude drugs of plants belonging to the family Oleaceae or their extracts and one or more crude drugs or extracts thereof belonging to plants belonging to the family Pesantaceae.

Such external skin preparations are particularly useful for preventing rough skin or acne,
Effective for treatment or treatment.

Hereinafter, the configuration of the present invention will be explained in detail.

In the present invention, crude drugs of plants of the family Oleaceae, plants of the Hypericaceae family, and optionally plants of the family Pecanaceae or extracts thereof are used. As a plant of Oleaceae family (OI. eaceae), Forsythia (Forsythia susp.
nsaVahl. ), Satotrine cat (Fraxinus
japonica Blume), Aodamo (Pra
xinus lanuginosa Koidzumi
), Oubai (Jasn+inus+ nudiflo
rlJm Lind+. ), Jasminu
n odora TISSIMUM L. ), Shioji (
Fraxinuspaethiana Lingels
heim. ), Yadachimo (Fraxinusmnnds)
hurica Rupr. ). Osmanthus (Osmanus)
nthusfragrants Lour. ). Holly (Osmanthus ilicifolius)
illefert), Jasminum of
ficinale L. ), Yamatorengyō (For
Sythia japonica Makino), Syringa reticulata ll
ara), lilac (Syringa vulgar)
is L. ). Osmanthus asi
atticus Nakai. ). Ligu
strum japonicumihumb), Myaaibota (Ligustrum tschonoskii)
(Decaisne). +Z Tonbatago (Chio
nant. hus rejususLindl. ). Ligustrum obt.usifol
iullSieb. ) or Ligu
strun ovalifoliumi1ask). Hypericaceae
As a plant, for example, llypericu
m patulunThun b. ). Willow (llypericum chinense L.),
1.Tlypericum Ascyron
L. ), Hypericum ere
ctun Tbumb. ), tlyper
icum hakonense Franch, etc.
Sav. ), Ilypericum
kamtschat. icum Ledeb. ), Hypericum yezoense
Maxim. ). Azeo 1゛giri (llypericu)
moliganthum Franch. etSav
．． ), Ilypericum jap
onicum Thumb. ) or Kokeo 1 Giri (
llypericum Iaxum Koidz. ) is used. An example of a plant in the Paeoniaceae family is Paeonia suffrutic.
osa, Andr. ) or peony (Paeon
ia Iactiflora Pai1. ).

In the present invention, the herbal medicine of the plant, that is, the whole or a part of the plant (for example, whole plant, root, rhizome, stem, rhizome, leaf,
flowers) can be easily processed (e.g., dried, cut, powdered)
or its extract.

The method for producing the herbal medicine extract used in the present invention involves using the above-mentioned herbal medicine in a solvent such as hot water, a lower alcohol such as methanol or ethanol, a hydrous lower alcohol, a polyhydric alcohol such as brobylene glycol or I3-butylene glycol, or It can be obtained by extraction with a hydrous alcohol such as a hydrous polyhydric alcohol. In the skin external preparation of the present invention, the compounding amount of the herbal medicine or extract thereof from Oleaceae or Oleaceae family plants is 0.005 to 10% as dry matter, preferably 0.01%, based on the total amount of the skin external preparation. ~5% by weight. If it is less than 0.005% by weight, the desired effects of the present invention cannot be sufficiently achieved. Moreover, if the amount exceeds IO weight %, it is not preferable from the standpoint of formulation or skin irritation. When using herbal medicines or extracts of plants of the family Peony family in combination, 0.005 to 10% by weight, preferably 0.01% by weight of the dry matter in the total amount of the skin external preparation.
It is incorporated in an amount of ~5% by weight. If it is less than 0.005% by weight, the desired effects of the present invention cannot be sufficiently achieved. Moreover, if it exceeds 10% by weight, it is undesirable from the standpoint of formulation and skin irritation.

