JP7802367B2 - 膵臓がんのバイオマーカーとしてのマイクロｒｎａの使用 - Google Patents

膵臓がんのバイオマーカーとしてのマイクロｒｎａの使用

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Publication number
JP7802367B2
JP7802367B2 JP2022536442A JP2022536442A JP7802367B2 JP 7802367 B2 JP7802367 B2 JP 7802367B2 JP 2022536442 A JP2022536442 A JP 2022536442A JP 2022536442 A JP2022536442 A JP 2022536442A JP 7802367 B2 JP7802367 B2 JP 7802367B2
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pancreatic cancer
microrna
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amount
seq
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JPWO2022014670A1 (https=
Inventor
尊彦 阪上
英希 岩本
浩徳 古賀
義信 岡部
拓司 鳥村
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Kurume University
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Kurume University
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Plant Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2022536442A 2020-07-16 2021-07-15 膵臓がんのバイオマーカーとしてのマイクロｒｎａの使用 Active JP7802367B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025279752A JP2026040625A (ja) 2020-07-16 2025-12-24 膵臓がんのバイオマーカーとしてのマイクロｒｎａの使用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020122124 2020-07-16
JP2020122124 2020-07-16
PCT/JP2021/026597 WO2022014670A1 (ja) 2020-07-16 2021-07-15 膵臓がんのバイオマーカーとしてのマイクロｒｎａの使用

Related Child Applications (1)

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Publications (2)

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JPWO2022014670A1 JPWO2022014670A1 (https=) 2022-01-20
JP7802367B2 true JP7802367B2 (ja) 2026-01-20

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JP2022536442A Active JP7802367B2 (ja) 2020-07-16 2021-07-15 膵臓がんのバイオマーカーとしてのマイクロｒｎａの使用
JP2025279752A Pending JP2026040625A (ja) 2020-07-16 2025-12-24 膵臓がんのバイオマーカーとしてのマイクロｒｎａの使用

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US (1) US20230272481A1 (https=)
JP (2) JP7802367B2 (https=)
WO (1) WO2022014670A1 (https=)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009528070A (ja) 2006-03-02 2009-08-06 ザ オハイオ ステイト ユニバーシティ 膵臓癌に関連するマイクロｒｎａ発現プロファイル
JP2015107091A (ja) 2013-12-05 2015-06-11 東レ株式会社 膵臓がんの検出キット及び検出方法
JP2016123340A (ja) 2014-12-26 2016-07-11 株式会社エバンス 膵癌治療感受性の診断方法及び膵癌治療感受性の増強剤
WO2019117269A1 (ja) 2017-12-13 2019-06-20 国立大学法人広島大学 膵がんの検出を補助する方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102680815B1 (ko) * 2014-05-30 2024-07-03 국립연구개발법인 고쿠리츠간켄큐센터 췌장암의 검출 키트 또는 디바이스 및 검출 방법
EP3988668A3 (en) * 2016-03-31 2022-06-29 Toray Industries, Inc. Kit or device for detecting early stage pancreatic cancer or pancreatic cancer precursor lesions and detection method therefor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009528070A (ja) 2006-03-02 2009-08-06 ザ オハイオ ステイト ユニバーシティ 膵臓癌に関連するマイクロｒｎａ発現プロファイル
JP2015107091A (ja) 2013-12-05 2015-06-11 東レ株式会社 膵臓がんの検出キット及び検出方法
JP2016123340A (ja) 2014-12-26 2016-07-11 株式会社エバンス 膵癌治療感受性の診断方法及び膵癌治療感受性の増強剤
WO2019117269A1 (ja) 2017-12-13 2019-06-20 国立大学法人広島大学 膵がんの検出を補助する方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEN Shuo.et al.，MicroRNA-4516 suppresses pancreatic cancer development via negatively regulating orthodenticle homeo，Int. J. Biol. Sci.，2020年05月18日，Vol.16，p.2159-2169
光永 修一他，[特集]膵癌の早期診断最前線 ７．膵癌早期診断を目指した血清マイクロＲＮＡ検査の研究開発，膵臓，2017年，Vol.32，p.56-61
許 文聰他，膵臓がん患者血清中microRNAの網羅的解析による新規バイオマーカー探索，東医大誌，2017年，Vol.75，p.234-240

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US20230272481A1 (en) 2023-08-31
WO2022014670A1 (ja) 2022-01-20
JP2026040625A (ja) 2026-03-09
JPWO2022014670A1 (https=) 2022-01-20

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