JPH01268638A - Calcium aqueous solution - Google Patents
Calcium aqueous solutionInfo
- Publication number
- JPH01268638A JPH01268638A JP63097540A JP9754088A JPH01268638A JP H01268638 A JPH01268638 A JP H01268638A JP 63097540 A JP63097540 A JP 63097540A JP 9754088 A JP9754088 A JP 9754088A JP H01268638 A JPH01268638 A JP H01268638A
- Authority
- JP
- Japan
- Prior art keywords
- calcium
- acid
- aqueous solution
- benzoic acid
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011575 calcium Substances 0.000 title claims abstract description 41
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 41
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 39
- 239000007864 aqueous solution Substances 0.000 title abstract description 10
- 229960005069 calcium Drugs 0.000 claims abstract description 40
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims abstract description 19
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 11
- 239000005711 Benzoic acid Substances 0.000 claims abstract description 9
- 235000010233 benzoic acid Nutrition 0.000 claims abstract description 9
- 150000007524 organic acids Chemical class 0.000 claims abstract description 8
- 239000004227 calcium gluconate Substances 0.000 claims abstract description 6
- 229960004494 calcium gluconate Drugs 0.000 claims abstract description 6
- 235000013927 calcium gluconate Nutrition 0.000 claims abstract description 6
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims abstract description 6
- 235000002639 sodium chloride Nutrition 0.000 claims abstract 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract 3
- 239000011780 sodium chloride Substances 0.000 claims abstract 3
- 150000003839 salts Chemical class 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 8
- 235000019640 taste Nutrition 0.000 abstract description 5
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 238000002156 mixing Methods 0.000 abstract description 3
- 206010020751 Hypersensitivity Diseases 0.000 abstract description 2
- 230000007815 allergy Effects 0.000 abstract description 2
- 210000000988 bone and bone Anatomy 0.000 abstract description 2
- 210000002966 serum Anatomy 0.000 abstract description 2
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000036765 blood level Effects 0.000 abstract 1
- 230000002439 hemostatic effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 235000015165 citric acid Nutrition 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000013355 food flavoring agent Nutrition 0.000 description 3
- 239000003205 fragrance Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 150000001669 calcium Chemical class 0.000 description 2
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 description 2
- 239000001639 calcium acetate Substances 0.000 description 2
- 235000011092 calcium acetate Nutrition 0.000 description 2
- 229960005147 calcium acetate Drugs 0.000 description 2
- 239000001110 calcium chloride Substances 0.000 description 2
- 229910001628 calcium chloride Inorganic materials 0.000 description 2
- 229960002713 calcium chloride Drugs 0.000 description 2
- 235000011148 calcium chloride Nutrition 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- -1 hydrochloric acid Chemical class 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000008213 purified water Substances 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- 206010006956 Calcium deficiency Diseases 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 240000000560 Citrus x paradisi Species 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 235000011511 Diospyros Nutrition 0.000 description 1
- 244000055850 Diospyros virginiana Species 0.000 description 1
- 206010013911 Dysgeusia Diseases 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 208000003217 Tetany Diseases 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 229940043430 calcium compound Drugs 0.000 description 1
- 150000001674 calcium compounds Chemical class 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 description 1
- 239000001527 calcium lactate Substances 0.000 description 1
- 229960002401 calcium lactate Drugs 0.000 description 1
- 235000011086 calcium lactate Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 210000004379 membrane Anatomy 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 206010040400 serum sickness Diseases 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Non-Alcoholic Beverages (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明はカルシウム水溶液剤、更に詳細には、服用が容
易で１体内への吸収がよいにもかかわらず、血中濃度を
一時的に急激に上昇させることがなく安全で、しかも長
期間保存しても安定な飲料用のカルシウム水溶液剤に関
する。[Detailed Description of the Invention] [Field of Industrial Application] The present invention relates to an aqueous calcium solution, and more particularly, to a calcium aqueous solution, which is easy to take and has good absorption into the body, but which temporarily and rapidly lowers blood concentration. This invention relates to a calcium aqueous solution for drinking that is safe without causing any increase in calcium and is stable even when stored for a long period of time.
