JP7851648B2 - 間葉系幹細胞又はその培養上清の利用 - Google Patents

間葉系幹細胞又はその培養上清の利用

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Publication number
JP7851648B2
JP7851648B2 JP2024565886A JP2024565886A JP7851648B2 JP 7851648 B2 JP7851648 B2 JP 7851648B2 JP 2024565886 A JP2024565886 A JP 2024565886A JP 2024565886 A JP2024565886 A JP 2024565886A JP 7851648 B2 JP7851648 B2 JP 7851648B2
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mscs
culture
medium
cells
culture supernatant
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Japanese (ja)
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JPWO2024135853A5 (https=
JPWO2024135853A1 (https=
Inventor
康友 柳田
中豪 李家
一成 南
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Cell Exosome Therapeutics
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Cell Exosome Therapeutics
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Publication of JPWO2024135853A5 publication Critical patent/JPWO2024135853A5/ja
Priority to JP2025265768A priority patent/JP2026048907A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2024565886A 2022-12-23 2023-12-22 間葉系幹細胞又はその培養上清の利用 Active JP7851648B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2025021832A JP2025081432A (ja) 2022-12-23 2025-02-13 間葉系幹細胞又はその培養上清の利用
JP2025265768A JP2026048907A (ja) 2022-12-23 2025-12-18 間葉系幹細胞又はその培養上清の利用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2022207266 2022-12-23
JP2022207266 2022-12-23
PCT/JP2023/046277 WO2024135853A1 (ja) 2022-12-23 2023-12-22 間葉系幹細胞又はその培養上清の利用

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025021832A Division JP2025081432A (ja) 2022-12-23 2025-02-13 間葉系幹細胞又はその培養上清の利用

Publications (3)

Publication Number Publication Date
JPWO2024135853A1 JPWO2024135853A1 (https=) 2024-06-27
JPWO2024135853A5 JPWO2024135853A5 (https=) 2025-04-17
JP7851648B2 true JP7851648B2 (ja) 2026-04-27

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
JP2024565886A Active JP7851648B2 (ja) 2022-12-23 2023-12-22 間葉系幹細胞又はその培養上清の利用
JP2025021832A Pending JP2025081432A (ja) 2022-12-23 2025-02-13 間葉系幹細胞又はその培養上清の利用
JP2025265768A Pending JP2026048907A (ja) 2022-12-23 2025-12-18 間葉系幹細胞又はその培養上清の利用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2025021832A Pending JP2025081432A (ja) 2022-12-23 2025-02-13 間葉系幹細胞又はその培養上清の利用
JP2025265768A Pending JP2026048907A (ja) 2022-12-23 2025-12-18 間葉系幹細胞又はその培養上清の利用

Country Status (4)

Country Link
EP (1) EP4640838A1 (https=)
JP (3) JP7851648B2 (https=)
AU (1) AU2023411740A1 (https=)
WO (1) WO2024135853A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202536166A (zh) * 2023-12-25 2025-09-16 日商武田藥品工業股份有限公司 細胞的培養方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007023875A1 (ja) 2005-08-23 2007-03-01 Oriental Yeast Co., Ltd. ラミニン５を利用した間葉系幹細胞の培養技術
JP2010524504A (ja) 2007-04-23 2010-07-22 ワイス エルエルシー 抗老化化合物を使用するタンパク質の産生方法
JP2013518588A (ja) 2010-02-02 2013-05-23 ユニバーシティー オブ ロチェスター 間充織幹細胞の分離及び培養方法
CN109504649A (zh) 2017-09-15 2019-03-22 天津小西生物医药科技有限公司 使用兔皮提取物促进细胞增殖的方法
CN112094812A (zh) 2020-09-25 2020-12-18 郑州佐爵生物科技有限公司 一种促进骨髓间充质干细胞向神经元细胞分化的方法
WO2021200744A1 (ja) 2020-03-31 2021-10-07 Ｃｅｌｌ Ｅｘｏｓｏｍｅ Ｔｈｅｒａｐｅｕｔｉｃｓ株式会社 増殖細胞の生産方法、細胞生産物の生産方法、間葉系幹細胞集団およびその生産方法、幹細胞の培養上清およびその生産方法、並びに治療剤

