JPH01303151A - 人工皮膚および創傷カバー材ならびにその製造法 - Google Patents
人工皮膚および創傷カバー材ならびにその製造法Info
- Publication number
- JPH01303151A JPH01303151A JP63132557A JP13255788A JPH01303151A JP H01303151 A JPH01303151 A JP H01303151A JP 63132557 A JP63132557 A JP 63132557A JP 13255788 A JP13255788 A JP 13255788A JP H01303151 A JPH01303151 A JP H01303151A
- Authority
- JP
- Japan
- Prior art keywords
- collagen
- chitosan
- artificial skin
- wound covering
- composite material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000463 material Substances 0.000 title claims abstract description 45
- 238000004519 manufacturing process Methods 0.000 title claims description 17
- 229920001436 collagen Polymers 0.000 claims abstract description 116
- 108010035532 Collagen Proteins 0.000 claims abstract description 115
- 102000008186 Collagen Human genes 0.000 claims abstract description 115
- 239000002131 composite material Substances 0.000 claims abstract description 49
- 238000001035 drying Methods 0.000 claims abstract description 9
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 7
- 102000009123 Fibrin Human genes 0.000 claims abstract description 7
- 108010073385 Fibrin Proteins 0.000 claims abstract description 7
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims abstract description 7
- 108010067306 Fibronectins Proteins 0.000 claims abstract description 7
- 229950003499 fibrin Drugs 0.000 claims abstract description 7
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 7
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 7
- 229920002567 Chondroitin Polymers 0.000 claims abstract description 6
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 claims abstract description 6
- 229920001661 Chitosan Polymers 0.000 claims description 100
- 125000003047 N-acetyl group Chemical group 0.000 claims description 8
- 239000003431 cross linking reagent Substances 0.000 claims description 7
- 229920000045 Dermatan sulfate Polymers 0.000 claims description 6
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims description 6
- 229940051593 dermatan sulfate Drugs 0.000 claims description 6
- 230000005855 radiation Effects 0.000 claims description 6
- 229920001287 Chondroitin sulfate Polymers 0.000 claims description 5
- 125000003277 amino group Chemical group 0.000 claims description 5
- 230000001588 bifunctional effect Effects 0.000 claims description 5
- 229940094517 chondroitin 4-sulfate Drugs 0.000 claims description 5
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 claims description 5
- 238000004108 freeze drying Methods 0.000 claims description 5
- 102000009024 Epidermal Growth Factor Human genes 0.000 claims description 4
- 101800003838 Epidermal growth factor Proteins 0.000 claims description 4
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 229940116977 epidermal growth factor Drugs 0.000 claims description 4
- 239000000758 substrate Substances 0.000 claims description 4
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims description 4
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 150000004671 saturated fatty acids Chemical class 0.000 claims description 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 claims description 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 claims description 2
- 102100037362 Fibronectin Human genes 0.000 claims 3
- 102000018233 Fibroblast Growth Factor Human genes 0.000 claims 2
- 108050007372 Fibroblast Growth Factor Proteins 0.000 claims 2
- 230000000397 acetylating effect Effects 0.000 claims 2
- 229940126864 fibroblast growth factor Drugs 0.000 claims 2
- 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 claims 1
- 102100031706 Fibroblast growth factor 1 Human genes 0.000 claims 1
- 229940029303 fibroblast growth factor-1 Drugs 0.000 claims 1
- 239000012567 medical material Substances 0.000 abstract description 35
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 19
- 210000004204 blood vessel Anatomy 0.000 abstract description 15
- 239000002473 artificial blood Substances 0.000 abstract description 14
