JP2906215B2 - High concentration calcium containing liquid - Google Patents
High concentration calcium containing liquidInfo
- Publication number
- JP2906215B2 JP2906215B2 JP6221382A JP22138294A JP2906215B2 JP 2906215 B2 JP2906215 B2 JP 2906215B2 JP 6221382 A JP6221382 A JP 6221382A JP 22138294 A JP22138294 A JP 22138294A JP 2906215 B2 JP2906215 B2 JP 2906215B2
- Authority
- JP
- Japan
- Prior art keywords
- calcium
- high concentration
- present
- containing liquid
- drink
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
【０００１】[0001]
【産業上の利用分野】本発明は、カルシウムを高濃度に
含有することができ、しかも飲み易いカルシウム含有液
剤に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a calcium-containing solution which can contain calcium at a high concentration and is easy to drink.
【０００２】[0002]
【従来の技術】カルシウムは生体代謝に重要な役割を果
たす物質であり、特に骨格形成においては不可欠成分で
ある。従来から、我国においてはカルシウムの摂取不足
が指摘され、特に近年の飽食の時代においても、厚生省
による国民栄養調査結果では、カルシウムの摂取不足が
続いている。2. Description of the Related Art Calcium is a substance that plays an important role in metabolism in living organisms, and is an essential component particularly in skeleton formation. In the past, it has been pointed out that in Japan, the lack of calcium intake has been pointed out, and even in the recent satiety era, according to the results of the National Nutrition Survey by the Ministry of Health and Welfare, the lack of calcium intake has continued.
【０００３】このようなカルシウムの摂取不足を解消す
るため、各種のカルシウム補給剤が開発されている。例
えば、カルシウムを含有する固型剤が知られているが、
体内吸収の点で満足できるものではなく、多大のロスが
生じるという問題があった。[0003] Various calcium supplements have been developed to solve such a lack of calcium intake. For example, solid agents containing calcium are known,
There is a problem that the absorption in the body is not satisfactory and a large loss is caused.
【０００４】このため、体内吸収の点で好ましい液状の
ものも開発されている。従来、カルシウム含有液剤とし
ては、グルコン酸カルシウムを含有したものが知られて
いるが、グルコン酸カルシウムは溶解度が低いため、カ
ルシウム濃度の低い液剤しか得ることができず、特に液
剤を製造する際には他の成分も配合するため、配合でき
るカルシウム濃度はより低くなってしまい、ある一定量
のカルシウムを摂取するには量を多く飲まなければなら
なかった。また、液剤中のカルシウムの沈殿が生じやす
いという問題もあった。特に液剤においては、商品とし
た場合に沈殿が生じないということは非常に重要であ
る。一方、乳酸カルシウムは、グルコン酸カルシウムに
比べ溶解度は高いものの、高濃度で使用すると酸味、し
ぶみ等が強く、味が悪いため、液剤には使用されていな
かった。[0004] For this reason, a liquid which is preferable in terms of absorption into the body has been developed. Conventionally, calcium-containing liquid preparations containing calcium gluconate are known.However, calcium gluconate has low solubility, so that only a liquid preparation having a low calcium concentration can be obtained. Because other ingredients are also added, the calcium concentration that can be added becomes lower, and in order to ingest a certain amount of calcium, the user had to drink a large amount. There is also a problem that precipitation of calcium in the solution is likely to occur. In particular, in the case of a liquid preparation, it is very important that no precipitation occurs when the product is manufactured. Calcium lactate, on the other hand, has higher solubility than calcium gluconate, but when used at a high concentration, it has a strong sourness, sliminess and the like, and has a poor taste.
【０００５】[0005]
【発明が解決しようとする課題】従って、本発明の目的
は、カルシウムを高濃度に含有することができ、しかも
飲み易いカルシウム含有液剤を提供することにある。SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to provide a calcium-containing solution which can contain calcium at a high concentration and is easy to drink.
