JPH0222229A - 神経細胞及び神経繊維の疾患もしくは傷害の治療に用いる組み合わせ調合剤 - Google Patents
神経細胞及び神経繊維の疾患もしくは傷害の治療に用いる組み合わせ調合剤Info
- Publication number
- JPH0222229A JPH0222229A JP1022466A JP2246689A JPH0222229A JP H0222229 A JPH0222229 A JP H0222229A JP 1022466 A JP1022466 A JP 1022466A JP 2246689 A JP2246689 A JP 2246689A JP H0222229 A JPH0222229 A JP H0222229A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- tebonine
- preparation
- preparation according
- combination preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 50
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 27
- 201000010099 disease Diseases 0.000 title claims description 10
- 210000004126 nerve fiber Anatomy 0.000 title claims description 10
- 210000002569 neuron Anatomy 0.000 title claims description 10
- 230000006378 damage Effects 0.000 title description 6
- 208000027418 Wounds and injury Diseases 0.000 title description 5
- 208000014674 injury Diseases 0.000 title description 5
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims abstract description 22
- VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 claims abstract description 14
- MPJKWIXIYCLVCU-UHFFFAOYSA-N Folinic acid Natural products NC1=NC2=C(N(C=O)C(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)CC(=O)O)CN2)C(=O)N1 MPJKWIXIYCLVCU-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000008191 folinic acid Nutrition 0.000 claims abstract description 14
- 239000011672 folinic acid Substances 0.000 claims abstract description 14
- 229960001691 leucovorin Drugs 0.000 claims abstract description 14
- 239000002253 acid Substances 0.000 claims abstract description 13
- 235000019152 folic acid Nutrition 0.000 claims abstract description 12
- 239000011724 folic acid Substances 0.000 claims abstract description 12
- 235000008100 Ginkgo biloba Nutrition 0.000 claims abstract description 11
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229960000304 folic acid Drugs 0.000 claims abstract description 11
- -1 flavone glycoside Chemical class 0.000 claims abstract description 10
- 235000011201 Ginkgo Nutrition 0.000 claims abstract description 9
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 claims abstract description 9
- 239000013543 active substance Substances 0.000 claims abstract description 9
- 229930003944 flavone Natural products 0.000 claims abstract description 9
- 235000011949 flavones Nutrition 0.000 claims abstract description 9
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229930182470 glycoside Natural products 0.000 claims abstract description 8
- 239000000284 extract Substances 0.000 claims abstract description 6
- 235000019156 vitamin B Nutrition 0.000 claims abstract description 6
- 239000011720 vitamin B Substances 0.000 claims abstract description 6
- 229930003270 Vitamin B Natural products 0.000 claims abstract description 4
- AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 claims abstract 2
- AGBQKNBQESQNJD-UHFFFAOYSA-N alpha-Lipoic acid Natural products OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 claims abstract 2
- 235000019136 lipoic acid Nutrition 0.000 claims abstract 2
- 229960002663 thioctic acid Drugs 0.000 claims abstract 2
- KVUAALJSMIVURS-ZEDZUCNESA-L calcium folinate Chemical compound [Ca+2].C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)C=C1 KVUAALJSMIVURS-ZEDZUCNESA-L 0.000 claims description 17
- 239000007924 injection Substances 0.000 claims description 8
- 238000002347 injection Methods 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 6
- 244000194101 Ginkgo biloba Species 0.000 claims description 5
- 235000008207 calcium folinate Nutrition 0.000 claims description 5
- 239000011687 calcium folinate Substances 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 5
- 239000002504 physiological saline solution Substances 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims 6
- 229940088594 vitamin Drugs 0.000 claims 5
- 229930003231 vitamin Natural products 0.000 claims 5