栄養素としてのカルシウムは１発育期の幼小児の骨歯の
発育に欠くことのできないものであると共に、テタニー
、けいれん、血清病。Calcium as a nutrient is indispensable for the development of bones and teeth in young children during the 1st developmental period, and it also prevents tetany, convulsions, and serum sickness.
じんま疹等のアレルギーの予防及び治療に使用されてい
る。It is used to prevent and treat allergies such as hives.
わが国は火山国であり、酸性土壌が多いために、カルシ
ウム欠乏地域に属し、また農産物由来のカルシウムが少
ないために、一般の食事のみでは、どうしてもカルシウ
ムが不足しがちである。Japan is a volcanic country with a lot of acidic soil, which makes it a calcium-deficient region.Also, there is little calcium from agricultural products, so regular diets tend to be deficient in calcium.
斯かるカルシウムの欠乏を補うために、カルシウム全強
化した食品も上布されているが。In order to compensate for this calcium deficiency, foods that are completely fortified with calcium are also being marketed.
カルシウムの添加量が多くなると味が悪くなるので多量
の添加が困難である。また、医薬用のカルシウム剤とし
て、粉末、顆粒１錠剤。It is difficult to add a large amount of calcium because the taste deteriorates when the amount of calcium added increases. In addition, one tablet of powder and granules is available as a pharmaceutical calcium agent.
糖衣錠、カプセル剤等の固形製剤が提供されているが、
これらは服用量が多い、吸収が悪い１服用時水が必要で
ある等の問題があった。Solid preparations such as sugar-coated tablets and capsules are available, but
These drugs have problems such as large doses, poor absorption, and the need for water for each dose.
従って、カルシウム剤の溶液化が望まれ。 Therefore, it is desired to form a calcium agent into a solution.
次の製剤、■塩化化層ルシウムグルコン酸カル／ウム等
のカルシウム化合物の水浴液を半透膜を用いて電気分解
し、ｅｘ極側のカルシウムイオン水を分離した電解カル
シウム液、および■カキガラ（生薬名ニー？レイ）中の
カルシウム分を酢酸を用いて抽出して製造したカルシウ
ム酢酸溶液が提供されている。The following preparations, ■ Electrolytic calcium solution obtained by electrolyzing a water bath solution of a calcium compound such as calcium chloride layer lucium gluconate using a semipermeable membrane and separating the calcium ion water on the ex electrode side, and ■ Persimmon shell ( Calcium acetate solution is produced by extracting the calcium content of the herbal medicine (Nie? Lei) using acetic acid.
しかしながら、■の電解カルシウム液は、ｐＨ１１〜１
２の強アルカリ性であるため味が悪く飲み難いと共に、
粘膜をめらしたり胃内ｐＨを大きく変動させるおそれが
ある。空気中の炭酸ガスによって炭酸カルシウムの沈澱
金主じ保存安定性が悪い、カルシウムがイオン化されて
いるといわれているがカルシウム濃度は低く、水酸化カ
ルシウムの飽和溶液と大差がないなどの欠点があった。However, the electrolytic calcium solution (■) has a pH of 11 to 1.
Because it is strongly alkaline, it tastes bad and is difficult to drink.
There is a risk of staining the mucous membranes or significantly changing the pH in the stomach. It has disadvantages such as poor storage stability as calcium carbonate precipitates due to carbon dioxide gas in the air, and although calcium is said to be ionized, the calcium concentration is low and is not much different from a saturated solution of calcium hydroxide. Ta.
また■のカルシウム酢酸溶液は酢酸臭が強いと共に味が
悪く、服用が困難であるという欠点があった。In addition, the calcium acetate solution (2) had a strong acetic acid odor and bad taste, making it difficult to take.
従って、従来から、ＣＤ味がよくて服用し易い、＠吸収
がよく、シか４血中濃度の急激な上昇がなく安全である
。０長期間保存しても沈澱を生ずることがなく保存安定
性がよいカルシウム水溶液剤の開発が所望されていた。Therefore, CDs have been known to have a good taste, are easy to take, are well absorbed, and are safe because they do not cause a sudden increase in blood concentration. It has been desired to develop an aqueous calcium solution that does not form precipitates even when stored for a long period of time and has good storage stability.
斯かる実状において５本発明者は鋭意研究を行った結果
１次の成分を含有するカルシウム水溶液剤が上記目的全
具備することを見出し１本発明を完成した。Under such circumstances, the inventors of the present invention conducted extensive research and found that an aqueous calcium solution containing the following components satisfies all of the above objects, and completed the present invention.
すなわち１本発明は、カルシウム剤３〜ｌ Ｏｗ ／
ｖ％、安息香酸α０１〜αｉ ｗ ／ ｙ％、食塩α０
１〜α１ｗ／ｖ％及び有機酸を含有しｓ ｐ”ｔ ３
〜５に調整したことを特徴とするカルシウム水溶液剤を
提供するものである０
本発明においてカルシウム剤と１−ては１日本薬局方（
第１１改正）に収載されている沈降炭酸カルシウム、リ
ン酸水素カルシウム。That is, 1 the present invention provides a calcium agent 3~l Ow/
v%, benzoic acid α01~αi w/y%, salt α0
1 to α1 w/v% and an organic acid.
This invention provides an aqueous calcium solution characterized by having an aqueous calcium concentration of 1-5.
Precipitated calcium carbonate and calcium hydrogen phosphate listed in the 11th Amendment).
グルコン酸カルシウム、乳酸カルシウム、塩化カルシウ
ム等を使用することができるが、その中でもグルコン酸
カルシウムが特に好ましい。このカルシウム剤は３〜１
０ｗ／ｖ幅で配合される。Calcium gluconate, calcium lactate, calcium chloride, etc. can be used, and among these, calcium gluconate is particularly preferred. This calcium agent is 3 to 1
It is blended with a width of 0w/v.
安息香酸は防腐剤として機能すると共に、保存中にカル
シウム剤が白濁・沈澱するのを防止する作用を有する。Benzoic acid functions as a preservative and also has the effect of preventing calcium agents from becoming cloudy and precipitating during storage.
安息香酸の配合量ｒよ０．０１〜０．１ｗ／ｖ％が好ま
しい。面この安息香酸の溶解補助剤としてグロビレング
リコールを加えることもできる。The blending amount r of benzoic acid is preferably 0.01 to 0.1 w/v%. Globylene glycol can also be added as a solubilizing agent for benzoic acid.
食塩は矯味料として加えられるものであり。Salt is added as a flavoring agent.
その配合量はα０１〜α１ ｗ ／ ｖ％が好ま１−い
０
有機酸としては、クエン酸、酒石酸、リンゴ酸等が挙げ
られるが、その中でもクエン酸が好ましい。有機酸の配
合量はｐＨ全３〜５に調整できる量でおることが必要で
おり、グルコン酸カルシウム／クエン酸の場合には、重
量比で１００１５〜１００／１０の範囲が好ましい。尚
ｐｌｆの調整には上記有機酸に塩酸等の無機酸、水酸化
す） ＩＪウム等のアルカリを併用することもできる。The blending amount is preferably α01 to α1 w/v% 1-0. Examples of the organic acid include citric acid, tartaric acid, and malic acid, among which citric acid is preferred. The amount of organic acid blended must be in an amount that can adjust the total pH to 3 to 5, and in the case of calcium gluconate/citric acid, the weight ratio is preferably in the range of 10015 to 100/10. Incidentally, in order to adjust the plf, an inorganic acid such as hydrochloric acid, or an alkali such as hydroxide, etc. can be used in combination with the above organic acid.
本発明のカルシウム水溶液剤に＃：ｔ１上記必須成分の
ほかに、斯かる場合に一般に使用される任意成分１例え
ば甘味料、香料、他の薬効成分等を配合することができ
る。なお香料としてはカルシウム剤の沈澱を防止するた
めに精油成分が少ないもの１例えばカンキツ系１特に精
油成分含量の少ないグレープフルーツ系のものが好まし
い。In addition to the above-mentioned essential components #:t1, the calcium aqueous solution of the present invention may contain optional components commonly used in such cases, such as sweeteners, fragrances, and other medicinal components. In order to prevent precipitation of the calcium agent, as a flavoring agent, it is preferable to use one containing a small amount of essential oil, such as a citrus-based fragrance, and particularly a grapefruit-based fragrance containing a small amount of essential oil.
本発明のカルシウム水溶液剤は１例えば６０〜１００″
Ｃに加熱した水に有機酸、次いでカルシウム剤を加えて
溶解し、これに食塩、安息香酸及び他の任意成分を加え
た後ｐＨｋ調整し、最後に香料を添加することにより製
造される。The calcium aqueous solution of the present invention has a diameter of 1, for example 60 to 100''
It is produced by adding an organic acid and then a calcium agent to water heated to C and dissolving it, adding salt, benzoic acid and other optional ingredients, adjusting the pH, and finally adding a flavoring agent.
叙上の如くして得られる本発明のカルシウム水溶液剤は
、体内への吸収がよく、これをカルシウムとして１７０
〜４５０１ｔｌｉｔ全１日２〜３回に分けて服用すれば
血清中のカルシラ４！１度を恒状値の９〜１１００ｊ１
／ａに保つことができる０また。このカルシウム水溶液
剤は水なしで何処でも服用でき、しかも味がよいので服
用が容易であると共に、保存安定性もよい。The calcium aqueous solution of the present invention obtained as described above is well absorbed into the body, and has a calcium content of 170%.
~4501tlit If taken in 2 to 3 doses throughout the day, the serum Calcilla 4!1 degree will be reduced to the normal value of 9 to 1100j1
/a can also be kept at 0. This calcium aqueous solution can be taken anywhere without water, has a good taste, is easy to take, and has good storage stability.
次に実施例を挙げて説明する。 Next, an example will be given and explained.
実施例１
■ グルコン酸カルシウム ７５０ｆ■
クエン酸 ４５１ｅ） ソル
ビット １２５０Ｆ■食塩
６２
■ 安息香酸 １ｔ■ ？リエ
チレングリコール ５０ｆ■塩酸
適量
■ 水酸化ナトリウム 適量［相］ 精製
水 バランス合計
ＩＱＯＯＯｄ
く調製法〉
８０〜９０℃に加熱した精製水６５００ｍｌに■を溶解
してｐｉｉ ３〜５とし、これに■、■。Example 1 ■ Calcium gluconate 750f■
Citric acid 451e) Sorbitol 1250F■ Salt
62 ■ Benzoic acid 1t ■ ? Liethylene glycol 50f■ Hydrochloric acid
Appropriate amount■ Sodium hydroxide Appropriate amount [Phase] Purified water Balance total
Preparation method> Dissolve ■ in 6500 ml of purified water heated to 80 to 90°C to prepare pii 3 to 5, and add ■ and ■ to this.
■を溶解した。これに、■全量に溶かしたものを加え、
■及び■でｐＨを約４に調整し、最後に■を加え、更に
＠で全量１へ０００ ｍｌとしてカルシウム水溶液剤を
得た。■ was dissolved. To this, add the dissolved one to the total amount,
The pH was adjusted to about 4 with (1) and (2), and finally (2) was added, and the total volume was adjusted to 1,000 ml with @ to obtain a calcium aqueous solution.
以上
手続補正書（自発］
１． 事件の表示
昭和６３ 年特許願第 ９７５４０ 号２、 発明の
名称
カルシウム水溶液剤
３、 補正をする者
事件との関係 出願人
名 称 日水裏栗株式会社
４、代理人
住 所 同 上
６、補正の対象
明細書の「発明の詳細な説明」の欄
７、 補正の内容
（１） 明細書中、第９頁第２行
「９〜１００ｍｇ／ｄｚｊとめるｔ
［９〜１０ ｍｙ／ ｄｇ ｊと訂正する。Written amendment to the above procedures (voluntary) 1. Indication of the case: Patent Application No. 97540 of 19882, Name of the invention: Calcium aqueous solution 3, Person making the amendment Relationship to the case: Applicant name: Nissui Urakuri Co., Ltd. 4, Agent Personal address Same as above 6, "Detailed description of the invention" column 7 of the specification subject to amendment, Contents of amendment (1) In the specification, page 9, line 2, "9 to 100 mg/dzz stop [9 Corrected to ~10 my/dg j.