【０００６】[0006]
【課題を解決するための手段】かかる実情において、本
発明者らは鋭意研究を行った結果、グルコン酸カルシウ
ムと乳酸カルシウムを特定の割合で組合わせて用いれ
ば、相乗的に溶解度が高くなり、高濃度でしかも飲み易
いカルシウム含有液剤が得られることを見出し、本発明
を完成した。Means for Solving the Problems Under such circumstances, the present inventors have conducted intensive studies. As a result, when calcium gluconate and calcium lactate are used in combination at a specific ratio, the solubility increases synergistically, The present inventors have found that a calcium-containing solution having a high concentration and easy to drink can be obtained, and the present invention has been completed.
【０００７】すなわち、本発明は、乳酸カルシウムおよ
びグルコン酸カルシウムを、重量比が５：９５〜５５：
４５となるように含有するカルシウム含有液剤を提供す
るものである。That is, according to the present invention, calcium lactate and calcium gluconate are used in a weight ratio of 5:95 to 55:
It is intended to provide a calcium-containing solution containing 45 or more.
【０００８】本発明のカルシウム含有液剤には、乳酸カ
ルシウムとグルコン酸カルシウムを、重量比が５：９５
〜５５：４５となるように配合するが、この範囲内であ
ると液剤の味が良く、飲み易い。５：９５より乳酸カル
シウムが少ないと、カルシウムを高濃度に配合すること
ができず、５５：４５より乳酸カルシウムが多いと、味
が悪くなる。なお、乳酸カルシウムおよびグルコン酸カ
ルシウムは、水和物として得られる場合もあるが、本発
明においては、これらのいずれでも使用することができ
る。この場合の配合割合は、無水物としての重量比が前
記範囲内であることが必要である。The calcium-containing solution of the present invention contains calcium lactate and calcium gluconate in a weight ratio of 5:95.
It is blended so as to be ~ 55: 45, but when it is within this range, the liquid preparation has good taste and is easy to drink. If the amount of calcium lactate is less than 5:95, calcium cannot be blended at a high concentration, and if the amount of calcium lactate is more than 55:45, the taste becomes poor. In addition, calcium lactate and calcium gluconate may be obtained as hydrates, but any of these can be used in the present invention. In this case, it is necessary that the weight ratio of the anhydride be within the above range.
【０００９】また、乳酸カルシウムとグルコン酸カルシ
ウムは、２０℃におけるカルシウム濃度が４５０mg／１
００ml以上となるように配合するのが好ましく、特に６
００mg／１００ml以上、さらに１０００mg／１００ml以
上となるように配合するのが好ましい。[0009] Calcium lactate and calcium gluconate have a calcium concentration at 20 ° C of 450 mg / l.
It is preferable to mix them so that the amount is at least 00 ml.
It is preferable that the compounding be performed so as to be at least 00 mg / 100 ml, and more preferably at least 1000 mg / 100 ml.
【００１０】本発明のカルシウム含有液剤には、さらに
糖または糖アルコールを配合することができ、これらを
配合することにより、カルシウムの沈殿防止効果や吸収
促進効果を得ることができ、好ましい。The calcium-containing liquid preparation of the present invention may further contain sugar or sugar alcohol, and by adding these, an effect of preventing precipitation of calcium and an effect of promoting absorption can be obtained, which is preferable.
【００１１】ここで、糖としては、例えばブドウ糖、果
糖、ショ糖、麦芽糖、水飴、水溶性のオリゴ糖または多
糖類等を挙げることができ、糖アルコールとしては、例
えばソルビトール、マルチトール、還元麦芽糖水飴、還
元澱粉糖等を挙げることができる。これらのうち、糖ア
ルコール、特にソルビトール、還元麦芽糖水飴が好まし
い。これらの糖および糖アルコールは、１種または２種
以上を組合わせて用いることができ、全組成中に３〜３
０重量％、特に１０〜２０重量％配合するのが好まし
い。[0011] Here, sugars include, for example, glucose, fructose, sucrose, maltose, starch syrup, water-soluble oligosaccharides and polysaccharides, and sugar alcohols such as sorbitol, maltitol, reduced maltose. Examples include starch syrup and reduced starch sugar. Among them, sugar alcohols, particularly sorbitol and reduced maltose starch syrup, are preferred. These sugars and sugar alcohols can be used alone or in combination of two or more.
0% by weight, particularly preferably 10 to 20% by weight is blended.
【００１２】さらに、本発明のカルシウム含有液剤に
は、前記成分のほか、通常の液剤に配合される成分、例
えばアミノ酸類、鉄またはマグネシウムを含有する無機
または有機塩類、ビタミン類、核酸類、胆汁酸類、動植
物抽出液、乳蛋白質、香料、防腐剤、pH調整剤、有機
酸、着色剤等を、本発明の効果を損なわない範囲で必要
に応じて適宜配合することができる。Furthermore, in addition to the above-mentioned components, the calcium-containing liquid preparation of the present invention contains, in addition to the above-mentioned components, inorganic or organic salts containing amino acids, iron or magnesium, vitamins, nucleic acids, bile. Acids, animal and plant extracts, milk proteins, fragrances, preservatives, pH adjusters, organic acids, coloring agents, and the like can be appropriately blended as needed as long as the effects of the present invention are not impaired.
【００１３】本発明のカルシウム含有液剤は、グルコン
酸カルシウムおよび乳酸カルシウムを用い、液剤製造の
常法により製造することができる。The calcium-containing solution of the present invention can be produced by using calcium gluconate and calcium lactate by a conventional method for producing a solution.
【００１４】[0014]
【実施例】次に、実施例を挙げて本発明をさらに説明す
るが、本発明はこれら実施例に限定されるものではな
い。Next, the present invention will be further described with reference to examples, but the present invention is not limited to these examples.
【００１５】実施例１ 富山産業社製の溶出試験器（６連の容器を有する）の各
容器に５００mlの蒸留水を入れ、５０℃に加温する。こ
れに各混合比の乳酸カルシウム、グルコン酸カルシウム
粉体を入れ、パドルを２００r.p.m.で回転させながら６
０分間溶解させた。溶解した液を栓付きのガラス瓶に移
し、２０℃の部屋に放置した。１週間後、この溶液を目
視で観察し、透明で沈殿の発生していないものを溶解し
たと判定し、その溶解量を求めた。結果を表１に示す。Example 1 500 ml of distilled water was put into each container of a dissolution tester (having 6 containers) manufactured by Toyama Sangyo Co., Ltd., and heated to 50 ° C. Calcium lactate and calcium gluconate powders of each mixing ratio are added thereto, and the paddle is rotated at 200 rpm for 6 hours.
Dissolved for 0 minutes. The dissolved liquid was transferred to a glass bottle with a stopper, and left in a room at 20 ° C. One week later, the solution was visually observed, and it was determined that a solution which was transparent and did not generate a precipitate was dissolved, and the amount of the solution was determined. Table 1 shows the results.
【００１６】[0016]
【表１】 [Table 1]
【００１７】実施例２ 表２および表３に示す組成のカルシウム含有液剤を常法
により製造した。Example 2 Calcium-containing solutions having the compositions shown in Tables 2 and 3 were produced by a conventional method.
【００１８】[0018]
【表２】 [Table 2]
【００１９】[0019]
【表３】 [Table 3]
【００２０】本発明のカルシウム含有液剤は、いずれも
カルシウムを高濃度で含有し、１週間保存後も沈殿が生
じることもなく、しかも味が良く飲み易いものであっ
た。特に、糖および／または糖アルコールを含有するも
のは飲み易かった。これに対し、グルコン酸カルシウム
のみを含有する比較品１は、カルシウムを高濃度で配合
することができず、１週間保存後には沈殿が生じた。ま
た、乳酸カルシウムのみを含有する比較品２は、味が悪
く、非常に飲みにくいものであった。The calcium-containing liquid preparations of the present invention all contained calcium at a high concentration, did not precipitate even after storage for one week, and had good taste and were easy to drink. In particular, those containing sugar and / or sugar alcohol were easy to drink. On the other hand, Comparative Product 1 containing only calcium gluconate could not be mixed with calcium at a high concentration, and precipitated after storage for one week. Comparative product 2 containing only calcium lactate had a bad taste and was very difficult to drink.
