JPH0144170B2 - - Google Patents

Info

Publication number
JPH0144170B2
JPH0144170B2 JP58198411A JP19841183A JPH0144170B2 JP H0144170 B2 JPH0144170 B2 JP H0144170B2 JP 58198411 A JP58198411 A JP 58198411A JP 19841183 A JP19841183 A JP 19841183A JP H0144170 B2 JPH0144170 B2 JP H0144170B2
Authority
JP
Japan
Prior art keywords
group
hydrogen
acid
amino
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP58198411A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5995269A (ja
Inventor
Fuon Beebenburuku Uarutaa
Heeze Yoahimu
Engeru Yurugen
Teiire Kuruto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Evonik Operations GmbH
Original Assignee
Degussa GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Degussa GmbH filed Critical Degussa GmbH
Publication of JPS5995269A publication Critical patent/JPS5995269A/ja
Publication of JPH0144170B2 publication Critical patent/JPH0144170B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP58198411A 1982-10-27 1983-10-25 抗てんかん性医薬品 Granted JPS5995269A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3239790.9 1982-10-27
DE3239790 1982-10-27

Publications (2)

Publication Number Publication Date
JPS5995269A JPS5995269A (ja) 1984-06-01
JPH0144170B2 true JPH0144170B2 (OSRAM) 1989-09-26

Family

ID=6176726

Family Applications (2)

Application Number Title Priority Date Filing Date
JP58198412A Pending JPS5995270A (ja) 1982-10-27 1983-10-25 ２−アミノ−３−アシルアミノ−６−ベンジルアミノ−ピリジン誘導体、及びその製法
JP58198411A Granted JPS5995269A (ja) 1982-10-27 1983-10-25 抗てんかん性医薬品

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP58198412A Pending JPS5995270A (ja) 1982-10-27 1983-10-25 ２−アミノ−３−アシルアミノ−６−ベンジルアミノ−ピリジン誘導体、及びその製法

Country Status (8)

Country Link
US (1) US4554281A (OSRAM)
EP (1) EP0110091B1 (OSRAM)
JP (2) JPS5995270A (OSRAM)
AT (1) ATE25078T1 (OSRAM)
AU (1) AU561450B2 (OSRAM)
DE (1) DE3369315D1 (OSRAM)
ES (1) ES8406440A1 (OSRAM)
IT (2) IT1171880B (OSRAM)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3665538D1 (en) * 1985-01-23 1989-10-19 Asta Pharma Ag Synergistic combination of flupirtin and non-steroidal anti-phlogistics
NO860825L (no) * 1985-03-23 1986-09-24 Degussa Fremgangsmaate til fremstilling av 2-amino-3-nitro-6-(4-fluor-benzylamino)-pyridin samt 2-amino-3-karbetoksyamino-6-(4-fluor-benzylamino)-pyridin.
DE4327516A1 (de) * 1993-08-17 1995-02-23 Asta Medica Ag Primäre und sekundäre neuroprotektive Wirkung bei neurodegenerativen Erkrankungen von Flupirtin
ZA953078B (en) * 1994-04-28 1996-01-05 Alza Corp Effective therapy for epilepsies
US20040191314A1 (en) * 1994-04-28 2004-09-30 Frank Jao Antiepileptic dosage form and process for protecting antiepileptic drug
DE19835918A1 (de) * 1998-08-07 2000-02-10 Dresden Arzneimittel Neue antikonvulsiv wirkende 4-Amino-1-aryl-pyridin-2-one und Verfahren zu deren Herstellung
US20050089559A1 (en) * 2003-10-23 2005-04-28 Istvan Szelenyi Combinations of potassium channel openers and sodium channel inhibitors or sodium channel-influencing active compounds for treating pains
US20080287399A1 (en) * 2004-12-14 2008-11-20 Astrazeneca Ab Substituted Aminopyridines and Uses Thereof
US7960436B2 (en) * 2006-06-05 2011-06-14 Valeant Pharmaceuticals International Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators
NZ575652A (en) * 2006-08-23 2011-08-26 Valeant Pharmaceuticals Int Derivatives of 4-(n-azacycloalkyl) anilides as potassium channel modulators
US8993593B2 (en) * 2006-08-23 2015-03-31 Valeant Pharmaceuticals International N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators
US8722929B2 (en) * 2006-10-10 2014-05-13 Valeant Pharmaceuticals International N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators
BRPI0719590A2 (pt) * 2006-11-28 2014-01-21 Valeant Pharmaceuticals Int Análogos de retigabina 1,4 diamino bicíclica como modulares de canal de potássio
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
US8563566B2 (en) 2007-08-01 2013-10-22 Valeant Pharmaceuticals International Naphthyridine derivatives as potassium channel modulators
JP2009037141A (ja) 2007-08-03 2009-02-19 Ricoh Co Ltd 画像形成装置の管理装置及び管理システム
US7786146B2 (en) * 2007-08-13 2010-08-31 Valeant Pharmaceuticals International Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators
US20110003867A1 (en) * 2007-12-11 2011-01-06 Neurosearch A/S Novel 2-ethyl-methyl-amino-3-amido-6-amino-pyridine derivatives useful as potassium channel activators
WO2009074592A1 (en) * 2007-12-11 2009-06-18 Neurosearch A/S Novel 2-diethylamino-3-amido-6-amino-pyridine derivatives useful as potassium channel activators
JP2011506388A (ja) * 2007-12-11 2011-03-03 ノイロサーチ アクティーゼルスカブ カリウムチャネル活性化因子として有用な、新規の２−ジメチルアミノ−３−アミド−６−アミノ−ピリジン誘導体
JP2011506390A (ja) * 2007-12-11 2011-03-03 ノイロサーチ アクティーゼルスカブ カリウムチャネル活性化因子として有用な、新規の２−ピロリジニル−３−アミド−６−アミノ−ピリジン誘導体
CN102351786A (zh) * 2011-11-01 2012-02-15 东南大学 一种氟吡汀丙二酸盐及其制备方法
US11369593B2 (en) 2017-07-14 2022-06-28 Texas Tech University System Functionalized pyridine carbamates with enhanced neuroprotective activity
TWI886158B (zh) 2019-10-10 2025-06-11 加拿大商再諾製藥公司 選擇性鉀通道調節劑之固態晶型
JP2022553569A (ja) 2019-11-08 2022-12-23 ゼノン・ファーマシューティカルズ・インコーポレイテッド うつ病性障害の治療方法
WO2022173855A1 (en) 2021-02-09 2022-08-18 Xenon Pharmaceuticals Inc. Voltage-gated potassium channel opener for use in treating anhedonia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670523A1 (de) * 1966-05-12 1970-12-03 Degussa Verfahren zur Herstellung neuer substituierter Aminopyridine
BE764362R (en) * 1966-05-12 1971-09-16 Degussa Subst amino pyridienes production
JPS5541411B2 (OSRAM) * 1973-04-28 1980-10-24

