JPH0121831B2 - - Google Patents
Info
- Publication number
- JPH0121831B2 JPH0121831B2 JP59233033A JP23303384A JPH0121831B2 JP H0121831 B2 JPH0121831 B2 JP H0121831B2 JP 59233033 A JP59233033 A JP 59233033A JP 23303384 A JP23303384 A JP 23303384A JP H0121831 B2 JPH0121831 B2 JP H0121831B2
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- solution
- toluene
- group
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001875 compounds Chemical class 0.000 claims description 60
- -1 di-substituted phenyl Chemical group 0.000 claims description 33
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims description 11
- 239000001257 hydrogen Substances 0.000 claims description 11
- 125000004432 carbon atom Chemical group C* 0.000 claims description 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims description 7
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 6
- 229910052801 chlorine Inorganic materials 0.000 claims description 6
- 239000000460 chlorine Substances 0.000 claims description 6
- 150000002431 hydrogen Chemical class 0.000 claims description 6
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 5
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims description 5
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 5
- 229910052794 bromium Inorganic materials 0.000 claims description 5
- 229910052799 carbon Inorganic materials 0.000 claims description 5
- 229910052736 halogen Inorganic materials 0.000 claims description 5
- 150000002367 halogens Chemical class 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- 125000003003 spiro group Chemical group 0.000 claims description 5
- 125000003545 alkoxy group Chemical group 0.000 claims description 3
- 125000002723 alicyclic group Chemical group 0.000 claims description 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 2
- QFQNQKVJZNONIW-UHFFFAOYSA-N 1,3,3,5,6-pentamethylspiro[indole-2,3'-pyrido[3,2-f][1,4]benzoxazine] Chemical compound N1=CC=CC2=C(N=CC3(C(C)(C)C4=CC(C)=C(C)C=C4N3C)O3)C3=CC=C21 QFQNQKVJZNONIW-UHFFFAOYSA-N 0.000 claims 1
- FFKKFHGXHSFNBR-UHFFFAOYSA-N 3-ethyl-1,3,5,6-tetramethylspiro[indole-2,3'-pyrido[3,2-f][1,4]benzoxazine] Chemical compound N1=CC=CC2=C(N=CC3(N(C)C4=CC(C)=C(C)C=C4C3(C)CC)O3)C3=CC=C21 FFKKFHGXHSFNBR-UHFFFAOYSA-N 0.000 claims 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 111
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 50
- 239000000243 solution Substances 0.000 description 49
- 239000000463 material Substances 0.000 description 39
- 239000000203 mixture Substances 0.000 description 30
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 24
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 23
- JKJWYKGYGWOAHT-UHFFFAOYSA-N bis(prop-2-enyl) carbonate Chemical compound C=CCOC(=O)OCC=C JKJWYKGYGWOAHT-UHFFFAOYSA-N 0.000 description 23
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 21
- 239000000178 monomer Substances 0.000 description 21
- 229920005862 polyol Polymers 0.000 description 21
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 18
- 235000019441 ethanol Nutrition 0.000 description 18
- 238000000034 method Methods 0.000 description 18
- 150000003077 polyols Chemical class 0.000 description 17
- 239000007788 liquid Substances 0.000 description 15
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 14
- 238000006243 chemical reaction Methods 0.000 description 14
- 239000002904 solvent Substances 0.000 description 14
- ULDFPQKCKOFNOF-UHFFFAOYSA-N 5-nitrosoquinolin-6-ol Chemical compound N1=CC=CC2=C(N=O)C(O)=CC=C21 ULDFPQKCKOFNOF-UHFFFAOYSA-N 0.000 description 13
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 12
- 239000000047 product Substances 0.000 description 12
- 239000011541 reaction mixture Substances 0.000 description 12
- 239000000725 suspension Substances 0.000 description 12
- JHQVCQDWGSXTFE-UHFFFAOYSA-N 2-(2-prop-2-enoxycarbonyloxyethoxy)ethyl prop-2-enyl carbonate Chemical compound C=CCOC(=O)OCCOCCOC(=O)OCC=C JHQVCQDWGSXTFE-UHFFFAOYSA-N 0.000 description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 10
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 9
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 9
- 239000000843 powder Substances 0.000 description 9
- 229920000642 polymer Polymers 0.000 description 8
- 239000013078 crystal Substances 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
- 239000007787 solid Substances 0.000 description 7
- 238000005406 washing Methods 0.000 description 7
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 6
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 229920001577 copolymer Polymers 0.000 description 6
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 5
- 238000010992 reflux Methods 0.000 description 5
- WAOPPELONVRRKQ-UHFFFAOYSA-N 1h-indol-1-ium;iodide Chemical compound [I-].C1=CC=C2[NH2+]C=CC2=C1 WAOPPELONVRRKQ-UHFFFAOYSA-N 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 4
- XXROGKLTLUQVRX-UHFFFAOYSA-N allyl alcohol Chemical compound OCC=C XXROGKLTLUQVRX-UHFFFAOYSA-N 0.000 description 4
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 4
- 239000004926 polymethyl methacrylate Substances 0.000 description 4
- 238000004809 thin layer chromatography Methods 0.000 description 4
- PVTXJGJDOHYFOX-UHFFFAOYSA-N 2h-1,4-benzoxazine Chemical compound C1=CC=C2N=CCOC2=C1 PVTXJGJDOHYFOX-UHFFFAOYSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 240000007817 Olea europaea Species 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 3
- 229940081735 acetylcellulose Drugs 0.000 description 3
- 125000001931 aliphatic group Chemical group 0.000 description 3
- 125000002947 alkylene group Chemical group 0.000 description 3
- 229920002301 cellulose acetate Polymers 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 3
- 239000002178 crystalline material Substances 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 3
- 239000004922 lacquer Substances 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 3
- 239000004417 polycarbonate Substances 0.000 description 3
- 229920000515 polycarbonate Polymers 0.000 description 3
- 229920002223 polystyrene Polymers 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 125000001424 substituent group Chemical group 0.000 description 3
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 2
- APWNQPGYPRMREL-UHFFFAOYSA-M 3-ethyl-1,2,3,5,6-pentamethylindol-1-ium;iodide Chemical compound [I-].CC1=C(C)C=C2C(CC)(C)C(C)=[N+](C)C2=C1 APWNQPGYPRMREL-UHFFFAOYSA-M 0.000 description 2
- 229930185605 Bisphenol Natural products 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- DQEFEBPAPFSJLV-UHFFFAOYSA-N Cellulose propionate Chemical compound CCC(=O)OCC1OC(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C1OC1C(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C(COC(=O)CC)O1 DQEFEBPAPFSJLV-UHFFFAOYSA-N 0.000 description 2
- 229920002284 Cellulose triacetate Polymers 0.000 description 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- SMEGJBVQLJJKKX-HOTMZDKISA-N [(2R,3S,4S,5R,6R)-5-acetyloxy-3,4,6-trihydroxyoxan-2-yl]methyl acetate Chemical compound CC(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)OC(=O)C)O)O SMEGJBVQLJJKKX-HOTMZDKISA-N 0.000 description 2
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 125000001118 alkylidene group Chemical group 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- 230000001680 brushing effect Effects 0.000 description 2
- 229920006217 cellulose acetate butyrate Polymers 0.000 description 2
- 229920006218 cellulose propionate Polymers 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000010908 decantation Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 238000007598 dipping method Methods 0.000 description 2
- 238000000921 elemental analysis Methods 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 150000002334 glycols Chemical class 0.000 description 2
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 2
- 235000019239 indanthrene blue RS Nutrition 0.000 description 2
- UHOKSCJSTAHBSO-UHFFFAOYSA-N indanthrone blue Chemical compound C1=CC=C2C(=O)C3=CC=C4NC5=C6C(=O)C7=CC=CC=C7C(=O)C6=CC=C5NC4=C3C(=O)C2=C1 UHOKSCJSTAHBSO-UHFFFAOYSA-N 0.000 description 2
- 125000000654 isopropylidene group Chemical group C(C)(C)=* 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011368 organic material Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 239000002985 plastic film Substances 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 229920002689 polyvinyl acetate Polymers 0.000 description 2
