IL301385A - TYK2 inhibitors and their use - Google Patents
TYK2 inhibitors and their useInfo
- Publication number
- IL301385A IL301385A IL301385A IL30138523A IL301385A IL 301385 A IL301385 A IL 301385A IL 301385 A IL301385 A IL 301385A IL 30138523 A IL30138523 A IL 30138523A IL 301385 A IL301385 A IL 301385A
- Authority
- IL
- Israel
- Prior art keywords
- compound
- pharmaceutically acceptable
- stereoisomer
- solvate
- acceptable salt
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063079217P | 2020-09-16 | 2020-09-16 | |
| PCT/US2021/050649 WO2022060973A1 (en) | 2020-09-16 | 2021-09-16 | Tyk2 inhibitors and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL301385A true IL301385A (en) | 2023-05-01 |
Family
ID=78086111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL301385A IL301385A (en) | 2020-09-16 | 2021-09-16 | TYK2 inhibitors and their use |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230357273A1 (https=) |
| EP (1) | EP4214215A1 (https=) |
| JP (1) | JP7824938B2 (https=) |
| KR (1) | KR20230069984A (https=) |
| CN (1) | CN117279922B (https=) |
| AU (1) | AU2021345181A1 (https=) |
| CA (1) | CA3192621A1 (https=) |
| IL (1) | IL301385A (https=) |
| WO (1) | WO2022060973A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4423086A1 (en) | 2021-10-25 | 2024-09-04 | Kymera Therapeutics, Inc. | Tyk2 degraders and uses thereof |
| CA3245808A1 (en) * | 2022-03-16 | 2023-09-21 | Alumis Inc. | TYK2 INHIBITORS AND THEIR USES |
| CN119487037A (zh) * | 2022-03-16 | 2025-02-18 | 阿鲁米斯股份有限公司 | Tyk2抑制剂及其用途 |
| WO2023208244A1 (zh) * | 2022-04-29 | 2023-11-02 | 南京明德新药研发有限公司 | 大环类化合物及其应用 |
| JP2026512838A (ja) | 2023-03-31 | 2026-04-21 | 北京普祺医薬科技股▲分▼有限公司 | 大環化合物、医薬組成物及びその使用 |
| WO2024222807A1 (en) * | 2023-04-27 | 2024-10-31 | Hangzhou Highlightll Pharmaceutical Co., Ltd | Novel macrocyclic heteroaryl derivatives as kinase inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016287568B2 (en) | 2015-07-02 | 2020-08-20 | Turning Point Therapeutics, Inc. | Chiral diaryl macrocycles as modulators of protein kinases |
| US10479793B2 (en) * | 2015-11-18 | 2019-11-19 | Bristol-Myers Squibb Company | Imidazopyridazine compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses |
| ES2902995T3 (es) * | 2016-10-07 | 2022-03-30 | Bristol Myers Squibb Co | Compuestos de imidazopiridazina útiles como moduladores de respuestas a IL-12, IL-23 y/o IFN alfa |
| TWI808958B (zh) | 2017-01-25 | 2023-07-21 | 美商特普醫葯公司 | 涉及二芳基巨環化合物之組合療法 |
| CN113348021B (zh) * | 2019-01-23 | 2025-07-11 | 武田药品工业株式会社 | Tyk2抑制剂和其用途 |
| JP2022519696A (ja) * | 2019-02-07 | 2022-03-24 | ベンティックス バイオサイエンシーズ，インク． | Ｔｙｋ２偽キナーゼリガンド |
| CA3132632A1 (en) * | 2019-03-11 | 2020-09-17 | Esker Therapeutics, Inc. | Tyk2 inhibitors and uses thereof |
| CA3134814A1 (en) | 2019-03-26 | 2020-10-01 | Ventyx Biosciences, Inc. | Tyk2 pseudokinase ligands |
-
2021
- 2021-09-16 EP EP21789976.4A patent/EP4214215A1/en active Pending
- 2021-09-16 KR KR1020237012767A patent/KR20230069984A/ko active Pending
- 2021-09-16 IL IL301385A patent/IL301385A/en unknown
- 2021-09-16 WO PCT/US2021/050649 patent/WO2022060973A1/en not_active Ceased
- 2021-09-16 CN CN202180076687.5A patent/CN117279922B/zh active Active
- 2021-09-16 AU AU2021345181A patent/AU2021345181A1/en active Pending
- 2021-09-16 US US18/026,309 patent/US20230357273A1/en active Pending
- 2021-09-16 CA CA3192621A patent/CA3192621A1/en active Pending
- 2021-09-16 JP JP2023517268A patent/JP7824938B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2021345181A9 (en) | 2024-06-20 |
| CN117279922B (zh) | 2025-12-19 |
| JP2023541203A (ja) | 2023-09-28 |
| AU2021345181A1 (en) | 2023-05-04 |
| JP7824938B2 (ja) | 2026-03-05 |
| WO2022060973A1 (en) | 2022-03-24 |
| US20230357273A1 (en) | 2023-11-09 |
| CN117279922A (zh) | 2023-12-22 |
| EP4214215A1 (en) | 2023-07-26 |
| CA3192621A1 (en) | 2022-03-24 |
| KR20230069984A (ko) | 2023-05-19 |
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