JPH0134966B2 - - Google Patents
Info
- Publication number
- JPH0134966B2 JPH0134966B2 JP14701279A JP14701279A JPH0134966B2 JP H0134966 B2 JPH0134966 B2 JP H0134966B2 JP 14701279 A JP14701279 A JP 14701279A JP 14701279 A JP14701279 A JP 14701279A JP H0134966 B2 JPH0134966 B2 JP H0134966B2
- Authority
- JP
- Japan
- Prior art keywords
- nacl
- hydroxyapatite
- mgcl
- composition
- test
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 31
- 239000000203 mixture Substances 0.000 claims description 19
- 239000011780 sodium chloride Substances 0.000 claims description 15
- 239000000551 dentifrice Substances 0.000 claims description 9
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 6
- 239000000606 toothpaste Substances 0.000 claims description 6
- 229940034610 toothpaste Drugs 0.000 claims description 6
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 6
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 3
- 239000006072 paste Substances 0.000 claims 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 13
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 239000012153 distilled water Substances 0.000 description 6
- 239000011247 coating layer Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 210000003298 dental enamel Anatomy 0.000 description 4
- 229920006395 saturated elastomer Polymers 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 3
- 229910052586 apatite Inorganic materials 0.000 description 3
- 239000001506 calcium phosphate Substances 0.000 description 3
- 229910000389 calcium phosphate Inorganic materials 0.000 description 3
- 235000011010 calcium phosphates Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 235000012239 silicon dioxide Nutrition 0.000 description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 2
- 229910001424 calcium ion Inorganic materials 0.000 description 2
- 229940043256 calcium pyrophosphate Drugs 0.000 description 2
- 235000010418 carrageenan Nutrition 0.000 description 2
- 239000000679 carrageenan Substances 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- 229940113118 carrageenan Drugs 0.000 description 2
- 210000004268 dentin Anatomy 0.000 description 2
- 235000019821 dicalcium diphosphate Nutrition 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000033558 biomineral tissue development Effects 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 230000002308 calcification Effects 0.000 description 1
- 150000003841 chloride salts Chemical class 0.000 description 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229940005657 pyrophosphoric acid Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Description
本発明は歯磨組成物に関する。
本発明によれば、合成ハイドロキシアパタイト
