JPH0193600A - ５αリダクターゼの阻害剤としての１７β―アシル―４―アザ―５α―アンドロスタ―１―エン―３―オン類 - Google Patents

５αリダクターゼの阻害剤としての１７β―アシル―４―アザ―５α―アンドロスタ―１―エン―３―オン類

Info

Publication number
JPH0193600A
JPH0193600A JP63135348A JP13534888A JPH0193600A JP H0193600 A JPH0193600 A JP H0193600A JP 63135348 A JP63135348 A JP 63135348A JP 13534888 A JP13534888 A JP 13534888A JP H0193600 A JPH0193600 A JP H0193600A
Authority
JP
Japan
Prior art keywords
methyl
aza
compound
hydrogen
androst
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63135348A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0541638B2 (en:Method
Inventor
Gary H Rasmusson
ギヤレイ　エツチ．ラスムソン
Glenn F Reynolds
グレン　エフ．レイノルズ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27078980&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPH0193600(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of JPH0193600A publication Critical patent/JPH0193600A/ja
Publication of JPH0541638B2 publication Critical patent/JPH0541638B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/38—Unsaturated compounds containing keto groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/16—Benz[e]indenes; Hydrogenated benz[e]indenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP63135348A 1984-02-27 1988-06-01 ５αリダクターゼの阻害剤としての１７β―アシル―４―アザ―５α―アンドロスタ―１―エン―３―オン類 Granted JPH0193600A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58406184A 1984-02-27 1984-02-27
US58406284A 1984-02-27 1984-02-27
US584,061 1984-02-27
US584,062 1984-02-27

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP60036714A Division JPS60222497A (ja) 1984-02-27 1985-02-27 ５αリダクターゼの阻害剤としての１７β―Ｎ―モノ置換カルバモイル―４―アザ―５α―アンドロスタ―１―エン―３―オン類

Publications (2)

Publication Number Publication Date
JPH0193600A true JPH0193600A (ja) 1989-04-12
JPH0541638B2 JPH0541638B2 (en:Method) 1993-06-24

Family

ID=27078980

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63135348A Granted JPH0193600A (ja) 1984-02-27 1988-06-01 ５αリダクターゼの阻害剤としての１７β―アシル―４―アザ―５α―アンドロスタ―１―エン―３―オン類

Country Status (16)

Country Link
EP (1) EP0155096B1 (en:Method)
JP (1) JPH0193600A (en:Method)
KR (1) KR900001206B1 (en:Method)
AU (4) AU584321B2 (en:Method)
CA (1) CA1314541C (en:Method)
CY (1) CY1553A (en:Method)
DE (2) DE3573429D1 (en:Method)
DK (1) DK166704B1 (en:Method)
ES (1) ES8702430A1 (en:Method)
GR (1) GR850483B (en:Method)
HK (1) HK63090A (en:Method)
IE (2) IE922862L (en:Method)
IL (1) IL74365A (en:Method)
NL (1) NL930005I2 (en:Method)
NZ (1) NZ211145A (en:Method)
PT (1) PT80010B (en:Method)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03169891A (ja) * 1989-08-21 1991-07-23 Merck & Co Inc ５α―還元酵素阻害剤の１７β―アシル―４―アザ―５α―アンドロスト―１―エン―３―オン
CN1314241C (zh) * 2002-09-27 2007-05-02 华为技术有限公司 在城域网相同虚容器映射通道内传送不同用户数据的方法

