JP5266627B2 - Oral composition - Google Patents

Description

  The present invention relates to an oral composition in which the unpleasant odor exhibited by chitin, chitosan and / or a salt or derivative thereof, bitterness typified by astringency and sashimi is reduced.

  Chitin and chitosan are a kind of functional dietary fiber, which inhibits lipid digestion and absorption (Patent Document 1), suppresses serum cholesterol concentration increase (Non-patent Document 1), suppresses serum uric acid level increase effect and serum uric acid It is known to have a value improvement effect or the like (Patent Document 2). In addition to these, chitin and chitosan have excellent actions in antibacterial properties, wound healing action, cohesiveness, moisture retention and the like.

  Foods containing chitin, chitosan, or easily soluble chitosan (Patent Document 3) have been developed for the purpose of efficiently enjoying such effects. However, the problem when using such chitosan or its derivatives as food is its unpleasant taste and flavor. In particular, chitosan and easily soluble chitosan have a peculiar smell (raw odor) and bitterness such as astringency and savory taste, and are an obstacle to taking chitosan continuously or in large quantities.

  As a method for improving the flavor of foods and drinks containing chitin and chitosan, a method of adding calcium salt and / or sulfate of inorganic acid (Patent Document 4), a method of adding bamboo leaf powder or bamboo leaf extract (Patent Document 5), a method of adding sugars such as trehalose, glycine, xanthan gum and the like (Patent Document 6) are known.

  However, these methods have not yet sufficiently suppressed the unpleasant odor and bitterness of chitin and chitosan.

Japanese Patent No. 2667351 Japanese Patent Application No. 11-344708 JP 63-225602 A JP-A-5-236888 JP-A-8-208709 JP 2001-316271 A Maezaki et al., 1998, FOOD Style 21, 67-71

  An object of the present invention is to provide a chitosan-containing food that improves the unpleasant odor and bitterness of chitosan, and allows daily intake of large amounts of chitosan without difficulty.

  The present inventors have found that an unpleasant odor and bitterness of chitosan are improved by blending taurine, which is itself tasteless and odorless, and an oral composition that is easier to take can be obtained. completed.

(1) An oral composition containing 0.1 to 10% by weight of taurine and chitin, chitosan and / or a salt or derivative thereof.

(2) The oral composition according to (1), comprising 2 to 100 parts by weight of taurine with respect to 1 part by weight of chitin, chitosan and / or a salt or derivative thereof.

(3) The composition for oral administration according to (1) or (2), which is a beverage.

(4) The oral composition according to (3), wherein the pH is 2.5-7.

  The composition of the present invention can provide an oral composition that is extremely easy to take and has improved odor and bitterness of chitin, chitosan and / or salts or derivatives thereof, which have been considered as a problem in the past. In particular, since taurine itself is tasteless and odorless, it is possible to mask the odor and bitterness of chitin, chitosan and / or their salts or derivatives by using an appropriate perfume and flavoring agent. A composition can be provided.

  Physiological effects of chitin and chitosan, such as lipid digestion and absorption inhibitory effect, serum cholesterol level increase inhibitory effect, serum uric acid level increase inhibitory effect, serum uric acid level improvement effect, other antibacterial properties, wound healing effect, cohesiveness, moisture retention It is important to increase the intake of chitin, chitosan and / or their salts or derivatives, but ingesting large amounts of chitin, chitosan and / or their salts or derivatives at the same time It means that the smell or bitterness is felt longer or stronger. The present invention can reduce the odor and bitterness that are easily felt when taking a large amount of chitin, chitosan and / or a salt or derivative thereof by means of taurine, which itself has various benefits for human health. Therefore, it is possible to simultaneously enjoy the benefits derived from large intakes of chitin, chitosan and / or their salts or derivatives and the effects derived from taurine.

  Chitin is generally produced by decalcification and deproteinization of crustacean crusts such as crabs, shrimps and krill, insect crusts such as beetles and grasshoppers, and squid bones. . It can also be obtained from mushrooms and microorganisms. This chitin is further deacetylated to produce chitosan.