Claims (1)
〜０．１ｗ／ｖ％、食塩０．０１〜０．１ｗ／ｖ％及び
有機酸を含有し、ｐＨを３〜５に調整したことを特徴と
するカルシウム水溶液剤。 ２、グルコン酸カルシウム３〜１０ｗ／ｖ％、安息香酸
０．０１〜０．１ｗ／ｖ％、食塩０．０１〜０．１ｗ／
ｖ％及びクエン酸を含有し、ｐＨを３〜５に調整したこ
とを特徴とするカルシウム水溶液剤。[Claims] 1. Calcium agent 3-10 w/v%, benzoic acid 0.01
-0.1 w/v%, 0.01-0.1 w/v% of common salt, and an organic acid, and has a pH adjusted to 3-5. 2. Calcium gluconate 3-10w/v%, benzoic acid 0.01-0.1w/v%, salt 0.01-0.1w/
An aqueous calcium solution containing v% and citric acid, and having a pH adjusted to 3 to 5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63097540A JP2665764B2 (en) | 1988-04-20 | 1988-04-20 | Calcium aqueous solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63097540A JP2665764B2 (en) | 1988-04-20 | 1988-04-20 | Calcium aqueous solution |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01268638A true JPH01268638A (en) | 1989-10-26 |
| JP2665764B2 JP2665764B2 (en) | 1997-10-22 |
Family
ID=14195078
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63097540A Expired - Fee Related JP2665764B2 (en) | 1988-04-20 | 1988-04-20 | Calcium aqueous solution |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2665764B2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07277967A (en) * | 1994-04-06 | 1995-10-24 | Yoshida Yakuhin Kogyo Kk | Aqueous calcium preparation for oral administration and its preparation |
| JP2006288331A (en) * | 2005-04-14 | 2006-10-26 | Nittetsu Fine Prod:Kk | Method for producing nutritious functional food by using unpolished rice, and nutritious functional food obtained by the same |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5588685A (en) * | 1978-12-27 | 1980-07-04 | Taishi Iogi | Health drink composition |
| JPS5931710A (en) * | 1982-08-17 | 1984-02-20 | Masaki Takahara | Drinking solution for supplying calcium |
| JPS62501846A (en) * | 1985-02-19 | 1987-07-23 | ボ−ド・オブ・リ−ジェンツ・ザ・ユニバ−シティ−・オブ・テキサス・システム | liquid dietary calcium supplement |
| JPS6322522A (en) * | 1986-07-01 | 1988-01-30 | サンド・アクチエンゲゼルシャフト | Improvement on calcium salts |
| JPH02212A (en) * | 1987-10-14 | 1990-01-05 | Takeda Chem Ind Ltd | Aqueous drug preparation for oral administration |
-
1988
- 1988-04-20 JP JP63097540A patent/JP2665764B2/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5588685A (en) * | 1978-12-27 | 1980-07-04 | Taishi Iogi | Health drink composition |
| JPS5931710A (en) * | 1982-08-17 | 1984-02-20 | Masaki Takahara | Drinking solution for supplying calcium |
| JPS62501846A (en) * | 1985-02-19 | 1987-07-23 | ボ−ド・オブ・リ−ジェンツ・ザ・ユニバ−シティ−・オブ・テキサス・システム | liquid dietary calcium supplement |
| JPS6322522A (en) * | 1986-07-01 | 1988-01-30 | サンド・アクチエンゲゼルシャフト | Improvement on calcium salts |
| JPH02212A (en) * | 1987-10-14 | 1990-01-05 | Takeda Chem Ind Ltd | Aqueous drug preparation for oral administration |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07277967A (en) * | 1994-04-06 | 1995-10-24 | Yoshida Yakuhin Kogyo Kk | Aqueous calcium preparation for oral administration and its preparation |
| JP2006288331A (en) * | 2005-04-14 | 2006-10-26 | Nittetsu Fine Prod:Kk | Method for producing nutritious functional food by using unpolished rice, and nutritious functional food obtained by the same |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2665764B2 (en) | 1997-10-22 |
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