- 235000013343 vitamin Nutrition 0.000 claims 5
- 239000011782 vitamin Substances 0.000 claims 5
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims 4
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims 3
- 150000003722 vitamin derivatives Chemical class 0.000 claims 3
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 2
- RMRCNWBMXRMIRW-BYFNXCQMSA-M cyanocobalamin Chemical compound N#C[Co+]N([C@]1([H])[C@H](CC(N)=O)[C@]\2(CCC(=O)NC[C@H](C)OP(O)(=O)OC3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)C)C/2=C(C)\C([C@H](C/2(C)C)CCC(N)=O)=N\C\2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O RMRCNWBMXRMIRW-BYFNXCQMSA-M 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims 2
- 229960002477 riboflavin Drugs 0.000 claims 2
- 229940046001 vitamin b complex Drugs 0.000 claims 2
- 229940011671 vitamin b6 Drugs 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 208000034693 Laceration Diseases 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims 1
- 239000013078 crystal Substances 0.000 claims 1
- 229960002104 cyanocobalamin Drugs 0.000 claims 1
- 235000000639 cyanocobalamin Nutrition 0.000 claims 1
- 239000011666 cyanocobalamin Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 229960003966 nicotinamide Drugs 0.000 claims 1
- 235000005152 nicotinamide Nutrition 0.000 claims 1
- 239000011570 nicotinamide Substances 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 235000008160 pyridoxine Nutrition 0.000 claims 1
- 239000011677 pyridoxine Substances 0.000 claims 1
- 229960004172 pyridoxine hydrochloride Drugs 0.000 claims 1
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 claims 1
- 239000011764 pyridoxine hydrochloride Substances 0.000 claims 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 13
- 241000218628 Ginkgo Species 0.000 abstract description 7
- 230000008929 regeneration Effects 0.000 abstract description 2
- 238000011069 regeneration method Methods 0.000 abstract description 2
- VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 abstract 1
- 229930182478 glucoside Natural products 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 description 14
- 239000008280 blood Substances 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 8
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 6
- 206010012601 diabetes mellitus Diseases 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 206010036105 Polyneuropathy Diseases 0.000 description 3
- 239000003708 ampul Substances 0.000 description 3
- 239000003978 infusion fluid Substances 0.000 description 3
- 230000007824 polyneuropathy Effects 0.000 description 3
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
- 239000009429 Ginkgo biloba extract Substances 0.000 description 2
- 229960001138 acetylsalicylic acid Drugs 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 229940068052 ginkgo biloba extract Drugs 0.000 description 2
- 235000020686 ginkgo biloba extract Nutrition 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
- 229930182837 (R)-adrenaline Natural products 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 208000007514 Herpes zoster Diseases 0.000 description 1
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 210000000467 autonomic pathway Anatomy 0.000 description 1
- 208000003295 carpal tunnel syndrome Diseases 0.000 description 1
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- 229920001436 collagen Polymers 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
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- 229960005139 epinephrine Drugs 0.000 description 1
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- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
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- 230000002093 peripheral effect Effects 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 239000012673 purified plant extract Substances 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3802567.1 | 1988-01-28 | ||
| DE3802567 | 1988-01-28 | ||
