JPS5931710A - Drinking solution for supplying calcium - Google Patents

Abstract

PURPOSE:A drinking solution for supplying calcium having improved solubility of calcium phosphate and/or calcium malate in water and absorption from digestive tubes, obtained by blending calcium phosphate and/or calcium malate with sugaralcohol and an organic acid, dissolving it in water transparently. CONSTITUTION:Calcium phosphate and/or calcium malate is blended with sugaralcohol, an organic acid, and water, and dissolved transparently, to give a drinking solution for supplying calcium useful as a medical drinking, containing 2,400 mg/100ml calculated as calcium ion concentration of calcium phosphate and/or calcium malate, 28-98pts.wt. sugaralcohol and 3-7pts.wt. organic acid based on 1pt.wt. calcium phosphate and/or calcium malate. Since the drinking solution can contain calcium in a high concentration, it shows effects with a small amount, and it is well absorbable from digestive tubes since calcium is completely dissolved. It has a number of merits such as extremely good palatability when the calcium ion concentration is <=800mg/100ml.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a drinking liquid for replenishing calcium that can be widely used as a medical or track maintenance drink.

Calcium, along with iron, is one of the inorganic components that are most easily deficient in the human body. Since calcium is deposited in bones in the form of phosphate, it is desirable that the ratio of calcium to phosphorus in body fluids be close to the ratio of calcium to phosphorus in bones. Therefore, it was considered most preferable to use calcium phosphate for calcium supplementation.

However, calcium phosphate has extremely low solubility in water and is almost insoluble, so even if it is mixed with water as it is, it cannot produce a drinkable liquid.

In addition, absorption from the gastrointestinal tract is extremely poor, making it unsuitable for the purpose of calcium supplementation. moreover,
Since it has no taste, it gives an unpleasant sensation of chewing sand, making it unsuitable for long-term use. Therefore, eliminating these shortcomings has been desired by the pharmaceutical industry for many years.

Calcium lactate is known as a water-soluble calcium salt. However, calcium lactate has the drawback that overdosing causes side effects such as skeletal muscle relaxation, anorexia, weight loss, muscle pain, arthralgia, constipation, and stone disease.

Furthermore, as a method for obtaining an aqueous solution containing calcium ions, a method described in Japanese Patent Publication No. 48-33875 is known. , - proposes a method of producing a saturated aqueous solution of calcium ions in the cathode chamber by electrolyzing an aqueous solution of calcium salts such as calcium lactate and calcium gluconate. However, the product obtained by this method has a calcium ion content of 2 (8 at 1'C), which is highly alkaline and cannot be taken in large quantities.
51□18/' 10 (l ml (saturated water) 8 liquids)
However, its concentration was low, and it also had the disadvantage of absorbing carbonic acid in the air and easily forming calcium carbonate precipitates.

As a result of repeated research in an attempt to obtain a calcium solution that does not have the drawbacks mentioned in -1-, the inventor discovered that adding an organic acid (e.g. citric acid) to a water suspension of calcium phosphate fine powder causes calcification. It was discovered that the liquid became slightly transparent, and that by adding a sugar alcohol (for example, sorbitol), a clear solution could be obtained. It has also been found that calcium malate can be used similarly. Note that, if only a sugar alcohol is used without using an organic acid, no transparency effect can be obtained at all.

This invention was made based on such knowledge.

The present invention is a drinking liquid for replenishing calcium, which is obtained by mixing calcium phosphate and/or calcium malate with sugar alcohol, organic acid, and water and dissolving the mixture transparently.

The calcium phosphate used in this invention is calcium phosphate (C
u3(1'(')J2, Ca1-fPo, ・2112
0, etc.), as well as beef bones whose main component is calcium phosphate,
Contains bone powder such as fist bones and fish bones. One of the suitable ones is
It is called colloidal calcium phosphate (fine particulate calcium phosphate with a size of 1.08 microns or less). Sugar alcohols include sorbitol, malnatol (reduced maltose), etc. 70
Used as a ~75% aqueous solution. As the organic acid, lower fatty acids or polyvalent fatty acids suitable for medicine and drinking, such as citric acid, tartaric acid, fumaric acid, and malic acid, are used. In addition, ]-, the sugar alcohol or organic acid is
Two or more types of J- may be used in combination.

