JP7824938B2 - Ｔｙｋ２阻害剤およびその使用 - Google Patents
Ｔｙｋ２阻害剤およびその使用Info
- Publication number
- JP7824938B2 JP7824938B2 JP2023517268A JP2023517268A JP7824938B2 JP 7824938 B2 JP7824938 B2 JP 7824938B2 JP 2023517268 A JP2023517268 A JP 2023517268A JP 2023517268 A JP2023517268 A JP 2023517268A JP 7824938 B2 JP7824938 B2 JP 7824938B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- stereoisomer
- acceptable salt
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063079217P | 2020-09-16 | 2020-09-16 | |
| US63/079,217 | 2020-09-16 | ||
| PCT/US2021/050649 WO2022060973A1 (en) | 2020-09-16 | 2021-09-16 | Tyk2 inhibitors and uses thereof |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023541203A JP2023541203A (ja) | 2023-09-28 |
| JP2023541203A5 JP2023541203A5 (https=) | 2024-09-17 |
| JPWO2022060973A5 JPWO2022060973A5 (https=) | 2024-09-17 |
| JP7824938B2 true JP7824938B2 (ja) | 2026-03-05 |
Family
ID=78086111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023517268A Active JP7824938B2 (ja) | 2020-09-16 | 2021-09-16 | Ｔｙｋ２阻害剤およびその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230357273A1 (https=) |
| EP (1) | EP4214215A1 (https=) |
| JP (1) | JP7824938B2 (https=) |
| KR (1) | KR20230069984A (https=) |
| CN (1) | CN117279922B (https=) |
| AU (1) | AU2021345181A1 (https=) |
| CA (1) | CA3192621A1 (https=) |
| IL (1) | IL301385A (https=) |
| WO (1) | WO2022060973A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2024539280A (ja) | 2021-10-25 | 2024-10-28 | カイメラ セラピューティクス， インコーポレイテッド | Ｔｙｋ２分解剤およびそれらの使用 |
| JP2025509596A (ja) * | 2022-03-16 | 2025-04-11 | アルミス インコーポレイテッド | Ｔｙｋ２阻害剤およびその使用 |
| WO2023178235A1 (en) * | 2022-03-16 | 2023-09-21 | Alumis Inc. | Tyk2 inhibitors and uses thereof |
| WO2023208244A1 (zh) * | 2022-04-29 | 2023-11-02 | 南京明德新药研发有限公司 | 大环类化合物及其应用 |
| WO2024199479A1 (zh) | 2023-03-31 | 2024-10-03 | 北京普祺医药科技股份有限公司 | 一种大环化合物、药物组合物及其用途 |
| WO2024222807A1 (en) * | 2023-04-27 | 2024-10-31 | Hangzhou Highlightll Pharmaceutical Co., Ltd | Novel macrocyclic heteroaryl derivatives as kinase inhibitors |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018519343A (ja) | 2015-07-02 | 2018-07-19 | ティーピー・セラピューティクス・インコーポレイテッドＴｐ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | プロテインキナーゼのモジュレーターとしてのキラルジアリール大環状分子 |
| JP2019530699A (ja) | 2016-10-07 | 2019-10-24 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｉｌ−１２、ｉｌ−２３および／またはｉｆｎアルファ応答の調節剤として有用なイミダゾピリダジン化合物 |
| JP2020514409A (ja) | 2017-01-25 | 2020-05-21 | ターニング・ポイント・セラピューティクス・インコーポレイテッドＴｕｒｎｉｎｇ Ｐｏｉｎｔ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ジアリール大環状化合物を含む併用療法 |
| WO2020163778A1 (en) | 2019-02-07 | 2020-08-13 | Ventyx Biosciences, Inc. | Tyk2 pseudokinase ligands |
| JP2022529311A (ja) | 2019-03-26 | 2022-06-21 | ベンティックス バイオサイエンシーズ，インク． | Ｔｙｋ２偽キナーゼリガンド |
| JP7586829B2 (ja) | 2019-03-11 | 2024-11-19 | アルミス インコーポレイテッド | Ｔｙｋ２阻害剤およびその使用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10479793B2 (en) * | 2015-11-18 | 2019-11-19 | Bristol-Myers Squibb Company | Imidazopyridazine compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses |
| CN120865208A (zh) * | 2019-01-23 | 2025-10-31 | 武田药品工业株式会社 | Tyk2抑制剂和其用途 |
-
2021