- 239000011118 polyvinyl acetate Substances 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 238000004528 spin coating Methods 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 1
- ZTUKGBOUHWYFGC-UHFFFAOYSA-N 1,3,3-trimethyl-2-methylideneindole Chemical compound C1=CC=C2N(C)C(=C)C(C)(C)C2=C1 ZTUKGBOUHWYFGC-UHFFFAOYSA-N 0.000 description 1
- XHSCQSXDHUJDLV-UHFFFAOYSA-N 1,3,5,6-tetramethyl-2-methylidene-3-phenylindole Chemical compound C12=CC(C)=C(C)C=C2N(C)C(=C)C1(C)C1=CC=CC=C1 XHSCQSXDHUJDLV-UHFFFAOYSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- BOWPDIHRPLQRHN-UHFFFAOYSA-N 1-butyl-3,3,5,6-tetramethyl-2-methylideneindole Chemical compound CC1=C(C)C=C2N(CCCC)C(=C)C(C)(C)C2=C1 BOWPDIHRPLQRHN-UHFFFAOYSA-N 0.000 description 1
- HDIGOJOUQIWAPA-UHFFFAOYSA-N 1-butyl-3-ethyl-3-methyl-2-methylideneindole Chemical compound C1=CC=C2N(CCCC)C(=C)C(C)(CC)C2=C1 HDIGOJOUQIWAPA-UHFFFAOYSA-N 0.000 description 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-O 1H-indol-1-ium Chemical compound C1=CC=C2[NH2+]C=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-O 0.000 description 1
- MQXNNWDXHFBFEB-UHFFFAOYSA-N 2,2-bis(2-hydroxyphenyl)propane Chemical compound C=1C=CC=C(O)C=1C(C)(C)C1=CC=CC=C1O MQXNNWDXHFBFEB-UHFFFAOYSA-N 0.000 description 1
- XNWFRZJHXBZDAG-UHFFFAOYSA-N 2-METHOXYETHANOL Chemical compound COCCO XNWFRZJHXBZDAG-UHFFFAOYSA-N 0.000 description 1
- FYELSNVLZVIGTI-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-5-ethylpyrazol-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical group C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C=1C=NN(C=1CC)CC(=O)N1CC2=C(CC1)NN=N2 FYELSNVLZVIGTI-UHFFFAOYSA-N 0.000 description 1
- VPWNQTHUCYMVMZ-UHFFFAOYSA-N 4,4'-sulfonyldiphenol Chemical class C1=CC(O)=CC=C1S(=O)(=O)C1=CC=C(O)C=C1 VPWNQTHUCYMVMZ-UHFFFAOYSA-N 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 235000004692 Eucalyptus globulus Nutrition 0.000 description 1
- 240000007002 Eucalyptus tereticornis Species 0.000 description 1
- 235000019134 Eucalyptus tereticornis Nutrition 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 229920004142 LEXAN⢠Polymers 0.000 description 1
- 239000004418 Lexan Substances 0.000 description 1
- 239000000020 Nitrocellulose Substances 0.000 description 1
- ALQSHHUCVQOPAS-UHFFFAOYSA-N Pentane-1,5-diol Chemical compound OCCCCCO ALQSHHUCVQOPAS-UHFFFAOYSA-N 0.000 description 1
- 229920005372 Plexiglas® Polymers 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- ACIAHEMYLLBZOI-ZZXKWVIFSA-N Unsaturated alcohol Chemical compound CC\C(CO)=C/C ACIAHEMYLLBZOI-ZZXKWVIFSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- QVQLCTNNEUAWMS-UHFFFAOYSA-N barium oxide Chemical compound [Ba]=O QVQLCTNNEUAWMS-UHFFFAOYSA-N 0.000 description 1
- 229910001864 baryta Inorganic materials 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- IISBACLAFKSPIT-UHFFFAOYSA-N bisphenol A Chemical group C=1C=C(O)C=CC=1C(C)(C)C1=CC=C(O)C=C1 IISBACLAFKSPIT-UHFFFAOYSA-N 0.000 description 1
- 125000005587 carbonate group Chemical group 0.000 description 1
- 229920001727 cellulose butyrate Polymers 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 125000001033 ether group Chemical group 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 150000002476 indolines Chemical class 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- FUCOMWZKWIEKRK-UHFFFAOYSA-N iodocyclohexane Chemical compound IC1CCCCC1 FUCOMWZKWIEKRK-UHFFFAOYSA-N 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000002655 kraft paper Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
- 125000005394 methallyl group Chemical group 0.000 description 1
- REVOEHDVOKJIBK-UHFFFAOYSA-M methyl 1,2,3,3-tetramethylindol-1-ium-5-carboxylate;iodide Chemical compound [I-].COC(=O)C1=CC=C2[N+](C)=C(C)C(C)(C)C2=C1 REVOEHDVOKJIBK-UHFFFAOYSA-M 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- 125000002868 norbornyl group Chemical group C12(CCC(CC1)C2)* 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- 235000012736 patent blue V Nutrition 0.000 description 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- 229920001603 poly (alkyl acrylates) Polymers 0.000 description 1
- 229920002037 poly(vinyl butyral) polymer Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920006254 polymer film Polymers 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 description 1
- OVYWMEWYEJLIER-UHFFFAOYSA-N quinolin-6-ol Chemical compound N1=CC=CC2=CC(O)=CC=C21 OVYWMEWYEJLIER-UHFFFAOYSA-N 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
Landscapes
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
- Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Optical Filters (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Eyeglasses (AREA)
Description
ç£æ¥äžã®å©çšåé
æ¬çºæã¯æ°èŠã®ã¹ããïŒã€ã³ããªã³ïŒããªãã
ã³ãŸãªããµãžã³ååç©ã«é¢ããããããã¹ãã
ïŒã€ã³ããªã³ïŒããªããã³ãŸãªããµãžã³ååç©ã
å«ãçµæç©ã¯ããã¯ãããã¯ååç©ãšããŠããã
ãããã¯ãããã¯å¹æããããããããã¯ãããº
ã ãšã¯ãæ¥å ãŸãã¯æ°Žéçã®å ã®ãããªçŽ«å€ç·ã
å«ãå ã®æŸå°ã«æŽé²ããããšãã«å€è²ãã次ã«æŸ
å°ãåæ¢ããããããã¯ååç©ãææã«è²¯èµãã
ãªãã°å ã®è²ã«æ»ãååç©ã瀺ãå¯éççŸè±¡ã§ã
ãããã®çŸè±¡ã瀺ãååç©ãâããã¯ãããã¯å
åç©âãšç§°ãããã®ãããªå¹æãâããã¯ããã
ã¯å¹æâãšç§°ããã åŸæ¥ã®æè¡ çš®ã ã®åã®ããã¯ãããã¯ååç©ãåæãããŠ
ãããã€æ¥å ã«ãã€ãŠå€è²ãŸãã¯æè²åãèµ·ãã
çšéãžã®äœ¿çšãææ¡ãããŠãããç¹ã«ãç±³åœç¹èš±
第3562172å·ã第3578602å·ã第4215010å·ã第
4342668å·ã«èšèŒãããŠãããããªã¹ããïŒã€ã³
ããªã³ïŒããããªããµãžã³ååç©ã¯ãµã³ã°ã©ã¹ã
ãã³çŒçšã¬ã³ãºã®ããã«ç¹å¥ãªå©çã瀺ãããã
ãããã¯ãããã¯ååç©ã¯ãçµæ¶åœ¢ã§ããããã
ã¯éæãªåªè³ªäžã®æº¶æ¶²ãŸãã¯åæ£äœã§ãã€ãŠãã
æ¥å ãŸãã¯çŽ«å€ç·ã«æŽé²ããããšãæ¥éã«ç¡è²ç¶
æ ããéè²ã«å€è²ããææã«æŸçœ®ããããšã«ã
ãããããã¯åŒ·åãªçŽ«å€ç·ã®ç¡ãæã§ã¯å ã®ç¡è²
ã®ç¶æ ã«æ»ãã çºæã®å ·äœç説æ æ¬çºæã«ããã°ãäžèšã®äžè¬åŒ ã§ç€ºãããæ°èŠãªã¹ããïŒã€ã³ããªã³ïŒããªãã
ã³ãŸãªããµãžã³ååç©ãæäŸãããã äžèšäžè¬åŒäžãR1ã¯C1âC8ã¢ã«ãã«ãããš
ãã«ïŒC1âC4ïŒã¢ã«ãã«ããã³ã¢ãªã«ãããªã
矀ããéžã°ããã奜ãŸããã¯ãR1ã¯C1âC4ã¢ã«
ãã«ãŸãã¯ãã³ãžã«åºã§ããã åŒã®R2ïŒR3ã¯ããã®ãã®ãC1âC5ã¢ã«ãã«ã
ããšãã«ããªãã³ã«ã¢ããŒããã³ãžçœ®æããšã
ã«ããããªã矀ããéžã°ãããããã¯çµåããŠïŒ
âïŒåã®ççŽ ååïŒã¹ããççŽ ååãå«ãïŒãå«
ãèç°åŒç°ããã«ãã«ãã«ãã¢ããã³ãã«ãããª
ã矀ããéžã°ããç°åŒç°ã圢æãããããšãã«çœ®
æåºã¯C1âC4ã¢ã«ãã«ããã³C1âC5ã¢ã«ã³ãã·
åºããéžã¶ããšãã§ããã奜ãŸããã¯ãR2ïŒR3
ã¯ããã®ãã®ãC1âC5ã¢ã«ãã«ããéžã°ããã
R2ãŸãã¯R3ã®äžæ¹ã第äžããã«ãŸãã¯ç¬¬äžã¢ã
ã«ã®ãããªç¬¬äžã¢ã«ãã«åºã§ããå Žåã«ã¯ãä»æ¹
ã¯å¥œãŸããã¯ç¬¬äžã¢ã«ãã«åºä»¥å€ã®ã¢ã«ãã«åºã§
ããã äžè¬åŒäžã®R4ïŒR5ã¯ããã®ãã®ãæ°ŽçŽ ãC1
âC5ã¢ã«ãã«ãããã²ã³ãC1âC5ã¢ã«ã³ãã·ã
ã·ã¢ããC1âC8ã¢ã«ã³ãã·ã«ã«ããã«ãããªã
矀ããéžã°ãããR4ïŒR5ã¯ãååç©ã®ã€ã³ããª
ãéšåã®æå¹ãªççŽ ååãããªãã¡ïŒäœãŸãã¯ïŒ
äœãŸãã¯ïŒäœãŸãã¯ïŒäœã®ããããïŒã€ã®äœçœ®ã«
ååšããããšãã§ããã奜ãŸããã¯ã眮æåºR4ïŒ
R5ãæ°ŽçŽ ä»¥å€ã§ããå Žåããããã®çœ®æåºã¯ã€
ã³ããªãéšåã®ïŒäœãšïŒäœãŸãã¯ïŒäœãšïŒäœãŸã
ã¯ïŒäœãšïŒäœãŸãã¯ïŒäœãšïŒäœã®ççŽ ååã®æã«
ååšãããã©ããªããã²ã³ãããªãã¡å¡©çŽ ãè
çŽ ããšãŠçŽ ãåŒçŽ ã§ã䜿çšããããšãã§ãããã
å¡©çŽ ãèçŽ ãç¹ã«å¡©çŽ ã奜ãŸããã奜ãŸããã¯ã
R4ïŒR5ã¯æ°ŽçŽ ãC1âC2ã¢ã«ãã«ãå¡©çŽ ãèçŽ ã
C1âC5ã¢ã«ã³ãã·ãããªã矀ããéžã°ããã ç¹ã«èå³ã®ãããã®ã¯ãR1ãã¡ãã«ããšãã«ã
ïœâãããã«ãã€ãœãããã«ãïœâããã«ã第äº
ããã«ãã€ãœããã«ã第äžããã«ã®ãããªC1â
C4ã¢ã«ãã«ã§ããããã€R2ïŒR3ã®ãã®ãã®ãã¡
ãã«ãŸãã¯ãšãã«ãŸãã¯ããšãã«ã§ããããã€
R4ïŒR5ã®ãã®ãã®ãæ°ŽçŽ ãŸãã¯ã¡ãã«ãŸãã¯ã¡
ããã·ãŸãã¯ã¯ããã§ããäžè¬åŒã§ç€ºãããã
ãã¯ãããã¯ååç©ã§ããã æ¬çºæã®ããã¯ãããã¯ååç©ã¯ããã³ãŒã³ã
ãã«ãšã³ãã¯ãããã«ã ãé ¢é žãšãã«ãã¡ãã«ãš
ãã«ã±ãã³ãã¢ã»ãã³ããšãã«ã¢ã«ã³ãŒã«ãã¡ã
ã«ã¢ã«ã³ãŒã«ãã¢ã»ããããªã«ãããã©ãããã
ã©ã³ããžãªããµã³ããšãã¬ã³ã°ãªã³ãŒã«ã®ã¡ãã«
ãšãŒãã«ããžã¡ãã«ãã«ã ã¢ããããžã¡ãã«ã¹ã«
ããã·ããã¡ãã«ã»ããœã«ããã¢ã«ããªã³ããšã
ã¬ã³ã°ãªã³ãŒã«ã®ãããªéåžžã®ææ©æº¶åªã«æº¶è§£ã
ããããšãã§ãããŸãæ°Žãã¢ã«ã³ãŒã«ãããã³ä»
ã®æº¶åªãå«ã液äœäžã«åæ£ãããããšãã§ããã æ¬çºæã®ããã¯ãããã¯ååç©ã溶解ãããã
ã«çšãããã溶åªã®éã¯ããã¹ãææãžé©çšãã
ãšãããã¹ãææäžã«ããã¯ãããã¯éã®è©²åå
ç©ãäžããããã¯ãããã¯çµæç©ãæäŸããã®ã«
ååãªéã§ãªããã°ãªããªãã æ¬çºæã®ããã¯ãããã¯ååç©ã¯ãéæããªã
ãŒãŸãã¯ãããéæããªããŒã®ã³ããªããŒãŸãã¯
ãã¬ã³ããšé©åœãªææ©æº¶åªãšãã調補ãããç¡è²
ãŸãã¯éæ溶液ãäŸãã°ïŒçš®ä»¥äžã®äžæ²ã®ææ©æº¶
åªäžã«æº¶è§£ãããåŸè¿°ã®éæãã¹ãææã®ããªã
ãŒäžã«æº¶è§£ãããããšãã§ãããããã溶液ã®äŸ
ãšããŠã¯ãããªé ¢é žããã«ã»ã¢ã»ãã³æº¶æ¶²ããã
ãã»ã«ããŒã¹ã»ã¢ã»ããããªã«æº¶æ¶²ãããªå¡©åã
ãã«ã»ã¡ãã«ãšãã«ã±ãã³æº¶æ¶²ãããªã¡ã¿ã¯ãªã«
é žã¡ãã«ã»ã¢ã»ãã³æº¶æ¶²ãã¢ã»ãã«ã»ã«ããŒã¹ã»
ãžã¡ãã«ãã«ã ã¢ãã溶液ãããªããã«ãããªã
ã³ã»ã¢ã»ããããªã«æº¶æ¶²ãããªã¹ãã¬ã³ã»ãã³ãŒ
ã³æº¶æ¶²ããšãã«ã»ã«ããŒã¹ã»å¡©åã¡ãã¬ã³æº¶æ¶²ã
å«ãŸããã äžèšããã¯ãããã¯æº¶æ¶²ãŸãã¯çµæç©ã¯ãããª
ã¢ã»ãã«ã»ã«ããŒã¹ãŸãã¯ããªãšãã¬ã³ãã¬ãã¿
ã¬ãŒããŸãã¯ããªã¿çŽã®ãããªéææ¯æäœã«å¡åž
ãã也ç¥ããŠã玫å€ç·ã«ãã€ãŠéè²ã«çè²ããã
ãŠçŽ«å€ç·æºã®é€å»ã«ãã€ãŠç¡è²ã«æ»ãããã¯ãã
ãã¯ææãåŸãããšãã§ããã æ¬çºæã®ããã¯ãããã¯ååç©ãŸãã¯ãããå«
ãçµæç©ã¯ãåºäœéæéåææ©ææããªãã¡åæ
ãã©ã¹ããã¯ãã¹ãææãžå¡åžããŠãããããã
ãã¯è©²ææå ã«æ··å ¥ãããããšãã§ããã奜ãŸã
ãã¯ããã¹ãææã¯ãå åŠçã«éæãªææãäŸã
ã°çŒçšã¬ã³ãºã®ãããªçŒçšçŽ åã«é©ããææãŸã
ã¯çªã颚é²ã¬ã©ã¹ãªã©ã®ãããªçšéã«é©ããææ
ã§ãããæ¬çºæã®ããã¯ãããã¯ååç©å«ããã¹
ãææã¯ãããã¯ãããã¯ãã©ã¹ããã¯ãã€ã«
ã ãã·ãŒãããã³ã¬ã³ãºãäŸãã°ãµã³ã°ã©ã¹çšã¬
ã³ãºãã¹ããŒãŽãŒã¯ã«ããã€ã¶ãŒïŒvisorsïŒããµ
ã³ãã€ã¶ãŒãã«ã¡ã©ã¬ã³ãºããã³ãã€ã«ã¿ãŒã®è£œ
é ã«çšããããããæ¬æ现æžäžã§çšããâå åŠçŽ
åâãšããçšèªã¯ã¬ã³ãºããã³éæäœ
ïŒtransparenciesïŒãå«ããã®ãšããã æ¬çºæã®ããã¯ãããã¯ååç©ãšå ±ã«äœ¿çšã§ã
ãéæãã¹ãææã®äŸã«ã¯ãããªãªãŒã«ïŒã¢ãªã«
ã«ãŒãããŒãïŒã¢ãããŒã®ããªããŒãããªã¢ã¯ãª
ã¬ãŒããããªã¡ã¿ã¯ãªã«é žã¡ãã«ã®ãããªããª
ïŒã¢ã¯ãªã«é žã¢ã«ãã«ïŒãã¢ã»ãã«ã»ã«ããŒã¹ãã
ãªã¢ã»ãã«ã»ã«ããŒã¹ãé ¢é žããããªã³é žã»ã«ã
ãŒã¹ãé ¢é žé ªé žã»ã«ããŒã¹ãããªïŒé ¢é žããã«ïŒã
ããªïŒããã«ã¢ã«ã³ãŒã«ïŒãããªãŠã¬ã¿ã³ãããª
ã«ãŒãããŒããããªãšãã¬ã³ãã¬ãã¿ã¬ãŒããã
ãªã¹ãã¬ã³ãããªïŒã¹ãã¬ã³âã¡ã¿ã¯ãªã«é žã¡ã
ã«ïŒã³ããªããŒãããªïŒã¹ãã¬ã³âã¢ã¯ãªããã
ãªã«ïŒã³ããªããŒãããªããã«ããã©ãŒã«ãå«ãŸ
ãããéæãªã³ããªããŒããã³éæããªããŒã®ã
ã¬ã³ãããã¹ãææãšããŠé©åœã§ããã奜ãŸãã
ã¯ããã¹ãææã¯ãã¬ã¯ãµã³ïŒLEXANïŒã®åæš
ã§çºå£²ãããŠããããªïŒïŒïŒ4â²âãžãªãã·ãžããš
ããŒã«âïŒïŒïŒâãããã³ïŒã®ãããªããªã«ãŒã
ããŒãïŒãã¬ãã·ã°ã©ã¹ïŒPLEXIGLASïŒã®å
æšã§çºå£²ãããŠããææãããªããªã¡ã¿ã¯ãªã«é ž
ã¡ãã«ïŒããªãªãŒã«ïŒã¢ãªã«ã«ãŒãããŒãïŒãç¹
ã«CRâ39ã®åæšã§çºå£²ãããŠãããžãšãã¬ã³ã°
ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒãïŒãããã³ã
ã®äŸãã°é ¢é žããã«ãšã®ã³ããªããŒãäŸãã°ãžãš
ãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒãïŒ80
â90ïŒ ãšé ¢é žããã«10â20ïŒ ãšã®ã³ããªããŒãç¹
ã«ãžãšãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒ
ãïŒ80â85ïŒ ãšé ¢é žããã«15â20ïŒ ãšã®ã³ããªã
ãŒïŒã¢ã»ãã«ã»ã«ããŒã¹ãããããªã³é žã»ã«ããŒ
ã¹ãé ªé žã»ã«ããŒã¹ãããªã¹ãã¬ã³ããã³ãã®ã¡
ã¿ã¯ãªã«é žã¡ãã«ãé ¢é žããã«ãã¢ã¯ãªããããª
ã«ãšã®ã³ããªããŒããªãã³ã«é ¢é žé ªé žã»ã«ããŒã¹
ãã補é ãããå åŠçã«éæãªéåææ©ææã§ã
ãã éåããŠéæãã¹ãææã圢æããããšãã§ã
ãããªãªãŒã«ïŒã¢ãªã«ã«ãŒãããŒãïŒã¢ãããŒ
ã¯ãçŽéãŸãã¯åæéã®èèªæãŸãã¯è³éŠæ液äœ
ããªãªãŒã«ã®ã¢ãªã«ã«ãŒãããŒããäŸãã°èèªæ
ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒãïŒååç©ã
ããã¯ã¢ã«ããªãã³ãã¹ããšããŒã«ãã¹ïŒã¢ãªã«
ã«ãŒãããŒãïŒååç©ã§ããããããã®ã¢ãããŒ
ã¯ãããªãªãŒã«ãäŸãã°ã°ãªã³ãŒã«ã®äžé£œåããª
ã«ãŒãããŒããšèšãããšãã§ããããããã®ã¢ã
ããŒã¯ãæè¡äžå ¬ç¥ã®æ¹æ³ãäŸãã°ç±³åœç¹èš±ç¬¬
2370567å·ã第2403113å·èšèŒã®æ¹æ³ã§è£œé ããã
ãšãã§ããã ããªãªãŒã«ïŒã¢ãªã«ã«ãŒãããŒãïŒã¯ãäžè¬åŒ
ã§ç€ºãããšãã§ããã äžèšäžè¬åŒäžãã¯äžé£œåã¢ã«ã³ãŒã«ããèª
å°ãããåºã§ãããéåžžã¢ãªã«ãŸãã¯çœ®æã¢ãªã«
åºã§ãããRâ²ã¯ããªãªãŒã«ããèªå°ãããåºã§
ãããïœã¯ïŒâïŒã®æŽæ°ã§ã奜ãŸããã¯ïŒã§ã
ãã ã¢ãªã«åºïŒ²ã¯ãïŒäœã«æŒãŠãããã²ã³ãç¹ã«å¡©çŽ
ãŸãã¯èçŽ ããããã¯ïŒâïŒåã®ççŽ ååãå«ã
ã¢ã«ãã«åºãäžè¬ã«ã¡ãã«ãŸãã¯ãšãã«åºã§çœ®æ
ãããŠããŠããããåºã¯äžè¬åŒ ïŒäžèšäžè¬åŒäžãR0ã¯æ°ŽçŽ ãŸãã¯ããã²ã³ãŸ
ãã¯C1âC4ã¢ã«ãã«åºã§ããïŒã§ç€ºãããšãã§
ãããã®ç¹å¥ãªäŸã«ã¯ãã¢ãªã«ãïŒâã¯ããã¢
ãªã«ãïŒâããã¢ã¢ãªã«ãïŒâãã«ãªãã¢ãªã«ã
ïŒâã¡ãã«ã¢ãªã«ãïŒâãšãã«ã¢ãªã«ãïŒâã€ãœ
ãããã«ã¢ãªã«ãïŒâïœâãããã«ã¢ãªã«ãïŒâ
ïœâããã«ã¢ãªã«ãå«ãŸãããæãæ®éã«ã¯ã
ã¯ã¢ãªã«åºH2CïŒCHâCH2âã§ããã Râ²ã¯ãïŒåãŸãã¯ïŒåãŸãã¯ïŒåãŸãã¯ïŒå
ã®ããããã·åºãå«ãèèªæãŸãã¯è³éŠæã®ããª
ãªãŒã«ã§ããããšãã§ããããªãªãŒã«ããèªå°ã
ããå€äŸ¡åºã§ãããå žåçã«ã¯ãããªãªãŒã«ã¯ïŒ
åã®ããããã·åºãå«ã¿ãããªãã¡ã°ãªã³ãŒã«ãŸ
ãã¯ãã¹ããšããŒã«ã§ãããèèªæããªãªãŒã«ã¯
çŽéã§ãã€ãŠãåæéã§ãã€ãŠãããããã€ïŒâ
10åã®ççŽ ååãå«ããéåžžãèèªæããªãªãŒã«
ã¯ïŒâïŒåã®ççŽ ååãæããã¢ã«ãã¬ã³ã°ãªã³
ãŒã«ãŸãã¯ããªïŒC2âC4ïŒã¢ã«ãã¬ã³ã°ãªã³ãŒ
ã«ãäŸãã°ãšãã¬ã³ã°ãªã³ãŒã«ããããã¬ã³ã°ãª
ã³ãŒã«ãããªã¡ãã¬ã³ã°ãªã³ãŒã«ãããã©ã¡ãã¬
ã³ã°ãªã³ãŒã«ããããã¯ãžãšãã¬ã³ã°ãªã³ãŒã«ã
ããªãšãã¬ã³ã°ãªã³ãŒã«ãªã©ã§ããã è³éŠæããªãªãŒã«ã¯ãäžè¬åŒ ã§ç€ºãããšãã§ããã äžèšäžè¬åŒäžãã¯éç°åŒèèªæçåæ°ŽçŽ ã
ãèªå°ãããïŒäŸ¡ã®åºãäŸãã°ïŒâïŒåã®ççŽ å
åãæããã¢ã«ãã¬ã³ãŸãã¯ã¢ã«ããªãã³åºãäŸ
ãã°ã¡ãã¬ã³ããšãã¬ã³ããžã¡ãã«ã¡ãã¬ã³ïŒã€
ãœããããªãã³ïŒã§ãããRaã¯ïŒâïŒåã®ççŽ
ååã®äœçŽã¢ã«ãã«çœ®æåºã瀺ããïœã¯ïŒãŸãã¯
ïŒãŸãã¯ïŒãŸãã¯ïŒã§ããã奜ãŸããã¯ãããã
ã·ã«åºã¯ãªã«ããŸãã¯ãã©äœã«ããã Râ²åºã®ç¹å¥ãªäŸã«ã¯ããšãã¬ã³ïŒâCH2âCH2
âïŒãããªã¡ãã¬ã³ãã¡ãã«ãšãã¬ã³ãããã©ã¡
ãã¬ã³ããšãã«ãšãã¬ã³ããã³ã¿ã¡ãã¬ã³ããã
ãµã¡ãã¬ã³ãïŒâã¡ãã«ãããµã¡ãã¬ã³ããªã¯ã¿
ã¡ãã¬ã³ããã«ã¡ãã¬ã³ã®ãããªãïŒâ10åã®ç
çŽ ååãå«ãã¢ã«ãã¬ã³åºïŒâCH2ââCH2
âãâCH2âCH2ââCH2âCH2âãâCH2â
âCH2âCH2âãâCH2âCH2âCH2ââ
CH2CH2H2âã®ãããªã¢ã«ãã¬ã³ãšãŒãã«åºïŒ
âCH2CH2ââCH2CH2ââCH2CH2âãâ
CH2CH2CH2ââCH2CH2CH2ââ
CH2CH2CH2âã®ãããªã¢ã«ãã¬ã³ããªãšãŒãã«
åºïŒâCH2CH2ââCOââCH2CH2âã
CH2CH2ââCH2CH2ââCOââ
CH2CH2ââCH2CH2âã®ãããªã¢ã«ãã¬ã³ã«
ãŒãããŒãããã³ã¢ã«ãã¬ã³ãšãŒãã«ã«ãŒãããŒ
ãåºïŒãªãã³ã«ã€ãœããããªãã³ãã¹ïŒïœâããš
ãã«ïŒããªãã¡ ãå«ãŸãããæãæ®éã«ã¯ãRâ²ã¯âCH2CH2âãŸ
ãã¯âCH2CH2ââCH2CH2âãŸãã¯â
CH2CH2ââCH2CH2ââCH2CH2âã§ã
ãã ããªãªãŒã«ïŒã¢ãªã«ã«ãŒãããŒãïŒã¢ãããŒã®
ç¹å¥ãªäŸã«ã¯ããšãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒïŒâã¯
ããã¢ãªã«ã«ãŒãããŒãïŒããšãã¬ã³ã°ãªã³ãŒã«
ãã¹ïŒã¢ãªã«ã«ãŒãããŒãïŒããžãšãã¬ã³ã°ãªã³
ãŒã«ãã¹ïŒïŒâã¡ã¿ãªã«ã«ãŒãããŒãïŒããžãšã
ã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒãïŒãã
ãªãšãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒ
ãïŒããããã¬ã³ã°ãªã³ãŒã«ãã¹ïŒïŒâãšãã«ã¢
ãªã«ã«ãŒãããŒãïŒãïŒïŒïŒâãããã³ãžãªãŒã«
ãã¹ïŒã¢ãªã«ã«ãŒãããŒãïŒãïŒïŒïŒâãã¿ã³ãž
ãªãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒãïŒãïŒïŒïŒâã
ã¿ã³ãžãªãŒã«ãã¹ïŒïŒâããã¢ã¢ãªã«ã«ãŒãããŒ
ãïŒããžãããã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒ
ãããŒãïŒãããªã¡ãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒïŒâ
ãšãã«ã¢ãªã«ã«ãŒãããŒãïŒããã³ã¿ã¡ãã¬ã³ã°
ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒãïŒãã€ãœãã
ããªãã³ãã¹ããšããŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒ
ãïŒãå«ãŸããã æ¬çºæã«æ°èŠãªååç©ãçšããããšãã§ããå·¥
æ¥çã«éèŠãªããªãªãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒ
ãïŒã¢ãããŒã¯ ããªãšãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãã
ãŒãïŒ ãžãšãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒ
ãïŒ ãšãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒ
ãïŒã§ããããžãšãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«
ã«ãŒãããŒãïŒã奜ãŸããã ããªãªãŒã«ïŒã¢ãªã«ã«ãŒãããŒãïŒã¢ãããŒã
補é ããæ¹æ³ãããªãã¡ããªãªãŒã«ïŒãŸãã¯ã¢ãª
ã«ã¢ã«ã³ãŒã«ïŒã®ãã¹ã²ã³åããã³ãã®åŸã®ã¢ãª
ã«ã¢ã«ã³ãŒã«ïŒãŸãã¯ããªãªãŒã«ïŒã«ãããšã¹ã
ã«åã«ãã€ãŠè£œé ããæ¹æ³ã®ããã«ãã¢ãããŒç
æç©ã¯ãã¢ãªã«ã«ãŒãããŒãåºãçµåããéšåã
ïŒå以äžã®ã«ãŒãããŒãåºãå«ãé¢é£ã¢ãããŒçš®
ãå«ãå¯èœæ§ãããããããã®é¢é£ã¢ãããŒçš®ã¯
äžè¬åŒã§ç€ºãããã äžèšäžè¬åŒäžãã¯äžã§å®çŸ©ããéãã§ã
ããRbã¯ãžãªãŒã«ããèªå°ãããïŒäŸ¡åºãäŸã
ã°ã¢ã«ãã¬ã³ãŸãã¯ããšãã¬ã³ã§ãããïœã¯ïŒâ
ïŒã®æŽæ°ã§ããããžãšãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢
ãªã«ã«ãŒãããŒãïŒã®é¢é£ã¢ãããŒçš®ã¯äžè¬åŒ
ã§ç€ºãããšãã§ããã äžèšäžè¬åŒäžãïœã¯ïŒâïŒã®æŽæ°ã§ãããã
ãªãªãŒã«ïŒã¢ãªã«ã«ãŒãããŒãïŒã¢ãããŒã¯ãå ž
åçã«ã¯ïŒâ20ééïŒ ã®é¢é£ã¢ãããŒçš®ãå«ãã
ãšãã§ãããããé¢é£ã¢ãããŒçš®ã¯ãæ··åç©ããª
ãã¡ïŒïŒïŒïŒïŒãªã©ã«çããïœã«ãã€ãŠç€ºããã
çš®ã®æ··åç©ãšããŠååšããããšãã§ããã ããã«ãããªãªãŒã«ïŒã¢ãªã«ã«ãŒãããŒãïŒã¢
ãããŒã®éšåéå圢ã䜿çšããããšãã§ãããã
ã®å®æœæ æ§ã«æŒãŠã¯ãã¢ãããŒãå ç±ã«ãã€ãŠå¢
ç²ããããããããã¯å°éãäŸãã°0.5â1.5éšïŒ
100éšã¢ãããŒïŒphmïŒã®éå§å€ãçšããŠéšåé
åãããŠã²ã«ãå«ãŸãªããããç²çš ãªã¢ãããŒæ
æãäžããã æ¬æ现æžäžã§çšããããªãªãŒã«ïŒã¢ãªã«ã«ãŒã
ããŒãïŒã¢ãããŒãŸãã¯é¡äŒŒã®å称ãäŸãã°ãžãš
ãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒãïŒ
ã¯ããã®å称ã®ã¢ãããŒãŸãã¯ãã¬ããªããŒãã
ã³ãã®äžã«å«ãŸããé¢é£ã¢ãããŒçš®ãæå³ããã€
å«ããã®ãšããã ãã¹ãææãžå¡åžãŸãã¯è©²ææäžãžæ··å ¥ããã
ããã¯ãããã¯ååç©ãŸãã¯è©²ååç©ãå«ãçµæ
ç©ã®éã¯èšççã§ã¯ãªããäžè¬ã«ããã®ç §å°æã«
ææãªçµæç©ã®è²ã®åŒ·ãããã³ããã¯ãããã¯å
åç©ãæ··å ¥ãŸãã¯å¡åžããããã«çšããæ¹æ³ã«äŸ
åãããå žåçã«ã¯ãããã¯ãããã¯ååç©ã®æ·»
å éãå€ãçšãè²ã®åŒ·ãã¯å€§ãããªããäžè¬ã«ã
ãããéã¯ããã¯ãããã¯éãšèšèŒããããšãã§
ãããæ®éã«ã¯ããã¹ãææäžã«æ··å ¥ããããã
ã¯ãããã¯ååç©ã®éã¯ããã¹ãææã®ééã«å¯Ÿ
ããŠçŽ0.01âçŽ20ééïŒ ãããæ®éã«ã¯ãçŽ0.05
âçŽ10ééïŒ ã®ç¯å²ã§ãããå¥ã®èšãæ¹ããã
ãšãããã¯ãããã¯å¹æãåºãããã«çšãããã
ããã¯ãããã¯ååç©ã®éã¯ãå žåçã«ã¯ããã¹
ãææç©åã®åãã«ã¯ç¡é¢ä¿ã«ãã¹ãææã®è¡šé¢
6.4516cm2ïŒ1in2ïŒåœããããã¯ãããã¯ååç©çŽ
ïŒâçŽ10mgã®ç¯å²ã§ãããåŸã€ãŠãããã¯ããã
ã¯ååç©ã¯ãèãè©Šæããã€ã«ã ãŸãã¯ã³ãŒãã€
ã³ã°ã§ã¯é«æ¿åºŠã§ååšããåãè©Šæã§ã¯äœæ¿åºŠã§
ååšããã æ¬çºæã®ããã¯ãããã¯ååç©ã®ãšã¿ããŒã«æº¶
液ã¯ãå žåçã«ã¯ãç¡è²ãŸãã¯æ·¡ãé»è²ãŸãã¯ç·
è²ãŸãã¯éè²ã§ããããããã®æº¶æ¶²ã¯ã玫å€ç·ã«
æŽé²ããããšã玫è²ãŸãã¯éè²ã«æ¥æ¿ã«å€è²ãã
玫å€ç·æºãåãé€ããšå ã®è²ãŸãã¯ç¡è²ã®ç¶æ ã«
æ»ãããããè²å€åã¯å€æ°ååèŠå¯èœã§ããã æ¬çºæã®ããã¯ãããã¯ååç©ãŸãã¯çµæç©
ã¯ãæè¡äžå ¬ç¥ã®æ¹æ³ã§ãã¹ãææãžå¡åžãŸãã¯
該ææäžãžæ··å ¥ããããšãã§ããããããæ¹æ³ã«
ã¯ããã¹ãææäžãžã®ããã¯ãããã¯ååç©ã®æº¶
解ãŸãã¯åæ£ãããªãã¡æµžæŒ¬ãŸãã¯ç±ç移åãŸã
ã¯ã³ãŒãã€ã³ã°ã«ãããã¹ãææäžãžã®ããã¯ã
ããã¯ååç©ã®åžåïŒimbibationïŒãããã³é£æ¥
ãããã¹ãææå±€éã«å¥åã®å±€ãšããŠã®ããã¯ã
ããã¯ååç©ã®æ··å ¥ãå«ãŸãããâåžå
ïŒimbibationïŒâãŸãã¯âåžåããïŒimbibeïŒâãš
ããçšèªã¯ããã¹ãææäžãžã®ããã¯ãããã¯å
åç©åç¬ã®æ¡æ£ã溶åªæŽå©æ¡æ£ãå€åæ§ããªããŒ
äžãžã®ããã¯ãããã¯ååç©ã®åžåãæ°çžãã©ã³
ã¹ãã¢ãŒããã³ä»ã®ããããã©ã³ã¹ãã¢ãŒæ©æ§ã
æå³ããã€å«ããã®ãšãããäŸãã° (a) æ¬çºæã®ããã¯ãããã¯ååç©ãŸãã¯çµæç©
ãã硬åãããšå åŠçã«éæãªããªããŒãã¹ã
ææã圢æããéåæ§çµæç©ãšæ··åãããã€ã
ã®éåæ§çµæç©ããã€ã«ã ãŸãã¯ã·ãŒããŸãã¯
ã¬ã³ãºãšããŠæ³šåããããšãã§ãããããã¯å°
åºæ圢ãŸãã¯ãã®ä»ã®æ¹æ³ã§ã·ãŒããŸãã¯ã¬ã³
ãºã«æ圢ããããšãã§ããã (b) æ¬çºæã®ããã¯ãããã¯ååç©ãæ°ŽãŸãã¯ã¢
ã«ã³ãŒã«ãŸãã¯ä»ã®æº¶åªãŸãã¯æº¶åªæ··åç©ã«æº¶
解ãŸãã¯åæ£ãã次ã«ãããã溶液ãŸãã¯åæ£
液ã®æµŽäžã«ãã¹ãææãæ°åä¹è³æ°æéãäŸã
ã°ïŒâïŒåä¹è³ïŒâïŒæé浞挬ããããšã«ãã€
ãŠåºäœãã¹ãææäžã«åžåãããããšãã§ã
ãã济ã¯ãæ®éãé«æž©ã§ãããéåžžã50â120
âã®ç¯å²ã§ããããã®åŸã§ãã¹ãææã济ãã
åãåºããŠä¹Ÿç¥ããã (c) ããã¯ãããã¯ååç©ããã³çµæç©ã¯ãããª
ããŒçµåå€ã®ååšäžã§ããã¯ãããã¯ååç©ã®
溶液ãŸãã¯åæ£æ¶²ããã®å¹ä»ããå·æ¯å¡ããã¹
ãã³âå¡ããŸãã¯æµžæŒ¬å¡ãã®ãããªéåžžã®æ¹æ³
ã§ãã¹ãææã®è¡šé¢ã«å¡åžããããšãã§ããã
ãã®åŸã§ã該ãã¹ãææããäŸãã°ä¹Ÿç¥åšäž
ã§ã80â180âã®ç¯å²ã®æž©åºŠã§ïŒåä¹è³æ°æé
å ç±ããããšã«ãã€ãŠãããã¯ãããã¯ååç©
ããã¹ãææã«åžåãããã (d) äžèšåžåæ³ã®ïŒã€ã®å€æ³ã§ã¯ãããã¯ããã
ã¯ååç©ãŸãã¯çµæç©ãäžæçæ¯æäœãäŸãã°
ïŒæã®ã¯ã©ããçŽãã¢ã«ãç®ãããªããŒãã€ã«
ã ãŸãã¯åžäžã«å¡åžãã次ã«ãã¹ãææãšæ¥è§Š
ãããŠçœ®ããäŸãã°ä¹Ÿç¥åšäžã§å ç±ããããšã
ã§ããã (e) ããã¯ãããã¯ååç©ãéæããªããŒææäž
ã«æº¶è§£ãŸãã¯åæ£ããããããå¹ä»ããå·æ¯å¡
ããã¹ãã³å¡ããŸãã¯æµžæŒ¬å¡ãã®ãããªä»»æã®
é©åœãªæ¹æ³ã§å¯çãã€ã«ã ã®åœ¢ã§ãã¹ãã®è¡šé¢
ã«é©çšããããšãã§ããã (f) ããã«ãããã¯ãããã¯ååç©ããäžèšã®æ¹
æ³ã®ããããã«ãã€ãŠéæããªããŒææãžæ··å ¥
ãŸãã¯å¡åžãã次ãã§çžé£ããã¹ãææå±€ã®äž
éã®å¥åã®å±€ãšããŠãã¹ãææå ã«å ¥ããããš
ãã§ããã æ¬çºæã®ããã¯ãããã¯ååç©ã¯ã察å¿ããã
ãããœãŒããããã·ãããªã³ååç©ã察å¿ããã€
ã³ããªã³ïŒãã€ãã·ã€ãŒå¡©åºïŒãŸãã¯ã€ã³ããªãŠ
ã å¡©ïŒäŸãã°ãšãŠåç©ïŒååç©ãšåå¿ãããããš
ã«ãã€ãŠåæããããšãã§ããããã®ïŒã€ã®åé§
äœç©è³ªããããªãšãã«ã¢ãã³ã®ãããªå¡©åºãå«
ãããã«ãšã³ãŸãã¯ã€ãœãããããŒã«ã®ãããªé©
åœãªæº¶åªäžã§ãåå¿ãå®äºãããŸã§éæµãããã
ããã¯ãããã¯ååç©ã¯ãäŸãã°éã«ãã€ãŠå
å¿æ··åç©ããååãããå¿ èŠãªãã°åçµæ¶ã«ãã€
ãŠããçŽç²ãªçæç©ãåŸãã 以äžãæ¬çºæãå®æœäŸã«ãã€ãŠããã«èª¬æãã
ãããããã®å®æœäŸã¯ãæ°å€ãã®å€åãå€åœ¢ãåœ
æ¥è ã«ã¯æããã§ããã®ã§ã説æã®ããã®ã¿ã®ã
ã®ã§ããã å®æœäŸ ïŒ ïŒæ¹æ³ ïŒ¡ïŒ 70mlã®ãã«ãšã³äžã®ïŒâããããœâïŒâãããª
ããŒã«ïŒ1.74ïœã0.01ã¢ã«ïŒã®æžæ¿æ¶²ããæ¹æã
ãªãã100â108âã«å ç±ããããã®å ç±æžæ¿æ¶²
ã«ã2.01ïœã®ããªãšãã«ã¢ãã³ïŒ0.02ã¢ã«ïŒãš0.5
mlã®ãšã¿ããŒã«ãšãå«ã40mlã®ãã«ãšã³äžã«æžæ¿
ããã3.43ïœã®ãšãŠåïŒïŒïŒïŒïŒïŒïŒïŒïŒâãã³
ã¿ã¡ãã«âïŒâãšãã«ã€ã³ããªãŠã ïŒ0.01ã¢ã«ïŒ
ã15åéã«ããã€ãŠåŸã ã«æ·»å ããããšãŠåã€ã³
ããªãŠã ã®å ¥ã€ãŠãããã©ã¹ã³ã30mlã®ãã«ãšã³
ã§æŽãããã«ãšã³æŽæ¶²ãåå¿åšãžæ·»å ãããåå¿
åšäžã®æ··åç©ãïŒæééæµããåŸãåå¿æ··åç©ã
ãã«ã³ããŒã·ãšã³ããèžçºããŠã»ãšãã©ä¹Ÿåºãã
ããæç·è²ã¬ã ãšå°éã®çµæ¶æ§ç©è³ªãšã®æ··åç©ã
åŸããããã»ãšãã©ä¹Ÿç¥ããæ··åç©ãïŒâïŒmlã®
æ°ãããã«ãšã³ã§ãœãŒãã³ã°ããéããïŒmlã®
ãã«ãšã³ã§ïŒåæŽã€ãã液ãšæŽæ¶²ãšãåããã
èžçºããããçµæ¶æ§ç©è³ªã¯ãïŒæ¥éã®éã«åŸã ã«
ã¬ã ã«ãªã€ãããã®æ¿çš ãªã¬ã ãïŒâïŒmlã®ãšã¿
ããŒã«ã§ãœãŒãã³ã°ããéãããšã¿ããŒã«ã§æŽ
ãã颚也ãããé»ç·è²ç²æ«ïŒ0.81ïœïŒãåŸãã
ãã液ãšæŽæ¶²ãšãåãããèžçºãããŠãããã«
0.2ïœã®ç·è²çµæ¶æ§ç©è³ªãåŸãããã第ïŒã®çµæ¶
çæç©ãšåãããã ãã®å䜵ããç²è£œçæç©ãã¢ã»ãã³ïŒïœâãã
ãµããŒã«æ··åç©ïŒïŒïŒ3vïŒïœïŒããåçµæ¶ããã
é»ç·è²åŸ®çµæ¶æ§ç²æ«0.76ïœãåŸãããã®ãã®ã¯æ ž
ç£æ°å ±é³ŽïŒNMRïŒåå åæããã³å çŽ åæã«ã
ã€ãŠïŒïŒïŒïŒïŒïŒïŒâããã©ã¡ãã«âïŒâãšãã«
ã¹ãããã€ã³ããªã³âïŒïŒ3â²ãïŒïŒšãããªããïŒïŒ
ïŒâïœããïŒïŒïŒããã³ãŸãªããµãžã³ããšåå®ã
ãããåãåå¿æåãããäœãå¥ã®è£œé ã§åŸãç
æç©ã®è©Šæã®å çŽ åæã®çµæã¯ãççŽ 77.45éé
ïŒ ãæ°ŽçŽ 6.88ééïŒ ãçªçŽ 11.11ééïŒ ã§ãã€ãã
ãããã®å€ã¯ãçè«å€ã®ççŽ 77.60ééïŒ ãæ°ŽçŽ
6.78ééïŒ ãçªçŽ 11.31ééïŒ ãšã»ãŒäžèŽããŠã
ãã ïŒæ¹æ³ ïŒ¢ïŒ 30mlã®ã€ãœãããããŒã«äžã®ïŒâããããœâïŒ
âãããªããŒã«ïŒ0.73ïœã0.0042ã¢ã«ïŒã®æžæ¿æ¶²
ãéæµæž©åºŠã«å ç±ããŠããã®æžæ¿æ¶²ã«ã0.85ïœ
ïŒ0.0085ã¢ã«ïŒã®ããªãšãã«ã¢ãã³ãå«ã35mlã®
ã€ãœãããããŒã«äžã«æº¶è§£ãã1.44ïœïŒ0.0042ã¢
ã«ïŒã®ãšãŠåïŒïŒïŒïŒïŒïŒïŒïŒïŒâãã³ã¿ã¡ãã«
âïŒâãšãã«ã€ã³ããªãŠã ã15åéã«ããã€ãŠ
åŸã ã«æ·»å ãããåŸãããéè²ã®åå¿æ··åç©ãïŒ
æééæµãããåŸã宀枩ãžå·åŽãããããã®éè²
溶液ãïŒæ©äžèžçºããããšãã»ãšãã©ä¹Ÿç¥ãã溶
液å ã«çµæ¶ãçæããããã®çµæ¶ãéããçŽïŒ
mlã®ã€ãœãããããŒã«ã§æŽã€ãåŸã颚也ããæãª
ãªãŒãç·è²ã®ç²æ«ïŒ1.32ïœïŒãåŸãããã®ç²æ«ã
120mlã®æ²žéš°ïœâãããµã³ãžæ·»å ããäžæº¶ã®ç²æ«
ãéã«ãã€ãŠé€å»ããã液ã«æŽ»æ§çïŒ1.5ïœïŒ
ãå ããæ°åéæ¹æããåŸéããã掻æ§çé€å»
åŸã®æ¶²ã®å®¹éãçŽ40mlã«æžå°ããå·èµåº«å ã«ïŒ
æ©äžæŸçœ®ããæãé»è²çµæ¶ãæåºããŠããããã«
ã³ããŒã·ãšã³åŸããã®é»è²çµæ¶ãæ°ããïœâãã
ãµã³ã§æŽã€ãåŸã颚也ããã也ç¥ããçµæ¶ïŒ0.46
ïœïŒã¯ãNMRã«ãã€ãŠïŒïŒïŒïŒïŒïŒïŒâããã©
ã¡ãã«âïŒâãšãã«ã¹ãããã€ã³ããªã³âïŒïŒ
3â²ãïŒïŒšãããªããïŒïŒïŒâïœããïŒïŒïŒããã³ãŸ
ãªããµãžã³ããšåå®ãããã å®æœäŸ ïŒâïŒ äžè¬åŒã®ç¯å²å ã®ä»ã®ããã¯ãããã¯ååç©
ãã溶åªãšããŠãã«ãšã³ãçšããïŒâããããœâ
ïŒâãããªããŒã«ã第ïŒè¡šäžã«èšèŒãã眮æåºã
æããä»ã®ã€ã³ããªã³ãŸãã¯ãšãŠåã€ã³ããªãŠã
ãšåå¿ãããããšã«ãã€ãŠè£œé ããããšãŠåã€ã³
ããªãŠã ã䜿çšãããšãã«ã¯ãå®æœäŸïŒèšèŒã®ã
ãã«ããªãšãã«ã¢ãã³ã䜿çšãããåå¿çæç©
ã¯ãå®æœäŸïŒããã³æ¬çºæã®ããã¯ãããã¯åå
ç©ã®è£œé ã瀺ãä»ã®å®æœäŸã§äŸç€ºããããããª
çš®ã ã®éåžžã®ç²Ÿè£œæ¹æ³ã§ç²Ÿè£œããã
ã³ãŸãªããµãžã³ååç©ã«é¢ããããããã¹ãã
ïŒã€ã³ããªã³ïŒããªããã³ãŸãªããµãžã³ååç©ã
å«ãçµæç©ã¯ããã¯ãããã¯ååç©ãšããŠããã
ãããã¯ãããã¯å¹æããããããããã¯ãããº
ã ãšã¯ãæ¥å ãŸãã¯æ°Žéçã®å ã®ãããªçŽ«å€ç·ã
å«ãå ã®æŸå°ã«æŽé²ããããšãã«å€è²ãã次ã«æŸ
å°ãåæ¢ããããããã¯ååç©ãææã«è²¯èµãã
ãªãã°å ã®è²ã«æ»ãååç©ã瀺ãå¯éççŸè±¡ã§ã
ãããã®çŸè±¡ã瀺ãååç©ãâããã¯ãããã¯å
åç©âãšç§°ãããã®ãããªå¹æãâããã¯ããã
ã¯å¹æâãšç§°ããã åŸæ¥ã®æè¡ çš®ã ã®åã®ããã¯ãããã¯ååç©ãåæãããŠ
ãããã€æ¥å ã«ãã€ãŠå€è²ãŸãã¯æè²åãèµ·ãã
çšéãžã®äœ¿çšãææ¡ãããŠãããç¹ã«ãç±³åœç¹èš±
第3562172å·ã第3578602å·ã第4215010å·ã第
4342668å·ã«èšèŒãããŠãããããªã¹ããïŒã€ã³
ããªã³ïŒããããªããµãžã³ååç©ã¯ãµã³ã°ã©ã¹ã
ãã³çŒçšã¬ã³ãºã®ããã«ç¹å¥ãªå©çã瀺ãããã
ãããã¯ãããã¯ååç©ã¯ãçµæ¶åœ¢ã§ããããã
ã¯éæãªåªè³ªäžã®æº¶æ¶²ãŸãã¯åæ£äœã§ãã€ãŠãã
æ¥å ãŸãã¯çŽ«å€ç·ã«æŽé²ããããšãæ¥éã«ç¡è²ç¶
æ ããéè²ã«å€è²ããææã«æŸçœ®ããããšã«ã
ãããããã¯åŒ·åãªçŽ«å€ç·ã®ç¡ãæã§ã¯å ã®ç¡è²
ã®ç¶æ ã«æ»ãã çºæã®å ·äœç説æ æ¬çºæã«ããã°ãäžèšã®äžè¬åŒ ã§ç€ºãããæ°èŠãªã¹ããïŒã€ã³ããªã³ïŒããªãã
ã³ãŸãªããµãžã³ååç©ãæäŸãããã äžèšäžè¬åŒäžãR1ã¯C1âC8ã¢ã«ãã«ãããš
ãã«ïŒC1âC4ïŒã¢ã«ãã«ããã³ã¢ãªã«ãããªã
矀ããéžã°ããã奜ãŸããã¯ãR1ã¯C1âC4ã¢ã«
ãã«ãŸãã¯ãã³ãžã«åºã§ããã åŒã®R2ïŒR3ã¯ããã®ãã®ãC1âC5ã¢ã«ãã«ã
ããšãã«ããªãã³ã«ã¢ããŒããã³ãžçœ®æããšã
ã«ããããªã矀ããéžã°ãããããã¯çµåããŠïŒ
âïŒåã®ççŽ ååïŒã¹ããççŽ ååãå«ãïŒãå«
ãèç°åŒç°ããã«ãã«ãã«ãã¢ããã³ãã«ãããª
ã矀ããéžã°ããç°åŒç°ã圢æãããããšãã«çœ®
æåºã¯C1âC4ã¢ã«ãã«ããã³C1âC5ã¢ã«ã³ãã·
åºããéžã¶ããšãã§ããã奜ãŸããã¯ãR2ïŒR3
ã¯ããã®ãã®ãC1âC5ã¢ã«ãã«ããéžã°ããã
R2ãŸãã¯R3ã®äžæ¹ã第äžããã«ãŸãã¯ç¬¬äžã¢ã
ã«ã®ãããªç¬¬äžã¢ã«ãã«åºã§ããå Žåã«ã¯ãä»æ¹
ã¯å¥œãŸããã¯ç¬¬äžã¢ã«ãã«åºä»¥å€ã®ã¢ã«ãã«åºã§
ããã äžè¬åŒäžã®R4ïŒR5ã¯ããã®ãã®ãæ°ŽçŽ ãC1
âC5ã¢ã«ãã«ãããã²ã³ãC1âC5ã¢ã«ã³ãã·ã
ã·ã¢ããC1âC8ã¢ã«ã³ãã·ã«ã«ããã«ãããªã
矀ããéžã°ãããR4ïŒR5ã¯ãååç©ã®ã€ã³ããª
ãéšåã®æå¹ãªççŽ ååãããªãã¡ïŒäœãŸãã¯ïŒ
äœãŸãã¯ïŒäœãŸãã¯ïŒäœã®ããããïŒã€ã®äœçœ®ã«
ååšããããšãã§ããã奜ãŸããã¯ã眮æåºR4ïŒ
R5ãæ°ŽçŽ ä»¥å€ã§ããå Žåããããã®çœ®æåºã¯ã€
ã³ããªãéšåã®ïŒäœãšïŒäœãŸãã¯ïŒäœãšïŒäœãŸã
ã¯ïŒäœãšïŒäœãŸãã¯ïŒäœãšïŒäœã®ççŽ ååã®æã«
ååšãããã©ããªããã²ã³ãããªãã¡å¡©çŽ ãè
çŽ ããšãŠçŽ ãåŒçŽ ã§ã䜿çšããããšãã§ãããã
å¡©çŽ ãèçŽ ãç¹ã«å¡©çŽ ã奜ãŸããã奜ãŸããã¯ã
R4ïŒR5ã¯æ°ŽçŽ ãC1âC2ã¢ã«ãã«ãå¡©çŽ ãèçŽ ã
C1âC5ã¢ã«ã³ãã·ãããªã矀ããéžã°ããã ç¹ã«èå³ã®ãããã®ã¯ãR1ãã¡ãã«ããšãã«ã
ïœâãããã«ãã€ãœãããã«ãïœâããã«ã第äº
ããã«ãã€ãœããã«ã第äžããã«ã®ãããªC1â
C4ã¢ã«ãã«ã§ããããã€R2ïŒR3ã®ãã®ãã®ãã¡
ãã«ãŸãã¯ãšãã«ãŸãã¯ããšãã«ã§ããããã€
R4ïŒR5ã®ãã®ãã®ãæ°ŽçŽ ãŸãã¯ã¡ãã«ãŸãã¯ã¡
ããã·ãŸãã¯ã¯ããã§ããäžè¬åŒã§ç€ºãããã
ãã¯ãããã¯ååç©ã§ããã æ¬çºæã®ããã¯ãããã¯ååç©ã¯ããã³ãŒã³ã
ãã«ãšã³ãã¯ãããã«ã ãé ¢é žãšãã«ãã¡ãã«ãš
ãã«ã±ãã³ãã¢ã»ãã³ããšãã«ã¢ã«ã³ãŒã«ãã¡ã
ã«ã¢ã«ã³ãŒã«ãã¢ã»ããããªã«ãããã©ãããã
ã©ã³ããžãªããµã³ããšãã¬ã³ã°ãªã³ãŒã«ã®ã¡ãã«
ãšãŒãã«ããžã¡ãã«ãã«ã ã¢ããããžã¡ãã«ã¹ã«
ããã·ããã¡ãã«ã»ããœã«ããã¢ã«ããªã³ããšã
ã¬ã³ã°ãªã³ãŒã«ã®ãããªéåžžã®ææ©æº¶åªã«æº¶è§£ã
ããããšãã§ãããŸãæ°Žãã¢ã«ã³ãŒã«ãããã³ä»
ã®æº¶åªãå«ã液äœäžã«åæ£ãããããšãã§ããã æ¬çºæã®ããã¯ãããã¯ååç©ã溶解ãããã
ã«çšãããã溶åªã®éã¯ããã¹ãææãžé©çšãã
ãšãããã¹ãææäžã«ããã¯ãããã¯éã®è©²åå
ç©ãäžããããã¯ãããã¯çµæç©ãæäŸããã®ã«
ååãªéã§ãªããã°ãªããªãã æ¬çºæã®ããã¯ãããã¯ååç©ã¯ãéæããªã
ãŒãŸãã¯ãããéæããªããŒã®ã³ããªããŒãŸãã¯
ãã¬ã³ããšé©åœãªææ©æº¶åªãšãã調補ãããç¡è²
ãŸãã¯éæ溶液ãäŸãã°ïŒçš®ä»¥äžã®äžæ²ã®ææ©æº¶
åªäžã«æº¶è§£ãããåŸè¿°ã®éæãã¹ãææã®ããªã
ãŒäžã«æº¶è§£ãããããšãã§ãããããã溶液ã®äŸ
ãšããŠã¯ãããªé ¢é žããã«ã»ã¢ã»ãã³æº¶æ¶²ããã
ãã»ã«ããŒã¹ã»ã¢ã»ããããªã«æº¶æ¶²ãããªå¡©åã
ãã«ã»ã¡ãã«ãšãã«ã±ãã³æº¶æ¶²ãããªã¡ã¿ã¯ãªã«
é žã¡ãã«ã»ã¢ã»ãã³æº¶æ¶²ãã¢ã»ãã«ã»ã«ããŒã¹ã»
ãžã¡ãã«ãã«ã ã¢ãã溶液ãããªããã«ãããªã
ã³ã»ã¢ã»ããããªã«æº¶æ¶²ãããªã¹ãã¬ã³ã»ãã³ãŒ
ã³æº¶æ¶²ããšãã«ã»ã«ããŒã¹ã»å¡©åã¡ãã¬ã³æº¶æ¶²ã
å«ãŸããã äžèšããã¯ãããã¯æº¶æ¶²ãŸãã¯çµæç©ã¯ãããª
ã¢ã»ãã«ã»ã«ããŒã¹ãŸãã¯ããªãšãã¬ã³ãã¬ãã¿
ã¬ãŒããŸãã¯ããªã¿çŽã®ãããªéææ¯æäœã«å¡åž
ãã也ç¥ããŠã玫å€ç·ã«ãã€ãŠéè²ã«çè²ããã
ãŠçŽ«å€ç·æºã®é€å»ã«ãã€ãŠç¡è²ã«æ»ãããã¯ãã
ãã¯ææãåŸãããšãã§ããã æ¬çºæã®ããã¯ãããã¯ååç©ãŸãã¯ãããå«
ãçµæç©ã¯ãåºäœéæéåææ©ææããªãã¡åæ
ãã©ã¹ããã¯ãã¹ãææãžå¡åžããŠãããããã
ãã¯è©²ææå ã«æ··å ¥ãããããšãã§ããã奜ãŸã
ãã¯ããã¹ãææã¯ãå åŠçã«éæãªææãäŸã
ã°çŒçšã¬ã³ãºã®ãããªçŒçšçŽ åã«é©ããææãŸã
ã¯çªã颚é²ã¬ã©ã¹ãªã©ã®ãããªçšéã«é©ããææ
ã§ãããæ¬çºæã®ããã¯ãããã¯ååç©å«ããã¹
ãææã¯ãããã¯ãããã¯ãã©ã¹ããã¯ãã€ã«
ã ãã·ãŒãããã³ã¬ã³ãºãäŸãã°ãµã³ã°ã©ã¹çšã¬
ã³ãºãã¹ããŒãŽãŒã¯ã«ããã€ã¶ãŒïŒvisorsïŒããµ
ã³ãã€ã¶ãŒãã«ã¡ã©ã¬ã³ãºããã³ãã€ã«ã¿ãŒã®è£œ
é ã«çšããããããæ¬æ现æžäžã§çšããâå åŠçŽ
åâãšããçšèªã¯ã¬ã³ãºããã³éæäœ
ïŒtransparenciesïŒãå«ããã®ãšããã æ¬çºæã®ããã¯ãããã¯ååç©ãšå ±ã«äœ¿çšã§ã
ãéæãã¹ãææã®äŸã«ã¯ãããªãªãŒã«ïŒã¢ãªã«
ã«ãŒãããŒãïŒã¢ãããŒã®ããªããŒãããªã¢ã¯ãª
ã¬ãŒããããªã¡ã¿ã¯ãªã«é žã¡ãã«ã®ãããªããª
ïŒã¢ã¯ãªã«é žã¢ã«ãã«ïŒãã¢ã»ãã«ã»ã«ããŒã¹ãã
ãªã¢ã»ãã«ã»ã«ããŒã¹ãé ¢é žããããªã³é žã»ã«ã
ãŒã¹ãé ¢é žé ªé žã»ã«ããŒã¹ãããªïŒé ¢é žããã«ïŒã
ããªïŒããã«ã¢ã«ã³ãŒã«ïŒãããªãŠã¬ã¿ã³ãããª
ã«ãŒãããŒããããªãšãã¬ã³ãã¬ãã¿ã¬ãŒããã
ãªã¹ãã¬ã³ãããªïŒã¹ãã¬ã³âã¡ã¿ã¯ãªã«é žã¡ã
ã«ïŒã³ããªããŒãããªïŒã¹ãã¬ã³âã¢ã¯ãªããã
ãªã«ïŒã³ããªããŒãããªããã«ããã©ãŒã«ãå«ãŸ
ãããéæãªã³ããªããŒããã³éæããªããŒã®ã
ã¬ã³ãããã¹ãææãšããŠé©åœã§ããã奜ãŸãã
ã¯ããã¹ãææã¯ãã¬ã¯ãµã³ïŒLEXANïŒã®åæš
ã§çºå£²ãããŠããããªïŒïŒïŒ4â²âãžãªãã·ãžããš
ããŒã«âïŒïŒïŒâãããã³ïŒã®ãããªããªã«ãŒã
ããŒãïŒãã¬ãã·ã°ã©ã¹ïŒPLEXIGLASïŒã®å
æšã§çºå£²ãããŠããææãããªããªã¡ã¿ã¯ãªã«é ž
ã¡ãã«ïŒããªãªãŒã«ïŒã¢ãªã«ã«ãŒãããŒãïŒãç¹
ã«CRâ39ã®åæšã§çºå£²ãããŠãããžãšãã¬ã³ã°
ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒãïŒãããã³ã
ã®äŸãã°é ¢é žããã«ãšã®ã³ããªããŒãäŸãã°ãžãš
ãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒãïŒ80
â90ïŒ ãšé ¢é žããã«10â20ïŒ ãšã®ã³ããªããŒãç¹
ã«ãžãšãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒ
ãïŒ80â85ïŒ ãšé ¢é žããã«15â20ïŒ ãšã®ã³ããªã
ãŒïŒã¢ã»ãã«ã»ã«ããŒã¹ãããããªã³é žã»ã«ããŒ
ã¹ãé ªé žã»ã«ããŒã¹ãããªã¹ãã¬ã³ããã³ãã®ã¡
ã¿ã¯ãªã«é žã¡ãã«ãé ¢é žããã«ãã¢ã¯ãªããããª
ã«ãšã®ã³ããªããŒããªãã³ã«é ¢é žé ªé žã»ã«ããŒã¹
ãã補é ãããå åŠçã«éæãªéåææ©ææã§ã
ãã éåããŠéæãã¹ãææã圢æããããšãã§ã
ãããªãªãŒã«ïŒã¢ãªã«ã«ãŒãããŒãïŒã¢ãããŒ
ã¯ãçŽéãŸãã¯åæéã®èèªæãŸãã¯è³éŠæ液äœ
ããªãªãŒã«ã®ã¢ãªã«ã«ãŒãããŒããäŸãã°èèªæ
ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒãïŒååç©ã
ããã¯ã¢ã«ããªãã³ãã¹ããšããŒã«ãã¹ïŒã¢ãªã«
ã«ãŒãããŒãïŒååç©ã§ããããããã®ã¢ãããŒ
ã¯ãããªãªãŒã«ãäŸãã°ã°ãªã³ãŒã«ã®äžé£œåããª
ã«ãŒãããŒããšèšãããšãã§ããããããã®ã¢ã
ããŒã¯ãæè¡äžå ¬ç¥ã®æ¹æ³ãäŸãã°ç±³åœç¹èš±ç¬¬
2370567å·ã第2403113å·èšèŒã®æ¹æ³ã§è£œé ããã
ãšãã§ããã ããªãªãŒã«ïŒã¢ãªã«ã«ãŒãããŒãïŒã¯ãäžè¬åŒ
ã§ç€ºãããšãã§ããã äžèšäžè¬åŒäžãã¯äžé£œåã¢ã«ã³ãŒã«ããèª
å°ãããåºã§ãããéåžžã¢ãªã«ãŸãã¯çœ®æã¢ãªã«
åºã§ãããRâ²ã¯ããªãªãŒã«ããèªå°ãããåºã§
ãããïœã¯ïŒâïŒã®æŽæ°ã§ã奜ãŸããã¯ïŒã§ã
ãã ã¢ãªã«åºïŒ²ã¯ãïŒäœã«æŒãŠãããã²ã³ãç¹ã«å¡©çŽ
ãŸãã¯èçŽ ããããã¯ïŒâïŒåã®ççŽ ååãå«ã
ã¢ã«ãã«åºãäžè¬ã«ã¡ãã«ãŸãã¯ãšãã«åºã§çœ®æ
ãããŠããŠããããåºã¯äžè¬åŒ ïŒäžèšäžè¬åŒäžãR0ã¯æ°ŽçŽ ãŸãã¯ããã²ã³ãŸ
ãã¯C1âC4ã¢ã«ãã«åºã§ããïŒã§ç€ºãããšãã§
ãããã®ç¹å¥ãªäŸã«ã¯ãã¢ãªã«ãïŒâã¯ããã¢
ãªã«ãïŒâããã¢ã¢ãªã«ãïŒâãã«ãªãã¢ãªã«ã
ïŒâã¡ãã«ã¢ãªã«ãïŒâãšãã«ã¢ãªã«ãïŒâã€ãœ
ãããã«ã¢ãªã«ãïŒâïœâãããã«ã¢ãªã«ãïŒâ
ïœâããã«ã¢ãªã«ãå«ãŸãããæãæ®éã«ã¯ã
ã¯ã¢ãªã«åºH2CïŒCHâCH2âã§ããã Râ²ã¯ãïŒåãŸãã¯ïŒåãŸãã¯ïŒåãŸãã¯ïŒå
ã®ããããã·åºãå«ãèèªæãŸãã¯è³éŠæã®ããª
ãªãŒã«ã§ããããšãã§ããããªãªãŒã«ããèªå°ã
ããå€äŸ¡åºã§ãããå žåçã«ã¯ãããªãªãŒã«ã¯ïŒ
åã®ããããã·åºãå«ã¿ãããªãã¡ã°ãªã³ãŒã«ãŸ
ãã¯ãã¹ããšããŒã«ã§ãããèèªæããªãªãŒã«ã¯
çŽéã§ãã€ãŠãåæéã§ãã€ãŠãããããã€ïŒâ
10åã®ççŽ ååãå«ããéåžžãèèªæããªãªãŒã«
ã¯ïŒâïŒåã®ççŽ ååãæããã¢ã«ãã¬ã³ã°ãªã³
ãŒã«ãŸãã¯ããªïŒC2âC4ïŒã¢ã«ãã¬ã³ã°ãªã³ãŒ
ã«ãäŸãã°ãšãã¬ã³ã°ãªã³ãŒã«ããããã¬ã³ã°ãª
ã³ãŒã«ãããªã¡ãã¬ã³ã°ãªã³ãŒã«ãããã©ã¡ãã¬
ã³ã°ãªã³ãŒã«ããããã¯ãžãšãã¬ã³ã°ãªã³ãŒã«ã
ããªãšãã¬ã³ã°ãªã³ãŒã«ãªã©ã§ããã è³éŠæããªãªãŒã«ã¯ãäžè¬åŒ ã§ç€ºãããšãã§ããã äžèšäžè¬åŒäžãã¯éç°åŒèèªæçåæ°ŽçŽ ã
ãèªå°ãããïŒäŸ¡ã®åºãäŸãã°ïŒâïŒåã®ççŽ å
åãæããã¢ã«ãã¬ã³ãŸãã¯ã¢ã«ããªãã³åºãäŸ
ãã°ã¡ãã¬ã³ããšãã¬ã³ããžã¡ãã«ã¡ãã¬ã³ïŒã€
ãœããããªãã³ïŒã§ãããRaã¯ïŒâïŒåã®ççŽ
ååã®äœçŽã¢ã«ãã«çœ®æåºã瀺ããïœã¯ïŒãŸãã¯
ïŒãŸãã¯ïŒãŸãã¯ïŒã§ããã奜ãŸããã¯ãããã
ã·ã«åºã¯ãªã«ããŸãã¯ãã©äœã«ããã Râ²åºã®ç¹å¥ãªäŸã«ã¯ããšãã¬ã³ïŒâCH2âCH2
âïŒãããªã¡ãã¬ã³ãã¡ãã«ãšãã¬ã³ãããã©ã¡
ãã¬ã³ããšãã«ãšãã¬ã³ããã³ã¿ã¡ãã¬ã³ããã
ãµã¡ãã¬ã³ãïŒâã¡ãã«ãããµã¡ãã¬ã³ããªã¯ã¿
ã¡ãã¬ã³ããã«ã¡ãã¬ã³ã®ãããªãïŒâ10åã®ç
çŽ ååãå«ãã¢ã«ãã¬ã³åºïŒâCH2ââCH2
âãâCH2âCH2ââCH2âCH2âãâCH2â
âCH2âCH2âãâCH2âCH2âCH2ââ
CH2CH2H2âã®ãããªã¢ã«ãã¬ã³ãšãŒãã«åºïŒ
âCH2CH2ââCH2CH2ââCH2CH2âãâ
CH2CH2CH2ââCH2CH2CH2ââ
CH2CH2CH2âã®ãããªã¢ã«ãã¬ã³ããªãšãŒãã«
åºïŒâCH2CH2ââCOââCH2CH2âã
CH2CH2ââCH2CH2ââCOââ
CH2CH2ââCH2CH2âã®ãããªã¢ã«ãã¬ã³ã«
ãŒãããŒãããã³ã¢ã«ãã¬ã³ãšãŒãã«ã«ãŒãããŒ
ãåºïŒãªãã³ã«ã€ãœããããªãã³ãã¹ïŒïœâããš
ãã«ïŒããªãã¡ ãå«ãŸãããæãæ®éã«ã¯ãRâ²ã¯âCH2CH2âãŸ
ãã¯âCH2CH2ââCH2CH2âãŸãã¯â
CH2CH2ââCH2CH2ââCH2CH2âã§ã
ãã ããªãªãŒã«ïŒã¢ãªã«ã«ãŒãããŒãïŒã¢ãããŒã®
ç¹å¥ãªäŸã«ã¯ããšãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒïŒâã¯
ããã¢ãªã«ã«ãŒãããŒãïŒããšãã¬ã³ã°ãªã³ãŒã«
ãã¹ïŒã¢ãªã«ã«ãŒãããŒãïŒããžãšãã¬ã³ã°ãªã³
ãŒã«ãã¹ïŒïŒâã¡ã¿ãªã«ã«ãŒãããŒãïŒããžãšã
ã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒãïŒãã
ãªãšãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒ
ãïŒããããã¬ã³ã°ãªã³ãŒã«ãã¹ïŒïŒâãšãã«ã¢
ãªã«ã«ãŒãããŒãïŒãïŒïŒïŒâãããã³ãžãªãŒã«
ãã¹ïŒã¢ãªã«ã«ãŒãããŒãïŒãïŒïŒïŒâãã¿ã³ãž
ãªãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒãïŒãïŒïŒïŒâã
ã¿ã³ãžãªãŒã«ãã¹ïŒïŒâããã¢ã¢ãªã«ã«ãŒãããŒ
ãïŒããžãããã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒ
ãããŒãïŒãããªã¡ãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒïŒâ
ãšãã«ã¢ãªã«ã«ãŒãããŒãïŒããã³ã¿ã¡ãã¬ã³ã°
ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒãïŒãã€ãœãã
ããªãã³ãã¹ããšããŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒ
ãïŒãå«ãŸããã æ¬çºæã«æ°èŠãªååç©ãçšããããšãã§ããå·¥
æ¥çã«éèŠãªããªãªãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒ
ãïŒã¢ãããŒã¯ ããªãšãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãã
ãŒãïŒ ãžãšãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒ
ãïŒ ãšãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒ
ãïŒã§ããããžãšãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«
ã«ãŒãããŒãïŒã奜ãŸããã ããªãªãŒã«ïŒã¢ãªã«ã«ãŒãããŒãïŒã¢ãããŒã
補é ããæ¹æ³ãããªãã¡ããªãªãŒã«ïŒãŸãã¯ã¢ãª
ã«ã¢ã«ã³ãŒã«ïŒã®ãã¹ã²ã³åããã³ãã®åŸã®ã¢ãª
ã«ã¢ã«ã³ãŒã«ïŒãŸãã¯ããªãªãŒã«ïŒã«ãããšã¹ã
ã«åã«ãã€ãŠè£œé ããæ¹æ³ã®ããã«ãã¢ãããŒç
æç©ã¯ãã¢ãªã«ã«ãŒãããŒãåºãçµåããéšåã
ïŒå以äžã®ã«ãŒãããŒãåºãå«ãé¢é£ã¢ãããŒçš®
ãå«ãå¯èœæ§ãããããããã®é¢é£ã¢ãããŒçš®ã¯
äžè¬åŒã§ç€ºãããã äžèšäžè¬åŒäžãã¯äžã§å®çŸ©ããéãã§ã
ããRbã¯ãžãªãŒã«ããèªå°ãããïŒäŸ¡åºãäŸã
ã°ã¢ã«ãã¬ã³ãŸãã¯ããšãã¬ã³ã§ãããïœã¯ïŒâ
ïŒã®æŽæ°ã§ããããžãšãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢
ãªã«ã«ãŒãããŒãïŒã®é¢é£ã¢ãããŒçš®ã¯äžè¬åŒ
ã§ç€ºãããšãã§ããã äžèšäžè¬åŒäžãïœã¯ïŒâïŒã®æŽæ°ã§ãããã
ãªãªãŒã«ïŒã¢ãªã«ã«ãŒãããŒãïŒã¢ãããŒã¯ãå ž
åçã«ã¯ïŒâ20ééïŒ ã®é¢é£ã¢ãããŒçš®ãå«ãã
ãšãã§ãããããé¢é£ã¢ãããŒçš®ã¯ãæ··åç©ããª
ãã¡ïŒïŒïŒïŒïŒãªã©ã«çããïœã«ãã€ãŠç€ºããã
çš®ã®æ··åç©ãšããŠååšããããšãã§ããã ããã«ãããªãªãŒã«ïŒã¢ãªã«ã«ãŒãããŒãïŒã¢
ãããŒã®éšåéå圢ã䜿çšããããšãã§ãããã
ã®å®æœæ æ§ã«æŒãŠã¯ãã¢ãããŒãå ç±ã«ãã€ãŠå¢
ç²ããããããããã¯å°éãäŸãã°0.5â1.5éšïŒ
100éšã¢ãããŒïŒphmïŒã®éå§å€ãçšããŠéšåé
åãããŠã²ã«ãå«ãŸãªããããç²çš ãªã¢ãããŒæ
æãäžããã æ¬æ现æžäžã§çšããããªãªãŒã«ïŒã¢ãªã«ã«ãŒã
ããŒãïŒã¢ãããŒãŸãã¯é¡äŒŒã®å称ãäŸãã°ãžãš
ãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒãããŒãïŒ
ã¯ããã®å称ã®ã¢ãããŒãŸãã¯ãã¬ããªããŒãã
ã³ãã®äžã«å«ãŸããé¢é£ã¢ãããŒçš®ãæå³ããã€
å«ããã®ãšããã ãã¹ãææãžå¡åžãŸãã¯è©²ææäžãžæ··å ¥ããã
ããã¯ãããã¯ååç©ãŸãã¯è©²ååç©ãå«ãçµæ
ç©ã®éã¯èšççã§ã¯ãªããäžè¬ã«ããã®ç §å°æã«
ææãªçµæç©ã®è²ã®åŒ·ãããã³ããã¯ãããã¯å
åç©ãæ··å ¥ãŸãã¯å¡åžããããã«çšããæ¹æ³ã«äŸ
åãããå žåçã«ã¯ãããã¯ãããã¯ååç©ã®æ·»
å éãå€ãçšãè²ã®åŒ·ãã¯å€§ãããªããäžè¬ã«ã
ãããéã¯ããã¯ãããã¯éãšèšèŒããããšãã§
ãããæ®éã«ã¯ããã¹ãææäžã«æ··å ¥ããããã
ã¯ãããã¯ååç©ã®éã¯ããã¹ãææã®ééã«å¯Ÿ
ããŠçŽ0.01âçŽ20ééïŒ ãããæ®éã«ã¯ãçŽ0.05
âçŽ10ééïŒ ã®ç¯å²ã§ãããå¥ã®èšãæ¹ããã
ãšãããã¯ãããã¯å¹æãåºãããã«çšãããã
ããã¯ãããã¯ååç©ã®éã¯ãå žåçã«ã¯ããã¹
ãææç©åã®åãã«ã¯ç¡é¢ä¿ã«ãã¹ãææã®è¡šé¢
6.4516cm2ïŒ1in2ïŒåœããããã¯ãããã¯ååç©çŽ
ïŒâçŽ10mgã®ç¯å²ã§ãããåŸã€ãŠãããã¯ããã
ã¯ååç©ã¯ãèãè©Šæããã€ã«ã ãŸãã¯ã³ãŒãã€
ã³ã°ã§ã¯é«æ¿åºŠã§ååšããåãè©Šæã§ã¯äœæ¿åºŠã§
ååšããã æ¬çºæã®ããã¯ãããã¯ååç©ã®ãšã¿ããŒã«æº¶
液ã¯ãå žåçã«ã¯ãç¡è²ãŸãã¯æ·¡ãé»è²ãŸãã¯ç·
è²ãŸãã¯éè²ã§ããããããã®æº¶æ¶²ã¯ã玫å€ç·ã«
æŽé²ããããšã玫è²ãŸãã¯éè²ã«æ¥æ¿ã«å€è²ãã
玫å€ç·æºãåãé€ããšå ã®è²ãŸãã¯ç¡è²ã®ç¶æ ã«
æ»ãããããè²å€åã¯å€æ°ååèŠå¯èœã§ããã æ¬çºæã®ããã¯ãããã¯ååç©ãŸãã¯çµæç©
ã¯ãæè¡äžå ¬ç¥ã®æ¹æ³ã§ãã¹ãææãžå¡åžãŸãã¯
該ææäžãžæ··å ¥ããããšãã§ããããããæ¹æ³ã«
ã¯ããã¹ãææäžãžã®ããã¯ãããã¯ååç©ã®æº¶
解ãŸãã¯åæ£ãããªãã¡æµžæŒ¬ãŸãã¯ç±ç移åãŸã
ã¯ã³ãŒãã€ã³ã°ã«ãããã¹ãææäžãžã®ããã¯ã
ããã¯ååç©ã®åžåïŒimbibationïŒãããã³é£æ¥
ãããã¹ãææå±€éã«å¥åã®å±€ãšããŠã®ããã¯ã
ããã¯ååç©ã®æ··å ¥ãå«ãŸãããâåžå
ïŒimbibationïŒâãŸãã¯âåžåããïŒimbibeïŒâãš
ããçšèªã¯ããã¹ãææäžãžã®ããã¯ãããã¯å
åç©åç¬ã®æ¡æ£ã溶åªæŽå©æ¡æ£ãå€åæ§ããªããŒ
äžãžã®ããã¯ãããã¯ååç©ã®åžåãæ°çžãã©ã³
ã¹ãã¢ãŒããã³ä»ã®ããããã©ã³ã¹ãã¢ãŒæ©æ§ã
æå³ããã€å«ããã®ãšãããäŸãã° (a) æ¬çºæã®ããã¯ãããã¯ååç©ãŸãã¯çµæç©
ãã硬åãããšå åŠçã«éæãªããªããŒãã¹ã
ææã圢æããéåæ§çµæç©ãšæ··åãããã€ã
ã®éåæ§çµæç©ããã€ã«ã ãŸãã¯ã·ãŒããŸãã¯
ã¬ã³ãºãšããŠæ³šåããããšãã§ãããããã¯å°
åºæ圢ãŸãã¯ãã®ä»ã®æ¹æ³ã§ã·ãŒããŸãã¯ã¬ã³
ãºã«æ圢ããããšãã§ããã (b) æ¬çºæã®ããã¯ãããã¯ååç©ãæ°ŽãŸãã¯ã¢
ã«ã³ãŒã«ãŸãã¯ä»ã®æº¶åªãŸãã¯æº¶åªæ··åç©ã«æº¶
解ãŸãã¯åæ£ãã次ã«ãããã溶液ãŸãã¯åæ£
液ã®æµŽäžã«ãã¹ãææãæ°åä¹è³æ°æéãäŸã
ã°ïŒâïŒåä¹è³ïŒâïŒæé浞挬ããããšã«ãã€
ãŠåºäœãã¹ãææäžã«åžåãããããšãã§ã
ãã济ã¯ãæ®éãé«æž©ã§ãããéåžžã50â120
âã®ç¯å²ã§ããããã®åŸã§ãã¹ãææã济ãã
åãåºããŠä¹Ÿç¥ããã (c) ããã¯ãããã¯ååç©ããã³çµæç©ã¯ãããª
ããŒçµåå€ã®ååšäžã§ããã¯ãããã¯ååç©ã®
溶液ãŸãã¯åæ£æ¶²ããã®å¹ä»ããå·æ¯å¡ããã¹
ãã³âå¡ããŸãã¯æµžæŒ¬å¡ãã®ãããªéåžžã®æ¹æ³
ã§ãã¹ãææã®è¡šé¢ã«å¡åžããããšãã§ããã
ãã®åŸã§ã該ãã¹ãææããäŸãã°ä¹Ÿç¥åšäž
ã§ã80â180âã®ç¯å²ã®æž©åºŠã§ïŒåä¹è³æ°æé
å ç±ããããšã«ãã€ãŠãããã¯ãããã¯ååç©
ããã¹ãææã«åžåãããã (d) äžèšåžåæ³ã®ïŒã€ã®å€æ³ã§ã¯ãããã¯ããã
ã¯ååç©ãŸãã¯çµæç©ãäžæçæ¯æäœãäŸãã°
ïŒæã®ã¯ã©ããçŽãã¢ã«ãç®ãããªããŒãã€ã«
ã ãŸãã¯åžäžã«å¡åžãã次ã«ãã¹ãææãšæ¥è§Š
ãããŠçœ®ããäŸãã°ä¹Ÿç¥åšäžã§å ç±ããããšã
ã§ããã (e) ããã¯ãããã¯ååç©ãéæããªããŒææäž
ã«æº¶è§£ãŸãã¯åæ£ããããããå¹ä»ããå·æ¯å¡
ããã¹ãã³å¡ããŸãã¯æµžæŒ¬å¡ãã®ãããªä»»æã®
é©åœãªæ¹æ³ã§å¯çãã€ã«ã ã®åœ¢ã§ãã¹ãã®è¡šé¢
ã«é©çšããããšãã§ããã (f) ããã«ãããã¯ãããã¯ååç©ããäžèšã®æ¹
æ³ã®ããããã«ãã€ãŠéæããªããŒææãžæ··å ¥
ãŸãã¯å¡åžãã次ãã§çžé£ããã¹ãææå±€ã®äž
éã®å¥åã®å±€ãšããŠãã¹ãææå ã«å ¥ããããš
ãã§ããã æ¬çºæã®ããã¯ãããã¯ååç©ã¯ã察å¿ããã
ãããœãŒããããã·ãããªã³ååç©ã察å¿ããã€
ã³ããªã³ïŒãã€ãã·ã€ãŒå¡©åºïŒãŸãã¯ã€ã³ããªãŠ
ã å¡©ïŒäŸãã°ãšãŠåç©ïŒååç©ãšåå¿ãããããš
ã«ãã€ãŠåæããããšãã§ããããã®ïŒã€ã®åé§
äœç©è³ªããããªãšãã«ã¢ãã³ã®ãããªå¡©åºãå«
ãããã«ãšã³ãŸãã¯ã€ãœãããããŒã«ã®ãããªé©
åœãªæº¶åªäžã§ãåå¿ãå®äºãããŸã§éæµãããã
ããã¯ãããã¯ååç©ã¯ãäŸãã°éã«ãã€ãŠå
å¿æ··åç©ããååãããå¿ èŠãªãã°åçµæ¶ã«ãã€
ãŠããçŽç²ãªçæç©ãåŸãã 以äžãæ¬çºæãå®æœäŸã«ãã€ãŠããã«èª¬æãã
ãããããã®å®æœäŸã¯ãæ°å€ãã®å€åãå€åœ¢ãåœ
æ¥è ã«ã¯æããã§ããã®ã§ã説æã®ããã®ã¿ã®ã
ã®ã§ããã å®æœäŸ ïŒ ïŒæ¹æ³ ïŒ¡ïŒ 70mlã®ãã«ãšã³äžã®ïŒâããããœâïŒâãããª
ããŒã«ïŒ1.74ïœã0.01ã¢ã«ïŒã®æžæ¿æ¶²ããæ¹æã
ãªãã100â108âã«å ç±ããããã®å ç±æžæ¿æ¶²
ã«ã2.01ïœã®ããªãšãã«ã¢ãã³ïŒ0.02ã¢ã«ïŒãš0.5