【００２１】実施例３ 実施例２の本発明品５において、さらに下記の成分を配
合してカルシウム含有液剤を製造した。得られた液剤
は、非常に飲み易いものであった。アスパラギン酸マグ
ネシウム、β−カロチン、塩酸チアミン、リボフラビ
ン、酢酸トコフェロール、アスコルビン酸、タウリン、
ウルソデスオキシコール酸、カゼインナトリウム、カン
ゾウエキス、ヨクイニンエキス、サケ白子エキスExample 3 A calcium-containing solution was prepared by further mixing the following components with the product 5 of the present invention of Example 2. The resulting liquid was very easy to drink. Magnesium aspartate, β-carotene, thiamine hydrochloride, riboflavin, tocopherol acetate, ascorbic acid, taurine,
Ursodesoxycholic acid, sodium caseinate, licorice extract, yokinin extract, salmon milt extract
【００２２】[0022]
【発明の効果】本発明のカルシウム含有液剤は、カルシ
ウムを高濃度で含有することができ、保存中に沈殿が生
じることもない。さらに、味が良く非常に飲み易いもの
であり、カルシウムの摂取不足を解消するための飲料な
どとして有用である。The calcium-containing solution of the present invention can contain calcium at a high concentration and does not precipitate during storage. Furthermore, it has a good taste and is very easy to drink, and is useful as a beverage for resolving insufficient intake of calcium.
───────────────────────────────────────────────────── フロントページの続き (58)調査した分野(Int.Cl.6，ＤＢ名) A61K 31/19 A61K 9/08 A61K 33/06 ＣＡ（ＳＴＮ) ＭＥＤＬＩＮＥ（ＳＴＮ)────────────────────────────────────────────────── ─── Continued on the front page (58) Fields surveyed (Int. Cl. 6 , DB name) A61K 31/19 A61K 9/08 A61K 33/06 CA (STN) MEDLINE (STN)
Claims (3)
ウムを、重量比が５：９５〜５５：４５となるように含
有するカルシウム含有液剤。1. A calcium-containing solution containing calcium lactate and calcium gluconate in a weight ratio of 5:95 to 55:45.
mg／１００ml以上である請求項１記載のカルシウム含有
液剤。2. A calcium concentration at 20 ° C. of 450
2. The calcium-containing liquid preparation according to claim 1, which is at least mg / 100 ml.
る請求項１又は２記載のカルシウム含有液剤。3. The calcium-containing liquid preparation according to claim 1, further comprising a sugar or a sugar alcohol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6221382A JP2906215B2 (en) | 1994-09-16 | 1994-09-16 | High concentration calcium containing liquid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6221382A JP2906215B2 (en) | 1994-09-16 | 1994-09-16 | High concentration calcium containing liquid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0881367A JPH0881367A (en) | 1996-03-26 |
| JP2906215B2 true JP2906215B2 (en) | 1999-06-14 |
Family
ID=16765909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6221382A Expired - Lifetime JP2906215B2 (en) | 1994-09-16 | 1994-09-16 | High concentration calcium containing liquid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2906215B2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3648587B2 (en) * | 1998-03-04 | 2005-05-18 | サンスター株式会社 | Periodontal disease prevention or periodontal disease progression food composition |
| JP5035865B2 (en) * | 2005-09-26 | 2012-09-26 | 国立大学法人高知大学 | Method for inhibiting growth and movement of Helicobacter pylori strain |
-
1994
- 1994-09-16 JP JP6221382A patent/JP2906215B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0881367A (en) | 1996-03-26 |
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