Also Published As

Publication number Publication date
AU2058283A (en) 1984-05-03
IT1171879B (it) 1987-06-10
AU561450B2 (en) 1987-05-07
EP0110091B1 (de) 1987-01-21
JPS5995270A (ja) 1984-06-01
EP0110091A1 (de) 1984-06-13
DE3369315D1 (en) 1987-02-26
IT8349223A0 (it) 1983-10-26
ES526765A0 (es) 1984-07-01
ES8406440A1 (es) 1984-07-01
IT8349222A0 (it) 1983-10-26
IT8349222A1 (it) 1985-04-26
IT1171880B (it) 1987-06-10
JPS5995269A (ja) 1984-06-01
US4554281A (en) 1985-11-19
ATE25078T1 (de) 1987-02-15
IT8349223A1 (it) 1985-04-26

Similar Documents

Publication Publication Date Title
JPH0144170B2 (OSRAM)
EP0241809B1 (de) Synergistische Kombination von Amantadin und Selegilin
AU2021215274B2 (en) Targeted drug rescue with novel compositions, combinations, and methods thereof
KR102382188B1 (ko) NamPT 억제용 신규 화합물 및 이를 포함하는 조성물
JP2014513101A (ja) 新規のビスアミノキノリン化合物、それから調製した医薬組成物、及びそれらの使用
AU2012276114B2 (en) Substituted cinnamamide derivative, preparation method and use thereof
DE3337593A1 (de) 2-amino-3-acylamino-6-benzylamino-pyridin-derivate mit antiepileptischer wirkung
KR102465988B1 (ko) 항암, 항염증 효능을 가진 삼원환의 약학적 조성물
US8722701B2 (en) 1,2,3,4,5 6,7,8-octohydro-9-phenylacetamidoacridine, the preparation method and medical use thereof
EP3059232B1 (en) Chromene derivatives substituted by alkoxide as inhibitors of the tcr-nck interaction
JPWO2005079845A1 (ja) 片頭痛予防薬
KR101047387B1 (ko) 뇌신경 보호를 위한 병용요법
KR20010013387A (ko) 통증을 치료하기 위한 드라플라진-유사체의 용도
EP3048886B1 (en) 3, 4-bis-benzylsulfonylbutanenitrile and its pharmaceutical use
Lippmann et al. The effects of tandamine, a new potential antidepressant agent, on biogenic amine uptake mechanisms and related activities
KR20210046115A (ko) 니아신 유도체 및 이를 함유하는 약학 조성물
JP3681770B2 (ja) 老年性痴呆症又はアルツハイマー病治療剤
CN112004539A (zh) 用于预防或治疗干眼的组合物
KR101035522B1 (ko) 뇌신경 보호를 위한 병용요법
EP3110412B1 (en) 4-benzylsulfonyl-2-butenenitrile
US4153696A (en) Dihydroxyphenylethylaminoalkyl theophyllines
US3502687A (en) Dioxinopiperidines
DE1618916C3 (de) Aminoäther von 9,10-Äthano-9,10dihydroanthranolen-(9) und ihre Salze, Verfahren zu ihrer Herstellung, sowie diese Verbindungen enthaltende pharmazeutische Mittel
CN110627757B (zh) 依地普仑衍生物及其制备方法和用途
WO2015054008A1 (en) 4-methylsulfonyl-2-butenenitrile and its pharmaceutical use