In addition to the above-mentioned essential ingredients, the skin external preparation of the present invention may optionally include various ingredients commonly used in cosmetics, quasi-drugs, pharmaceuticals, etc., and aqueous ingredients, within the range that does not impair the effects of the present invention. Moisturizers, thickeners, preservatives, antioxidants, fragrances, coloring agents, drugs, etc. can be blended, and the form of the external skin preparation of the present invention is arbitrary, such as cream, milky lotion, lotion, etc. It can take the following dosage forms. The external skin preparation of the present invention is particularly effective as an acne treatment agent or rough skin treatment agent. The skin external preparation of the present invention generally contains 0.00001 to 0.02 g/day of herbal medicine or its extract (dry weight) as an active ingredient per 200 cm of human skin.
, preferably 0.00002-0.01 g/da
Apply the amount that becomes y.

(Effects of the invention) The skin external preparation according to the present invention can prevent rough skin or acne,
Effective in therapy and treatment.

(Example) Sorbitol (70%) Glycerin Allantoin Water 1 Nohi 1 part Berberine Forsythia extract (dried) 0.02 g 0.1 g Polyoxyethylene hydrogenated castor oil derivative 0.5 g Ethanol 20.0 g Perfumery To a liquid prepared by mixing and dissolving an appropriate amount of each component in the water part, a liquid prepared by mixing and dissolving each component in the alcohol part was added under stirring to obtain a homogeneous solution of a lotion.

Sorbitol (70%) 3.0
g◆Glycerin 5.
0g allantoin 0.1
g water
70.8 g Ettounidimensional amount Berberine 0.02 g Azeo-otori extract (dried product) 3.0 g Polyoxyethylene hydrogenated castor oil derivative 0.5 g Ethanol 20.0 g Fragrance Appropriate amount Mix and dissolve each component in the water part A liquid prepared by mixing and dissolving each component of the alcohol part was added to the liquid prepared by mixing and dissolving each component of the alcohol part under stirring to obtain a lotion as a homogeneous solution.

Sorbitol (70%) 3.0 g
Glycerin 5.0g Allantoin 0.1g Water
70.
8 g Etouni Tsutomawari Berberine 0.02 g Iwaotogiri extract (dried product) 0.05 g Polyoxyethylene hydrogenated human oil derivative 0.5 g Ethanol 20.0 g Fragrance Mix and dissolve each component in the water part with proper stirring. A liquid prepared by mixing and dissolving each component of the alcohol part was added to the prepared liquid under stirring to obtain a lotion as a homogeneous solution.

Sorbitol (70%) Glycerin 3.0g 5.0g Allantoin 0.1g Water 7
0.8 g Two clay plates Berberine 0.02 g Kinshibai extract' [i (dried) 0.05
g Polyoxyethylene hydrogenated castor oil 16 conductors 0.5G
Ethanol 20.0 g
Fragrance: To a liquid prepared by mixing and dissolving an appropriate amount of each ingredient in the water part, mix and dissolve 41 of each ingredient in the alcohol part and add the "ζ!IN'!!L" liquid under stirring to make a homogeneous solution and make a lotion. Sorbitol (70%) 3.0 g Glycerin 5.0 g Water
67.
7 g Eto and two Ashtray Forsythia extract (dried) 3.0 g
Polyoxyethylene hydrogenated castor oil derivative 0.5 g Ethanol 20,0 g Fragrance Appropriate amount Add the liquid prepared by mixing and dissolving each component of the alcohol part to the liquid prepared by mixing and dissolving each component of the wood part with stirring. In addition, a lotion was obtained as a homogeneous solution.

Sorbitol (70%) 3.0
g Glycerin 5, Og Allantoin 0.1g Water
70.8
gヱDodan and Nitogun Berberine 0.02 g
Hypericum perforatum extract (dried) 0.5 g
Peony extract (dried) 0.5
g Borioxyethylene hydrogenated castor oil derivative 0.5 g Ethanol 20.0 g Fragrance Add the liquid prepared by mixing and dissolving each component in the alcohol part to the liquid prepared by mixing and dissolving each component in the water part with stirring. In addition, a lotion was obtained as a homogeneous solution.

Actual difference J Keno U [ Sorbi 1-le (70%) 3.0
g Glycerin 5.0 g
Allantoin 0.1 g water
70.8 g Etouni Kako Herherin 0.02g Hypericum perforatum extract (dried v! IJ) 3.0
G button extract (dried) 0.5
gBorioxyethylene hydrogenated castor oil derivative 0.5
g ethanol 20.0
g Perfumery To a liquid prepared by mixing and dissolving an appropriate amount of each component in the water part, a liquid prepared by mixing and dissolving each component in the alcohol part was added under stirring to obtain a homogeneous solution of a lotion.

