JPS61172822A - Ionized calcium preparation for oral administration containing electrolyzed oyster shell - Google Patents

Abstract

PURPOSE:To provide the titled preparation having excellent transintestinal absorbability and mitigated irritation and unagreeable feeling to the mouth and gastric mucosa in the administration of ionized calcium preparation, by adding reduced maltose and/or citric acid to ionized calcium of electrolyzed oyster shell. CONSTITUTION:The ionized calcium of electrolyzed oyster shell is a Ca preparation produced from electrolyzed oyster shell obtained by the electrolytic purification of oyster shell, and has remarkably high transintestinal absorbability compared with conventional Ca preparation. However, it has strong alkalinity and is liable to cause stimulation and nausea when administered in a empty stomach. It has been found that the disagreeable feeling of the ionized calcium of electrolyzed oyster shell can be mitigated without lowering the transintestinal absorbability of the ionized calcium by adjusting the pH of the preparation with reduced maltose and/or citric acid. The amounts of the reduced maltose and citric acid are preferably 0.3-3pts. and 1-2pts. per 1pt. of the ionized calcium of electrolyzed oyster shell.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an oral calcium preparation that reduces irritation and discomfort to the mucous membranes of the mouth and stomach when ionized calcium is taken.

It has recently been discovered that calcium is not only a building block for strong bones and teeth, but also plays an important role in purifying the blood and maintaining human life in areas such as the brain, nerves, heart, and muscles. This has been elucidated one after another through research.

In particular, many scholars have pointed out that most of the so-called adult diseases are caused by a lack of minerals such as calcium, and the Ministry of Health and Welfare has also announced that the health status of 100 million and a half people today is due to a lack of calcium. It has become clear that it will.

The main source of calcium supplementation for humans is milk and water, which contain ionized calcium, but since Japan's national treasure is made of volcanic soil, the water in Japan is only about B compared to water in Europe. Because it contains only 100% of calcium, Japanese people suffer from a chronic calcium deficiency, which leads to impairments in the various functions mentioned above.

Therefore, it goes without saying that to improve this semi-healthy state, it is necessary to supplement with sufficient calcium, but even if you eat fish bones and seaweed that contain a lot of calcium, very little of it is absorbed by the body. Calcium is an element that originally exists in the form of ions, so it cannot be absorbed by the body unless it is ionized.

Due to the complicated absorption mechanism of calcium preparations, not much effort has been made in the formulation or manufacturing method, but in order to effectively absorb large amounts of calcium and completely eliminate discomfort, more efforts have now been made. Several problems had to be resolved.

Therefore, ionized calcium preparations have recently been developed.

In view of this situation, the present applicant has previously developed a calcium preparation containing other minerals, using electrolytic borey obtained by electrolytically refining oyster shells as a raw material.

The ionization concentration of this electrolyzed polay ionized calcium was determined to be 10,000μS/1117F by measuring the electrical conductivity by the Japan Food Research Center Foundation! (25℃)
It has a high measurement value of 81 to 790μS/α (at 25℃) of other commercially available calcium preparations, and has excellent intestinal absorption, and is currently used in medical institutions such as university hospitals. It is actively used for the prevention and treatment of diseases caused by calcium deficiency.

Regarding the intestinal absorption of electrolyzed ionized calcium, please refer to "Pharmaceutical Factory", Vol. 4, No. 1, published by Medical Journal Co., Ltd.
No. 2 (1984), Professor Takuo Fujita of the Third Department of Internal Medicine, Kobe University School of Medicine reported.

However, this electropolymerized ionized calcium preparation, which has excellent intestinal absorption, has the disadvantage that when taken on an empty stomach, some people, especially the elderly and people with weak stomachs, may find it irritating and may be accompanied by a window of vomiting.

The present inventor found that the cause of this was due to H, which is a strong alkali of electrolytic ionized calcium, and as a result of extensive research, the present invention was achieved.

In other words, if you take electrolyzed boley ionized calcium that is strongly alkaline with a pH of 10 or higher and dissolve it all at once, it will suddenly become strongly alkaline, causing a rapid neutralization reaction with the acid in the stomach (PH 1-2), and reducing the acidic situation in the stomach. This is thought to result in a lack of balance, which manifests itself in vomiting windows and stomach pain.

Therefore, the pH of electrolytic boley ionized calcium was set to 10 to 4.
The conclusion was that by making it slightly alkaline and dissolving it gradually in the stomach, or neutralizing it even if it suddenly dissolves, changes such as the vomiting window and stomach pain may not occur. As a result of examining various H adjusters, we found that reduced maltose and citric acid can adjust the pH without reducing the intestinal absorption of electrolyzed ionized calcium. This has led to the completion of the present invention.

The mixing ratio (weight ratio) of reduced maltose and citric acid to electrolytic boley ionized calcium is not very strict, but as a guide, it is 0.5 to 3 for reduced maltose and 0.5 to 3 for citric acid to 1 part electrolytic boley ionized calcium. is preferably 1 to 2, and similar effects were obtained even when reduced maltose and citric acid were used together.

Prescription example l.

Electrolytic Borei ionized calcium 30% (by weight) Powder Unreduced maltose 70% or more is mixed with water, granulated, dried, and then tableted using a tablet machine.

Formulation Example 2゜Polymerized 50% ionized calcium and 50% powdered unreduced maltose were compressed into tablets in the same manner as in Formulation 1.

Formulation Example 3゜Electrolytic Borei 40% ionized calcium and 60% citric acid were compressed into tablets in the same manner as in Formulation 1.

Formulation Example 4゜Electrolytic Borei ionized calcium was 33%, powdered unreduced maltose was changed to 50%, and citric acid was changed to 17%, and the tablets were compressed in the same manner as in Formulation 1.

All of the electrolytic Borei ionized calcium preparations prepared according to the above formulations did not cause discomfort unlike conventional ones when taken.

Patent Applicant: Fuji Planning Co., Ltd. Written Amendment to Procedural Procedures (voluntarily submitted) June 4, 1985 Manabu Shiga, Director General of the Patent Office1, Indication of the Case 1985 Patent Application No. 136082, Name of the Invention Oral Electrolytic Boray Ionization Calcium Preparation 3, Relationship with the Amendment Case Patent Applicant Address 5-59-4 Yoyogi, Shibuya-ku, Tokyo Name
Fuji Planning Co., Ltd. 4. As stated in the agent's attachment 7. Contents of the amendment (1) On page 1, line 18 of the specification, "Mineral deficiency" is amended to read "Mineral deficiency."

(2) On page 2, line 4, "milk and water" is corrected to "milk and natural water."

(3) Page 3, lines 5 to 7 “The applicant also...
developed. '' should be amended to ``In view of this situation, the present applicant has also developed an electrolytic boley ionized calcium preparation containing minerals obtained by electrolytically refining bull's-tail shells.''

(4) On page 4, lines 15 and 16, "there...gradually" is corrected to "gradually apply electrolytic ionized calcium there."

(5) On page 5, lines 15 and 16, "the above is...compressed into tablets." is replaced with "the above is compressed into tablets using a general formulation method."
and correct it.

Claims (1)

[Claims] An oral electrolytic Borei ionized calcium preparation characterized by blending electrolytic Borei ionized calcium with reduced maltose and/or citric acid.