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5151429A (en) * 1984-02-27 1992-09-29 Merck & Co., Inc. 17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α reductase inhibitors
US5120742A (en) * 1984-02-27 1992-06-09 Merck & Co., Inc. 17 β-acyl-4-aza-5 α-androst-1-ene-3-ones as 5 α-reductase inhibitors
US5138063A (en) * 1984-02-27 1992-08-11 Merck & Co., Inc. 17β-methoxycarbonyl-4-aza-androsten-1-en-3-ones
US5571817A (en) * 1984-02-27 1996-11-05 Merck & Co., Inc. Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones]
US5049562A (en) * 1984-02-27 1991-09-17 Merck & Co., Inc. 17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α-reductase inhibitors
JPS62201896A (ja) * 1986-02-28 1987-09-05 Shiseido Co Ltd 多毛症治療剤
ATE78827T1 (de) * 1986-11-20 1992-08-15 Merck & Co Inc Topisches arzneimittel enthaltend 17-beta-methoxy-carbonyl-4-methyl-4-aza-5-alpha androst-1-en-3- one.
US4845104A (en) * 1986-11-20 1989-07-04 Merck & Co., Inc. Oxidized analogs of 17β-N-monosubstituted-carbamoyl-4-aza-5-α-androstan-3-ones
US4888336A (en) * 1987-01-28 1989-12-19 Smithkline Beckman Corporation Steroid 5-alpha-reductase inhibitors
EP0285383B1 (en) * 1987-04-03 1994-03-16 Merck & Co. Inc. Treatment of prostatic carcinoma with 17beta-n-monosubstituted-carbamoyl-4-aza-5alpha-androst-1-en-3-ones
DE3888994T2 (de) * 1987-04-03 1994-11-03 Merck & Co Inc Behandlung von androgener Alopecia mit 17-beta-n-mono-substituierten-carbamoyl-4-aza-5-alpha-androst-1-en-3-onen.
NZ225100A (en) * 1987-06-29 1991-09-25 Merck & Co Inc Reaction of steroids (including 4-azasteroids) with a silylating agent in the presence of a quinone to introduce a delta' double bond and silylated intermediates
US5084574A (en) * 1988-04-18 1992-01-28 Merck & Co., Inc. Dehydrogenation process
US5116983A (en) * 1988-04-18 1992-05-26 Merck & Co., Inc. Dehydrogenation process intermediates
US5237061A (en) * 1988-10-31 1993-08-17 Merck & Co., Inc. Methods of synthesizing benign prostatic hypertropic agents and their intermediates
US5021575A (en) * 1989-11-13 1991-06-04 Merck & Co., Inc. Method for introducing a 1,2 double bond into azasteroids
GB9002922D0 (en) * 1990-02-09 1990-04-04 Erba Carlo Spa 17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation
EP0462664A3 (en) * 1990-06-20 1992-11-25 Merck & Co. Inc. Specific 17beta-thiobenzoyl-4-aza-5alpha-androst-1-en-3-ones as antiandrogenic agents
EP0462662A3 (en) * 1990-06-20 1992-08-19 Merck & Co. Inc. 17beta-n-monosubstituted adamantyl/norbornanyl carbamoyl-4-aza-5alpha-androst-1-en-3-ones and androstan-3-ones
EP0462665A3 (en) * 1990-06-20 1993-06-30 Merck & Co. Inc. Selected 17beta-polyaroyl-4-aza-5alpha-androst-1-en-3-ones as steroidal reductase inhibitors
US5162332A (en) * 1990-06-20 1992-11-10 Merck & Co., Inc. Selected 17 β-polyaroyl-4-aza-5 α-androst-1-en-3-ones as steroidal reductase inhibitors
US5061802A (en) * 1990-06-20 1991-10-29 Merck & Co. Inc. 17β-aminobenzoyl-4-aza-5α-androst-1-en-3-ones as benign prostatic hypertrophy agents
US5151430A (en) * 1990-06-20 1992-09-29 Merck & Co., Inc. Specific 17β-thiobenzoyl-4-aza-5α-androst-1-en-3-ones as antiandrogen agents
US5098908A (en) * 1990-06-20 1992-03-24 Merck & Co., Inc. 17β-hydroxybenzoyl-4-aza-5α-androst-1-en-3-ones as testosterone reductase inhibitors
US5091380A (en) * 1990-06-28 1992-02-25 Merck & Co., Inc. N-monosubstituted adamantyl/norbornanyl 17β-carbamides of 3-carboxy-androst-3,5-dienes as testosterone 5α-reductase inhibitors
US5091534A (en) * 1990-08-27 1992-02-25 Merck & Co., Inc. Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-AZA-5α-androstan-3-one steroids
US5120847A (en) * 1990-08-27 1992-06-09 Merck & Co., Inc. Process for iodinating or brominating the α-methylenic carbon of a secondary amide
CA2050824A1 (en) * 1990-09-24 1992-03-25 John M. Williams Process for making 3-oxo-4-aza-androst-1-ene 17-.beta.-ketones
US5061803A (en) * 1990-09-24 1991-10-29 Merck & Co., Inc. Process for making 17-beta alkanoyl 3-oxo-4-aza-5-α-androst-1-enes
US5061801A (en) * 1990-09-24 1991-10-29 Merck & Co., Inc. Intermediate for making 3-oxo-4-aza-androst-1-ene 17β-ketones
IE76452B1 (en) * 1990-10-29 1997-10-22 Sankyo Co Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use
NZ241979A (en) * 1991-03-20 1996-01-26 Merck & Co Inc Treatment of benign prostatic hyperplasia using 5alpha-reductase inhibitor and an alpha1-adrenergic recepter blocker
GB9115676D0 (en) * 1991-07-19 1991-09-04 Erba Carlo Spa Process for the preparation of 17 beta substituted-4-aza-5 alpha-androstan-3-one derivatives
US5304562A (en) * 1991-10-09 1994-04-19 Ciba-Geigy Corporation 17β-substituted Aza-androstane derivatives
EP0547687A1 (en) * 1991-12-18 1993-06-23 Merck & Co. Inc. 17B-N-Substituted adamantyl/norbonanyl carbamoyl-4-aza-5a-and-rost-1-en-3-ones and androstan-3 ones
WO1993013124A1 (en) * 1991-12-20 1993-07-08 Glaxo Inc. Inhibitors of 5-alpha-testosterone reductase
EP0725074A3 (en) * 1992-04-20 1996-11-20 Sankyo Co Intermediate compounds for the preparation of androst-3,5-diene-3-carboxy derivatives
US5698720A (en) * 1992-04-20 1997-12-16 Sankyo Company, Limited Steroid derivatives
FI945442L (fi) * 1992-05-20 1994-11-18 Merck & Co Inc Uudet 7beta-substituoidut 4-atsa-5alfa-kolestanonit 5alfa-reduktaasi-inhibiittoreina