Sorbitol (70%) Glycerin 3.0g 5.0g Water 6
9.5 gヱ'Ghi-y dish Peony extract (dried) 1.0
g Hypericum perforatum extract (dried) 1.0
g Polyoxyethylene hydrogenated castor oil derivative 0.5g Ethanol 20. Og Fragrance: To a solution prepared by mixing and dissolving an appropriate amount of each component in the water part, each component in the alcohol part was added under stirring to obtain a homogeneous solution of lotion.

Sorbitol (70%) Glycerin water 7'/L = D-Furi■ Hypericum perforatum extract Th (dried product) Botanica extract (dry product) Polyoxyethylene hydrogenated castor oil R, W Quaternary ethanol 3.0 g 5. Og 69.5 g 1.5 0.5 0.5 20,0 Fragrance Add an appropriate amount of the liquid prepared by mixing and dissolving each ingredient in the water part to the liquid prepared by mixing and dissolving each ingredient in the alcohol part while stirring. In addition, a lotion was obtained as a homogeneous solution. Sorbitol (70%
) 3.0 g glycerin
5.0g water
70.5 g Ehiuni Eben Hypericum perforatum extract (dried) 0.5 g
Forsythia extract v! /J (dry material) 0.
5 g polyoxyethylene hydrogenated castor oil derivative 0.5
g ethanol 20.0
g Fragrance To a liquid prepared by mixing and dissolving appropriate amounts of each component of the wood part, a liquid prepared by mixing and dissolving each component of the alcohol part was added under stirring to obtain a homogeneous solution of a lotion.

U11LL dihydric L water sorbitol (70%) 3.0
g Glycerin 5.0g Water
69
．． 5 g Pressure Uni Torigara Peony extract (dried) 0.7 g
Forsythia extract (dried) 1.3 g
Polyoxyethylene hardened mustard oil (ml) 0.5g Ethanol 20.0g Fragrance Stir the liquid prepared by mixing and dissolving each component in the alcohol part with the liquid prepared by mixing and dissolving each component in the water part. In addition, a lotion was obtained as a homogeneous solution.

Sorbitol (70%) Glycerin water 3.0 g 5.0 g 69.5 g Peony extract (dried) 0.3 g
Botanpi extract (dried) 1.0 g Hypericum perforatum extract (dried) 0.7 g
Polyoxyethylene hydrogenated castor oil derivative 0.5 g Ethanol 20.0 g Fragrance Appropriate amount Add the liquid prepared by mixing and dissolving each component in the alcohol part to the liquid prepared by mixing and dissolving each component in the water part while stirring. In addition, a lotion was obtained as a homogeneous solution.

Sorbitol (70%) Glycerin water 12 liters Peony 1 Higashide product (dried product) Botanpi extract (dried product) Forsythia extract (dried product) Polyoxyethylene hydrogenated castor oil derivative 3.0 g 5,0g 69 .5 g 1.0 0.3 0.7 0.5 Ethanol 20.0 g
Fragrance: To a liquid prepared by mixing and dissolving appropriate amounts of each component of the wood part, a liquid prepared by mixing and dissolving each component of the alcohol part was added under stirring to obtain a lotion as a homogeneous solution.

;-14: Ku1-Mumirou 10.0 g
Paraffin wax 6.0 g Lanolin 3.0 g Isobrobyl myristate 6,0 g Squalane 8.0 g Liquid paraffin 25.0 g Elephant lily extract (dried) 0.2 g Sulfur
2. Og polyoxyethylene sorbitan monostearate 1.7 g
Sorbitan monostearate 4.2 g preservative
Mix appropriate amounts of each of the above ingredients,
The oil phase was prepared by heating and dissolving at about 75°C.

Brobylene glycol 2. Og borax 0.7g purified water
The remaining oil phase heated to about 75°C was added to the mixed liquid consisting of each of these components while stirring, cooled, and added with aroma at 55°C.
i! ? ! The mixture was added, stirring was continued until the temperature reached 45°C, and the mixture was left to stand to obtain Cree-1.

