JPH0214062B2 - - Google Patents
Info
- Publication number
- JPH0214062B2 JPH0214062B2 JP56026707A JP2670781A JPH0214062B2 JP H0214062 B2 JPH0214062 B2 JP H0214062B2 JP 56026707 A JP56026707 A JP 56026707A JP 2670781 A JP2670781 A JP 2670781A JP H0214062 B2 JPH0214062 B2 JP H0214062B2
- Authority
- JP
- Japan
- Prior art keywords
- polymer
- component
- additive
- value
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229920000642 polymer Polymers 0.000 claims description 131
- 239000000654 additive Substances 0.000 claims description 50
- 230000000996 additive effect Effects 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 32
- 239000004814 polyurethane Substances 0.000 claims description 25
- 239000011159 matrix material Substances 0.000 claims description 24
- 229920002635 polyurethane Polymers 0.000 claims description 23
- 239000008280 blood Substances 0.000 claims description 22
- 210000004369 blood Anatomy 0.000 claims description 22
- 239000000758 substrate Substances 0.000 claims description 19
- 229920005601 base polymer Polymers 0.000 claims description 6
- 239000012530 fluid Substances 0.000 claims description 6
- 229920006294 polydialkylsiloxane Polymers 0.000 claims description 3
- 229920001400 block copolymer Polymers 0.000 description 26
- -1 polysiloxanes Polymers 0.000 description 24
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 15
- 229920001519 homopolymer Polymers 0.000 description 15
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 13
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 13
- 239000004721 Polyphenylene oxide Substances 0.000 description 12
- 229920001577 copolymer Polymers 0.000 description 12
- 239000004205 dimethyl polysiloxane Substances 0.000 description 12
- 229920000570 polyether Polymers 0.000 description 12
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 10
- 239000002904 solvent Substances 0.000 description 10
- 239000000463 material Substances 0.000 description 9
- 229920001296 polysiloxane Polymers 0.000 description 9
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 8
- 238000005859 coupling reaction Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 6
- 229920001897 terpolymer Polymers 0.000 description 6
- 229920000578 graft copolymer Polymers 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 229920001169 thermoplastic Polymers 0.000 description 5
- 239000004416 thermosoftening plastic Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 229920002959 polymer blend Polymers 0.000 description 4
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 4
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000005755 formation reaction Methods 0.000 description 3
- 230000009477 glass transition Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 230000000704 physical effect Effects 0.000 description 3
- 229920000728 polyester Polymers 0.000 description 3
- UPMLOUAZCHDJJD-UHFFFAOYSA-N 4,4'-Diphenylmethane Diisocyanate Chemical compound C1=CC(N=C=O)=CC=C1CC1=CC=C(N=C=O)C=C1 UPMLOUAZCHDJJD-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 2
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 238000010528 free radical solution polymerization reaction Methods 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 238000001746 injection moulding Methods 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 229920000162 poly(ureaurethane) Polymers 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 230000001603 reducing effect Effects 0.000 description 2
- 229910052710 silicon Inorganic materials 0.000 description 2
- 239000010703 silicon Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- KGRVJHAUYBGFFP-UHFFFAOYSA-N 2,2'-Methylenebis(4-methyl-6-tert-butylphenol) Chemical compound CC(C)(C)C1=CC(C)=CC(CC=2C(=C(C=C(C)C=2)C(C)(C)C)O)=C1O KGRVJHAUYBGFFP-UHFFFAOYSA-N 0.000 description 1