mlã®ãšã¿ããŒã«ãšãå«ã40mlã®ãã«ãšã³äžã«æžæ¿
ããã3.43ïœã®ãšãŠåïŒïŒïŒïŒïŒïŒïŒïŒïŒâãã³
ã¿ã¡ãã«âïŒâãšãã«ã€ã³ããªãŠã ïŒ0.01ã¢ã«ïŒ
ã15åéã«ããã€ãŠåŸã ã«æ·»å ããããšãŠåã€ã³
ããªãŠã ã®å ¥ã€ãŠãããã©ã¹ã³ã30mlã®ãã«ãšã³
ã§æŽãããã«ãšã³æŽæ¶²ãåå¿åšãžæ·»å ãããåå¿
åšäžã®æ··åç©ãïŒæééæµããåŸãåå¿æ··åç©ã
ãã«ã³ããŒã·ãšã³ããèžçºããŠã»ãšãã©ä¹Ÿåºãã
ããæç·è²ã¬ã ãšå°éã®çµæ¶æ§ç©è³ªãšã®æ··åç©ã
åŸããããã»ãšãã©ä¹Ÿç¥ããæ··åç©ãïŒâïŒmlã®
æ°ãããã«ãšã³ã§ãœãŒãã³ã°ããéããïŒmlã®
ãã«ãšã³ã§ïŒåæŽã€ãã液ãšæŽæ¶²ãšãåããã
èžçºããããçµæ¶æ§ç©è³ªã¯ãïŒæ¥éã®éã«åŸã ã«
ã¬ã ã«ãªã€ãããã®æ¿çš ãªã¬ã ãïŒâïŒmlã®ãšã¿
ããŒã«ã§ãœãŒãã³ã°ããéãããšã¿ããŒã«ã§æŽ
ãã颚也ãããé»ç·è²ç²æ«ïŒ0.81ïœïŒãåŸãã
ãã液ãšæŽæ¶²ãšãåãããèžçºãããŠãããã«
0.2ïœã®ç·è²çµæ¶æ§ç©è³ªãåŸãããã第ïŒã®çµæ¶
çæç©ãšåãããã ãã®å䜵ããç²è£œçæç©ãã¢ã»ãã³ïŒïœâãã
ãµããŒã«æ··åç©ïŒïŒïŒ3vïŒïœïŒããåçµæ¶ããã
é»ç·è²åŸ®çµæ¶æ§ç²æ«0.76ïœãåŸãããã®ãã®ã¯æ ž
ç£æ°å ±é³ŽïŒNMRïŒåå åæããã³å çŽ åæã«ã
ã€ãŠïŒïŒïŒïŒïŒïŒïŒâããã©ã¡ãã«âïŒâãšãã«
ã¹ãããã€ã³ããªã³âïŒïŒ3â²ãïŒïŒšãããªããïŒïŒ
ïŒâïœããïŒïŒïŒããã³ãŸãªããµãžã³ããšåå®ã
ãããåãåå¿æåãããäœãå¥ã®è£œé ã§åŸãç
æç©ã®è©Šæã®å çŽ åæã®çµæã¯ãççŽ 77.45éé
ïŒ ãæ°ŽçŽ 6.88ééïŒ ãçªçŽ 11.11ééïŒ ã§ãã€ãã
ãããã®å€ã¯ãçè«å€ã®ççŽ 77.60ééïŒ ãæ°ŽçŽ
6.78ééïŒ ãçªçŽ 11.31ééïŒ ãšã»ãŒäžèŽããŠã
ãã ïŒæ¹æ³ ïŒ¢ïŒ 30mlã®ã€ãœãããããŒã«äžã®ïŒâããããœâïŒ
âãããªããŒã«ïŒ0.73ïœã0.0042ã¢ã«ïŒã®æžæ¿æ¶²
ãéæµæž©åºŠã«å ç±ããŠããã®æžæ¿æ¶²ã«ã0.85ïœ
ïŒ0.0085ã¢ã«ïŒã®ããªãšãã«ã¢ãã³ãå«ã35mlã®
ã€ãœãããããŒã«äžã«æº¶è§£ãã1.44ïœïŒ0.0042ã¢
ã«ïŒã®ãšãŠåïŒïŒïŒïŒïŒïŒïŒïŒïŒâãã³ã¿ã¡ãã«
âïŒâãšãã«ã€ã³ããªãŠã ã15åéã«ããã€ãŠ
åŸã ã«æ·»å ãããåŸãããéè²ã®åå¿æ··åç©ãïŒ
æééæµãããåŸã宀枩ãžå·åŽãããããã®éè²
溶液ãïŒæ©äžèžçºããããšãã»ãšãã©ä¹Ÿç¥ãã溶
液å ã«çµæ¶ãçæããããã®çµæ¶ãéããçŽïŒ
mlã®ã€ãœãããããŒã«ã§æŽã€ãåŸã颚也ããæãª
ãªãŒãç·è²ã®ç²æ«ïŒ1.32ïœïŒãåŸãããã®ç²æ«ã
120mlã®æ²žéš°ïœâãããµã³ãžæ·»å ããäžæº¶ã®ç²æ«
ãéã«ãã€ãŠé€å»ããã液ã«æŽ»æ§çïŒ1.5ïœïŒ
ãå ããæ°åéæ¹æããåŸéããã掻æ§çé€å»
åŸã®æ¶²ã®å®¹éãçŽ40mlã«æžå°ããå·èµåº«å ã«ïŒ
æ©äžæŸçœ®ããæãé»è²çµæ¶ãæåºããŠããããã«
ã³ããŒã·ãšã³åŸããã®é»è²çµæ¶ãæ°ããïœâãã
ãµã³ã§æŽã€ãåŸã颚也ããã也ç¥ããçµæ¶ïŒ0.46
ïœïŒã¯ãNMRã«ãã€ãŠïŒïŒïŒïŒïŒïŒïŒâããã©
ã¡ãã«âïŒâãšãã«ã¹ãããã€ã³ããªã³âïŒïŒ
3â²ãïŒïŒšãããªããïŒïŒïŒâïœããïŒïŒïŒããã³ãŸ
ãªããµãžã³ããšåå®ãããã å®æœäŸ ïŒâïŒ äžè¬åŒã®ç¯å²å ã®ä»ã®ããã¯ãããã¯ååç©
ãã溶åªãšããŠãã«ãšã³ãçšããïŒâããããœâ
ïŒâãããªããŒã«ã第ïŒè¡šäžã«èšèŒãã眮æåºã
æããä»ã®ã€ã³ããªã³ãŸãã¯ãšãŠåã€ã³ããªãŠã
ãšåå¿ãããããšã«ãã€ãŠè£œé ããããšãŠåã€ã³
ããªãŠã ã䜿çšãããšãã«ã¯ãå®æœäŸïŒèšèŒã®ã
ãã«ããªãšãã«ã¢ãã³ã䜿çšãããåå¿çæç©
ã¯ãå®æœäŸïŒããã³æ¬çºæã®ããã¯ãããã¯åå
ç©ã®è£œé ã瀺ãä»ã®å®æœäŸã§äŸç€ºããããããª
çš®ã ã®éåžžã®ç²Ÿè£œæ¹æ³ã§ç²Ÿè£œããã
ãè¡šã
å®æœäŸïŒâïŒã®åååç©ã®ãšã¿ããŒã«æº¶æ¶²ã¯ã
宀枩ã«æŒãŠçŽ«å€ç·ã§ç §å°ãããšãéè²ã«å€åã
ãããããã®æº¶æ¶²ã¯ã玫å€ç·ãåãå»ã€ãåŸã¯ã
ãããã®å ã®è²çžãŸãã¯ç¡è²ã«æ»ã€ãã å®æœäŸ 10 30mlã®ãã«ãšã³äžã®ïŒâããããœâïŒâãããª
ããŒã«ïŒ1.05ïœã0.006ã¢ã«ïŒã®æžæ¿æ¶²ããæ¹æ
ããªããéæµæž©åºŠã«å ç±ããããã®å æãã溶液
ã«ã20mlã®ãã«ãšã³äžã«æº¶è§£ãã1.37ïœã®ïŒâã
ãã«âïŒâã¡ãã«âïŒâãšãã«âïŒâã¡ãã¬ã³ã€
ã³ããªã³ïŒ0.006ã¢ã«ïŒã20åéã«ããã€ãŠåŸã
ã«æ·»å ãããåå¿åšäžã®æ··åç©ãïŒæééæµãã
åŸãåå¿æ··åç©ãèžçºç¿ãžç§»ããèžçºãããŠã»ãš
ãã©ä¹Ÿåºãããããã®ã»ãšãã©ä¹Ÿåºããæ··åç©ã
ïŒmlã®æ°ãããã«ãšã³ã§ãœãŒãã³ã°ããéãã
ïŒmlã®ãã«ãšã³ã§ïŒåæŽæµããã液ãšæŽæ¶²ãšã
åãããèžçºãããŠãç²çš ãªæéè²ã¬ã ãåŸãã
åŸãããã¬ã ããŒã¹ããçŽ20mlã®ãžãšãã«ãšãŒã
ã«ã«å溶解ããéãã液ãããŒãäžã§èžçºã
ããããã®ãšãŒãã«æº¶æ¶²ïŒæ»Žããšã¿ããŒã«ã§åžé
ãã宀枩ã§çŽ30ç§é玫å€ç·ç §å°ãããšã溶液ã¯é
è²ã«å€è²ããããã®éè²ã¯ã玫å€ç·ãåãå»ã
ãšãçŽïŒååŸã«æ¶å€±ããã ãšãŒãã«æº¶æ¶²ãèžçºãããŠåŸãã¬ã ããŒã¹ãã
ç空ãã·ã±ãŒã¿ãŒå ã§æ°æ¥é也ç¥ãããããã®ä¹Ÿ
ç¥ããŒã¹ãã10mlã®ãã«ãšã³ã«æº¶è§£ãã5.6ïœã®
ç¡«é žãããªãŠã ã§è±æ°ŽããéããïŒmlã®ãã«ãš
ã³ã§æŽã€ãã液ãšæŽæ¶²ãšãåãããããŒãäžã§
èžçºãããŠæéè²ããŒã¹ããåŸãã å®æœäŸ 11 å®æœäŸïŒâ10ã®ããã¯ãããã¯ååç©ïŒéšã10
éšã®åžè²©ã©ãã«ãŒïŒ3M瀟ã©ãã«ãŒNo.2253ïŒãš10
éšã®ãã«ãšã³ãš10éšã®ã¡ãã«ãšãã«ã±ãã³ãšã®å¹
ä»ãçšã©ãã«ãŒæº¶æ¶²äžã«æ·»å ããããã®ã©ãã«ãŒ
溶液ãããžãšãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒ
ãããŒãïŒãã補é ãã2.54cmïŒ1inïŒÃ2.54cm
ïŒ1inïŒÃåãïŒmmã®ããªããŒã¯ãŒãã³ã®è¡šé¢ã«å¹
ä»ããã也ç¥åŸããã®è¢«èŠã¯ãŒãã³ã空æ°ä¹Ÿç¥åš
äžã§160âã§20åéå ç±ãããå·åŸãæ®çã©ãã«
ãŒãæ¥çããŒãã§å¥é¢ããã¢ã»ãã³ã§æ¹¿ãããã¯
ãã¹ã§è¡šé¢ãæž æããããã®ããã¯ãããã¯ã¿ã
ã¬ããã®äººå·¥æ¥å ã«ãã掻æ§åã«å¯Ÿããããã¯ã
ããã¯æå¿ãè©Šéšãããçµæã第ïŒè¡šã«ç€ºãã
宀枩ã«æŒãŠçŽ«å€ç·ã§ç §å°ãããšãéè²ã«å€åã
ãããããã®æº¶æ¶²ã¯ã玫å€ç·ãåãå»ã€ãåŸã¯ã
ãããã®å ã®è²çžãŸãã¯ç¡è²ã«æ»ã€ãã å®æœäŸ 10 30mlã®ãã«ãšã³äžã®ïŒâããããœâïŒâãããª
ããŒã«ïŒ1.05ïœã0.006ã¢ã«ïŒã®æžæ¿æ¶²ããæ¹æ
ããªããéæµæž©åºŠã«å ç±ããããã®å æãã溶液
ã«ã20mlã®ãã«ãšã³äžã«æº¶è§£ãã1.37ïœã®ïŒâã
ãã«âïŒâã¡ãã«âïŒâãšãã«âïŒâã¡ãã¬ã³ã€
ã³ããªã³ïŒ0.006ã¢ã«ïŒã20åéã«ããã€ãŠåŸã
ã«æ·»å ãããåå¿åšäžã®æ··åç©ãïŒæééæµãã
åŸãåå¿æ··åç©ãèžçºç¿ãžç§»ããèžçºãããŠã»ãš
ãã©ä¹Ÿåºãããããã®ã»ãšãã©ä¹Ÿåºããæ··åç©ã
ïŒmlã®æ°ãããã«ãšã³ã§ãœãŒãã³ã°ããéãã
ïŒmlã®ãã«ãšã³ã§ïŒåæŽæµããã液ãšæŽæ¶²ãšã
åãããèžçºãããŠãç²çš ãªæéè²ã¬ã ãåŸãã
åŸãããã¬ã ããŒã¹ããçŽ20mlã®ãžãšãã«ãšãŒã
ã«ã«å溶解ããéãã液ãããŒãäžã§èžçºã
ããããã®ãšãŒãã«æº¶æ¶²ïŒæ»Žããšã¿ããŒã«ã§åžé
ãã宀枩ã§çŽ30ç§é玫å€ç·ç §å°ãããšã溶液ã¯é
è²ã«å€è²ããããã®éè²ã¯ã玫å€ç·ãåãå»ã
ãšãçŽïŒååŸã«æ¶å€±ããã ãšãŒãã«æº¶æ¶²ãèžçºãããŠåŸãã¬ã ããŒã¹ãã
ç空ãã·ã±ãŒã¿ãŒå ã§æ°æ¥é也ç¥ãããããã®ä¹Ÿ
ç¥ããŒã¹ãã10mlã®ãã«ãšã³ã«æº¶è§£ãã5.6ïœã®
ç¡«é žãããªãŠã ã§è±æ°ŽããéããïŒmlã®ãã«ãš
ã³ã§æŽã€ãã液ãšæŽæ¶²ãšãåãããããŒãäžã§
èžçºãããŠæéè²ããŒã¹ããåŸãã å®æœäŸ 11 å®æœäŸïŒâ10ã®ããã¯ãããã¯ååç©ïŒéšã10
éšã®åžè²©ã©ãã«ãŒïŒ3M瀟ã©ãã«ãŒNo.2253ïŒãš10
éšã®ãã«ãšã³ãš10éšã®ã¡ãã«ãšãã«ã±ãã³ãšã®å¹
ä»ãçšã©ãã«ãŒæº¶æ¶²äžã«æ·»å ããããã®ã©ãã«ãŒ
溶液ãããžãšãã¬ã³ã°ãªã³ãŒã«ãã¹ïŒã¢ãªã«ã«ãŒ
ãããŒãïŒãã補é ãã2.54cmïŒ1inïŒÃ2.54cm
ïŒ1inïŒÃåãïŒmmã®ããªããŒã¯ãŒãã³ã®è¡šé¢ã«å¹
ä»ããã也ç¥åŸããã®è¢«èŠã¯ãŒãã³ã空æ°ä¹Ÿç¥åš
äžã§160âã§20åéå ç±ãããå·åŸãæ®çã©ãã«
ãŒãæ¥çããŒãã§å¥é¢ããã¢ã»ãã³ã§æ¹¿ãããã¯
ãã¹ã§è¡šé¢ãæž æããããã®ããã¯ãããã¯ã¿ã
ã¬ããã®äººå·¥æ¥å ã«ãã掻æ§åã«å¯Ÿããããã¯ã
ããã¯æå¿ãè©Šéšãããçµæã第ïŒè¡šã«ç€ºãã
ãè¡šã
ãè¡šã
å®æœäŸ 12
å
è¡æè¡ã®ããã¯ãããã¯ååç©ããå®æœäŸ11
èšèŒãšåãæ¹æ³ã§ããžãšãã¬ã³ã°ãªã³ãŒã«ãã¹
ïŒã¢ãªã«ã«ãŒãããŒãïŒãã補é ããã¯ãŒãã³ã«
å¡åžããããããã®ç©åã®ããã¯ãããã¯æå¿ã
å®æœäŸïŒïŒïŒïŒïŒããã®ç©åãšæ¯èŒããŠç¬¬ïŒè¡šã«
瀺ãããããã®ããã¯ãããã¯ååç©ã¯äžèšã®äž
è¬åŒã§ç€ºãããšãã§ããã äžèšäžè¬åŒäžãR4ïŒR5ïŒR6ïŒïŒžã¯ç¬¬ïŒè¡šäžã«
èšèŒããŠããã
èšèŒãšåãæ¹æ³ã§ããžãšãã¬ã³ã°ãªã³ãŒã«ãã¹
ïŒã¢ãªã«ã«ãŒãããŒãïŒãã補é ããã¯ãŒãã³ã«
å¡åžããããããã®ç©åã®ããã¯ãããã¯æå¿ã
å®æœäŸïŒïŒïŒïŒïŒããã®ç©åãšæ¯èŒããŠç¬¬ïŒè¡šã«
瀺ãããããã®ããã¯ãããã¯ååç©ã¯äžèšã®äž
è¬åŒã§ç€ºãããšãã§ããã äžèšäžè¬åŒäžãR4ïŒR5ïŒR6ïŒïŒžã¯ç¬¬ïŒè¡šäžã«
èšèŒããŠããã
ãè¡šã
å®æœäŸ 13
20mlã®ãã«ãšã³äžã®ïŒâããããœâïŒâãããª
ããŒã«ïŒ0.52ïœã0.003ã¢ã«ïŒã®æžæ¿æ¶²ããæ¹æ
ããªããçŽ100âã«å ç±ããããã®å ç±ããæžæ¿
液ã«ã0.60ïœã®ããªãšãã«ã¢ãã³ïŒ0.006ã¢ã«ïŒ
ãå«ã20mlã®ãã«ãšã³äžã«æžæ¿ããã1.75ïœ
ïŒ0.003ã¢ã«ïŒã®ãšãŠåïŒïŒïŒâãžã¡ãã«âïŒïŒïŒ
âãã¹ïŒïŒ°âã¡ããã·ããšãã«ïŒã€ã³ããªãŠã
ããçŽ20åéã«ããã€ãŠåŸã ã«æ·»å ãããåå¿åš
äžã®æ··åç©ãçŽ100âã§25æéä¿ã¡ãåå¿ã®åºŠå
ãèå±€ã¯ãããã°ã©ãã€ãŒïŒTLCïŒã§ç£èŠããã
åå¿ã¯ïŒæéåŸã«ã»ãŒå®äºãããçŽ100âã§2.5æ
éåŸãããã«0.17ïœïŒ0.001ã¢ã«ïŒã®ïŒâããã
ãœâïŒâãããªããŒã«ãåå¿åšãžæ·»å ããããçŽ
100âã§ïŒæéåŸã§ããšãŠåã€ã³ããªãŠã åå¿æ
åã®å®å šåå¿ã¯åŸãããªãã€ãããã«ã³ããŒã·ãš
ã³ã«ãã€ãŠåå¿æ··åç©äžã®åºäœãåé¢ããæ®ãã®
液äœãèžçºãããŠã»ãšãã©ä¹Ÿåºãããããã®ã»ãš
ãã©ä¹ŸåºããããŒã¹ãäžã«ãªãªãŒãç·è²ã®çµæ¶ã
çæããããã®ã»ãšãã©ä¹Ÿåºããçæç©ãïŒmlã®
æ°ãããã«ãšã³ã§ãœãŒãã³ã°ããéããïŒmlã®
ãã«ãšã³ã§åŸã ã«æŽã€ããå€éã®çµæ¶æ§ç²æ«çæ
ç©ããã«ãšã³ã«æº¶è§£ããªãã€ãããã®äžæº¶æ§ã®çµ
æ¶æ§ç²æ«ããšã¿ããŒã«ã§æŽã€ãŠé¢šä¹ŸãããªãªãŒã
ç·è²ç²æ«ïŒ0.79ïœïŒãåŸãããã®ç²æ«ã®è©Šæããš
ã¿ããŒã«ã«æº¶è§£ãã玫å€ç·ïŒ366nmïŒã§çŽ30ç§é
ç §å°ããã溶液ã¯æ·¡ç·è²ããéè²ã«å€ããã玫å€
ç·ãåãå»ã€ããšããæ·¡ç·è²ã«æ»ã€ãã å®æœäŸ 14 35mlã®ãã«ãšã³äžã®ïŒâããããœâïŒâãããª
ããŒã«ïŒ1.39ïœã0.008ã¢ã«ïŒã®æžæ¿æ¶²ããæ¹æ
ããªããçŽ100âã«å ç±ããããã®å ç±ããæžæ¿
液ã«ã1.6ïœã®ããªãšãã«ã¢ãã³ïŒ0.016ã¢ã«ïŒã
å«ã35mlã®ãã«ãšã³äžã«æžæ¿ããã295ïœã®ãšãŠ
åïŒïŒïŒïŒïŒïŒïŒâããã©ã¡ãã«âïŒïŒïŒâã¹ã
ãïŒã·ã¯ãããã·ã«ïŒâã3Hãã€ã³ããªãŠã ã
20â30åéã«ããã€ãŠåŸã ã«æ·»å ãããåå¿ã®é²
è¡ç¶æ³ã¯TLCã§èª¿ã¹ããåå¿åšäžã®æ··åç©ãçŽ
100âã§ïŒæéä¿ã€ãåŸãåå¿æ··åç©ïŒæè€è²æº¶
液ïŒãèžçºãããŠã»ãšãã©ä¹ŸåºããããåŸããã
ããŒã¹ããïŒmlã®æ°ãããã«ãšã³ã§æ°åé浞挬
ããéããŠäžæº¶ç©ãé€å»ããåŸãããåºäœãïŒ
mlã®ãã«ãšã³ã§æŽæµããã液ãšæŽæ¶²ãšãåã
ããèžçºãããæè€è²ããŒã¹ãïŒ2.07ïœïŒãåŸ
ãããã®ããŒã¹ãã®å°éïŒçŽïŒmgïŒãçŽïŒâïŒml
ã®ãšã¿ããŒã«ã«æº¶è§£ããåŸããã溶液ãã宀枩ã§
玫å€ç·ïŒ366nmïŒã«æŽé²ããã溶液ã¯æ·¡éè²ã«å€
è²ãã玫å€ç·æºãåãå»ã€ãåŸãçŽïŒåéã§å ã®
è²çžã«æ»ã€ãã å®æœäŸ 15 å®æœäŸ14ã®æäœã«åŸã€ãŠã1.22ïœïŒ0.007ã¢ã«ïŒ
ã®ïŒâããããœâïŒâãããªããŒã«ãã60mlã®ã
ã«ãšã³äžã®1.70ïœïŒ0.007ã¢ã«ïŒã®ïŒâã¢ãªã«â
ïŒïŒïŒïŒïŒâããªã¡ãã«âïŒâãšãã«âïŒâã¡ã
ã¬ã³ã€ã³ããªã³ãšãçŽ100âã§çŽïŒæéåå¿ãã
ããåå¿æ··åç©ãèžçºãããŠã»ãšãã©ä¹ŸåºããåŸ
ãããããŒã¹ããïŒmlã®ãã«ãšã³ã§æ°åéãœãŒã
ã³ã°ããåŸãéãããäžæº¶ç©ãïŒmlã®ãã«ãšã³
ã§æŽæµããã液ãšæŽæ¶²ãšãåãããèžçºãã
ãŠãæïŒåž¯ç·ïŒè€è²ããŒã¹ãïŒ2.49ïœïŒãåŸãã
ãã®ããŒã¹ãã®å°éãïŒâïŒmlã®ãšã¿ããŒã«ã«æº¶
解ããåŸãããæ·¡é»è²æº¶æ¶²ã玫å€ç·ïŒ366nmïŒã«
æŽé²ããã溶液ã¯ç·è²ã«å€ããã玫å€ç·æºãåã
å»ã€ãåŸãçŽïŒâïŒåã§å ã®è²çžã«æ»ã€ãã å®æœäŸ 16 å®æœäŸ14ã®æäœã«åŸã€ãŠã40mlã®ãã«ãšã³äžã®
1.74ïœïŒ0.01ã¢ã«ïŒã®ïŒâããããœâïŒâãããª
ããŒã«ã®æžæ¿æ¶²ããïŒïœïŒ0.02ã¢ã«ïŒã®ããªãšã
ã«ã¢ãã³ãå«ã40mlã®ãã«ãšã³äžã®3.57ïœïŒ0.01
ã¢ã«ïŒã®ãšãŠåïŒïŒïŒâãžãšãã«âïŒïŒïŒïŒïŒïŒ
ïŒâããã©ã¡ãã«ã€ã³ããªãŠã ãšåå¿ããããïŒ
æéã®åå¿åŸãæéç·è²ã®æº¶æ¶²ãåŸããã®æº¶æ¶²ã
èžçºãããŠã»ãšãã©ä¹ŸåºããããåŸãããããŒã¹
ããïŒmlã®ãã«ãšã³ã§æ°åéãœãŒãã³ã°ããé
ãããåŸãããåºäœãïŒmlã®ãã«ãšã³ã§æŽããæŽ