The concentration of calcium phosphate and/or calcium malate in the drinking liquid for calcium supplementation of the present invention is 2400 n+g/100 pal or less in terms of calcium. If it is more than this, the transparentizing effect will not be achieved regardless of the amount of sugar alcohol and organic acid. There is no particular restriction on the lower limit, but in light of the purpose of use, the lower limit is 20+')
mg/ml or higher is preferred. Calcium phosphate or/
And the weight ratio of calcium malate, sugar alcohol and organic acid is 1 (calcium equivalent): 28-99:3-
It is 7. If it deviates from this range, the transparency effect will not be achieved (if it is below the lower limit), or no further transparency effect will be obtained, and it will be economically disadvantageous (if it is below the lower limit).

When mixing these various components, it is desirable to use a stirring device such as a mixer. The temperature during mixing is preferably room temperature or higher. Mixing and dissolving can be carried out either batchwise or continuously.

=4-1q The solution contains fruit juice, sweeteners such as sugar, flavoring agents,
It is not possible to add coloring agents, natural ingredients (stabilizers), alcohol, etc. It can also be diluted (for example, 50 times) by mixing with other beverages or diluents.

According to the invention, a drinking liquid containing a high concentration of calcium (for example 240 flog/100 ml as calcium ions) is obtained. Therefore, the calcium replenishing drinking liquid of the present invention is suitable as a calcium replenishing agent for pregnant women, which is effective in small amounts. For example, the average lucium deficiency per eye for pregnant women is said to be 452 U (according to the Ministry of Health, Labor and Welfare's 1978 revised "Nutritional Requirements for Japanese People 1"). So, you can compensate for the lack of calcium by taking only 18.7n+l.

In addition, the drinking liquid of the present invention has good absorption rate because calcium is completely dissolved. In addition, especially when the calcium ion concentration is below 800mg/100+nl,
The sugar alcohol provides a moderate taste and the organic acid provides a moderate sourness, resulting in an extremely good drinking liquid. Furthermore, since it is slightly acidic, it does not harm the stomach and intestines even if consumed in large quantities, unlike strongly alkaline drinks, so it is suitable for long-term use.

-1- It has good stability and does not form a precipitate even when mixed with a drink or left in air containing carbon dioxide.

Moreover, it can be manufactured simply by combining and mixing each component, which requires less production equipment costs. Also, during production, there is no danger involved as in the case of electrolysis. Thus, the present invention has excellent effects.

Next, the present invention will be explained in more detail using examples.

Example 1 Container with stirrer (Matsushita Electric juice mixer, capacity ft.
1000ml)) 70% sorbitol 500ml (
1.30.6508 (specific gravity: 1.30.6508), and while stirring, gradually added beef bone powder (main component: calcium phosphate N, 3.5 g (*Lucium content: 500 f) m). uniformly (d,
After dispersing, add citric acid (anhydrous) 258, continue stirring for about 7 to 20 minutes, leave to stand, and after the bubbles have completely disappeared, check to see if the solution is transparent. If it is not clear, add a small amount of citric acid and stir further. A portion of the solution was diluted 5 times in total and centrifuged (3000lii/
The end point is when no precipitate is observed after 3 minutes.

In this way, 1 (1) diluted clear drinking liquid (100B
/loo+nl) -) and requested analysis of 11 bottles at the Food Analysis Center (No.(') S 2 !i l'l 6
(No.-1288), the result of 1. is qrt.

1. Test [1] Test whether calcium exists in the sample solution as calcium ions.

2. Test) J method (1) Quantify calcium in the test solution.

(2) Pour 10+nl of the sample solution into a cation exchange resin (Granix 51 wx 8, H type) and add 50ml of pure water.
1 and place the calcium on the eluate.

(3) Test solution 5t111 was treated with an anion exchange resin (GREX IX8, CI type) in the same manner as in (2).