  The present invention is effective for chitin and chitosan thus obtained. In addition, as long as chitin or chitosan having an unpleasant odor or bitter taste is contained, the degree of purification of chitin or chitosan is not limited, and may be an unpurified product or a partially purified product.

  In addition, various natural chitin and chitosan or their derivatives have been developed for the purpose of improving the solubility and flavor of chitin and chitosan, and some of them are commercially available. Among these derivatives, there are odors unique to chitin and chitosan. The present invention can be applied to those having a bitter taste.

  In the present invention, taurine (aminoethylsulfonic acid), which has an action to improve the bitterness and flavor of the chitin, chitosan and / or salt or derivative thereof, is a sulfur-containing amino acid having a simple chemical structure with a molecular weight of 125.15. . Taurine belongs to amino acids in terms of chemical structure, but unlike amino acids that constitute proteins, taurine has actions like vitamins and hormones, as well as various pharmacological actions including cranial nervous system, circulatory system, and hepatobiliary system. It has been known. Thus, taurine has attracted attention and has been used as a physiologically active substance, but its properties are colorless or white crystalline powder, and it has no odor or taste. It is not used as a masking ingredient for strong bitterness.

  In general, the effective dose of chitin and chitosan is 1.5 to 3 g per day for healthy adults. In the present invention, 2 to 100 parts by weight of taurine can be blended and used with respect to 1 part by weight of chitin and chitosan and / or their salts or derivatives. Is a preferred embodiment. In terms of the total weight of the composition, the amount of taurine per composition may be 0.1 to 10% by weight, preferably 0.1 to 5% by weight, more preferably 1 to 3% by weight.

  By this combination, the relatively strong bitterness exhibited by chitin and chitosan and / or their salts or derivatives can be reduced by tasteless and odorless taurine.

  Since all of chitin, chitosan and taurine with improved water solubility are relatively stable compounds in an aqueous solution, the preferred form in the present invention is a beverage, and particularly has a pH of 2.5 to 7, preferably 4 It is a packaged beverage that is adjusted to .5 to 6.5. In the drink which is the composition for oral use of this invention, it was confirmed that a feeling of dosing improves more by setting to pH of this range.

  The pH may be adjusted using an appropriate pH adjuster. As the pH adjuster, organic and inorganic edible acids can be used. The acids may be used in their undissociated form or in the form of their respective salts, such as potassium or sodium hydrogen phosphate, potassium dihydrogen phosphate or sodium salt. Preferred acids are edible organic acids including citric acid, malic acid, fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, phosphoric acid or mixtures thereof. Bicarbonate can also be used.

  In order to produce the oral composition according to the present invention as a beverage whose pH is adjusted in this way, the beverage is preferably produced in a container form. There are no particular restrictions on the type of container, but any container such as a molded container (so-called PET bottle) mainly composed of polyethylene terephthalate, a metal can, a paper container combined with a metal foil or plastic film, or a bottle should be used. Can do.

  In addition, in the oral composition of the present invention, it is also advantageous to make so-called sports drinks and isotonic drinks by blending sodium ions and potassium ions, which are physiological electrolytes. In addition to sodium ions and potassium ions, calcium, chromium, copper, iron, magnesium, manganese, phosphorus, selenium, silicon, molybdenum, zinc, or the like can be added as minerals.

  Furthermore, in order to improve palatability, you may select and mix | blend a sweetener suitably. For example, natural sweeteners such as stevia, artificial sweeteners such as aspartame, carbohydrates such as sucrose, sugar alcohols such as sorbitol, erythritol, and xylitol, and glycerols such as glycerin can be used.

  In the preparation of the oral composition of the present invention, special additives such as surfactants are not essential, but other known additives, excipients, etc. may be added to an appropriate dosage form as necessary. And may be processed. For example, in the case of a liquid agent, an antioxidant, a colorant, a flavoring agent, a surfactant, a plasticizer, a pH adjuster, etc. can be mixed to obtain an oral product such as a dry syrup agent or a liquid agent. If it is a solid agent, an excipient, a disintegrant, a binder, a lubricant, an antioxidant, a coating agent, a coloring agent, a corrigent, a surfactant, a plasticizer, etc. are mixed in a conventional manner. Granules, powders, capsules, tablets and the like can be produced.