- 2021-09-16 AU AU2021345181A patent/AU2021345181A1/en active Pending
- 2021-09-16 JP JP2023517268A patent/JP7824938B2/ja active Active
- 2021-09-16 IL IL301385A patent/IL301385A/en unknown
- 2021-09-16 WO PCT/US2021/050649 patent/WO2022060973A1/en not_active Ceased
- 2021-09-16 US US18/026,309 patent/US20230357273A1/en active Pending
- 2021-09-16 CA CA3192621A patent/CA3192621A1/en active Pending
- 2021-09-16 KR KR1020237012767A patent/KR20230069984A/ko active Pending
- 2021-09-16 EP EP21789976.4A patent/EP4214215A1/en active Pending
- 2021-09-16 CN CN202180076687.5A patent/CN117279922B/zh active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018519343A (ja) | 2015-07-02 | 2018-07-19 | ティーピー・セラピューティクス・インコーポレイテッドＴｐ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | プロテインキナーゼのモジュレーターとしてのキラルジアリール大環状分子 |
| JP2019530699A (ja) | 2016-10-07 | 2019-10-24 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｉｌ−１２、ｉｌ−２３および／またはｉｆｎアルファ応答の調節剤として有用なイミダゾピリダジン化合物 |
| JP2020514409A (ja) | 2017-01-25 | 2020-05-21 | ターニング・ポイント・セラピューティクス・インコーポレイテッドＴｕｒｎｉｎｇ Ｐｏｉｎｔ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | ジアリール大環状化合物を含む併用療法 |
| WO2020163778A1 (en) | 2019-02-07 | 2020-08-13 | Ventyx Biosciences, Inc. | Tyk2 pseudokinase ligands |
| JP7586829B2 (ja) | 2019-03-11 | 2024-11-19 | アルミス インコーポレイテッド | Ｔｙｋ２阻害剤およびその使用 |
| JP2022529311A (ja) | 2019-03-26 | 2022-06-21 | ベンティックス バイオサイエンシーズ，インク． | Ｔｙｋ２偽キナーゼリガンド |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2021345181A9 (en) | 2024-06-20 |
| WO2022060973A1 (en) | 2022-03-24 |
| CA3192621A1 (en) | 2022-03-24 |
| AU2021345181A1 (en) | 2023-05-04 |
| IL301385A (en) | 2023-05-01 |
| JP2023541203A (ja) | 2023-09-28 |
| CN117279922A (zh) | 2023-12-22 |
| US20230357273A1 (en) | 2023-11-09 |
| KR20230069984A (ko) | 2023-05-19 |
| EP4214215A1 (en) | 2023-07-26 |
| CN117279922B (zh) | 2025-12-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7824938B2 (ja) | Ｔｙｋ２阻害剤およびその使用 | |
| US11731956B2 (en) | Substituted 1,2,4-triazoles as intermediates in the synthesis of TYK2 inhibitors | |
| JP7586829B2 (ja) | Ｔｙｋ２阻害剤およびその使用 | |
| JP2025509596A (ja) | Ｔｙｋ２阻害剤およびその使用 | |
| JP2025509594A (ja) | Ｔｙｋ２阻害剤およびその使用 | |
| HK40105557B (zh) | Tyk2抑制剂及其用途 | |
| HK40105557A (zh) | Tyk2抑制剂及其用途 | |
| RU2813233C2 (ru) | Ингибиторы tyk2 и пути их применения | |
| HK40120037B (en) | Tyk2 inhibitors and uses thereof | |
| HK40119624A (en) | Tyk2 inhibitors and uses thereof | |
| HK40120037A (en) | Tyk2 inhibitors and uses thereof | |
| HK40119624B (en) | Tyk2 inhibitors and uses thereof | |
| WO2024127363A1 (en) | Tyk2 pseudokinase ligands and uses thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20240906 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20240906 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20250729 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20250731 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20251028 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20260105 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20260130 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20260220 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7824938 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |