JP7803855B2 - 選択的な感覚神経の遮断のある局所麻酔薬 - Google Patents

選択的な感覚神経の遮断のある局所麻酔薬

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Publication number
JP7803855B2
JP7803855B2 JP2022525711A JP2022525711A JP7803855B2 JP 7803855 B2 JP7803855 B2 JP 7803855B2 JP 2022525711 A JP2022525711 A JP 2022525711A JP 2022525711 A JP2022525711 A JP 2022525711A JP 7803855 B2 JP7803855 B2 JP 7803855B2
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unsubstituted
substituted
compound
alkyl
formula
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JP2022525711A
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English (en)
Japanese (ja)
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JP2023500682A5 (https=
JP2023500682A (ja
JPWO2021087113A5 (https=
Inventor
コハネ，ダニエル，エス．
ジェン，ユーチン
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Boston Childrens Hospital
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Boston Childrens Hospital
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Publication of JP2023500682A publication Critical patent/JP2023500682A/ja
Publication of JP2023500682A5 publication Critical patent/JP2023500682A5/ja
Publication of JPWO2021087113A5 publication Critical patent/JPWO2021087113A5/ja
Priority to JP2025135404A priority Critical patent/JP2026004274A/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2022525711A 2019-10-30 2020-10-29 選択的な感覚神経の遮断のある局所麻酔薬 Active JP7803855B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025135404A JP2026004274A (ja) 2019-10-30 2025-08-15 選択的な感覚神経の遮断のある局所麻酔薬

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962928177P 2019-10-30 2019-10-30
US62/928,177 2019-10-30
US201962941624P 2019-11-27 2019-11-27
US62/941,624 2019-11-27
PCT/US2020/057963 WO2021087113A1 (en) 2019-10-30 2020-10-29 Local anesthetics with selective-sensory nerve blockade

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025135404A Division JP2026004274A (ja) 2019-10-30 2025-08-15 選択的な感覚神経の遮断のある局所麻酔薬

Publications (4)

Publication Number Publication Date
JP2023500682A JP2023500682A (ja) 2023-01-10
JP2023500682A5 JP2023500682A5 (https=) 2023-11-08
JPWO2021087113A5 JPWO2021087113A5 (https=) 2023-11-08
JP7803855B2 true JP7803855B2 (ja) 2026-01-21

Family

ID=75714697

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022525711A Active JP7803855B2 (ja) 2019-10-30 2020-10-29 選択的な感覚神経の遮断のある局所麻酔薬
JP2025135404A Pending JP2026004274A (ja) 2019-10-30 2025-08-15 選択的な感覚神経の遮断のある局所麻酔薬

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025135404A Pending JP2026004274A (ja) 2019-10-30 2025-08-15 選択的な感覚神経の遮断のある局所麻酔薬

Country Status (6)

Country Link
US (1) US12454509B2 (https=)
EP (1) EP4051254A4 (https=)
JP (2) JP7803855B2 (https=)
AU (1) AU2020373030A1 (https=)
CA (1) CA3159752A1 (https=)
WO (1) WO2021087113A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116023322B (zh) * 2022-01-05 2025-10-31 天津键凯科技有限公司 一种n-乙酰苯胺类阳离子化合物及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024428A1 (en) 1996-12-02 1998-06-11 Brigham & Women's Hospital, Inc. Long-acting local anesthetics
CN103601650A (zh) 2013-01-16 2014-02-26 四川大学华西医院 N-二乙氨基乙酰-2,6-二甲基苯胺衍生物、制备方法及用途
CN106928126A (zh) 2015-12-31 2017-07-07 四川海思科制药有限公司 一种酰胺衍生物及其制备方法和在药学上的应用
JP2017523175A (ja) 2014-08-01 2017-08-17 ウェストチャイナホスピタル、スーチョワンユニバーシティ ジメチルアニリン類長鎖化合物、及びその調製、自己組織化構造及び用途
WO2019189756A1 (ja) 2018-03-30 2019-10-03 ロート製薬株式会社 外用油性固形組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3050559A (en) 1962-08-21 Substituted phenylcyclopropylamjnes
GB866604A (en) 1958-05-31 1961-04-26 T & H Smith Ltd New quaternary salts
US3255207A (en) * 1962-02-09 1966-06-07 Astra Ab Quaternary ammonium salts containing anilido groups
US3998815A (en) 1974-06-24 1976-12-21 Interx Research Corporation 1-hydrocarbonoyloxymethyl-3-carbamoyl or 3-carboethoxy-pyridinium salts
CH618842A5 (en) 1975-09-30 1980-08-29 Ciba Geigy Ag Pesticides
CA3039767C (en) * 2015-12-22 2023-11-14 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for treatment, amelioration, and prevention of anesthesia-induced hypothermia

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998024428A1 (en) 1996-12-02 1998-06-11 Brigham & Women's Hospital, Inc. Long-acting local anesthetics
CN103601650A (zh) 2013-01-16 2014-02-26 四川大学华西医院 N-二乙氨基乙酰-2,6-二甲基苯胺衍生物、制备方法及用途
JP2017523175A (ja) 2014-08-01 2017-08-17 ウェストチャイナホスピタル、スーチョワンユニバーシティ ジメチルアニリン類長鎖化合物、及びその調製、自己組織化構造及び用途
CN106928126A (zh) 2015-12-31 2017-07-07 四川海思科制药有限公司 一种酰胺衍生物及其制备方法和在药学上的应用
WO2019189756A1 (ja) 2018-03-30 2019-10-03 ロート製薬株式会社 外用油性固形組成物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BANASIAK, L. et al.，Fungicidal quaternary ammonium compounds derived from betain，Tagungsbericht-Akademie der Landwirtschaftswissenschaften，1990年，Vol.291，pp.269-277
NIELSEN, A B. et al.，Bioreversible quaternary N-acyloxymethyl derivatives of the tertiary amines bupivacaine and lidocaine-synthesis, aqueous solubility and stability in buffer, human plasma and simulated intestinal fluid，European Journal of Pharmaceutical Sciences，2005年，Vol.24, No.5，pp.433-440

Also Published As

Publication number Publication date
EP4051254A4 (en) 2023-12-13
WO2021087113A1 (en) 2021-05-06
JP2023500682A (ja) 2023-01-10
US12454509B2 (en) 2025-10-28
EP4051254A1 (en) 2022-09-07
CA3159752A1 (en) 2021-05-06
AU2020373030A1 (en) 2022-05-19
US20240092736A1 (en) 2024-03-21
JP2026004274A (ja) 2026-01-14

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