-- 115: Ku I-Mumitsuwa 10.0 g
Baraffin Wanx 6.0g Lanolin 3.0g Isobrobyl Myristate 6.0g Squalane
8.0g liquid paraffin
25.0 g Forsythia extract (
dry matter) 0.2 g sulfur
2. O g polyoxyethylene sorbitan monostearate 1.7 g sorbitan monostearate} 4.2 g preservative Appropriate amount The above components were mixed and heated at approximately 75°C to dissolve and prepare the oil phase. .

Brobylene glycol 2. Og borax 0.7g purified water
The remaining oil phase heated to about 75°C is added to the mixed liquid consisting of each of these components while stirring, cooled, and an appropriate amount of fragrance is added at 55°C, stirring is continued until 45'C. Leave to stand and get cream.

16: Ku I-Mumizwa 10.0 g
Paraffin wax 6.0 g Lanolin 3.0 g Isobrobyl myrite [・6.0 g Squalane 8,0 g Liquid paraffin 25.0 g Hypericum perforatum extract (dried) 0.5 g Sulfur
2. O g boroxyethylene sorbitan monostearate 1.7 g sorbitan monostearate 4.2 g preservative
Mix appropriate amounts of each of the above ingredients,
The oil phase was prepared by heating at about 75°C to dissolve it. Brobylene glycol 2. O g Borax 0.7 g Purified water Remainder To the mixed liquid consisting of each of these components, add the above-mentioned oil phase heated to about 75°C with stirring, cool it, and add fragrance at 55°C. A jar was added, stirring was continued until the temperature reached 45°C, and the mixture was left to stand to obtain a cream.

17: Ku1-Mumitsurou to. og
Paraffin wax 6.0 g Lanolin 3.0 g Isobrobyl myristate 6.0 g Squalane 8.0 g Liquid paraffin 25.0 g Hypericum perforatum extract (dried) 0.3 g Botanbi extract (dry) 0.2 g sulfur
2. Og polyoxyethylene sorbitan monostearate-h 1.7 g sorbitan monostearate 4.2 g preservative
An oil phase was prepared by mixing appropriate amounts of each of the above components and heating at about 75°C to dissolve them.

Propylene glycol 2. Og borax 0.7 g purified water
Remaining 1'l' L of the above-mentioned Aburakabe heated to about 75°C was added to the mixed liquid consisting of each of these components while stirring, cooled, and an appropriate amount of fragrance was added at 55°C, and the mixture was stirred to 45°C. The mixture was left to stand until the cream was obtained.

8: Kui-mu beeswax 10.0 g
Paraffin wax 6.0 g Lanolin 3.0 g Isobrobyl myristate 6.0 g Squalane 8. Og Liquid Paraffin 25.0 g Hypericum perforatum extract (dried) 0.3 g Peony extract (dry)' 0.2 g Sulfur
2. Og polyoxyethylene sorbitan monostearate 1.7 g sorbitan monostearate 4.2 g preservative
Mix appropriate amounts of each of the above ingredients,
The oil phase was prepared by heating and dissolving at about 75°C.

Propylene glycol 2. Og borax 0.7 g purified water
The remaining oil phase heated to about 75°C is added to the mixed liquid consisting of each of these components while stirring, cooled, and an appropriate amount of fragrance is added at 55°C, stirring is continued until the temperature reaches 45°C. Leave to stand and get cream.

″ 19: Ku1-Mumizwa 10.0 g
Paraffin wax 6.0 g Lanolin 3.0 g Isoprobyl myristate 6.0 g Squalane 8.0 g Liquid paraffin 25.0 g Paraffin extract (dried) 0.2 g Botanpi extract (dried) 0.3 g Sulfur
2. O g polyoxyethylene sorbicun monostearate 1.7 g sorbitan monostearate 4.2 g preservative
An oil phase was prepared by mixing appropriate amounts of each of the above components and heating them at about 75°C to dissolve them.

