JP7768880B2 - Ｅｚｈ２を阻害するためのキノリン化合物および組成物 - Google Patents

Ｅｚｈ２を阻害するためのキノリン化合物および組成物

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Publication number
JP7768880B2
JP7768880B2 JP2022530800A JP2022530800A JP7768880B2 JP 7768880 B2 JP7768880 B2 JP 7768880B2 JP 2022530800 A JP2022530800 A JP 2022530800A JP 2022530800 A JP2022530800 A JP 2022530800A JP 7768880 B2 JP7768880 B2 JP 7768880B2
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JP
Japan
Prior art keywords
amino
methyl
chloro
methylquinolin
cyclohexyl
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Active
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JP2022530800A
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English (en)
Japanese (ja)
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JP2023538159A5 (cg-RX-API-DMAC10.html
JP2023538159A (ja
Inventor
ダイ，シュアン
ドーレ，マイケル
グー，シャンジュ，ジャスティン
リー，リン
チン リウ，クン
イェウン，フランキー マク，シン
ミ，ユアン
オヤン，カウンド
パピヨン，ジュリエン
キー，ウェイ
ヤン，シャオシャオ
ユ，チェンティアン
ユー チャン，ジ
ザオ，キハオ
Original Assignee
ノバルティス アーゲー
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2022530800A 2020-08-10 2021-08-10 Ｅｚｈ２を阻害するためのキノリン化合物および組成物 Active JP7768880B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2020/108213 2020-08-10
CN2020108213 2020-08-10
PCT/CN2021/111910 WO2022033492A1 (en) 2020-08-10 2021-08-10 Quinoline compounds and compositions for inhibiting ezh2

Publications (3)

Publication Number Publication Date
JP2023538159A JP2023538159A (ja) 2023-09-07
JP2023538159A5 JP2023538159A5 (cg-RX-API-DMAC10.html) 2024-08-16
JP7768880B2 true JP7768880B2 (ja) 2025-11-12

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022530800A Active JP7768880B2 (ja) 2020-08-10 2021-08-10 Ｅｚｈ２を阻害するためのキノリン化合物および組成物

Country Status (12)

Country Link
US (1) US12473273B2 (cg-RX-API-DMAC10.html)
EP (1) EP4041725B1 (cg-RX-API-DMAC10.html)
JP (1) JP7768880B2 (cg-RX-API-DMAC10.html)
KR (1) KR20230051116A (cg-RX-API-DMAC10.html)
CN (2) CN114555589B (cg-RX-API-DMAC10.html)
AR (1) AR123185A1 (cg-RX-API-DMAC10.html)
AU (1) AU2021323828B2 (cg-RX-API-DMAC10.html)
CA (1) CA3180139A1 (cg-RX-API-DMAC10.html)
ES (1) ES2985111T3 (cg-RX-API-DMAC10.html)
IL (1) IL297332B2 (cg-RX-API-DMAC10.html)
TW (1) TWI910207B (cg-RX-API-DMAC10.html)
WO (1) WO2022033492A1 (cg-RX-API-DMAC10.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR123185A1 (es) 2020-08-10 2022-11-09 Novartis Ag Compuestos y composiciones para inhibir ezh2
PE20241731A1 (es) * 2022-02-01 2024-08-19 Lilly Co Eli Procesos para la preparacion de degradadores selectivos del receptor de estrogeno
CN117384153A (zh) * 2022-07-12 2024-01-12 上海赛岚生物科技有限公司 一类甲基转移酶抑制剂及其用途
CN118515653B (zh) * 2024-07-23 2024-12-10 西湖制药(杭州)有限公司 一种ezh2特异性抑制剂及其制备方法和用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006501186A (ja) 2002-07-08 2006-01-12 アストラゼネカ アクチボラグ Ｍｃｈ１ｒアンタゴニスト
JP2006124387A (ja) 2004-09-30 2006-05-18 Taisho Pharmaceut Co Ltd 新規なキノリン、テトラヒドロキナゾリン、及びピリミジン誘導体と、これらを使用することに関連した治療方法
JP2017519013A (ja) 2014-06-17 2017-07-13 ファイザー・インク 置換ジヒドロイソキノリノン化合物
CN109912576A (zh) 2019-03-20 2019-06-21 华东理工大学 环状或螺环二胺类嘧啶-异羟肟酸及其用途
JP2019524872A (ja) 2016-06-20 2019-09-05 ノバルティス アーゲー 癌の治療に有用なイミダゾピリミジン化合物