AU675225B2 (en) * 1992-05-20 1997-01-30 Merck & Co., Inc. 17-amino substituted 4-azasteroid 5alpha-reductase inhibitors
WO1993023051A1 (en) * 1992-05-20 1993-11-25 Merck & Co., Inc. New 17-ester, amide, and ketone derivatives of 3-oxo-4-azasteroids as 5a-reductase inhibitors
US5237064A (en) * 1992-05-20 1993-08-17 Merck & Co., Inc. Process for producing 7β-substituted-aza-5αandrostan-3-ones
WO1993023420A1 (en) * 1992-05-20 1993-11-25 Merck & Co., Inc. NEW 7β-SUBSTITUTED-4-AZA-5α-ANDROSTAN-3-ONES AS 5α-REDUCTASE INHIBITORS
DE69329149T2 (de) * 1992-05-20 2001-03-29 Merck & Co., Inc. 4-azasteroide als 5-alpha-reduktase
WO1993023039A1 (en) * 1992-05-20 1993-11-25 Merck & Co., Inc. Substituted 4-aza-5a-androstan-ones as 5a-reductase inhibitors
WO1993023041A1 (en) * 1992-05-20 1993-11-25 Merck & Co., Inc. Ester derivatives of 4-aza-steroids
EP0641204B1 (en) * 1992-05-20 2000-08-16 Merck & Co. Inc. 17-ethers and thioethers of 4-aza-steroids
RU2141967C1 (ru) * 1992-05-21 1999-11-27 Андорешерш Инк. ИНГИБИТОРЫ ТЕСТОСТЕРОН 5α-РЕДУКТАЗЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ИНГИБИРОВАНИЯ АКТИВНОСТИ ТЕСТОСТЕРОН 5α-РЕДУКТАЗЫ
GB9216329D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa 17beta-substituted 4-aza-5alpha-androstan-3-one derivatives
GB9216284D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives
US5302589A (en) * 1992-08-07 1994-04-12 Glaxo, Inc. Heterocyclic inhibitors of 5-α-testosterone reductase
HU212459B (en) * 1992-10-02 1996-06-28 Richter Gedeon Vegyeszet Process for producing new 17-beta-substituted 4-aza-androstane-derivatives and pharmaceutical compositions containing them
US5278159A (en) * 1992-10-06 1994-01-11 Merck & Co., Inc. Aryl ester derivatives of 3-oxo-4-aza-androstane 17-β-carboxylates as 5-α-reductase inhibitors
US5468860A (en) * 1992-11-19 1995-11-21 Merck & Co., Inc. New finasteride processes
US5359071A (en) * 1993-03-12 1994-10-25 Merck & Co., Inc. 15-substituted 4-azasteroids
AU6413594A (en) * 1993-03-24 1994-10-11 Merck & Co., Inc. Substituted 3-phenanthridinone derivatives as 5alpha-reductase inhibitors
CA2166090C (en) * 1993-06-24 2006-01-24 Zoltan Tuba Novel process for preparing 17.beta.-substituted 4-azaandrostane derivatives
EP0711164B1 (en) * 1993-06-28 1997-09-17 Merck & Co. Inc. 4-aza-pregnane 5-alpha-reductase isozyme 1 inhibitors
US5438061A (en) * 1993-07-16 1995-08-01 Merck & Co., Inc. 7-substituted-δ4-6-azasteroid derivatives as 5α-reductase inhibitors
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5547957A (en) * 1993-10-15 1996-08-20 Merck & Co., Inc. Method of treating androgenic alopecia with 5-α reductase inhibitors
TW382595B (en) * 1993-10-15 2000-02-21 Merck & Co Inc Pharmaceutical composition for use in arresting and reversing androgenic alopecia
IL111357A (en) * 1993-10-21 2001-01-28 Merck & Co Inc 16-Substituted-4-aza-androstanes their preparation and pharmaceutical compositions containing them
GB9415178D0 (en) * 1994-07-28 1994-09-21 Erba Carlo Spa 4-azasteroids with side-chain fluoroketones
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5595996A (en) * 1994-10-25 1997-01-21 Merck & Co., Inc. 7-substituted 4-aza cholanic acid derivatives and their use
US5656613A (en) * 1995-01-04 1997-08-12 Merck & Co., Inc. Treatment of hyperandrogenic conditions
GB0026876D0 (en) 2000-11-03 2000-12-20 Glaxo Group Ltd Process
WO2003020311A1 (fr) * 2001-08-28 2003-03-13 Fujisawa Pharmaceutical Co., Ltd. Remedes contre les maladies de la peau
PT1501517E (pt) 2002-04-24 2007-05-31 Boehringer Ingelheim Pharma Combinação farmacêutica para o tratamento da hiperplasia benigna da próstata ou para a prevenção a longo prazo da retenção urinária aguda.
HU227117B1 (en) 2002-05-10 2010-07-28 Richter Gedeon Nyrt Process for dehydrogenation of aza-androstane compounds
KR100508019B1 (ko) * 2003-07-19 2005-08-17 한미약품 주식회사 고순도 1-안드로스텐 유도체의 제조 방법
US7998970B2 (en) 2004-12-03 2011-08-16 Proteosys Ag Use of finasteride, dutasteride and related compounds for the prevention or treatment of neurologically-associated disorders
EP2050436A1 (en) 2007-12-21 2009-04-22 Siegfried Generics International AG Pharmaceutical composition containing dutasteride
CN104292293B (zh) * 2014-09-17 2016-04-06 广东众生药业股份有限公司 一种度他雄胺杂质i的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54145669A (en) * 1978-04-13 1979-11-14 Merck & Co Inc 44azaa177substitutedd5 alphaaandrostanee33one which is testosteronee5 alphaareductase repressor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3285918A (en) * 1962-04-18 1966-11-15 Norman J Doorenbos 1', 4', 5', 6'-tetrahydropyrimidino[a-4, 3]-4-aza-5-cholestene
US4377584A (en) * 1978-04-13 1983-03-22 Merck & Co., Inc. 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
AU527030B2 (en) * 1978-04-13 1983-02-10 Merck & Co., Inc. 4-aza-17-substituted-5a-androstan-3-ones
US4220775A (en) * 1979-03-15 1980-09-02 Merck & Co., Inc. Preparation of 4-aza-17-substituted-5α-androstan-3-ones useful as 5α-reductase inhibitors
GB8505862D0 (en) * 1985-03-07 1985-04-11 Erba Farmitalia Steroidic 5alpha-reductase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54145669A (en) * 1978-04-13 1979-11-14 Merck & Co Inc 44azaa177substitutedd5 alphaaandrostanee33one which is testosteronee5 alphaareductase repressor