| DE19883802895 DE3802895A1 (de) | 1988-02-01 | 1988-02-01 | Kombinationspraeparat zur behandlung von nervenzell- und nervenfasererkrankungen und verletzungen |
| DE3802895.6 | 1988-02-01 | ||
| DE3813451.9 | 1988-04-21 | ||
| DE3813451 | 1988-04-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH0222229A true JPH0222229A (ja) | 1990-01-25 |
Family
ID=27197115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1022466A Pending JPH0222229A (ja) | 1988-01-28 | 1989-01-30 | 神経細胞及び神経繊維の疾患もしくは傷害の治療に用いる組み合わせ調合剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5118505A (enExample) |
| EP (1) | EP0326034B1 (enExample) |
| JP (1) | JPH0222229A (enExample) |
| DE (1) | DE58902094D1 (enExample) |
| ES (1) | ES2043897T3 (enExample) |
| GR (1) | GR3006061T3 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006129826A (ja) * | 2004-11-09 | 2006-05-25 | Sanei Gen Ffi Inc | α−リポ酸の劣化抑制方法およびα−リポ酸劣化抑制剤 |
Families Citing this family (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0557708A1 (de) * | 1992-01-18 | 1993-09-01 | Rabien, Margarethe | Arzneimittel die Liponsäure und Pantothensäure enthalten |
| ES2111659T3 (es) * | 1992-03-11 | 1998-03-16 | Asta Medica Ag | Comprimidos, granulados y nodulos con alto contenido en sustancias activas para formas de administracion solidas de alta concentracion. |
| US5569670A (en) * | 1992-06-05 | 1996-10-29 | Asta Medica Aktiengesellschaft | Combination medications containing alpha-lipoic acid and related |
| ES2256838T3 (es) * | 1993-10-11 | 2006-07-16 | VIATRIS GMBH & CO. KG | Preparado destinado al tratamiento de la hipertension. |
| DE4400269C2 (de) * | 1994-01-10 | 1998-10-01 | Asta Medica Ag | Tabletten mit Thioctsäure bestimmter Korngröße |
| AU2776495A (en) * | 1994-06-20 | 1996-01-15 | Kv Pharmaceutical Company | Vitamin/nutrient dosage regimentation |
| DE4447599C2 (de) * | 1994-11-08 | 1998-02-26 | Asta Medica Ag | Verwendung von R,S-(+/-)-alpha-Liponsäure, R-(+)-alpha-Liponsäure, S-(-)-alpha-Liponsäure in reduzierter oder oxidierter Form oder der Metabolite sowie deren Salze, Ester, Amide zur Behandlung von Hörstörungen |
| US20020032160A1 (en) * | 1995-02-24 | 2002-03-14 | Nyce Jonathan W. | Compositions & formulations with an epiandrosterone or a ubiquinone & kits & their use for treatment of asthma symptoms & for reducing adenosine/adenosine receptor levels |
| US5660835A (en) * | 1995-02-24 | 1997-08-26 | East Carolina University | Method of treating adenosine depletion |
| ES2218662T3 (es) | 1996-01-31 | 2004-11-16 | South Alabama Medical Science Foundation | Preparaciones de alimento y vitaminas que contienen isomeros naturales de folatos reducidos. |
| US5948443A (en) * | 1996-02-23 | 1999-09-07 | Medical Doctor's Research Institute, Inc. | Acetylsalicylic acid and micronutrient supplementation for nutritional losses and coronary heart disease |
| US5976568A (en) * | 1997-02-21 | 1999-11-02 | Medical Doctors' Research Institute, Inc. | Modular system of dietary supplement compositions for optimizing health benefits and methods |
| DE19807659A1 (de) * | 1998-02-24 | 1999-08-26 | Bender | Mittel zum Dekoagulieren von Blutplättchen |
| US6043259A (en) * | 1998-07-09 | 2000-03-28 | Medicure Inc. | Treatment of cardiovascular and related pathologies |
| CN1311665A (zh) * | 1998-08-03 | 2001-09-05 | 新生制药公司 | 一种新的止痛、抗炎和创伤治疗剂 |
| US6274170B1 (en) | 1999-02-18 | 2001-08-14 | Richard Heibel | Compounds for cardiovascular treatment comprising multi-vitamin and anti-platelet aggregating agents and methods for making and using the same |
| PT1169322E (pt) | 1999-03-08 | 2007-04-30 | Medicure Inc | Análogos de piridoxal para o tratamento de desordens causadas por uma deficiência em vitamina b-6. |
| EP1196171A2 (en) | 1999-07-13 | 2002-04-17 | Medicure Inc. | Use of pyridoxin derivatives for the treatment of diabetes and related complications |
| AU783855B2 (en) * | 1999-08-24 | 2005-12-15 | Medicure International Inc. | Compositions for the treatment of cardiovascular diseases containing pyridoxal compounds and cardiovascular compounds |