- 108010007568 Protamines Proteins 0.000 abstract description 7
- 102000007327 Protamines Human genes 0.000 abstract description 7
- 230000002439 hemostatic effect Effects 0.000 abstract description 7
- 229940048914 protamine Drugs 0.000 abstract description 7
- 238000004132 cross linking Methods 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 6
- 238000006243 chemical reaction Methods 0.000 abstract description 5
- 102000016359 Fibronectins Human genes 0.000 abstract description 4
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract description 4
- 229920000669 heparin Polymers 0.000 abstract description 4
- 229960002897 heparin Drugs 0.000 abstract description 4
- 229920002683 Glycosaminoglycan Polymers 0.000 abstract description 2
- 239000008280 blood Substances 0.000 abstract description 2
- 210000004369 blood Anatomy 0.000 abstract description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 4
- -1 artificial skin Substances 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 34
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 33
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 18
- 206010052428 Wound Diseases 0.000 description 17
- 208000027418 Wounds and injury Diseases 0.000 description 17
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- 239000000203 mixture Substances 0.000 description 14
- 238000002360 preparation method Methods 0.000 description 12
- 210000003491 skin Anatomy 0.000 description 10
- 108010045569 atelocollagen Proteins 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 239000007864 aqueous solution Substances 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 description 4
- 230000002785 anti-thrombosis Effects 0.000 description 4
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 4
- 150000001244 carboxylic acid anhydrides Chemical class 0.000 description 4
- 238000007385 chemical modification Methods 0.000 description 4
- 239000000515 collagen sponge Substances 0.000 description 4
- 230000006196 deacetylation Effects 0.000 description 4
- 238000003381 deacetylation reaction Methods 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 230000035876 healing Effects 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 229940014800 succinic anhydride Drugs 0.000 description 4
- 229920002101 Chitin Polymers 0.000 description 3
- 229920004934 Dacron® Polymers 0.000 description 3
- 239000005057 Hexamethylene diisocyanate Substances 0.000 description 3
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 239000005020 polyethylene terephthalate Substances 0.000 description 3
- 229920001059 synthetic polymer Polymers 0.000 description 3
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 2
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 2
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 2
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 2
- 230000006181 N-acylation Effects 0.000 description 2
- IDCBOTIENDVCBQ-UHFFFAOYSA-N TEPP Chemical compound CCOP(=O)(OCC)OP(=O)(OCC)OCC IDCBOTIENDVCBQ-UHFFFAOYSA-N 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- MSWZFWKMSRAUBD-QZABAPFNSA-N beta-D-glucosamine Chemical compound N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-QZABAPFNSA-N 0.000 description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000000850 deacetylating effect Effects 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229960002442 glucosamine Drugs 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 229950006780 n-acetylglucosamine Drugs 0.000 description 2