粉末を含む練歯磨組成物であつて、この組成物の
重量に対して0.1〜20重量％のNaClと0.003〜３重
量％のMgCl2とを含有することを特徴とする歯磨
組成物が提供される。
本発明に係る歯磨組成物は歯に付着したプラー
ク（細菌塊）の除去に有効であるとともに、歯牙
表面の強化及び再石灰化の促進に極めて有効であ
るということが見出されたものである。
即ち、本発明の歯磨組成物は歯質表面に対し
て、極めて効果的に、ハイドロキシアパタイトの
結晶を析出せしめて、これをコーテイングするの
である。これは、上記の如き塩化物の存在によつ
てハイドロキシアパタイトの水に対する溶解度が
増大することによるものと考えられる。即ち、ハ
イドロキシアパタイトは水に超難溶性の塩である
から、歯磨中ではイオン化している〔Ca++〕
〔HPO4 --〕などのイオンのイオン積量は小さい。
即ち歯質表面のコーテイング即ち歯質表面におけ
るハイドロキシアパタイト結晶の析出のための推
進力としてのイオン積量が小さいのである。しか
るに、このようなハイドロキシアパタイトを含む
歯磨中にNaCl及びMgCl2が加わると、Ca++と
HPO4 --の溶解度が急激に増大し、これによつて
コーテイング効果がより促進されるのであると考
えられるのである。
本発明の歯磨組成物中に含まれるNaCl及び
MgCl2の量がそれぞれ上記に規定した量よりも小
さい場合にはコーテイング効果は不十分となり、
逆に上記規定量よりも大きい場合には使用に際し
て満足すべきフイーリングを与えることが困難と
なる。
尚本発明の歯磨組成物は通常用いられる種々の
添加剤を含んでいてもよく、また所望ならばクエ
ン酸、乳酸、酢酸、ピロリン酸やグルタミン、プ
ロリン、セリン、グリシンなどを含んでいてもよ
い。
以下、例によつて本発明を更に説明する。
以下の例において、例１〜６は歯磨組成物の組
成例を重量部で示すものであつて、例４，５及び
６は本発明歯磨組成物の効果を明らかにするため
のものである。
例 １
練歯磨
アパタイト粉末 10.0
燐酸カルシウム 25.0
CMCナトリウム塩 0.3
カラギーナン 1.2
グリセリン 10.0
ソルビツト 15.0
ラウリル硫酸ナトリウム 2.0
香 料 1.2
サツカリンナトリウム 0.1
二酸化珪素 2.0
NaCl 0.27
MgCl2 0.01
水 32.92
例 ２
練歯磨
アパタイト粉末 5.0
燐酸カルシウム 10.0
ピロリン酸カルシウム 20.0
CMCナトリウム塩 1.0
アルギン酸ナトリウム 0.1
グリセリン 10.0
ソルビツト 10.0
ラウリル硫酸ナトリウム 1.5
ラウロイルザルコシンナトリウム 0.5
香 料 0.5
サツカリンナトリウム 0.1
二酸化珪素 2.5
NaCl 3.0
MgCl2 0.2
水 35.0
例 ３
練歯磨
アパタイト粉末 35.0
CMCナトリウム塩 1.0
カラギーナン 0.3
グリセリン 35.0
ラウリル硫酸ナトリウム 2.0
香 料 1.0
サツカリンナトリウム 0.1
二酸化珪素 2.5
NaCl 2.0
MgCl2 0.1
KCl 1.0
水 20.0
例 ４
37℃の蒸留水1000mlに１ｇのハイドロキシアパ
タイト粉末を投入し、NaCl及びMgCl2を異なる
濃度で添加してカルシウムイオン濃度を測定して
ハイドロキシアパタイトの溶解度がNaCl及び
MgCl2の添加により増大することを確認した。液
の調製10日後のカルシウムイオン濃度は、それぞ
れ次のようであつた。
TECHNICAL FIELD The present invention relates to dentifrice compositions. According to the present invention, there is provided a toothpaste composition comprising synthetic hydroxyapatite powder, which contains 0.1 to 20% by weight of NaCl and 0.003 to 3% by weight of MgCl 2 based on the weight of the composition. A dentifrice composition is provided. It has been discovered that the dentifrice composition according to the present invention is effective in removing plaque (bacterial mass) adhering to teeth, and is extremely effective in strengthening tooth surfaces and promoting remineralization. . That is, the dentifrice composition of the present invention very effectively precipitates hydroxyapatite crystals on the tooth surface and coats the tooth surface with hydroxyapatite crystals. This is thought to be because the solubility of hydroxyapatite in water increases due to the presence of chlorides as described above. In other words, since hydroxyapatite is a salt that is extremely poorly soluble in water, it becomes ionized during tooth brushing [Ca ++ ].
The ion volume of ions such as [HPO 4 -- ] is small.