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03169891A (ja) * 1989-08-21 1991-07-23 Merck & Co Inc ５α―還元酵素阻害剤の１７β―アシル―４―アザ―５α―アンドロスト―１―エン―３―オン
CN1314241C (zh) * 2002-09-27 2007-05-02 华为技术有限公司 在城域网相同虚容器映射通道内传送不同用户数据的方法

Also Published As

Publication number Publication date
DK85985D0 (da) 1985-02-26
DK166704B1 (da) 1993-06-28
AU2748192A (en) 1993-03-18
EP0155096A2 (en) 1985-09-18
AU7083591A (en) 1991-07-11
GR850483B (en:Method) 1985-06-26
NL930005I2 (nl) 1993-09-16
NL930005I1 (nl) 1993-04-01
AU651741B2 (en) 1994-07-28
ES8702430A1 (es) 1987-01-01
PT80010A (en) 1985-03-01
AU584321B2 (en) 1989-05-25
DK85985A (da) 1985-10-22
IE850476L (en) 1985-08-27
JPH0541638B2 (en:Method) 1993-06-24
AU626293B2 (en) 1992-07-30
EP0155096B1 (en) 1989-10-04
ES540705A0 (es) 1987-01-01
AU3916785A (en) 1985-09-05
IE922862L (en) 1985-08-27
KR900001206B1 (ko) 1990-02-28
DE3584172D1 (de) 1991-10-24
DE3573429D1 (en) 1989-11-09
NZ211145A (en) 1988-10-28
HK63090A (en) 1990-08-17
CY1553A (en) 1991-03-22
CA1314541C (en) 1993-03-16
IL74365A (en) 1990-07-26
AU3313589A (en) 1989-08-10
PT80010B (pt) 1987-09-18
IL74365A0 (en) 1985-05-31
IE58058B1 (en) 1993-06-16
KR850006185A (ko) 1985-10-02
EP0155096A3 (en) 1986-07-02