3. Test results 4. Discussion When calcium is dissolved in an aqueous solution, calcium ions as cations or calcium complexes as anions can be considered, but from the test results, the calcium in the test solution is All are adsorbed on the cation exchange resin and not on the anion exchange resin. That is, it is considered that all the calcium in the test solution exists as calcium ions.

- It can be seen that in Example 1, all of the calcium in the calcium phosphate was dissolved in the form of calcium ions.

Example 2 The clear solution obtained in Example 1 (Calcium 500oII1
g8- / 500 + a l ) 10 ++ l water 171
) ml, citric acid o, 1B, BXIl equivalent mouse sugar, and 20+^1 orange juice are added, and stirred thoroughly to prepare a drinking liquid.

Example 3 The clear solution obtained in Example 1 (calcium 5oool II
Add an equivalent amount of sugar and stir thoroughly. Add a sterilized lactic acid drink equivalent to 0.8% non-fat milk solids to this,
Add water to make a total volume of 200ml and stir thoroughly to prepare a drinking liquid. This product does not coagulate and precipitate milk solids even if left standing.

Examples 4 to 7 Clear drinking liquids were obtained using the raw materials in the proportions shown in the table below and operating in the same manner as in Example].

Example 8 125 g of colloidal calcium phosphate obtained by finely powdering beef bone meal (5 g of calcium), 40 g of malic acid, and 500+ n of maltitol (reduced maltose, 75% aqueous solution)
1 was treated in the same manner as in Example] to obtain a drinking liquid (calcium 5
0 (l OII+g/500IIll) is obtained.

The calcium ion concentrations in the drinking liquids prepared in Examples 4 to 8 above and the conventional product (according to Japanese Patent Publication No. 48-33875) (both calcium ion-saturated aqueous flk) are shown in FIG. It can be seen from FIG. 1 that the calcium ion saturated Jli liquid of the present invention contains about 12 to 28 times more calcium ions than the conventional product.

[Brief explanation of drawings]

FIG. 1 is a diagram showing calcium ion concentrations in the drinking liquids obtained in Examples 4 to 8 and conventional products. Patent applicant Tadashi Takahara Patent attorney Hajime Aoyama (and one other person) 11- Figure 1 12- Commissioner of the Patent Office Display of the case 1982 Patent application No. 143149 Name of the invention Correction of drinking liquid for calcium supplementation Patent applicant address: 86 Midorigaoka, Yamahara, Kawanishi City, Hyogo Prefecture Name: Masaki Takahara Date of attorney's amendment order - Subject of voluntary amendment Column 7 for detailed explanation of the invention filed, details of the amendment The following points have been corrected in this document. (]) Page 44 55 It says 7? Corrected to "normal". (2) Page 5, lines 5-7 ``No more'' 2...no more. It says “r5400”&/
Although the transparency effect can be achieved up to a concentration of about 100 ml5, at such a high concentration the viscosity is too high and the fluidity is poor, making it extremely inconvenient to handle. Therefore, in practice, as above < 2400■/100m1
The following is desirable. ” and corrected. (3) Page 5, line 8 r200+111//mJj is r200#If/
Corrected to "100-". (4) Insert the following sentence between lines 11 and 12 on page 7. "In addition to taking the drinking liquid of the present invention as it is, it may also be added to other drinks and foods as a calcium-fortifying additive." (Page 5112, lines 3-6 [(Both ...Drinking liquid" is replaced with "The concentration of calcium ions in the liquid is shown in Figure 1. From Figure 1, the concentration of calcium ions in this invention is shown.
Corrected. Above 83

Claims (1)

[Scope of Claims] (]) A drinking liquid for calcium replenishment, which is obtained by mixing at least one of calcilla phosphoric acid and calcium malate, a sugar alcohol, an organic acid, and water and dissolving the mixture transparently. (2) Calcium content of at least one of calcium phosphate and calcium malate: 2400mg 7100ml
The drinking liquid according to claim 1, which contains the following concentration and uses 28 to 98 parts by weight of sugar alcohol and 3 to 7 parts by weight of organic acid per 1 part by weight of calcium.