| DE19941217A1 (de) * | 1999-08-30 | 2001-03-15 | Asta Medica Ag | Behandlung der Migräne durch Verabreichung von alpha-Liponsäure oder Derivaten derselben |
| US6573299B1 (en) | 1999-09-20 | 2003-06-03 | Advanced Medical Instruments | Method and compositions for treatment of the aging eye |
| WO2001064692A1 (en) | 2000-02-29 | 2001-09-07 | Medicure International Inc. | Cardioprotective phosphonates and malonates |
| US7442689B2 (en) * | 2000-02-29 | 2008-10-28 | Medicure International Inc. | Cardioprotective phosphonates and malonates |
| NL1014636C2 (nl) * | 2000-03-14 | 2002-07-16 | Gales Anton | Vitaminepreparaat. |
| EP1278526A2 (en) | 2000-03-28 | 2003-01-29 | Medicure International Inc. | Treatment of cerebrovascular disease |
| US20040058015A1 (en) * | 2000-06-01 | 2004-03-25 | Yuanjin Tao | Compositions and methods for treating eye discomfort and eye disease |
| AU2001275159A1 (en) | 2000-06-01 | 2001-12-11 | Theralife, Inc. | Compositions for treating eye discomfort containing herbals and/or nutritional supplements and/or minerals and/or vitamins |
| EP1289538A2 (en) * | 2000-06-01 | 2003-03-12 | Theralife, Inc. | Compositions for enhancing therapeutic effects, containing herbals and/or nutritional supplements and/or minerals and/or vitamins |
| DE10027968A1 (de) * | 2000-06-08 | 2001-12-13 | Asta Medica Ag | Mittel zur Therapie von Demenzen |
| US6548519B1 (en) | 2001-07-06 | 2003-04-15 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: novel uses |
| US6897228B2 (en) * | 2000-07-07 | 2005-05-24 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: new uses |
| CA2414188A1 (en) | 2000-07-07 | 2002-01-17 | Medicure International Inc. | Pyridoxine and pyridoxal analogues: cardiovascular therapeutics |
| US8669282B2 (en) * | 2000-10-31 | 2014-03-11 | Hill's Pet Nutrition, Inc. | Companion animal compositions including lipoic acid and methods of use thereof |
| US20020076470A1 (en) * | 2000-10-31 | 2002-06-20 | Colgate-Palmolive Company | Composition and method |
| US20040121988A1 (en) * | 2001-03-28 | 2004-06-24 | Medicure International Inc. | Treatment of cerebrovascular disease |
| WO2002085296A2 (en) * | 2001-04-24 | 2002-10-31 | Epigenesis Pharmaceuticals, Inc. | Composition, formulations and kit for treatment of respiratory and lung disease with non-glucocorticoid steroids and/or ubiquinone and a bronchodilating agent |
| WO2002085297A2 (en) * | 2001-04-24 | 2002-10-31 | East Carolina University | Compositions & formulations with a non-glucocorticoid steroid &/or a ubiquinone & kit for treatment of respiratory & lung disease |
| ITGE20020026A1 (it) * | 2002-03-25 | 2003-09-25 | Segre Silvia Perella | Composto da impiegare nel trattamento scleroterapico,nell'insufficienza venosa e nelle alterazioni del microcircolo. |
| US7030154B2 (en) | 2002-06-07 | 2006-04-18 | Juvenon, Inc. | Stability of lipoic acid |
| BR0311885A (pt) * | 2002-06-17 | 2005-04-05 | Epigenesis Pharmaceuticals Llc | Composição farmacêutica em pó, kit, e, métodos para a profilaxia ou tratamento da asma, para a profilaxia ou tratamento de doença pulmonar obstrutiva crÈnica, para reduzir ou exaurir a adenosina no tecido de um paciente, e para a profilaxia ou tratamento de um distúrbio ou condição associados com altos nìveis ou sensibilidade à adenosina no tecido de um paciente |
| US7405207B2 (en) * | 2002-06-17 | 2008-07-29 | Epigenesis Pharmaceuticals, Inc. | Nebulizer formulations of dehydroepiandrosterone and methods of treating asthma or chronic obstructive pulmonary disease using compositions thereof |
| US20040186077A1 (en) * | 2003-03-17 | 2004-09-23 | Medicure International Inc. | Novel heteroaryl phosphonates as cardioprotective agents |
| US20090285899A1 (en) * | 2003-07-31 | 2009-11-19 | Robinson Cynthia B | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a methylxanthine derivative for treatment of asthma or chronic obstructive pulmonary disease |