Similar Documents

Publication Publication Date Title
JPH0193600A (ja) ５αリダクターゼの阻害剤としての１７β―アシル―４―アザ―５α―アンドロスタ―１―エン―３―オン類
EP0285383B1 (en) Treatment of prostatic carcinoma with 17beta-n-monosubstituted-carbamoyl-4-aza-5alpha-androst-1-en-3-ones
US4760071A (en) 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
US4377584A (en) 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
JP2592870B2 (ja) １７β−Ｎ−モノ置換カルバモイル−４−アザ−５α−アンドロスタン−３−オンの酸化同族体
US5494914A (en) Inhibitors for testosterone 5α-reductase activity
US5049562A (en) 17β-acyl-4-aza-5α-androst-1-ene-3-ones as 5α-reductase inhibitors
US4859681A (en) 17 α-Acyl-4-aza-5a-androst-1-en-3-ones as 5 alpha-reductase inhibitors
EP0285382B1 (en) Treatment of androgenic alopecia with 17beta-n-monosubstituted-carbamoyl-4-aza-5alpha-androst-1-en-3-ones
JPS63139196A (ja) ５α還元酵素阻害剤である１７β−アシル−４−アザ−５α−アンドロスト−１−エン−３−オン類
US5120742A (en) 17 β-acyl-4-aza-5 α-androst-1-ene-3-ones as 5 α-reductase inhibitors
US5571817A (en) Methods of treating androgenic alopecia with finasteride [17β-N-mono-substituted-carbamoyl-4-aza-5-α-androst-1-en-ones]
JPH03169891A (ja) ５α―還元酵素阻害剤の１７β―アシル―４―アザ―５α―アンドロスト―１―エン―３―オン
JPH04230296A (ja) ５αレダクターゼ物質である、１７β−Ｎ−モノ置換アダマンチル／ノルボルナニルカルバモイル−４−アザ−５α−アンドロスト−１−エン−３−オン及びアンドロスタン−３−オン
JPH04230297A (ja) 良性前立腺肥大症薬としての新規な１７β−アミノ−ベンゾイル−４−アザ−５α−アンドロスト−１−エン−３−オン
JP2538489B2 (ja) １７β−Ｎ−モノ置換カルバモイル−４−アザ−５α−アンドロスト−１−エン−３−オンによる前立腺癌予防剤
US5138063A (en) 17β-methoxycarbonyl-4-aza-androsten-1-en-3-ones
JPH08504813A (ja) １７β−Ｎ−モノ置換−カルバモイル−４−アザ−５α−アンドロスト−１−エン−３−オンを含む慢性前立腺炎の治療に有用な薬剤の製造法
JPS60222497A (ja) ５αリダクターゼの阻害剤としての１７β―Ｎ―モノ置換カルバモイル―４―アザ―５α―アンドロスタ―１―エン―３―オン類
JPS63152320A (ja) ４−アザ−１７−置換−５α−アンドロスタン−３−オンを含むテストステロン−５α−レダクターゼ阻害剤組成物
JPH05255383A (ja) ５α−レダクターゼ阻害剤である、１７β−Ｎ−置換アダマンチル／ノルボルナニルカルバモイル−４−アザ−５α−アンドロスト−１−エン−３−オン及びアンドロスタン−３−オン
AU718358B2 (en) Inhibitors of testosterone 5-alpha reductase activity
BG61203B2 (bg) 17 бета-n-моносубституирани карбамоил-4-аза-5-андрост- 1-ен-3-они действуващи като инхибитори на тестостерон 5 алфа-редуктазата
JPH05255382A (ja) １７β−アシル−４−アザ−５α−アンドロスト−１−エン−３−オンによる前立腺癌予防剤
NZ280175A (en) Inhibiting testosterone 5alpha-reductase activity using an A ring modified 4-aza-3-oxo-cyclopentanoperhydrophenarthrene substituted in position-17beta by amino or acylamino