- 102000004506 Blood Proteins Human genes 0.000 description 1
- 108010017384 Blood Proteins Proteins 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004433 Thermoplastic polyurethane Substances 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 238000000137 annealing Methods 0.000 description 1
- 210000002376 aorta thoracic Anatomy 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 210000001715 carotid artery Anatomy 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 229920000891 common polymer Polymers 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 125000005442 diisocyanate group Chemical group 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- KPUWHANPEXNPJT-UHFFFAOYSA-N disiloxane Chemical class [SiH3]O[SiH3] KPUWHANPEXNPJT-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000003822 epoxy resin Substances 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000012948 isocyanate Substances 0.000 description 1
- 150000002513 isocyanates Chemical class 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920005749 polyurethane resin Polymers 0.000 description 1
- 229920003226 polyurethane urea Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 238000000935 solvent evaporation Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 230000002861 ventricular Effects 0.000 description 1
- 238000004073 vulcanization Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L83/00—Compositions of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon only; Compositions of derivatives of such polymers
- C08L83/10—Block- or graft-copolymers containing polysiloxane sequences
- C08L83/12—Block- or graft-copolymers containing polysiloxane sequences containing polyether sequences
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/062—Mixtures of macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/06—Use of macromolecular materials
- A61L33/068—Use of macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/08—Processes
- C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
- C08G18/40—High-molecular-weight compounds
- C08G18/61—Polysiloxanes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/42—Block-or graft-polymers containing polysiloxane sequences
- C08G77/452—Block-or graft-polymers containing polysiloxane sequences containing nitrogen-containing sequences
- C08G77/455—Block-or graft-polymers containing polysiloxane sequences containing nitrogen-containing sequences containing polyamide, polyesteramide or polyimide sequences
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/42—Block-or graft-polymers containing polysiloxane sequences
- C08G77/458—Block-or graft-polymers containing polysiloxane sequences containing polyurethane sequences
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G77/00—Macromolecular compounds obtained by reactions forming a linkage containing silicon with or without sulfur, nitrogen, oxygen or carbon in the main chain of the macromolecule
- C08G77/42—Block-or graft-polymers containing polysiloxane sequences
- C08G77/46—Block-or graft-polymers containing polysiloxane sequences containing polyether sequences
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
- C08L75/04—Polyurethanes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Materials Engineering (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12584580A | 1980-02-29 | 1980-02-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56136565A JPS56136565A (en) | 1981-10-24 |
| JPH0214062B2 true JPH0214062B2 (fr) | 1990-04-06 |
Family
ID=22421689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2670781A Granted JPS56136565A (en) | 1980-02-29 | 1981-02-25 | Polymer surface as blood contacting surface of biological medical device and its forming method |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPS56136565A (fr) |