That is, the amount of ions acting as a driving force for coating the tooth surface, that is, for the precipitation of hydroxyapatite crystals on the tooth surface, is small. However, when NaCl and MgCl2 are added to toothpaste containing hydroxyapatite, Ca ++ and
It is thought that the solubility of HPO 4 -- increases rapidly, thereby further promoting the coating effect. NaCl contained in the dentifrice composition of the present invention and
If the amount of MgCl 2 is smaller than the amount specified above, the coating effect will be insufficient,
On the other hand, if the amount is larger than the specified amount, it becomes difficult to provide a satisfactory feeling during use. The dentifrice composition of the present invention may contain various commonly used additives, and may also contain citric acid, lactic acid, acetic acid, pyrophosphoric acid, glutamine, proline, serine, glycine, etc., if desired. . The invention will now be further explained by way of examples. In the following examples, Examples 1 to 6 show composition examples of dentifrice compositions in parts by weight, and Examples 4, 5, and 6 are for clarifying the effects of the dentifrice compositions of the present invention. Example 1 Toothpaste apatite powder 10.0 Calcium phosphate 25.0 CMC sodium salt 0.3 Carrageenan 1.2 Glycerin 10.0 Sorbiturate 15.0 Sodium lauryl sulfate 2.0 Flavoring 1.2 Sodium saccharin 0.1 Silicon dioxide 2.0 NaCl 0.27 MgCl 2 0.01 Water 32.92 Examples 2 Toothpaste Apatite Powder 5.0 Calcium Phosphate 10.0 Calcium pyrophosphate 20.0 CMC sodium salt 1.0 Sodium alginate 0.1 Glycerin 10.0 Sorbit 10.0 Sodium lauryl sulfate 1.5 Sodium lauroyl sarcosine 0.5 Flavor 0.5 Sodium saccharin 0.1 Silicon dioxide 2.5 NaCl 3.0 MgCl 2 0.2 Water 35.0 Example 3 Kneading Toothpaste Apatite Powder 35.0 CMC Sodium Salt 1.0 Carrageenan 0.3 Glycerin 35.0 Sodium lauryl sulfate 2.0 Flavor 1.0 Satucalin sodium 0.1 Silicon dioxide 2.5 NaCl 2.0 MgCl 2 0.1 KCl 1.0 Water 20.0 Example 4 Add 1 g of hydroxyapatite powder to 1000 ml of distilled water at 37°C, and add NaCl and MgCl. 2 was added at different concentrations and the calcium ion concentration was measured to determine the solubility of hydroxyapatite in NaCl and
It was confirmed that the increase was caused by the addition of MgCl 2 . The calcium ion concentrations 10 days after the preparation of the solutions were as follows.
【表】
例５ （参考例）
(1) 試験方法
成人永久歯をそのエナメル小柱に切り、約
200μｍの厚さの切片とし、そのエナメル質部分
を取り除き、象牙質部分を露出させた。その切片
に対し、それぞれ
Ａ：蒸留水；
Ｂ：蒸留水にハイドロキシアパタイトを飽和させ
た溶液、及び
Ｃ：0.001％のMgCl2及び0.9％のNaClを含む蒸留
水にハイドロキシアパタイトを飽和させた溶
液
を0.6ml／minの流速で通過させ、１日後に表面
を偏光顕微鏡により観察した。
(2) 試験結果
Ａの場合には、歯質表面のコーテイング層（石
灰化層）は全く認められなかつた。
Ｂの場合には、厚さ約2μｍのコーテイング層
が認められた。
Ｃの場合には、厚さ約5μｍのコーテイング層
が歯質表面全面に認められた。
このことはMgCl2，NaClの存在でハイドロキ
シアパタイトの再石灰化が促進されることを示し
ている。
例 ６
例５と同様に、成人永久歯をそのエナメル小柱
に平行に切り、約200μｍの厚さの切片とし、そ
のエナメル質部分を取り除き、象牙質部分を露出
させた、その切片に0.003％のMgCl及び0.3％の
NaClを含む蒸留水にハイドロキシアパタイトを
飽和させた溶液を用いて、例５と同様の試験を行
なつた結果、例５と同様の結果をえた。
例 ７
(1) 試験方法
実施例２）の組成よりリン酸塩、NaCl，
MgCl2以外の添加物を除いた組成(B)とこの組成よ
りNaCl，MgCl2を除いた組成(A)とを用いて例５）
と同様の試験方法で以下の試験を行なつた。
テスト１：ハイドロキシアパタイト、リン酸カル
シウム、ピロリン酸カルシウムを１：２：
４の割り合いで蒸留水に加えて飽和させた
溶液(A)
テスト２：3.0％のNaClおよび0.2％のMgCl2を含
む蒸留水にＡと同じ組成物を飽和させた溶
液(B)
(2) 試験結果
テスト１：厚さ1μｍ以下のコーテイング層が認
められた。
テスト２：厚さ約2μｍのコーテイング層が認め
られた。
このことはハイドロキシアパタイトだけを飽和
させた溶液に比べて石灰化は起こり難いが、
NaCl，MgCl2の存在で石灰化が促進されること
を示している。[Table] Example 5 (Reference example) (1) Test method Cut an adult permanent tooth into its enamel trabeculae, and
A section with a thickness of 200 μm was prepared, and the enamel portion was removed to expose the dentin portion. The sections were treated with A: distilled water; B: a solution of hydroxyapatite saturated in distilled water; and C: a solution of hydroxyapatite saturated in distilled water containing 0.001% MgCl2 and 0.9% NaCl. It was passed through at a flow rate of 0.6 ml/min, and the surface was observed using a polarizing microscope one day later. (2) Test results In case A, no coating layer (calcified layer) on the tooth surface was observed. In case B, a coating layer with a thickness of approximately 2 μm was observed. In case C, a coating layer with a thickness of approximately 5 μm was observed over the entire tooth surface. This indicates that the presence of MgCl 2 and NaCl promotes remineralization of hydroxyapatite. Example 6 In the same manner as in Example 5, adult permanent teeth were cut parallel to their enamel trabeculae to obtain sections approximately 200 μm thick.The enamel portion was removed to expose the dentin portion. MgCl and 0.3%
The same test as in Example 5 was conducted using a solution of hydroxyapatite saturated in distilled water containing NaCl, and the same results as in Example 5 were obtained. Example 7 (1) Test method From the composition of Example 2), phosphate, NaCl,
Example 5) Using a composition (B) excluding additives other than MgCl 2 and a composition (A) excluding NaCl and MgCl 2 from this composition
The following tests were conducted using the same test method. Test 1: Hydroxyapatite, calcium phosphate, calcium pyrophosphate 1:2:
Test 2: A saturated solution of the same composition as A in distilled water containing 3.0% NaCl and 0.2% MgCl 2 (B) (2 ) Test results Test 1: A coating layer with a thickness of 1 μm or less was observed. Test 2: A coating layer with a thickness of approximately 2 μm was observed. This means that mineralization is less likely to occur compared to a solution saturated with hydroxyapatite alone, but
This shows that the presence of NaCl and MgCl 2 promotes calcification.
Claims (1)
組成物であつて、この組成物の練成物の重量に対
して0.1〜20重量％のNaClと0.003〜３重量％の
MgCl2とを含有することを特徴とする歯磨組成
物。1 A dentifrice composition containing synthetic hydroxyapatite powder, which contains 0.1 to 20% by weight of NaCl and 0.003 to 3% by weight based on the weight of the paste of this composition.
A toothpaste composition characterized by containing MgCl2 .
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14701279A JPS5673015A (en) | 1979-11-15 | 1979-11-15 | Toothpaste composition |
| EP80304018A EP0029332A1 (en) | 1979-11-15 | 1980-11-11 | Dentifrice compositions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14701279A JPS5673015A (en) | 1979-11-15 | 1979-11-15 | Toothpaste composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5673015A JPS5673015A (en) | 1981-06-17 |
| JPH0134966B2 true JPH0134966B2 (en) | 1989-07-21 |
Family
ID=15420547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14701279A Granted JPS5673015A (en) | 1979-11-15 | 1979-11-15 | Toothpaste composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5673015A (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6075411A (en) * | 1983-10-01 | 1985-04-27 | Lion Corp | Dentifrice |
| GB8628068D0 (en) * | 1986-11-24 | 1986-12-31 | Unilever Plc | Aqueous gel comprising carrageenan |
| JPS6470408A (en) * | 1987-09-10 | 1989-03-15 | Hairu Kk | Dentifrice composition |
| AU4723297A (en) * | 1996-10-23 | 1998-05-15 | Sunstar Inc. | Oral preparations containing biologically active crystallized glass |
| CN102378621A (en) | 2009-04-02 | 2012-03-14 | 高露洁-棕榄公司 | Exfoliating dentifrice composition and method of use |
| JP2013163656A (en) * | 2012-02-10 | 2013-08-22 | Gc Corp | Dentifrice |
| TWI854109B (en) * | 2020-03-30 | 2024-09-01 | 日商西尾股份有限公司 | Treatment kit for tooth strengthening method |
-
1979
- 1979-11-15 JP JP14701279A patent/JPS5673015A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5673015A (en) | 1981-06-17 |
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