- RAFYDKXYXRZODZ-UHFFFAOYSA-N octanoyl octanoate Chemical compound CCCCCCCC(=O)OC(=O)CCCCCCC RAFYDKXYXRZODZ-UHFFFAOYSA-N 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001732 thrombotic effect Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 241000131500 Chionoecetes opilio Species 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 208000005422 Foreign-Body reaction Diseases 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- OEERIBPGRSLGEK-UHFFFAOYSA-N carbon dioxide;methanol Chemical compound OC.O=C=O OEERIBPGRSLGEK-UHFFFAOYSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000037029 cross reaction Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 229950008679 protamine sulfate Drugs 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 125000002730 succinyl group Chemical group C(CCC(=O)*)(=O)* 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63132557A JPH01303151A (ja) | 1988-06-01 | 1988-06-01 | 人工皮膚および創傷カバー材ならびにその製造法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63132557A JPH01303151A (ja) | 1988-06-01 | 1988-06-01 | 人工皮膚および創傷カバー材ならびにその製造法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60093868A Division JPS61253065A (ja) | 1985-05-02 | 1985-05-02 | キトサン誘導体およびコラ−ゲンの複合材の医用材料およびその製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01303151A true JPH01303151A (ja) | 1989-12-07 |
| JPH0567300B2 JPH0567300B2 (fr) | 1993-09-24 |
Family
ID=15084075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63132557A Granted JPH01303151A (ja) | 1988-06-01 | 1988-06-01 | 人工皮膚および創傷カバー材ならびにその製造法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH01303151A (fr) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004507472A (ja) * | 2000-08-30 | 2004-03-11 | デピュイ・アクロメッド・インコーポレイテッド | コラーゲン／多糖類二層性マトリックス |
| CN111150881A (zh) * | 2020-01-16 | 2020-05-15 | 南京艾澜德生物科技有限公司 | 一种医用重组胶原蛋白喷雾及其制备方法 |
| CN115845126A (zh) * | 2022-12-26 | 2023-03-28 | 深圳钧兴生物科技有限公司 | 一种仿生胶原液体敷料及其制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5643301A (en) * | 1979-09-18 | 1981-04-22 | Kureha Chem Ind Co Ltd | Chitinoid molding material |
| JPS56133344A (en) * | 1980-03-21 | 1981-10-19 | Kureha Chem Ind Co Ltd | Novel composite material |
-
1988
- 1988-06-01 JP JP63132557A patent/JPH01303151A/ja active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5643301A (en) * | 1979-09-18 | 1981-04-22 | Kureha Chem Ind Co Ltd | Chitinoid molding material |
| JPS56133344A (en) * | 1980-03-21 | 1981-10-19 | Kureha Chem Ind Co Ltd | Novel composite material |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004507472A (ja) * | 2000-08-30 | 2004-03-11 | デピュイ・アクロメッド・インコーポレイテッド | コラーゲン／多糖類二層性マトリックス |
| CN111150881A (zh) * | 2020-01-16 | 2020-05-15 | 南京艾澜德生物科技有限公司 | 一种医用重组胶原蛋白喷雾及其制备方法 |
| CN115845126A (zh) * | 2022-12-26 | 2023-03-28 | 深圳钧兴生物科技有限公司 | 一种仿生胶原液体敷料及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0567300B2 (fr) | 1993-09-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS6359706B2 (fr) | ||
| JP2520858B2 (ja) | コラ―ゲンの架橋を容易にするためのコラ―ゲン処理方法 | |
| JP4214051B2 (ja) | エラスチン架橋体およびその製造方法 | |
| US5415619A (en) | Method of manufacturing a vascular graft impregnated with polysaccharide derivatives | |
| Klemm et al. | Nanocelluloses as innovative polymers in research and application | |
| US6706684B1 (en) | Method for preparing a collagen material with controlled in vivo degradation | |
| US4980403A (en) | Collagen products | |
| JP2002536465A (ja) | ヒアルロン酸をポリマーに架橋する方法 | |
| US20090035356A1 (en) | Modified biodegradable polymers, preparation and use thereof for making biomaterials and dressings | |
| JPH02500723A (ja) | コラーゲンとキトサンとグリコサミノグリカンとの混合物を基材とする新規な生体材料、その製造法及び人間の医薬にそれらの応用 | |
| GB2314842A (en) | Protein/oxidised regenerated cellulose complexes | |
| US20090074837A1 (en) | Bioresorbable Calcium-Deficient Hydroxyapatite Hydrogel Composite | |
| US4690973A (en) | Production process of an antithrombogenic and antiadhesive material for medical use | |
| CN111303452B (zh) | 一种仿生抗菌高粘附的双网络水凝胶及其制备方法和应用 | |
| JPH10502663A (ja) | 抗癒着剤 | |
| JPH04275346A (ja) | キトサンを含有している相容性配合物 | |
| WO1996003147A1 (fr) | Synthese de gels chimiques a partir de polysaccharides polyelectrolytiques par irradiation gamma | |
| JPH0679616B2 (ja) | 架橋化医用品 | |
| JPS6341541A (ja) | 表面にキトサン成分を有する高分子成形物及びその製造方法 | |
| JPH01303151A (ja) | 人工皮膚および創傷カバー材ならびにその製造法 | |
| Kim et al. | Biocompatible hydrogel formation of gelatin from cold water fish via enzymatic networking | |
| JPH01303153A (ja) | 人工血管およびその製造法 | |
| KR19990049107A (ko) | 고분자 전해질 복합체 스폰지의 제조방법 | |
| JPH01303152A (ja) | 止血材およびその製造法 | |
| JPH0622580B2 (ja) | サクシニルキトサンより構成された医用材料 |