| AT (1) | AT385041B (fr) |
| AU (1) | AU548194B2 (fr) |
| CA (1) | CA1206668A (fr) |
| DE (1) | DE3153664C2 (fr) |
| FR (2) | FR2491938B1 (fr) |
| GB (2) | GB2073219B (fr) |
| IL (1) | IL62183A (fr) |
| IT (1) | IT1210997B (fr) |
| MX (1) | MX159062A (fr) |
| NL (1) | NL8100975A (fr) |
| ZA (1) | ZA811107B (fr) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4675361A (en) * | 1980-02-29 | 1987-06-23 | Thoratec Laboratories Corp. | Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming |
| US4861830A (en) * | 1980-02-29 | 1989-08-29 | Th. Goldschmidt Ag | Polymer systems suitable for blood-contacting surfaces of a biomedical device, and methods for forming |
| EP0068385B1 (fr) * | 1981-06-22 | 1986-09-24 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Elastomères thermoplastiques pour leur application thérapeutique en tant que articles moulés mis en contact direct avec le sang |
| JPS57211358A (en) * | 1981-06-22 | 1982-12-25 | Kanegafuchi Chemical Ind | Anti-thrombus elastomer and method |
| DE3130646C2 (de) * | 1981-07-28 | 1983-09-15 | Wilfried Dr.-Ing. 1000 Berlin Lemm | Verfahren zum Herstellen von Gegenständen aus Polyurethan, die in gewissen Oberflächenbereichen mit Polydimethylsiloxan angereichert sind |
| JPS58185647A (ja) * | 1982-03-17 | 1983-10-29 | Nippon Zeon Co Ltd | 抗血栓表面を与える安定な重合体エマルジョン組成物 |
| DK103483A (da) * | 1982-04-15 | 1983-10-16 | Ethicon Inc | Siliconebelagt kirurgisk haefteklamme |
| JPS6045357A (ja) * | 1983-08-23 | 1985-03-11 | 日本ゼオン株式会社 | 血液接触医療器具の製造方法 |
| JPH0622591B2 (ja) * | 1983-10-13 | 1994-03-30 | 日本ゼオン株式会社 | 血液接触医療器具の製造方法 |
| CA1257425A (fr) * | 1984-05-21 | 1989-07-11 | Th. Goldschmidt Ag | Materiaux permeables a la vapeur d'eau |
| US4883699A (en) * | 1984-09-21 | 1989-11-28 | Menlo Care, Inc. | Polymeric article having high tensile energy to break when hydrated |
| US4911691A (en) * | 1984-09-21 | 1990-03-27 | Menlo Care, Inc. | Assembly for adminstering IV solution |
| JPS6176152A (ja) * | 1984-09-25 | 1986-04-18 | 学校法人東京女子医科大学 | 医療用チユ−ブ |
| JPS61154674A (ja) * | 1984-12-28 | 1986-07-14 | 日本ゼオン株式会社 | 抗血栓性材料 |
| US5512650A (en) * | 1986-06-20 | 1996-04-30 | Minnesota Mining And Manufacturing Company | Block copolymer, method of making the same, diamine precursors of the same, method of making such diamines and end products comprising the block copolymer |
| US5214119A (en) * | 1986-06-20 | 1993-05-25 | Minnesota Mining And Manufacturing Company | Block copolymer, method of making the same, dimaine precursors of the same, method of making such diamines and end products comprising the block copolymer |
| US5221724A (en) * | 1987-08-12 | 1993-06-22 | Wisconsin Alumni Research Foundation | Polysiloxane polyurea urethanes |
| US4906465A (en) * | 1987-10-19 | 1990-03-06 | Massachusetts Institute Of Technology | Antithrombogenic devices containing polysiloxanes |
| US4939007A (en) * | 1988-03-07 | 1990-07-03 | Becton, Dickinson And Company | Article having a hemocompatible surface |
| US4840796A (en) * | 1988-04-22 | 1989-06-20 | Dow Corning Corporation | Block copolymer matrix for transdermal drug release |
| US4951657A (en) * | 1988-04-22 | 1990-08-28 | Dow Corning Corporation | Heat sealable membrane for transdermal drug release |
| GB8811868D0 (en) * | 1988-05-19 | 1988-06-22 | Ici Plc | Release film |
| DE3922079C2 (de) * | 1989-07-05 | 1996-06-13 | Hanse Chemie Gmbh | Polysiloxandispersion, Verfahren zu ihrer Herstellung und ihre Verwendung |
| DE69320470T2 (de) * | 1992-04-24 | 1999-04-29 | Polymer Technology Group Inc | Copolymere, sowie daraus hergestellte nichtporöse halbdurchlässige membranen und ihre verwendung zum filtern von molekülen in einem vorgegebenen molekulargewichtbereich |