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US2779780A (en) 1955-03-01 1957-01-29 Du Pont 1, 4-diamino-2, 3-dicyano-1, 4-bis (substituted mercapto) butadienes and their preparation
EP0647450A1 (en) 1993-09-09 1995-04-12 BEHRINGWERKE Aktiengesellschaft Improved prodrugs for enzyme mediated activation
JP2002532415A (ja) 1998-12-16 2002-10-02 ワーナー−ランバート・カンパニー Ｍｅｋ阻害剤による関節炎の治療
AU7349801A (en) 2000-07-19 2002-01-30 Warner Lambert Co Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids
CA2478065C (en) 2002-03-08 2013-01-08 Eisai Co. Ltd. Macrocyclic compounds useful as pharmaceuticals
SG2013013339A (en) 2002-03-13 2014-12-30 Array Biopharma Inc N3 alkylated benzimidazole derivatives as mek inhibitors
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
MX2008002114A (es) 2005-07-21 2008-04-17 Ardea Biosciences Inc Inhibidores de n-(arilamino)-sulfonamida de mek.
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
BRPI0816769A2 (pt) 2007-09-12 2016-11-29 Hoffmann La Roche combinações de compostos inibidores de fosfoinositida 3-cinase e agentes quimioterapêuticos, e métodos de uso
WO2009055730A1 (en) 2007-10-25 2009-04-30 Genentech, Inc. Process for making thienopyrimidine compounds
US8168784B2 (en) 2008-06-20 2012-05-01 Abbott Laboratories Processes to make apoptosis promoters
WO2012068589A2 (en) * 2010-11-19 2012-05-24 Constellation Pharmaceuticals Modulators of methyl modifying enzymes, compositions and uses thereof
WO2018195450A1 (en) 2017-04-21 2018-10-25 Epizyme, Inc. Combination therapies with ehmt2 inhibitors
DK4034535T3 (da) * 2019-09-26 2026-04-07 Novartis Ag Aza-quinolinforbindelser og anvendelser deraf
AR123185A1 (es) 2020-08-10 2022-11-09 Novartis Ag Compuestos y composiciones para inhibir ezh2

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006501186A (ja) 2002-07-08 2006-01-12 アストラゼネカ アクチボラグ Ｍｃｈ１ｒアンタゴニスト
JP2006124387A (ja) 2004-09-30 2006-05-18 Taisho Pharmaceut Co Ltd 新規なキノリン、テトラヒドロキナゾリン、及びピリミジン誘導体と、これらを使用することに関連した治療方法
JP2017519013A (ja) 2014-06-17 2017-07-13 ファイザー・インク 置換ジヒドロイソキノリノン化合物
JP2019524872A (ja) 2016-06-20 2019-09-05 ノバルティス アーゲー 癌の治療に有用なイミダゾピリミジン化合物
CN109912576A (zh) 2019-03-20 2019-06-21 华东理工大学 环状或螺环二胺类嘧啶-异羟肟酸及其用途

Also Published As

Publication number Publication date
AR123185A1 (es) 2022-11-09
TWI910207B (zh) 2026-01-01
CA3180139A1 (en) 2022-02-17
US20230167100A1 (en) 2023-06-01
EP4041725A1 (en) 2022-08-17
WO2022033492A1 (en) 2022-02-17
KR20230051116A (ko) 2023-04-17
US12473273B2 (en) 2025-11-18
JP2023538159A (ja) 2023-09-07
AU2021323828A1 (en) 2022-05-19
CN119431341A (zh) 2025-02-14
IL297332B1 (en) 2025-10-01
ES2985111T3 (es) 2024-11-04
IL297332A (en) 2022-12-01
EP4041725B1 (en) 2024-03-27
CN114555589B (zh) 2024-10-25
CN114555589A (zh) 2022-05-27
IL297332B2 (en) 2026-02-01
TW202220979A (zh) 2022-06-01
AU2021323828B2 (en) 2026-07-30

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