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1551399A4 (en) 2002-09-30 2011-01-05 Mark A Babizhayev METHOD FOR THE TOPICAL TREATMENT OF EYE DISEASES AND COMPOSITION AND DEVICE FOR THIS TREATMENT
JP4631463B2 (ja) 2005-02-23 2011-02-16 東亞合成株式会社 新規なカルノシンエステル化合物
KR100908481B1 (ko) * 2006-04-24 2009-07-21 코아스템(주) 중간엽 줄기세포 배양 배지 및 이를 이용한 중간엽줄기세포의 배양 방법
JP2010031004A (ja) 2008-07-04 2010-02-12 Yaizu Suisankagaku Industry Co Ltd 新規イミダゾール誘導体及びその製造方法並びに該イミダゾール誘導体を利用したヒスチジンアミド誘導体の製造方法
JP5590646B2 (ja) 2009-10-08 2014-09-17 国立大学法人大阪大学 ヒト多能性幹細胞用培養基材およびその利用
WO2012137970A1 (ja) 2011-04-08 2012-10-11 国立大学法人大阪大学 改変ラミニンおよびその利用
CN104884468B (zh) 2012-12-28 2018-08-31 国立大学法人大阪大学 附加有胶原结合性分子的改造层粘连蛋白及其利用
CN106559994A (zh) 2014-07-16 2017-04-05 国立大学法人大阪大学 层粘连蛋白片段的细胞培养基质活性增强方法
JP2019131532A (ja) 2017-09-05 2019-08-08 株式会社トクヤマ 酸無水物、および該酸無水物を用いたｌ−カルノシンの製造方法
JP2020022433A (ja) 2018-08-01 2020-02-13 東海物産株式会社 イミダゾールジペプチドの製造方法
CN109777771B (zh) * 2019-03-26 2020-08-21 广东先康达生物科技有限公司 原代脐带间充质干细胞的无血清培养基及其使用方法
KR20220111374A (ko) * 2021-02-02 2022-08-09 연세대학교 산학협력단 골질환의 예방 또는 치료용 약학 조성물

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007023875A1 (ja) 2005-08-23 2007-03-01 Oriental Yeast Co., Ltd. ラミニン５を利用した間葉系幹細胞の培養技術
JP2010524504A (ja) 2007-04-23 2010-07-22 ワイス エルエルシー 抗老化化合物を使用するタンパク質の産生方法
JP2013518588A (ja) 2010-02-02 2013-05-23 ユニバーシティー オブ ロチェスター 間充織幹細胞の分離及び培養方法
CN109504649A (zh) 2017-09-15 2019-03-22 天津小西生物医药科技有限公司 使用兔皮提取物促进细胞增殖的方法
WO2021200744A1 (ja) 2020-03-31 2021-10-07 Ｃｅｌｌ Ｅｘｏｓｏｍｅ Ｔｈｅｒａｐｅｕｔｉｃｓ株式会社 増殖細胞の生産方法、細胞生産物の生産方法、間葉系幹細胞集団およびその生産方法、幹細胞の培養上清およびその生産方法、並びに治療剤
CN112094812A (zh) 2020-09-25 2020-12-18 郑州佐爵生物科技有限公司 一种促进骨髓间充质干细胞向神经元细胞分化的方法

Also Published As

Publication number Publication date
WO2024135853A1 (ja) 2024-06-27
JP2025081432A (ja) 2025-05-27
EP4640838A1 (en) 2025-10-29
JPWO2024135853A1 (https=) 2024-06-27
AU2023411740A1 (en) 2025-07-31
JP2026048907A (ja) 2026-03-17

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