| DE4217165C1 (fr) * | 1992-05-23 | 1993-08-19 | Rehau Ag + Co, 8673 Rehau, De | |
| US5670598A (en) * | 1995-03-24 | 1997-09-23 | Minnesota Mining And Manufacturing Company | Diblock and triblock polydiorganosiloxane-polyurea block copolymers |
| DE19641335A1 (de) * | 1996-10-08 | 1998-04-09 | Inst Textil & Faserforschung | Triblockterpolymer, seine Verwendung für chirurgisches Nahtmaterial und Verfahren zur Herstellung |
| AUPO251096A0 (en) | 1996-09-23 | 1996-10-17 | Cardiac Crc Nominees Pty Limited | Polysiloxane-containing polyurethane elastomeric compositions |
| DE19641334A1 (de) * | 1996-10-08 | 1998-04-09 | Inst Textil & Faserforschung | Triblockterpolymer, seine Verwendung für medizinische Produkte und Verfahren zur Herstellung |
| US5863627A (en) * | 1997-08-26 | 1999-01-26 | Cardiotech International, Inc. | Hydrolytically-and proteolytically-stable polycarbonate polyurethane silicone copolymers |
| CN1224430C (zh) * | 1998-01-30 | 2005-10-26 | 钟渊化学工业株式会社 | 气囊导管、其所用的导管轴和气囊的制造方法 |
| US20050220835A1 (en) * | 2004-03-30 | 2005-10-06 | Jayaraman Ramesh B | Agent eluting bioimplantable devices and polymer systems for their preparation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4929350A (fr) * | 1972-07-15 | 1974-03-15 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3562352A (en) * | 1968-09-06 | 1971-02-09 | Avco Corp | Polysiloxane-polyurethane block copolymers |
| US4002794A (en) * | 1975-07-18 | 1977-01-11 | Nashua Corporation | Adhesive material and articles incorporating same |
| US4100309A (en) * | 1977-08-08 | 1978-07-11 | Biosearch Medical Products, Inc. | Coated substrate having a low coefficient of friction hydrophilic coating and a method of making the same |
| US4196731A (en) * | 1978-03-17 | 1980-04-08 | Baxter Travenol Laboratories, Inc. | Silicone-containing thermoplastic polymers for medical uses |
-
1981
- 1981-02-18 CA CA000371214A patent/CA1206668A/fr not_active Expired
- 1981-02-19 ZA ZA00811107A patent/ZA811107B/xx unknown
- 1981-02-20 IL IL62183A patent/IL62183A/xx unknown
- 1981-02-23 GB GB8105685A patent/GB2073219B/en not_active Expired
- 1981-02-23 AU AU67551/81A patent/AU548194B2/en not_active Ceased
- 1981-02-24 MX MX186106A patent/MX159062A/es unknown
- 1981-02-24 AT AT0083581A patent/AT385041B/de not_active IP Right Cessation
- 1981-02-25 JP JP2670781A patent/JPS56136565A/ja active Granted
- 1981-02-27 NL NL8100975A patent/NL8100975A/nl not_active Application Discontinuation
- 1981-02-27 FR FR8103961A patent/FR2491938B1/fr not_active Expired
- 1981-02-27 DE DE3153664A patent/DE3153664C2/de not_active Expired - Lifetime
- 1981-02-27 IT IT8120027A patent/IT1210997B/it active
-
1982
- 1982-02-08 FR FR8201981A patent/FR2497217B1/fr not_active Expired
-
1984
- 1984-03-22 GB GB08407417A patent/GB2140444B/en not_active Expired
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS4929350A (fr) * | 1972-07-15 | 1974-03-15 |
Also Published As
| Publication number | Publication date |
|---|---|
| IL62183A (en) | 1984-10-31 |
| IT1210997B (it) | 1989-09-29 |
| JPS56136565A (en) | 1981-10-24 |
| GB2140444B (en) | 1985-06-05 |
| MX159062A (es) | 1989-04-14 |
| AU6755181A (en) | 1981-09-03 |
| FR2491938B1 (fr) | 1985-10-25 |
| ZA811107B (en) | 1982-03-31 |
| IT8120027A0 (it) | 1981-02-27 |
| CA1206668A (fr) | 1986-06-24 |
| GB8407417D0 (en) | 1984-05-02 |
| GB2073219A (en) | 1981-10-14 |
| FR2497217B1 (fr) | 1986-05-23 |
| FR2497217A1 (fr) | 1982-07-02 |
| DE3153664C2 (fr) | 1991-07-25 |
| GB2140444A (en) | 1984-11-28 |
| ATA83581A (de) | 1987-07-15 |
| AU548194B2 (en) | 1985-11-28 |
| FR2491938A1 (fr) | 1982-04-16 |
| IL62183A0 (en) | 1981-03-31 |
| NL8100975A (nl) | 1981-10-01 |
| AT385041B (de) | 1988-02-10 |
| GB2073219B (en) | 1985-02-27 |
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