KR840001942B1 - Toothpaste composition - Google Patents

Abstract

A dentifrice includes synthetic hydroxyapatite powder. This compsn. was found effective in removing plaque from teeth surfaces and in the remineralization of the enamel. The toothpaste consists of 5-35% synthetic hydroxyapatite powder, 30-35% abrasive material that contains calcium phosphate or calcium pyrophosphate, 20-35% filler that contains a glycerine or sorbitol group, 0.1-20% NaCl, 0.003-3% MgCl2, and 30-35% water by weight. The compositon should be either neutral or alkali.

Description

Skirt composition

The present invention relates to a skirt composition. According to the present invention there is provided a skirt composition comprising a synthetic hydroxyapatite powder. It is preferable that this composition is neutral or weakly alkaline, and the suitable maximum pH value is about 9.

The skirt composition of the present invention is effective for removing plaque from the surface of the skirt and has a certain strengthening and remineralization effect on the enamel layer of the tooth. I found that.

Generally, conventional dentifrices contain minerals such as colloidal silica as tooth cleaning and abrasives. These abrasives are used to remove contaminants on the teeth, but it is important that they do not damage the teeth.

The skirt compositions of the present invention contain a suitable amount of synthetic hydroxyapatite which can effectively remove tooth contaminants and plaques. We believe that this is due to the fact that synthetic hydroxyapatite has a hardness similar to that of tooth enamel, which can give a proper polishing effect when brushing. This is also due to the fact that synthetic hydroxyapatite having an average particle diameter of hydroxyapatite which is about 2 mu and a maximum particle diameter of 10 mu or less in a suitable composition has a large surface area and excellent absorption capacity.

In accordance with the present invention the skirt composition again comprises 0.1 to 20% by weight of NaCl and / or KCl and 0.03 to 3% by weight of MgCl _{2 based} on the weight of the precursor composition.

The presence of a mixture of NaCl, or KCl, and MgCl ₂ in the skirt composition containing synthetic hydroxyapatite promotes the removal of plaque from the teeth and the strengthening and remineralization of the tooth surface compared to these chloride-free compositions. It was found to be further improved.

More specifically, the skirt composition of the present invention can precipitate crystals of hydroxyapatite on the surface of the teeth more effectively than these chloride-free compositions. We believe that this is due to the fact that the water solubility of hydroxyapatite increases in the presence of the chloride defined above. More specifically, the hydroxy of dilution is poorly water-soluble (水難溶性) salt, because it is soluble in water in the dentifrice, the ionizing his ion _{^{(Ca ++), (HPO 4}} -) ion, such as product is low. This means that there are less ionic products present to promote the coating of the surface of the tooth, ie to precipitate the crystals of hydroxyapatite on the surface of the tooth. However, the hydroxy dentifrice containing apatite Applying the NaCl and / or KCl, and MgCl _{2 4} Ca ⁺⁺ and HPO ^- solubility is significantly increased, perhaps so as the increase of the covering effect of the teeth would be observed .

When the amount of NaCl and / or KCl and MgCl ₂ contained in the skirt composition of the present invention is less than the amount, the improvement of the coating effect is insufficient as compared to the improvement achieved by the composition of the present invention without these chlorides. On the other hand, compositions containing more than the prescribed amount make it difficult to give a pleasure when using the dentifrice composition.

The skirt composition of the present invention may include various additives commonly used in a dentifrice, and may again include citric acid, lactic acid, acetic acid, pyrrole acid, glutamine, proline, serine, glycine, and the like.

The invention will be explained in more detail with reference to the following examples. Examples 1 to 7 and 11 to 17 respectively indicate the formulation of the skirt composition in accordance with the present invention in parts by weight, and Examples 8 to 10, 18 and 19 are intended to demonstrate the effect of the composition of the present invention.

Example 1

Example 2

Example 3

Example 4

Example 5

Example 6

Example 7

Example 8

A 0.1% neutral red solution was applied to the anterior teeth of each of three males A, B and C (22-25 years old), who had used conventional commercial toothpaste. Then, one day after they started using the skirting agent of Example 1, the same dyeing operation was performed to compare the plaque contamination area before and after the replacement of the skirting agent. In case of A, the contaminated area after replacement was about 10% of the original contaminated area, so the degree of decontamination at the plaque area was about 90%. In case of B and C, decontamination degree of plaque was about 50%.

Example 9

The polishing effect of the skirting agent was tested by using a plate-like body made of sintered hydroxyapatite having a hardness similar to that of the enamel of the tooth, instead of the tooth. Each plate was brushed for 60 minutes with a toothbrush embedded with various dentifrices.

The weight loss of each platelet was measured. As a result, the polishing effect of the skirt composition of the present invention was similar to that of commercial skirting agents (white and white and denterion).

Example 10

The use of prismaanamantinium divides one permanent tooth of the adult into two to make a piece of about 200 μm thick. A saturated solution of hydroxyapatite was prepared by stirring the hydroxyapatite powder in distilled water in an amount of 1 g of hydroxyapatite per 100 ml water. Supernatant was passed over the tooth block at a flow rate of 0.6 ml / min. The membrane was continuously observed using a polarizing microscope, and it was confirmed that the membrane was coated with a substance such as apatite crystals at a thickness of about 1 μm after 14 hours.

Example 11

Example 12

Example 13

Example 14

Example 15

Example 16

Example 17

Example 18

1 g of hydroxyapatite powder was added to 100 ml of distilled water at 37 DEG C and NaCl and MgCl ₂ were added at various concentrations. By measuring the calcium ion concentration of each solution, it was confirmed that the solubility of hydroxyapatite was increased by adding NaCl and MgCl ₂ . 10 days after the solution was prepared, the calcium ion concentration was as follows.

NaCl concentration: 0 0.3 0.3 3.0 3.0 (%)

MgCl ₂ concentration: 0 0.03 0.3 0.03 0.3 (%)

Ca ⁺⁺ concentration: 4.9 26.0 31.2 31.5 36.7 (ppm)

Example 19

Permanent teeth of an adult were divided by using prisma adamantium to make a piece of about 200 mu m in thickness. The enamel was exfoliated to expose the dentin. A solution of hydroxyapatite saturated in distilled water containing 0.001% MgCl ₂ and 0.9% NaCl was passed over the tooth block at a flow rate of 0.6 ml / min. The film was continuously observed with a polarizing microscope, and it was confirmed that all four sides of the film were coated with a material resembling apatite crystals having a thickness of about 5 µm.

Claims (1)

5 to 35 parts by weight of synthetic hydroxyapatite and the remainder thereof are composed of 30 to 35 parts by weight of a polishing base comprising at least one component selected from the group consisting of calcium phosphate and calcium pyrophosphate, and glycerin and sorbitol 20. To 35 parts by weight of at least one filler selected from the group consisting of, and 30 to 35 parts by weight of water, the composition is a toothpaste skirt composition, characterized in that the composition is neutral or slightly alkaline.