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| US20050026879A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease |
| US20050038004A1 (en) * | 2003-07-31 | 2005-02-17 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
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| US20050026884A1 (en) * | 2003-07-31 | 2005-02-03 | Robinson Cynthia B. | Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a beta-agonist bronchodilator for treatment of asthma or chronic obstructive pulmonary disease |
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| US20070060549A1 (en) * | 2004-08-10 | 2007-03-15 | Friesen Albert D | Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders |
| US7459468B2 (en) | 2004-10-28 | 2008-12-02 | Medicure International, Inc. | Aryl sulfonic pyridoxines as antiplatelet agents |
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| US20090176864A1 (en) * | 2004-11-24 | 2009-07-09 | Hill's Pet Nutrition, Inc. | Methods For Improving Hepatic and Immune Function In An Animal |
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| ES2436181T3 (es) | 2004-12-29 | 2013-12-27 | Hill's Pet Nutrition Inc. | Métodos para inhibir un declive en el aprendizaje y/o la memoria en animales |
| US8148325B2 (en) * | 2004-12-30 | 2012-04-03 | Hill's Pet Nutrition, Inc. | Methods for enhancing the quality of life of a senior animal |
| US8252742B2 (en) | 2004-12-30 | 2012-08-28 | Hill's Pet Nutrition, Inc. | Methods for enhancing the quality of life of a senior animal |
| CA2615060C (en) * | 2005-07-14 | 2016-06-21 | Hill's Pet Nutrition, Inc. | Method for prolonging the life of animals |
| JP2009517411A (ja) * | 2005-11-28 | 2009-04-30 | メディキュア インターナショナル インコーポレーテッド | 心血管及び関連病状の処置のための調剤 |
| US7282225B1 (en) | 2006-09-27 | 2007-10-16 | Occular Technologies, Inc. | Composition and methods for improving retinal health |
| US20090054513A1 (en) * | 2007-08-22 | 2009-02-26 | Response Scientific, Inc. | Method of managing blood glucose levels, insulin levels and/or insulin receptor functionality in individuals with diabetes, polycystic ovarian syndrome and/or alzheimer's disease |
| US7943163B2 (en) * | 2007-08-22 | 2011-05-17 | Response Scientific, Inc. | Medical food or nutritional supplement, method of manufacturing same, and method of managing diabetes |
| US20100099751A1 (en) * | 2008-10-21 | 2010-04-22 | Al-Mulla Fahd | Method of treating diabetes-related vascular complications |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3338995A1 (de) * | 1983-10-27 | 1985-05-09 | Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe | Bilobalid enthaltende arzneimittel |
| FR2518406A1 (fr) * | 1981-12-22 | 1983-06-24 | Prodipharm | Nouveau procede d'obtention de substances vaso-actives extraites de feuilles de ginkgo |
| ATE55905T1 (de) * | 1984-03-07 | 1990-09-15 | Roshdy Ismail | Mittel zur behandlung und zum schutz der haut. |
| US4753929A (en) * | 1986-03-12 | 1988-06-28 | Daicel Chemical Industries, Ltd. | Flavone glycoside |
-
1989
- 1989-01-20 EP EP89100984A patent/EP0326034B1/de not_active Expired - Lifetime
- 1989-01-20 ES ES89100984T patent/ES2043897T3/es not_active Expired - Lifetime
- 1989-01-20 DE DE8989100984T patent/DE58902094D1/de not_active Expired - Lifetime
- 1989-01-25 US US07/301,424 patent/US5118505A/en not_active Expired - Fee Related
- 1989-01-30 JP JP1022466A patent/JPH0222229A/ja active Pending
-
1992
- 1992-10-22 GR GR920402386T patent/GR3006061T3/el unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006129826A (ja) * | 2004-11-09 | 2006-05-25 | Sanei Gen Ffi Inc | α−リポ酸の劣化抑制方法およびα−リポ酸劣化抑制剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2043897T3 (es) | 1994-01-01 |
| US5118505A (en) | 1992-06-02 |
| EP0326034A2 (de) | 1989-08-02 |
| EP0326034B1 (de) | 1992-08-26 |
| GR3006061T3 (enExample) | 1993-06-21 |
| DE58902094D1 (de) | 1992-10-01 |
| EP0326034A3 (en) | 1990-11-07 |
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