Propylene glycol 2. Og borax 0.7 g purified water
The remaining oil phase heated to about 75°C is added to the mixed liquid consisting of each of these components while stirring, cooled, and an appropriate amount of fragrance is added at 55°C, stirring is continued until the temperature reaches 45°C. Leave to stand and get cream.

-No 120: Cream Beeswax paraffin wax lanolin isoprovil myristate Squalane liquid paraffin Peony extract (dried) Button extract (dried) Hypericum perforatum extract (dried) sulfur polyoxyethylene sorbitan monostearate sorbitan monostearate Preservative Mix each of the above ingredients, about 7 Aburasaro was prepared.

Propylene glycol borax purified water 10.0 6.0 3.0 6.0 8.0 25.0 0.2 0.1 0.2 2.0 1.7g 4.2g Appropriate amount heated at 5°C Solution 2, Og 0.7g Remaining: Add the oil phase heated to about 75°C with stirring to the mixed solution consisting of each of these components, cool it, add an appropriate amount of fragrance at 55°C, and heat to 45°C. Stirring was continued until the temperature was reached and cream was obtained.

11” 1LLE East! Solid paraffin 10.0 g Peace wax 10.0 g Squalane 10.0 g Peony extract IFI (dried) 1.0 g
Potampi extract (dried) 1.0
g Hypericum perforatum extract (dried) 1.0
g Sulfur 2. Og
Fragrance Appropriate amount Vaseline 66.5
g The above-mentioned components were mixed, the mixture was heated to 80°C to dissolve it, and then cooled with stirring to obtain an ointment.

1. Reason M Next, the effect of the skin external preparation of the present invention will be explained in more detail by giving a clinical example. The effects of the cosmetic creams obtained in Examples on acne and rough skin were tested as follows. The cream of Comparative Example 1 was used as a control (Comparative Example is a product from which crude drug extracts have been removed). To: Ku I-Mumizwa 10.0 g
Paraffin wax 6.0g Lanolin 3, Og isobrobyl myristate 6.0g Squalane 8.0g Liquid paraffin 25. Og sulfur
2. Og polyoxyethylene sorbitan g monostearate
1.7g sorbitan monostearate 4
．． 2 g Preservative Appropriate amount The above components were mixed and heated at about 75°C to dissolve, thereby preparing an oil phase.

Brobylene glycol 2. Og borax 0.7 g purified water
The remaining oil phase heated to about 75°C was added to the mixed liquid consisting of each of these components while stirring, cooled, and an appropriate amount of fragrance was added at 55°C, and stirring was continued until the temperature reached 45°C. , left to stand and got cream.

(Subject) A test sample was applied to each subject, and the results were compared before and after use, and the effects were examined using the following criteria. The subjects were 60 boys and 40 girls with rough skin, 60 boys and 40 girls with acne, and their ages were 15 to 35 years old.

(Test method) Subjects were given a small amount of cream (approximately 0.2
g/200c4) After two treatments, the symptom-improving effect was evaluated.

(evaluation) The severity of each symptom was classified into the following four categories.

Fully cured; all symptoms disappeared.

Author: Effective; Remarkably effective.

Effective; everything becomes light.

Ineffective: No change before and after use.

The results are shown in Table 1.

Text 1 Table 1 (V?.ki) Note) Efficacy rate is the percentage of cases that are more than effective.

As is clear from the results in Table 1, the skin preparation containing crude drug ingredients of the present invention exhibited excellent effects in improving rough skin and skin irritation.

Moreover, the skin external preparations of Examples other than those shown in Table 1 have similarly effective effects.

Claims (1)

[Scope of Claims] 1. An external preparation for skin, characterized by containing one or more crude drugs of Hypericulaceae plants or extracts thereof. 2. A skin preparation for external use, which is characterized by containing at least one crude drug from a plant of the Hypericaceae family or an extract thereof, and one or more crude medicines from a plant of the Botanaceae family or an extract thereof. 3. A skin preparation for external use, characterized by containing one or more crude drugs of Oleaceae plants or extracts thereof. 4. A skin preparation for external use, which is characterized by containing one or more crude drugs of plants belonging to the Oleaceae family or their extracts and one or more crude drugs or extracts thereof of plants belonging to the Pesceum family.