液ã液ãšåããããåŸãããæè²æº¶æ¶²ãèžçºã
ããŠ3.28ïœã®æç·è²ããŒã¹ããåŸãããã®ããŒã¹
ãã®å°éããå®æœäŸ14ã®æ¹æ³ã§ããã¯ããã·ãã€
ïŒphotochromicityïŒã®è©Šéšãè¡ã€ãããã®ããŒ
ã¹ãã®ãšã¿ããŒã«æº¶æ¶²ã¯æ·¡ç·è²ã ã€ããã玫å€ç·
ã«æŽé²ãããšæ·±éè²ã«ãªã€ãããã®æº¶æ¶²ã¯ã玫å€
ç·ãé€å»åŸãçŽïŒâïŒåã§æ·¡ç·è²ã«æ»ã€ãã å®æœäŸ 17 å®æœäŸ14ã®æäœã«åŸã€ãŠã1.74ïœïŒ0.01ã¢ã«ïŒ
ã®ïŒâããããœâïŒâãããªããŒã«ãš2.57ïœã®ïŒ
âããã«âïŒâãšãã«âïŒïŒïŒïŒïŒâããªã¡ãã«
âïŒâã¡ãã¬ã³ã€ã³ããªã³ãšãã70mlã®ãã«ãšã³
äžã§ïŒæééæµããããåŸãããçæç©ã¯æéè²
ããŒã¹ãã§ãã€ãããã®ããŒã¹ãã®å°éã®ãšã¿ã
ãŒã«æº¶æ¶²ã¯æ·¡ä¹è³äžæ¿åºŠã®éè²ã§ãã€ããã玫å€
ç·æŽé²ã«ãã€ãŠã¹ã«ã€ãã«ãŒã«ãªã€ãããã®æº¶æ¶²
ã¯ã玫å€ç·ãé€å»ãããšãçŽïŒååŸã«å ã®è²çžã«
æ»ã€ãã å®æœäŸ 18 å®æœäŸ14ã®æäœã«åŸãã1.22ïœã®ïŒâããããœ
âïŒâãããªããŒã«ã50mlã®ç±ãã«ãšã³äžã«æžæ¿
ãããããã®æžæ¿æ¶²ã«ã20mlã®ãã«ãšã³ã§åžéã
ã1.70ïœã®ïŒâããã«âïŒïŒïŒïŒïŒïŒïŒâããã©
ã¡ãã«âïŒâã¡ãã¬ã³ã€ã³ããªã³ãçŽ10åéã«ã
ãã€ãŠåŸã ã«æ·»å ãããåŸãããæ··åç©ãïŒæé
éæµããããåŸãããçæç©ã®ãšã¿ããŒã«æº¶æ¶²
ã¯ã玫å€ç·ã«æŽé²ãããšæéè²ã«å€ããã玫å€ç·
ãåãå»ããšçŽïŒâïŒååŸã«å ã®è²çžã«æ»ã€ãã ã€ãœãããããŒã«ã溶åªãšããŠäžèšã®æäœãç¹°
è¿ãããçæç©ã¯æ¥µããŠæãç·è²ããŒã¹ãã§ãã€
ãã å®æœäŸ 19 2.04ïœïŒ0.007ã¢ã«ïŒã®ãã€ãã·ã€ãŒå¡©åºïŒâ
ãã³ãžã«âïŒïŒïŒïŒïŒâããªã¡ãã«âïŒâãšãã«
âïŒâã¡ãã¬ã³ã€ã³ããªã³ãçšãã以å€ã¯ãå®æœ
äŸ18ã®æäœã«åŸã€ããåŸãããçæç©ã®ãšã¿ããŒ
ã«æº¶æ¶²ã¯æ·¡ç·è²ã§ããã玫å€ç·ã«æŽé²ãããšäžçš
床ã®éè²ã«å€åãã玫å€ç·ãåãé€ããšçŽïŒâïŒ
ååŸã«å ã®è²çžã«æ»ã€ãã å®æœäŸ 20 沞隰ã€ãœãããããŒã«äžã®0.89ïœïŒ0.005ã¢ã«ïŒ
ã®ïŒâããããœâïŒâãããªããŒã«ã®æžæ¿æ¶²ã«ã
25mlã®ã€ãœãããããŒã«äžã«æº¶è§£ãã1.32ïœ
ïŒ0.005ã¢ã«ïŒã®ïŒïŒïŒïŒïŒïŒïŒâããã©ã¡ãã«â
ïŒâããšãã«âïŒâã¡ãã¬ã³ã€ã³ããªã³ãåŸã ã«
æ·»å ããåå¿æ··åç©ãïŒæééæµããããåŸãã
ãæéè²åå¿æº¶æ¶²ãïŒæ©äžèžçºãããæéïŒã»ãš
ãã©é»ïŒè²ã®ã¬ã ãåŸããããã«èžçºããããšç¡¬
ãã±ãŒããçæããããªãå解ããããã®ã¬ã ã
èå±€ã¯ãããã°ã©ãã€ãŒãã¬ãŒãäžã§ã¯ãããã°
ã©ãã€ãŒãè¡ã€ãåŸãã·ãªã«ã²ã«ãããªãã¯ã¹äž
ã§çæç©ã®ããã¯ããã·ãã€ã確èªããã å®æœäŸ17â20ã®ååç©ã®èŠçŽã第ïŒè¡šã«ç€ºãã
ããŒã«ïŒ0.52ïœã0.003ã¢ã«ïŒã®æžæ¿æ¶²ããæ¹æ
ããªããçŽ100âã«å ç±ããããã®å ç±ããæžæ¿
液ã«ã0.60ïœã®ããªãšãã«ã¢ãã³ïŒ0.006ã¢ã«ïŒ
ãå«ã20mlã®ãã«ãšã³äžã«æžæ¿ããã1.75ïœ
ïŒ0.003ã¢ã«ïŒã®ãšãŠåïŒïŒïŒâãžã¡ãã«âïŒïŒïŒ
âãã¹ïŒïŒ°âã¡ããã·ããšãã«ïŒã€ã³ããªãŠã
ããçŽ20åéã«ããã€ãŠåŸã ã«æ·»å ãããåå¿åš
äžã®æ··åç©ãçŽ100âã§25æéä¿ã¡ãåå¿ã®åºŠå
ãèå±€ã¯ãããã°ã©ãã€ãŒïŒTLCïŒã§ç£èŠããã
åå¿ã¯ïŒæéåŸã«ã»ãŒå®äºãããçŽ100âã§2.5æ
éåŸãããã«0.17ïœïŒ0.001ã¢ã«ïŒã®ïŒâããã
ãœâïŒâãããªããŒã«ãåå¿åšãžæ·»å ããããçŽ
100âã§ïŒæéåŸã§ããšãŠåã€ã³ããªãŠã åå¿æ
åã®å®å šåå¿ã¯åŸãããªãã€ãããã«ã³ããŒã·ãš
ã³ã«ãã€ãŠåå¿æ··åç©äžã®åºäœãåé¢ããæ®ãã®
液äœãèžçºãããŠã»ãšãã©ä¹Ÿåºãããããã®ã»ãš
ãã©ä¹ŸåºããããŒã¹ãäžã«ãªãªãŒãç·è²ã®çµæ¶ã
çæããããã®ã»ãšãã©ä¹Ÿåºããçæç©ãïŒmlã®
æ°ãããã«ãšã³ã§ãœãŒãã³ã°ããéããïŒmlã®
ãã«ãšã³ã§åŸã ã«æŽã€ããå€éã®çµæ¶æ§ç²æ«çæ
ç©ããã«ãšã³ã«æº¶è§£ããªãã€ãããã®äžæº¶æ§ã®çµ
æ¶æ§ç²æ«ããšã¿ããŒã«ã§æŽã€ãŠé¢šä¹ŸãããªãªãŒã
ç·è²ç²æ«ïŒ0.79ïœïŒãåŸãããã®ç²æ«ã®è©Šæããš
ã¿ããŒã«ã«æº¶è§£ãã玫å€ç·ïŒ366nmïŒã§çŽ30ç§é
ç §å°ããã溶液ã¯æ·¡ç·è²ããéè²ã«å€ããã玫å€
ç·ãåãå»ã€ããšããæ·¡ç·è²ã«æ»ã€ãã å®æœäŸ 14 35mlã®ãã«ãšã³äžã®ïŒâããããœâïŒâãããª
ããŒã«ïŒ1.39ïœã0.008ã¢ã«ïŒã®æžæ¿æ¶²ããæ¹æ
ããªããçŽ100âã«å ç±ããããã®å ç±ããæžæ¿
液ã«ã1.6ïœã®ããªãšãã«ã¢ãã³ïŒ0.016ã¢ã«ïŒã
å«ã35mlã®ãã«ãšã³äžã«æžæ¿ããã295ïœã®ãšãŠ
åïŒïŒïŒïŒïŒïŒïŒâããã©ã¡ãã«âïŒïŒïŒâã¹ã
ãïŒã·ã¯ãããã·ã«ïŒâã3Hãã€ã³ããªãŠã ã
20â30åéã«ããã€ãŠåŸã ã«æ·»å ãããåå¿ã®é²
è¡ç¶æ³ã¯TLCã§èª¿ã¹ããåå¿åšäžã®æ··åç©ãçŽ
100âã§ïŒæéä¿ã€ãåŸãåå¿æ··åç©ïŒæè€è²æº¶
液ïŒãèžçºãããŠã»ãšãã©ä¹ŸåºããããåŸããã
ããŒã¹ããïŒmlã®æ°ãããã«ãšã³ã§æ°åé浞挬
ããéããŠäžæº¶ç©ãé€å»ããåŸãããåºäœãïŒ
mlã®ãã«ãšã³ã§æŽæµããã液ãšæŽæ¶²ãšãåã
ããèžçºãããæè€è²ããŒã¹ãïŒ2.07ïœïŒãåŸ
ãããã®ããŒã¹ãã®å°éïŒçŽïŒmgïŒãçŽïŒâïŒml
ã®ãšã¿ããŒã«ã«æº¶è§£ããåŸããã溶液ãã宀枩ã§
玫å€ç·ïŒ366nmïŒã«æŽé²ããã溶液ã¯æ·¡éè²ã«å€
è²ãã玫å€ç·æºãåãå»ã€ãåŸãçŽïŒåéã§å ã®
è²çžã«æ»ã€ãã å®æœäŸ 15 å®æœäŸ14ã®æäœã«åŸã€ãŠã1.22ïœïŒ0.007ã¢ã«ïŒ
ã®ïŒâããããœâïŒâãããªããŒã«ãã60mlã®ã
ã«ãšã³äžã®1.70ïœïŒ0.007ã¢ã«ïŒã®ïŒâã¢ãªã«â
ïŒïŒïŒïŒïŒâããªã¡ãã«âïŒâãšãã«âïŒâã¡ã
ã¬ã³ã€ã³ããªã³ãšãçŽ100âã§çŽïŒæéåå¿ãã
ããåå¿æ··åç©ãèžçºãããŠã»ãšãã©ä¹ŸåºããåŸ
ãããããŒã¹ããïŒmlã®ãã«ãšã³ã§æ°åéãœãŒã
ã³ã°ããåŸãéãããäžæº¶ç©ãïŒmlã®ãã«ãšã³
ã§æŽæµããã液ãšæŽæ¶²ãšãåãããèžçºãã
ãŠãæïŒåž¯ç·ïŒè€è²ããŒã¹ãïŒ2.49ïœïŒãåŸãã
ãã®ããŒã¹ãã®å°éãïŒâïŒmlã®ãšã¿ããŒã«ã«æº¶
解ããåŸãããæ·¡é»è²æº¶æ¶²ã玫å€ç·ïŒ366nmïŒã«
æŽé²ããã溶液ã¯ç·è²ã«å€ããã玫å€ç·æºãåã
å»ã€ãåŸãçŽïŒâïŒåã§å ã®è²çžã«æ»ã€ãã å®æœäŸ 16 å®æœäŸ14ã®æäœã«åŸã€ãŠã40mlã®ãã«ãšã³äžã®
1.74ïœïŒ0.01ã¢ã«ïŒã®ïŒâããããœâïŒâãããª
ããŒã«ã®æžæ¿æ¶²ããïŒïœïŒ0.02ã¢ã«ïŒã®ããªãšã
ã«ã¢ãã³ãå«ã40mlã®ãã«ãšã³äžã®3.57ïœïŒ0.01
ã¢ã«ïŒã®ãšãŠåïŒïŒïŒâãžãšãã«âïŒïŒïŒïŒïŒïŒ
ïŒâããã©ã¡ãã«ã€ã³ããªãŠã ãšåå¿ããããïŒ
æéã®åå¿åŸãæéç·è²ã®æº¶æ¶²ãåŸããã®æº¶æ¶²ã
èžçºãããŠã»ãšãã©ä¹ŸåºããããåŸãããããŒã¹
ããïŒmlã®ãã«ãšã³ã§æ°åéãœãŒãã³ã°ããé
ãããåŸãããåºäœãïŒmlã®ãã«ãšã³ã§æŽããæŽ
液ã液ãšåããããåŸãããæè²æº¶æ¶²ãèžçºã
ããŠ3.28ïœã®æç·è²ããŒã¹ããåŸãããã®ããŒã¹
ãã®å°éããå®æœäŸ14ã®æ¹æ³ã§ããã¯ããã·ãã€
ïŒphotochromicityïŒã®è©Šéšãè¡ã€ãããã®ããŒ
ã¹ãã®ãšã¿ããŒã«æº¶æ¶²ã¯æ·¡ç·è²ã ã€ããã玫å€ç·
ã«æŽé²ãããšæ·±éè²ã«ãªã€ãããã®æº¶æ¶²ã¯ã玫å€
ç·ãé€å»åŸãçŽïŒâïŒåã§æ·¡ç·è²ã«æ»ã€ãã å®æœäŸ 17 å®æœäŸ14ã®æäœã«åŸã€ãŠã1.74ïœïŒ0.01ã¢ã«ïŒ
ã®ïŒâããããœâïŒâãããªããŒã«ãš2.57ïœã®ïŒ
âããã«âïŒâãšãã«âïŒïŒïŒïŒïŒâããªã¡ãã«
âïŒâã¡ãã¬ã³ã€ã³ããªã³ãšãã70mlã®ãã«ãšã³
äžã§ïŒæééæµããããåŸãããçæç©ã¯æéè²
ããŒã¹ãã§ãã€ãããã®ããŒã¹ãã®å°éã®ãšã¿ã
ãŒã«æº¶æ¶²ã¯æ·¡ä¹è³äžæ¿åºŠã®éè²ã§ãã€ããã玫å€
ç·æŽé²ã«ãã€ãŠã¹ã«ã€ãã«ãŒã«ãªã€ãããã®æº¶æ¶²
ã¯ã玫å€ç·ãé€å»ãããšãçŽïŒååŸã«å ã®è²çžã«
æ»ã€ãã å®æœäŸ 18 å®æœäŸ14ã®æäœã«åŸãã1.22ïœã®ïŒâããããœ
âïŒâãããªããŒã«ã50mlã®ç±ãã«ãšã³äžã«æžæ¿
ãããããã®æžæ¿æ¶²ã«ã20mlã®ãã«ãšã³ã§åžéã
ã1.70ïœã®ïŒâããã«âïŒïŒïŒïŒïŒïŒïŒâããã©
ã¡ãã«âïŒâã¡ãã¬ã³ã€ã³ããªã³ãçŽ10åéã«ã
ãã€ãŠåŸã ã«æ·»å ãããåŸãããæ··åç©ãïŒæé
éæµããããåŸãããçæç©ã®ãšã¿ããŒã«æº¶æ¶²
ã¯ã玫å€ç·ã«æŽé²ãããšæéè²ã«å€ããã玫å€ç·
ãåãå»ããšçŽïŒâïŒååŸã«å ã®è²çžã«æ»ã€ãã ã€ãœãããããŒã«ã溶åªãšããŠäžèšã®æäœãç¹°
è¿ãããçæç©ã¯æ¥µããŠæãç·è²ããŒã¹ãã§ãã€
ãã å®æœäŸ 19 2.04ïœïŒ0.007ã¢ã«ïŒã®ãã€ãã·ã€ãŒå¡©åºïŒâ
ãã³ãžã«âïŒïŒïŒïŒïŒâããªã¡ãã«âïŒâãšãã«
âïŒâã¡ãã¬ã³ã€ã³ããªã³ãçšãã以å€ã¯ãå®æœ
äŸ18ã®æäœã«åŸã€ããåŸãããçæç©ã®ãšã¿ããŒ
ã«æº¶æ¶²ã¯æ·¡ç·è²ã§ããã玫å€ç·ã«æŽé²ãããšäžçš
床ã®éè²ã«å€åãã玫å€ç·ãåãé€ããšçŽïŒâïŒ
ååŸã«å ã®è²çžã«æ»ã€ãã å®æœäŸ 20 沞隰ã€ãœãããããŒã«äžã®0.89ïœïŒ0.005ã¢ã«ïŒ
ã®ïŒâããããœâïŒâãããªããŒã«ã®æžæ¿æ¶²ã«ã
25mlã®ã€ãœãããããŒã«äžã«æº¶è§£ãã1.32ïœ
ïŒ0.005ã¢ã«ïŒã®ïŒïŒïŒïŒïŒïŒïŒâããã©ã¡ãã«â
ïŒâããšãã«âïŒâã¡ãã¬ã³ã€ã³ããªã³ãåŸã ã«
æ·»å ããåå¿æ··åç©ãïŒæééæµããããåŸãã
ãæéè²åå¿æº¶æ¶²ãïŒæ©äžèžçºãããæéïŒã»ãš
ãã©é»ïŒè²ã®ã¬ã ãåŸããããã«èžçºããããšç¡¬
ãã±ãŒããçæããããªãå解ããããã®ã¬ã ã
èå±€ã¯ãããã°ã©ãã€ãŒãã¬ãŒãäžã§ã¯ãããã°
ã©ãã€ãŒãè¡ã€ãåŸãã·ãªã«ã²ã«ãããªãã¯ã¹äž
ã§çæç©ã®ããã¯ããã·ãã€ã確èªããã å®æœäŸ17â20ã®ååç©ã®èŠçŽã第ïŒè¡šã«ç€ºãã
ãè¡šã
å®æœäŸ 21
ïŒïŒïŒïŒïŒïŒïŒâããã©ã¡ãã«âïŒâã·ã¢ãâ
ã€ã³ããªãŠã ã¢ã€ãªãã€ãããã³ïŒïŒïŒïŒïŒïŒïŒ
âããã©ã¡ãã«âïŒâã·ã¢ãâã€ã³ããªãŠã ã¢ã€
ãªãã€ãã®ç°æ§äœæ··åç©ã®å šé1.97ïœïŒ0.006ã¢
ã«ïŒãäºãçªçŽ ã§ããŒãžãã100mlã®ãšã«ã¬ã³ã
ã€ã€ãŒåå¿ãã©ã¹ã³ã«æ·»å ããã25ïŒ ã®æ°Žé žåã
ããªãŠã ã®æº¶æ¶²5.7ïœïŒ0.035ã¢ã«ïŒããã³ã¡ãã¬
ã³ã¯ãã©ã€ãã®50mlããããŸããªãããã®åå¿ã
ã©ã¹ã³ã«å ãããåŸãããæ··åç©ãçªçŽ ããŒãžã®
ããšã«30åéã«ããããããŸããã€ãã§å液æŒæ
ã«ç§»ãããã¡ãã¬ã³ã¯ãã©ã€ããæµãåºããäžéš
ã®æ°Žæ§çžããã®åé¢ããã¡ãã¬ã³ã¯ãã©ã€ã溶åª
ã®10mlãã€ã§ïŒåæŽæµããããã®ã¡ãã¬ã³ã¯ãã©
ã€ã溶åªçžãç¡æ°Žçé žã«ãªãŠã ã§ä¹Ÿç¥ãããã®æº¶
åªãå転èžçºåšäžã§é€å»ããã ç¥çè²ã®æ²¹ç¶æ®æž£ã50mlã®ç¡æ°Žãšã¿ããŒã«äžã«
溶解ããæ¹ææ£ãçªçŽ å°å ¥å£ããã³å·åŽåšãããª
ãã250mlã®åå¿ãã©ã¹ã³ã«æ·»å ãããå šé1.16
ïœã®ïŒâããããœâïŒâããããã·ãããªã³ãã
ã®åå¿ãã©ã¹ã³ã«å ããåå¿æ··åç©ã72âã§ïŒæ
éã«ããããããŸããããã®åå¿æ··åç©ã宀枩ã§
ïŒå€éãããŸããã€ãã§80âã«å ç±ãïŒæéä¿æ
ããããã®åå¿æ··åç©äžã®æº¶åªãå転èžçºåšäžã§
é€å»ããããã®æ®æž£ã«50mlã®ã¡ãã¬ã³ã¯ãã©ã€ã
ãšäžç·ã«çŽïŒïœã®ã·ãªã«ã²ã«ãå ãããã¡ãã¬ã³
ã¯ãã©ã€ããé€å»ãããšç²è£œã®åå¿çæç©ã®å«æµž
ããã·ãªã«ã²ã«æ®æž£ãæ®ã€ãã ãã®ã·ãªã«ã²ã«æ®æž£ãã·ãªã«ã²ã«ããã³ããã¿
ã³ã®50mlïŒ25ïœïŒã§æ¹¿æœ€å å¡«ãããŠããã¬ã©ã¹ã¯
ãããã°ã©ãã€ãŒã«ã©ã ã«å ãããåå¿çæç©ã®
溶é¢ã¯200mlã®ããã¿ã³ã500mlã®10ïŒ90ïŒå®¹ç©ïŒ
ã®ãšãã«ã¢ã»ããŒãïŒããã¿ã³ã250mlã®30ïŒ70
ïŒå®¹ç©ïŒã®ãšãã«ã¢ã»ããŒãïŒããã¿ã³ããã³200
mlã®98ïŒïŒïŒå®¹ç©ïŒã®ã¯ãããã«ã ïŒãšã¿ããŒã«
ã§å®æœãããé»ç·è²ã®æº¶åªç»åãäžç·ã«ã溶åªã
å転èžçºåšäžã§é€å»ãããš1.5ïœã®é»ç·è²ã®åºäœ
æ®æž£ãåŸãããããã®åºäœããšãã«ã¢ã»ããŒãïŒ
ããã¿ã³ããåçµæ¶ãããšïŒïŒïŒïŒïŒâããªã¡ã
ã«âïŒ(6)âã·ã¢ãã¹ãããã€ã³ããªã³âïŒïŒ
3â²ãïŒïŒšãããªããïŒïŒïŒâïœããïŒïŒïŒãâãã³
ãŸããµãžã³ãã®ç°æ§äœæ··åç©ã®0.30ïœããã³0.60
ïœã®å¥ã ã®çµæ¶çŸ€ãåŸããããçµæ¶çæç©ã®ãã«
ãšã³æº¶æ¶²ã¯çŽ«å€ç·ç §å°ãããšçŽ«è²ã«å€ããã€ãã§
玫å€ç·ãåãå»ããšããšã®æº¶æ¶²ã®æ·¡é»è²ã«ãã©ã€
ãã å®æœäŸ 22 ïŒïŒïŒïŒïŒïŒïŒâããã©ã¡ãã«âïŒâã¡ããã·
ã«ã«ããã«ã€ã³ããªãŠã ã¢ã€ãªãã€ãã®å šéïŒïœ
ïŒ0.025ã¢ã«ïŒã500mlã®ãšã«ã¬ã³ãã€ã€ãŒãã©ã¹
ã³ã«æ·»å ãã25ïŒ ã®æ°Žé žåãããªãŠã ã®æº¶æ¶²15.2
ïœïŒ0.125ã¢ã«ïŒããã³ã¡ãã¬ã³ã¯ãã©ã€ãã®200
mlãšæ··åããããã®æ··åç©ã45åéã«ããã€ãŠã
ããŸãããã®ããã«ããŠåŸãããçžåœããã€ã³ã
ãªã³ååç©ãå®æœäŸ21ã«èšèŒããåé¢æ³ã«ãã€ãŠ
åé¢ããã ã€ã³ããªã³ååç©ãããªããã®é»è²ã®æ²¹ãç¡æ°Ž
ãšã¿ããŒã«ã®200mlã«æº¶è§£ãããã®æº¶æ¶²ãåå¿ã
ã©ã¹ã³ã«æ·»å ããããã®æº¶æ¶²ã85âã«å ç±ããã
ã®åŸãã®åå¿ãã©ã¹ã³ã«ïŒâããããœâïŒâãã
ããã·ãããªã³ã®4.8ïœïŒ0.025ã¢ã«ïŒãå ããã
ãã®åå¿æ··åç©ã85âã«ïŒæéã«ããã€ãŠä¿æã
ãããšã¿ããŒã«æº¶åªãã®ãããšé»è²ã®æ®æž£7.8ïœ
ãåŸãããããå®æœäŸ21ã«èšèŒãããšåãæ¹æ³ã§
粟補ããã粟補ç©ããªãããïŒïŒïŒïŒïŒâããªã¡
ãã«âïŒâã¡ããã·ã«ã«ããã«ã¹ããïŒã€ã³ããª
ã³âïŒïŒ3â²ãïŒïŒšãããªããïŒïŒïŒâïœããïŒïŒ
ïŒãâãã³ãŸããµãžã³ãã®ãã«ãšã³æº¶æ¶²ã¯çŽ«å€ç·
