JP7894318B2 - 抗ウイルスの構造的に安定化されたＳＡＲＳ－ＣｏＶ－２ペプチドおよびその使用 - Google Patents

抗ウイルスの構造的に安定化されたＳＡＲＳ－ＣｏＶ－２ペプチドおよびその使用

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JP7894318B2
JP7894318B2 JP2022552793A JP2022552793A JP7894318B2 JP 7894318 B2 JP7894318 B2 JP 7894318B2 JP 2022552793 A JP2022552793 A JP 2022552793A JP 2022552793 A JP2022552793 A JP 2022552793A JP 7894318 B2 JP7894318 B2 JP 7894318B2
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amino acid
seq
sars
cov
sequence
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JP2023517293A5 (enExample
JP2023517293A (ja
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ローレン ディー． ワレンスキー，
グレゴリー エイチ． バード，
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デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20033—Use of viral protein as therapeutic agent other than vaccine, e.g. apoptosis inducing or anti-inflammatory

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2022552793A 2020-03-04 2021-03-04 抗ウイルスの構造的に安定化されたＳＡＲＳ－ＣｏＶ－２ペプチドおよびその使用 Active JP7894318B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062985100P 2020-03-04 2020-03-04
US62/985,100 2020-03-04
PCT/US2021/020940 WO2021178714A2 (en) 2020-03-04 2021-03-04 ANTIVIRAL STRUCTURALLY-STABILIZED SARS-CoV-2 PEPTIDES AND USES THEREOF

Publications (3)

Publication Number Publication Date
JP2023517293A JP2023517293A (ja) 2023-04-25
JP2023517293A5 JP2023517293A5 (enExample) 2024-09-12
JP7894318B2 true JP7894318B2 (ja) 2026-07-23

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JP2022552793A Active JP7894318B2 (ja) 2020-03-04 2021-03-04 抗ウイルスの構造的に安定化されたＳＡＲＳ－ＣｏＶ－２ペプチドおよびその使用

Country Status (8)

Country Link
US (1) US20240124529A1 (enExample)
EP (1) EP4114431A2 (enExample)
JP (1) JP7894318B2 (enExample)
KR (1) KR20220148869A (enExample)
CN (1) CN115811984A (enExample)
AU (1) AU2021230544A1 (enExample)
CA (1) CA3173973A1 (enExample)
WO (1) WO2021178714A2 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023524911A (ja) * 2020-04-24 2023-06-13 ザ トラスティース オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク Ｓａｒｓ－ｃｏｖ－２抗ウイルス薬としての脂質－ペプチド融合物阻害剤
CN113817026B (zh) * 2021-09-16 2023-06-30 中国人民解放军海军军医大学 靶向刺突蛋白hr1的订书肽、制备方法及抗新型冠状病毒应用
CN113773370B (zh) * 2021-10-15 2022-07-22 哈尔滨吉象隆生物技术有限公司 一种抗病毒的多肽及其应用
US20260232759A1 (en) * 2021-10-22 2026-08-13 Wisconsin Alumni Research Foundation Peptides that inhibit infection by sars-cov-2, the virus that causes covid-19 disease
CN114437196A (zh) * 2022-02-16 2022-05-06 复旦大学 一种抑制SARS-CoV-2感染的蛋白及其用途
EP4611789A1 (en) * 2022-11-06 2025-09-10 Leyden Laboratories B.V. Sars-cov-2 binding polypeptide
WO2024186980A2 (en) * 2023-03-08 2024-09-12 Dana-Farber Cancer Institute, Inc. Hendra virus and nipah virus surface glycoprotein peptides, conjugates, and uses thereof
WO2025235945A1 (en) * 2024-05-10 2025-11-13 Red Queen Therapeutics, Inc. Methods of treating viral infections using a fusion inhibitor

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WO2005077103A2 (en) 2004-02-12 2005-08-25 Regents Of The University Of Colorado Compositions and methods for modification and prevention of sars coronavirus infectivity
US20060110758A1 (en) 2004-11-22 2006-05-25 The University Of Hong Kong Synthetic peptide targeting critical sites on the SARS-associated coronavirus spike protein responsible for viral infection and method of use thereof
JP2011510076A (ja) 2008-01-23 2011-03-31 ダナ ファーバー キャンサー インスティテュート インコーポレイテッド ウィルス感染症の治療のための組成物及び方法
WO2011094357A2 (en) 2010-01-26 2011-08-04 The Regents Of The University Of Colorado Conjugates utilizing platform technology for stimulating immune response
JP2012530720A (ja) 2009-06-18 2012-12-06 ダナ ファーバー キャンサー インスティテュート インコーポレイテッド 構築されたウィルス性ペプチド組成物及び使用方法
JP2013530720A (ja) 2010-07-19 2013-08-01 フィッシャー，アレクサンダー，ピー 植物栽培システムおよび方法
CN107022008A (zh) 2016-01-30 2017-08-08 复旦大学 广谱地抑制人类冠状病毒感染的多肽及其应用

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WO2005077103A2 (en) 2004-02-12 2005-08-25 Regents Of The University Of Colorado Compositions and methods for modification and prevention of sars coronavirus infectivity
US20060110758A1 (en) 2004-11-22 2006-05-25 The University Of Hong Kong Synthetic peptide targeting critical sites on the SARS-associated coronavirus spike protein responsible for viral infection and method of use thereof
JP2011510076A (ja) 2008-01-23 2011-03-31 ダナ ファーバー キャンサー インスティテュート インコーポレイテッド ウィルス感染症の治療のための組成物及び方法
JP2012530720A (ja) 2009-06-18 2012-12-06 ダナ ファーバー キャンサー インスティテュート インコーポレイテッド 構築されたウィルス性ペプチド組成物及び使用方法
WO2011094357A2 (en) 2010-01-26 2011-08-04 The Regents Of The University Of Colorado Conjugates utilizing platform technology for stimulating immune response
JP2013530720A (ja) 2010-07-19 2013-08-01 フィッシャー，アレクサンダー，ピー 植物栽培システムおよび方法
CN107022008A (zh) 2016-01-30 2017-08-08 复旦大学 广谱地抑制人类冠状病毒感染的多肽及其应用

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AU2021230544A1 (en) 2022-09-01
CA3173973A1 (en) 2021-09-10
CN115811984A (zh) 2023-03-17
WO2021178714A2 (en) 2021-09-10
US20240124529A1 (en) 2024-04-18
JP2023517293A (ja) 2023-04-25
WO2021178714A3 (en) 2022-02-17
KR20220148869A (ko) 2022-11-07
EP4114431A2 (en) 2023-01-11

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