JPH02124861A - イソポリペプチド及びその製造方法 - Google Patents
イソポリペプチド及びその製造方法Info
- Publication number
- JPH02124861A JPH02124861A JP63264255A JP26425588A JPH02124861A JP H02124861 A JPH02124861 A JP H02124861A JP 63264255 A JP63264255 A JP 63264255A JP 26425588 A JP26425588 A JP 26425588A JP H02124861 A JPH02124861 A JP H02124861A
- Authority
- JP
- Japan
- Prior art keywords
- general formula
- same
- compound
- group
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 210000002540 macrophage Anatomy 0.000 description 1
- 229940049920 malate Drugs 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 238000013048 microbiological method Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- CZFNISFYDPIDNM-UHFFFAOYSA-N n,n-dimethylformamide;oxolane Chemical compound CN(C)C=O.C1CCOC1 CZFNISFYDPIDNM-UHFFFAOYSA-N 0.000 description 1
- 230000001613 neoplastic effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229940039748 oxalate Drugs 0.000 description 1
- 125000000636 p-nitrophenyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)[N+]([O-])=O 0.000 description 1
- 238000004816 paper chromatography Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 238000005897 peptide coupling reaction Methods 0.000 description 1
- 210000003200 peritoneal cavity Anatomy 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000004445 quantitative analysis Methods 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000012146 running buffer Substances 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- MHQHHBYRYFICDV-UHFFFAOYSA-M sodium;pyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].O=C1CC(=O)[N-]C(=O)N1 MHQHHBYRYFICDV-UHFFFAOYSA-M 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000005740 tumor formation Effects 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polyamides (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU874723A HU202553B (en) | 1987-10-21 | 1987-10-21 | Process for producing isopolypeptides composed of diamino monokarboxylic acids and pharmaceutical compositions comprising same, as well as plant protective comprising polyisolysine |
| HU2251-4723/87 | 1987-10-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPH02124861A true JPH02124861A (ja) | 1990-05-14 |
Family
ID=10968769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63264255A Pending JPH02124861A (ja) | 1987-10-21 | 1988-10-21 | イソポリペプチド及びその製造方法 |
Country Status (13)
| Country | Link |
|---|---|
| JP (1) | JPH02124861A (es) |
| KR (1) | KR890006670A (es) |
| CN (1) | CN1033633A (es) |
| DE (1) | DE3835962A1 (es) |
| DK (1) | DK585988A (es) |
| ES (1) | ES2012559A6 (es) |
| FI (1) | FI884890A (es) |
| FR (1) | FR2622195A1 (es) |
| GB (2) | GB8824278D0 (es) |
| HU (1) | HU202553B (es) |
| IT (1) | IT1230584B (es) |
| NL (1) | NL8802604A (es) |
| SE (1) | SE8803765L (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006299013A (ja) * | 2005-04-18 | 2006-11-02 | Chisso Corp | ポリ−γ−Ｌ−ジアミノ酪酸及びその塩 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0220271A (ja) * | 1988-07-07 | 1990-01-23 | Chisso Corp | 食品保存用エタノール製剤 |
| HUT74379A (en) * | 1993-10-05 | 1996-12-30 | Unilever Nv | Improvements relating to antibacterial compositions |
| HUP9902217A3 (en) * | 1999-06-29 | 2002-07-29 | Szegoe Peter | Polycation based bioconjugates and process for producing thereof |
| CN101234122B (zh) * | 2008-03-03 | 2010-06-30 | 中国科学院化学研究所 | 多聚赖氨酸的新用途 |
| GB201409451D0 (en) | 2014-05-28 | 2014-07-09 | Ipabc Ltd | Antimicrobial preparations, methods for preparing the same and uses thereof to combat microorganisms |
-
1987
- 1987-10-21 HU HU874723A patent/HU202553B/hu unknown
-
1988
- 1988-10-17 GB GB888824278A patent/GB8824278D0/en active Pending
- 1988-10-20 CN CN88107253A patent/CN1033633A/zh active Pending
- 1988-10-21 KR KR1019880013784A patent/KR890006670A/ko not_active Application Discontinuation
- 1988-10-21 ES ES8803218A patent/ES2012559A6/es not_active Expired - Lifetime
- 1988-10-21 FR FR8813807A patent/FR2622195A1/fr not_active Withdrawn
- 1988-10-21 IT IT8822389A patent/IT1230584B/it active
- 1988-10-21 NL NL8802604A patent/NL8802604A/nl not_active Application Discontinuation
- 1988-10-21 SE SE8803765A patent/SE8803765L/ not_active Application Discontinuation
- 1988-10-21 FI FI884890A patent/FI884890A/fi not_active Application Discontinuation
- 1988-10-21 DK DK585988A patent/DK585988A/da not_active Application Discontinuation
- 1988-10-21 DE DE3835962A patent/DE3835962A1/de not_active Withdrawn
- 1988-10-21 JP JP63264255A patent/JPH02124861A/ja active Pending
- 1988-10-21 GB GB8824694A patent/GB2212810A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006299013A (ja) * | 2005-04-18 | 2006-11-02 | Chisso Corp | ポリ−γ−Ｌ−ジアミノ酪酸及びその塩 |
Also Published As
| Publication number | Publication date |
|---|---|
| FI884890A (fi) | 1989-04-22 |
| KR890006670A (ko) | 1989-06-15 |
| DK585988A (da) | 1989-04-22 |
| IT1230584B (it) | 1991-10-28 |
| NL8802604A (nl) | 1989-05-16 |
| SE8803765D0 (sv) | 1988-10-21 |
| DK585988D0 (da) | 1988-10-21 |
| SE8803765L (sv) | 1989-04-22 |
| FI884890A0 (fi) | 1988-10-21 |
| IT8822389A0 (it) | 1988-10-21 |
| GB8824278D0 (en) | 1988-11-23 |
| ES2012559A6 (es) | 1990-04-01 |
| DE3835962A1 (de) | 1989-06-01 |
| FR2622195A1 (fr) | 1989-04-28 |
| GB2212810A (en) | 1989-08-02 |
| CN1033633A (zh) | 1989-07-05 |
| HUT48279A (en) | 1989-05-29 |
| GB8824694D0 (en) | 1988-11-30 |
| HU202553B (en) | 1991-03-28 |
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