  Examples of the antioxidant include vitamin C, dibutylhydroxytoluene (BHT), propyl gallate, butylhydroxyanisole (BHT), α-tocopherol, and citric acid.

  Examples of the colorant include tar dyes and titanium oxide.

  Examples of the surfactant include polyglycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, sorbitan monostearate, sorbitan monopalmitate, sorbitan monolaurate, polyoxyethylene polyoxypropylene block copolymer, polysorbates, sodium lauryl sulfate, macro Examples include galls and sucrose fatty acid esters.

  In addition to taurine or chitosan, various physiologically active ingredients such as vitamins can be mixed as necessary. Preferable vitamins include vitamin A, vitamin B, vitamin C, vitamin D, vitamin E or various derivatives thereof.

  Moreover, in order to give palatability to the composition of this invention, you may add various fragrance | flavors.

  EXAMPLES The present invention will be described in more detail with reference to examples below, but the present invention is not limited to these examples.

  5 g of commercially available chitin (Yaizu Suisan Kagaku Kogyo Co., Ltd., trade name NA-COS-Y) and 10 g of taurine were dissolved in purified water to make a total volume of 1000 ml to obtain a beverage composition. The pH of this composition is 3.8.

  5 g of commercially available chitin (Yaizu Suisan Kagaku Kogyo Co., Ltd., trade name NA-COS-Y) and 30 g of taurine were dissolved in purified water to make a total volume of 1000 ml to obtain a beverage composition. The pH of this composition is 3.8.

  5 g of commercially available chitosan (Yaizu Suisan Kagaku Kogyo Co., Ltd., trade name COS-YS) and 10 g of taurine were dissolved in purified water to a total volume of 1000 ml to obtain a beverage composition. The pH of this composition is 4.4.

  5 g of commercially available chitosan (Yaizu Suisan Kagaku Kogyo Co., Ltd., trade name COS-YS) and 30 g of taurine were dissolved in purified water to make a total amount of 1000 ml to obtain a beverage composition. The pH of this composition is 4.4.

<Test example>
About the beverage composition prepared in Examples 1 to 4 and the flavors of the controls (controls 1 and 3 respectively) composed of compositions obtained by removing taurine from Examples 1 and 3, healthy in the 20s to 50s A panel of 6 adult males was surveyed.

  After the beverage compositions of Examples 1 to 4 and Controls 1 and 3 were each drunk by the paneler, “no feeling”: 5 points, “slightly feel”: 4 points, “feel a little” about the astringency of each beverage “: 3 points,“ feel ”: 2 points,“ feel strongly ”: 1 point was selected, and the total was determined.

  The sample was taken with double blinds, and the paneler took the sample in a situation where the contents were not understood. For data analysis, an absolute evaluation method by the SD method was used. The score for each beverage is shown in Table 1.

  Thus, it was confirmed that the astringency recognized by each of Controls 1 and 3 was improved by adding taurine.

  50 g of commercially available chitosan (Yaizu Suisan Chemical Co., Ltd., trade name COS-YS) and 100 g of taurine were mixed to obtain a powder composition.

50 g of commercially available chitosan (Yaizu Suisan Chemical Co., Ltd., trade name COS-YS) and 300 g of taurine were mixed to obtain a powder composition.

Claims (3)

1 to 3 % by weight of taurine and 0.5% by weight or more of chitin, chitosan and / or a salt thereof, and 2 to 10 parts by weight of taurine with respect to 1 part by weight of chitin, chitosan and / or a salt thereof Contains beverages. The beverage according to claim 1, having a pH of 2.5-7. 0.5 wt% or more of chitin, chitosan and / or in a beverage containing a salt thereof, chitin, chitosan and / or chitin by 2-10 parts by weight blended taurine to their salts 1 part by weight, A method for reducing odors and bitterness derived from chitosan and / or salts thereof.