ç §å°ãããšçŽ«è²ã«å€ããã€ãã§çŽ«å€ç·ãåãå»ã
ãšããšã®æº¶æ¶²ã®è²ã«ãã©ã€ãã 以äžãæ¬çºæããã®å¹Ÿã€ãã®å®æœã®æ æ§ã«ã€ã
ãŠç¹ã«è©³çŽ°ã«èª¬æããããããã詳现ã¯ãããã
ç¹èš±è«æ±ã®ç¯å²å ã«å«ãŸããããšä»¥å€ããã³å«ãŸ
ããçšåºŠä»¥å€ã¯æ¬çºæã®ç¯å²ãéå®ãããã®ãšèŠ
åãããã¹ãã§ã¯ãªãã
ã€ã³ããªãŠã ã¢ã€ãªãã€ãããã³ïŒïŒïŒïŒïŒïŒïŒ
âããã©ã¡ãã«âïŒâã·ã¢ãâã€ã³ããªãŠã ã¢ã€
ãªãã€ãã®ç°æ§äœæ··åç©ã®å šé1.97ïœïŒ0.006ã¢
ã«ïŒãäºãçªçŽ ã§ããŒãžãã100mlã®ãšã«ã¬ã³ã
ã€ã€ãŒåå¿ãã©ã¹ã³ã«æ·»å ããã25ïŒ ã®æ°Žé žåã
ããªãŠã ã®æº¶æ¶²5.7ïœïŒ0.035ã¢ã«ïŒããã³ã¡ãã¬
ã³ã¯ãã©ã€ãã®50mlããããŸããªãããã®åå¿ã
ã©ã¹ã³ã«å ãããåŸãããæ··åç©ãçªçŽ ããŒãžã®
ããšã«30åéã«ããããããŸããã€ãã§å液æŒæ
ã«ç§»ãããã¡ãã¬ã³ã¯ãã©ã€ããæµãåºããäžéš
ã®æ°Žæ§çžããã®åé¢ããã¡ãã¬ã³ã¯ãã©ã€ã溶åª
ã®10mlãã€ã§ïŒåæŽæµããããã®ã¡ãã¬ã³ã¯ãã©
ã€ã溶åªçžãç¡æ°Žçé žã«ãªãŠã ã§ä¹Ÿç¥ãããã®æº¶
åªãå転èžçºåšäžã§é€å»ããã ç¥çè²ã®æ²¹ç¶æ®æž£ã50mlã®ç¡æ°Žãšã¿ããŒã«äžã«
溶解ããæ¹ææ£ãçªçŽ å°å ¥å£ããã³å·åŽåšãããª
ãã250mlã®åå¿ãã©ã¹ã³ã«æ·»å ãããå šé1.16
ïœã®ïŒâããããœâïŒâããããã·ãããªã³ãã
ã®åå¿ãã©ã¹ã³ã«å ããåå¿æ··åç©ã72âã§ïŒæ
éã«ããããããŸããããã®åå¿æ··åç©ã宀枩ã§
ïŒå€éãããŸããã€ãã§80âã«å ç±ãïŒæéä¿æ
ããããã®åå¿æ··åç©äžã®æº¶åªãå転èžçºåšäžã§
é€å»ããããã®æ®æž£ã«50mlã®ã¡ãã¬ã³ã¯ãã©ã€ã
ãšäžç·ã«çŽïŒïœã®ã·ãªã«ã²ã«ãå ãããã¡ãã¬ã³
ã¯ãã©ã€ããé€å»ãããšç²è£œã®åå¿çæç©ã®å«æµž
ããã·ãªã«ã²ã«æ®æž£ãæ®ã€ãã ãã®ã·ãªã«ã²ã«æ®æž£ãã·ãªã«ã²ã«ããã³ããã¿
ã³ã®50mlïŒ25ïœïŒã§æ¹¿æœ€å å¡«ãããŠããã¬ã©ã¹ã¯
ãããã°ã©ãã€ãŒã«ã©ã ã«å ãããåå¿çæç©ã®
溶é¢ã¯200mlã®ããã¿ã³ã500mlã®10ïŒ90ïŒå®¹ç©ïŒ
ã®ãšãã«ã¢ã»ããŒãïŒããã¿ã³ã250mlã®30ïŒ70
ïŒå®¹ç©ïŒã®ãšãã«ã¢ã»ããŒãïŒããã¿ã³ããã³200
mlã®98ïŒïŒïŒå®¹ç©ïŒã®ã¯ãããã«ã ïŒãšã¿ããŒã«
ã§å®æœãããé»ç·è²ã®æº¶åªç»åãäžç·ã«ã溶åªã
å転èžçºåšäžã§é€å»ãããš1.5ïœã®é»ç·è²ã®åºäœ
æ®æž£ãåŸãããããã®åºäœããšãã«ã¢ã»ããŒãïŒ
ããã¿ã³ããåçµæ¶ãããšïŒïŒïŒïŒïŒâããªã¡ã
ã«âïŒ(6)âã·ã¢ãã¹ãããã€ã³ããªã³âïŒïŒ
3â²ãïŒïŒšãããªããïŒïŒïŒâïœããïŒïŒïŒãâãã³
ãŸããµãžã³ãã®ç°æ§äœæ··åç©ã®0.30ïœããã³0.60
ïœã®å¥ã ã®çµæ¶çŸ€ãåŸããããçµæ¶çæç©ã®ãã«
ãšã³æº¶æ¶²ã¯çŽ«å€ç·ç §å°ãããšçŽ«è²ã«å€ããã€ãã§
玫å€ç·ãåãå»ããšããšã®æº¶æ¶²ã®æ·¡é»è²ã«ãã©ã€
ãã å®æœäŸ 22 ïŒïŒïŒïŒïŒïŒïŒâããã©ã¡ãã«âïŒâã¡ããã·
ã«ã«ããã«ã€ã³ããªãŠã ã¢ã€ãªãã€ãã®å šéïŒïœ
ïŒ0.025ã¢ã«ïŒã500mlã®ãšã«ã¬ã³ãã€ã€ãŒãã©ã¹
ã³ã«æ·»å ãã25ïŒ ã®æ°Žé žåãããªãŠã ã®æº¶æ¶²15.2
ïœïŒ0.125ã¢ã«ïŒããã³ã¡ãã¬ã³ã¯ãã©ã€ãã®200
mlãšæ··åããããã®æ··åç©ã45åéã«ããã€ãŠã
ããŸãããã®ããã«ããŠåŸãããçžåœããã€ã³ã
ãªã³ååç©ãå®æœäŸ21ã«èšèŒããåé¢æ³ã«ãã€ãŠ
åé¢ããã ã€ã³ããªã³ååç©ãããªããã®é»è²ã®æ²¹ãç¡æ°Ž
ãšã¿ããŒã«ã®200mlã«æº¶è§£ãããã®æº¶æ¶²ãåå¿ã
ã©ã¹ã³ã«æ·»å ããããã®æº¶æ¶²ã85âã«å ç±ããã
ã®åŸãã®åå¿ãã©ã¹ã³ã«ïŒâããããœâïŒâãã
ããã·ãããªã³ã®4.8ïœïŒ0.025ã¢ã«ïŒãå ããã
ãã®åå¿æ··åç©ã85âã«ïŒæéã«ããã€ãŠä¿æã
ãããšã¿ããŒã«æº¶åªãã®ãããšé»è²ã®æ®æž£7.8ïœ
ãåŸãããããå®æœäŸ21ã«èšèŒãããšåãæ¹æ³ã§
粟補ããã粟補ç©ããªãããïŒïŒïŒïŒïŒâããªã¡
ãã«âïŒâã¡ããã·ã«ã«ããã«ã¹ããïŒã€ã³ããª
ã³âïŒïŒ3â²ãïŒïŒšãããªããïŒïŒïŒâïœããïŒïŒ
ïŒãâãã³ãŸããµãžã³ãã®ãã«ãšã³æº¶æ¶²ã¯çŽ«å€ç·
ç §å°ãããšçŽ«è²ã«å€ããã€ãã§çŽ«å€ç·ãåãå»ã
ãšããšã®æº¶æ¶²ã®è²ã«ãã©ã€ãã 以äžãæ¬çºæããã®å¹Ÿã€ãã®å®æœã®æ æ§ã«ã€ã
ãŠç¹ã«è©³çŽ°ã«èª¬æããããããã詳现ã¯ãããã
ç¹èš±è«æ±ã®ç¯å²å ã«å«ãŸããããšä»¥å€ããã³å«ãŸ
ããçšåºŠä»¥å€ã¯æ¬çºæã®ç¯å²ãéå®ãããã®ãšèŠ
åãããã¹ãã§ã¯ãªãã
Claims (1)
- ãç¹èš±è«æ±ã®ç¯å²ã ïŒ äžèšäžè¬åŒ ãäžèšäžè¬åŒäžã (a) R1ã¯C1âC8ã¢ã«ãã«ãããšãã«ïŒC1âC4ïŒ
ã¢ã«ãã«ããã³ã¢ãªã«ãããªã矀ããéžã°ãã (b) R2ããã³R3ã¯ããã®ãã®ãC1âC5ã¢ã«ãã«ã
ããšãã«ãC1âC4ã¢ã«ãã«ãªãã³ã«C1âC5ã¢
ã«ã³ãã·ã¢ãâããã³ãžçœ®æããšãã«ãããªã
矀ããéžã°ãããããã¯çµåããŠïŒâïŒåã®ç
çŽ ååïŒã¹ããççŽ ååãå«ãïŒãå«ãèç°åŒ
ç°ããã«ãã«ãã«ãã¢ããã³ãã«ãããªã矀ã
ãéžã°ããç°åŒç°ã圢æãã (c) R4ããã³R5ã¯ããã®ãã®ããæ°ŽçŽ ãC1âC5
ã¢ã«ãã«ãããã²ã³ãC1âC5ã¢ã«ã³ãã·ãã·
ã¢ããC1âC8ã¢ã«ã³ãã·ã«ã«ããã«ãããªã
矀ããéžã°ããã ã§ç€ºãããã¹ããïŒã€ã³ããªã³ïŒããªããã³ãŸãª
ããµãžã³ååç©ã ïŒ (a) R1ãC1âC4ã¢ã«ãã«ããã³ãžã«ãããª
ã矀ããéžã°ãã (b) R2ããã³R3ã®ãã®ãã®ããC1âC5ã¢ã«ãã«
ããéžã°ãã (c) R4ããã³R5ã®ãã®ãã®ãæ°ŽçŽ ãC1âC2ã¢ã«
ãã«ãå¡©çŽ ãèçŽ ãC1âC5ã¢ã«ã³ãã·ãããª
ã矀ããéžã°ãã ç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®ååç©ã ïŒ R1ãšR2ãšR3ãšãã¡ãã«ã§ãããã€R4ãšR5ãš
ãæ°ŽçŽ ã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®åå
ç©ã ïŒ R1ãšR2ãšR3ãšãã¡ãã«ã§ãããã€R4ãã¡ã
ãã·ã§ãããã€R5ãæ°ŽçŽ ã§ããç¹èš±è«æ±ã®ç¯å²
第ïŒé èšèŒã®ååç©ã ïŒ R1ãšR2ãšR3ãšR4ãšãã¡ãã«ã§ãããã€R5ã
ã¯ããã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®åå
ç©ã ïŒ ååç©ãïŒïŒïŒïŒïŒïŒïŒâããã©ã¡ãã«âïŒ
âãšãã«ã¹ãããã€ã³ããªã³âïŒïŒ3â²ãïŒïŒšãã
ãªããïŒïŒïŒâïœããïŒïŒïŒããã³ãŸãªããµãžã³ã
ã§ããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®ååç©ã ïŒ ååç©ãïŒïŒïŒïŒïŒïŒïŒïŒïŒâãã³ã¿ã¡ãã«
ã¹ãããã€ã³ããªã³âïŒïŒ3â²ãïŒïŒšãããªããïŒïŒ
ïŒâïœããïŒïŒïŒããã³ãŸãªããµãžã³ãã§ããç¹
èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®ååç©ã
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54860083A | 1983-11-04 | 1983-11-04 | |
| US548600 | 1983-11-04 | ||
| US635696 | 1984-07-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60112880A JPS60112880A (ja) | 1985-06-19 |
| JPH0121831B2 true JPH0121831B2 (ja) | 1989-04-24 |
Family
ID=24189575
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP59233033A Granted JPS60112880A (ja) | 1983-11-04 | 1984-11-05 | ã¹ããïŒã€ã³ããªã³ïŒããªããã³ãŸãªããµãžã³ååç© |
| JP24789185A Granted JPS61159458A (ja) | 1983-11-04 | 1985-11-05 | ããã¯ãããã¯ååç©ã®ããã¯ãããã¯éãå«æããåºäœéæéåææ©ãã¹ãææ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP24789185A Granted JPS61159458A (ja) | 1983-11-04 | 1985-11-05 | ããã¯ãããã¯ååç©ã®ããã¯ãããã¯éãå«æããåºäœéæéåææ©ãã¹ãææ |
Country Status (1)
| Country | Link |
|---|---|
| JP (2) | JPS60112880A (ja) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6210604A (ja) * | 1985-07-09 | 1987-01-19 | Kureha Chem Ind Co Ltd | 調å ã¬ã³ãº |
| GB8610709D0 (en) * | 1986-05-01 | 1986-06-04 | Plinkington Bros Plc | Photochromic lenses |
| JPH0666003B2 (ja) * | 1986-07-15 | 1994-08-24 | å矜ååŠå·¥æ¥æ ªåŒäŒç€Ÿ | 調å äœçšãæããåå æ§æš¹è補å åŠéšæã®è£œé æ¹æ³ |
| JPH0776225B2 (ja) * | 1986-09-26 | 1995-08-16 | ããŒããŒãžãŒã»ã€ã³ãã¹ããªãŒãºã»ã€ã³ã³ãŒãã¬ã€ããã | å å€è²æ§ååç© |
| JPS63175094A (ja) * | 1987-01-16 | 1988-07-19 | Toray Ind Inc | ããã¯ãããã¯æ§ãæããçµæç© |
| JPS63301288A (ja) * | 1987-06-01 | 1988-12-08 | Toray Ind Inc | ãã©ãã¯ãããã¯è€åäœ |
| JP2545606B2 (ja) * | 1988-07-05 | 1996-10-23 | å矜ååŠå·¥æ¥æ ªåŒäŒç€Ÿ | ãã©ãã¯ãããã¯ååç©ããã³ãã©ãã¯ãããã¯çµæç© |
| US4891667A (en) * | 1988-08-18 | 1990-01-02 | Eastman Kodak Company | Document platen for electrostatographic reproduction apparatus |
| US4994208A (en) * | 1989-04-18 | 1991-02-19 | Ppg Industries, Inc. | Photochromic polymeric article |
| JP2774830B2 (ja) * | 1989-09-08 | 1998-07-09 | æ ªåŒäŒç€Ÿãã¯ã€ã | ã¹ãããªããµãžã³ååç©åã³ãã®è£œé æ¹æ³ |
| US6114437A (en) * | 1998-02-04 | 2000-09-05 | General Electric Company | Polycarbonate articles with photochromic properties |
-
1984
- 1984-11-05 JP JP59233033A patent/JPS60112880A/ja active Granted
-
1985
- 1985-11-05 JP JP24789185A patent/JPS61159458A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS60112880A (ja) | 1985-06-19 |
| JPS61159458A (ja) | 1986-07-19 |
| JPS6149345B2 (ja) | 1986-10-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0141407B1 (en) | Photochromic compound and articles containing the same | |
| JP2635196B2 (ja) | ããã¯ãããã¯å åŠçŽ å | |
| US4816584A (en) | Photochromic spiro(indoline)benzoxazines | |
| US4720547A (en) | Photochromic compound and articles containing the same | |
| US4931219A (en) | Photochromic compound and articles containing the same | |
| JP2533277B2 (ja) | ããã¯ãããã¯ããããã©ã³ååç© | |
| US6281366B1 (en) | Photochromic [3H]naphtho[2,1-b]pyran compounds containing an acetylenic substituent, process for their manufacture, and photochromic materials and articles obtained | |
| US4968454A (en) | Variable-light transmittance article and method for preparing same | |
| JP2000515876A (ja) | æ°èŠãªãã¢ã¢ã¶ã¢ããã³ã¿ã³ã¹ãããªããµãžã³åã³çŒç§çšå åŠçŽ ååéã«ããããã®äœ¿çš | |
| JPH0418094A (ja) | ïŒå¡ç°ãå«ãã€ã³ããªããŒã¹ããããããµãªããªããµãžã³ç³»ã¯ãããã¯ååç©ããããã®è£œé æ³ããã®ãããªååç©ãå«ããã©ãã¯ãããã¯çµæç©ããã³ç©å | |
| US4936995A (en) | Photochromic compound and articles containing the same | |
| US4792224A (en) | Photochromic compound and articles containing the same | |
| US4986934A (en) | Photochromic compound and articles containing the same | |
| US5021196A (en) | Method for preparing variable-light transmittance article | |
| US5529725A (en) | Spirooxazines and use thereof in the field of ophthalmic optics | |
| JPH0121831B2 (ja) | ||
| US4909963A (en) | Photochromic article | |
| US20030099910A1 (en) | Photochromic spirobenzopyran compounds and their derivatives, spiropyran group-containing polymers, process for producing the same, compositions comprising said spiropyrans or spiropyran group-containing polymers and photochromic switch thin films prepared | |
| EP0324786B1 (en) | Photochromic spiro(indoline) benzoxazines and articles containing the same | |
| EP0358774B1 (en) | Novel spirooxazine compounds | |
| JPH07165762A (ja) | ãã©ãã¯ãããã¯ç©è³ªåã³ææ | |
| JPH0196282A (ja) | ãã¿ãã·ã¢ãã³èªå°äœ | |
| JPH03234786A (ja) | ãã©ãã¯ãããã¯ææ |