JP7760582B2 - 分析物の検出および定量化のための磁性ナノ粒子の使用 - Google Patents

分析物の検出および定量化のための磁性ナノ粒子の使用

Info

Publication number
JP7760582B2
JP7760582B2 JP2023515223A JP2023515223A JP7760582B2 JP 7760582 B2 JP7760582 B2 JP 7760582B2 JP 2023515223 A JP2023515223 A JP 2023515223A JP 2023515223 A JP2023515223 A JP 2023515223A JP 7760582 B2 JP7760582 B2 JP 7760582B2
Authority
JP
Japan
Prior art keywords
magnetic field
sample
magnetizable particles
field sensor
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2023515223A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2021237283A5 (enExample
JP2023528687A (ja
Inventor
ジェレミー キング ポール
イェーウン－ワー ロー カムデン
Original Assignee
クアンタム アイピー ホールディングス プロプライアタリー リミティド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by クアンタム アイピー ホールディングス プロプライアタリー リミティド filed Critical クアンタム アイピー ホールディングス プロプライアタリー リミティド
Publication of JP2023528687A publication Critical patent/JP2023528687A/ja
Publication of JPWO2021237283A5 publication Critical patent/JPWO2021237283A5/ja
Application granted granted Critical
Publication of JP7760582B2 publication Critical patent/JP7760582B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/72—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables
    • G01N27/74—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids
    • G01N27/745—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids for detecting magnetic beads used in biochemical assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • G01N33/547—Synthetic resin with antigen or antibody attached to the carrier via a bridging agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/12—Measuring magnetic properties of articles or specimens of solids or fluids
    • G01R33/1269—Measuring magnetic properties of articles or specimens of solids or fluids of molecules labeled with magnetic beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701—Details
    • G01N2333/4737—C-reactive protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/525—Tumor necrosis factor [TNF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/53—Colony-stimulating factor [CSF]
    • G01N2333/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/52—Assays involving cytokines
    • G01N2333/54—Interleukins [IL]
    • G01N2333/5412—IL-6
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/76—Assays involving albumins other than in routine use for blocking surfaces or for anchoring haptens during immunisation
    • G01N2333/765—Serum albumin, e.g. HSA
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Electrochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nanotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Compounds Of Iron (AREA)
  • Soft Magnetic Materials (AREA)
JP2023515223A 2020-05-25 2021-05-25 分析物の検出および定量化のための磁性ナノ粒子の使用 Active JP7760582B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2020904881 2020-05-25
AU2020904881 2020-05-25
PCT/AU2021/050497 WO2021237283A1 (en) 2020-05-25 2021-05-25 Use of magnetic nanoparticles for the detection and quantitation of analyte(s)

Publications (3)

Publication Number Publication Date
JP2023528687A JP2023528687A (ja) 2023-07-05
JPWO2021237283A5 JPWO2021237283A5 (enExample) 2024-05-23
JP7760582B2 true JP7760582B2 (ja) 2025-10-27

Family

ID=78745678

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023515223A Active JP7760582B2 (ja) 2020-05-25 2021-05-25 分析物の検出および定量化のための磁性ナノ粒子の使用

Country Status (11)

Country Link
US (2) US11604187B2 (enExample)
EP (1) EP3938785A4 (enExample)
JP (1) JP7760582B2 (enExample)
KR (1) KR20230013259A (enExample)
CN (1) CN114341641A (enExample)
AU (2) AU2021232687B2 (enExample)
BR (1) BR112022023995A2 (enExample)
CA (1) CA3180264A1 (enExample)
IL (1) IL298373A (enExample)
MX (1) MX2022014818A (enExample)
WO (1) WO2021237283A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114214391A (zh) * 2021-12-14 2022-03-22 徐州医科大学 Au/Fe3O4复合的磁纳米马达材料、制备方法及应用
JP2024142624A (ja) * 2023-03-30 2024-10-11 セイコーエプソン株式会社 生体物質抽出用磁性ビーズ
CN116660108A (zh) * 2023-05-31 2023-08-29 郑州轻工业大学 一种弱抗磁环境下的磁纳米颗粒核粒径分布信息估计方法
KR102852902B1 (ko) * 2023-09-19 2025-09-02 이화여자대학교 산학협력단 자성 센서에 기반하는 엔도뉴클레아제 동역학 측정장치 및 그 제조방법
CN117434141A (zh) * 2023-10-13 2024-01-23 中国计量科学研究院 样品检测方法、装置、计算机设备和存储介质
KR20250108313A (ko) 2024-01-08 2025-07-15 고려대학교 산학협력단 기전력이 결부된 비대칭적 자기 수송 특성을 측정하는 장치

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007256024A (ja) 2006-03-22 2007-10-04 Fujifilm Corp 標的化合物の検出方法
JP2009115529A (ja) 2007-11-05 2009-05-28 Hitachi High-Technologies Corp 磁気信号計測装置および磁気信号計測方法
JP2013228280A (ja) 2012-04-26 2013-11-07 Hitachi Ltd 交流磁場を用いた磁気的免疫検査方法及び検査装置
JP2017049257A (ja) 2010-03-12 2017-03-09 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 磁気センサに基づく結合反応速度の定量的な分析

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020123079A1 (en) * 2000-10-20 2002-09-05 Qi Chen Process for detecting or quantifying a biological rreaction using superparamagnetic label
US6825655B2 (en) * 2001-08-31 2004-11-30 Imego Ab Method and arrangement for detecting changes of a magnetic response in magnetic particles
EP1469311B1 (en) * 2002-01-29 2007-08-08 Asahi Kasei Kabushiki Kaisha Biosensor, magnetic molecule measurement method, and measurement object measuring method
KR20060052889A (ko) * 2003-07-30 2006-05-19 코닌클리케 필립스 일렉트로닉스 엔.브이. 생체 활성 분자 사이의 결합을 결정하기 위한 자기 입자의사용
US7906345B2 (en) * 2003-11-12 2011-03-15 The Board Of Trustees Of The Leland Stanford Junior University Magnetic nanoparticles, magnetic detector arrays, and methods for their use in detecting biological molecules
JP3962385B2 (ja) * 2004-03-11 2007-08-22 株式会社日立製作所 免疫検査装置及び免疫検査方法
GB0410980D0 (en) * 2004-05-17 2004-06-16 Randox Lab Ltd Magnetic particle detector system and method of performing binding assay
CA2609965A1 (en) * 2005-05-27 2006-11-30 Board Of Regents, The University Of Texas System Optical coherence tomographic detection of cells and compositions
CN101228440A (zh) * 2005-07-20 2008-07-23 因弗因斯医药瑞士股份有限公司 分析装置和方法
US20070197900A1 (en) * 2005-11-22 2007-08-23 Vanderbilt University Magnetic flow cytometer with SQUID microscopy
WO2007089564A2 (en) * 2006-01-26 2007-08-09 The Regents Of The University Of California Microchannel magneto-immunoassay
WO2011053435A1 (en) * 2009-10-05 2011-05-05 Scientific Nanomedicine, Inc. Cell detection using targeted nanoparticles and magnetic properties thereof
US20100253323A1 (en) * 2007-12-07 2010-10-07 Koninklijke Philips Electronics N.V. Magnetic washing for biosensor
EP2401625B1 (en) * 2009-02-26 2014-01-22 Regents of the University of Minnesota High magnetic moment particle detection
WO2011022093A2 (en) * 2009-04-13 2011-02-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and devices for detecting the presence of an analyte in a sample
US8153442B2 (en) * 2009-10-21 2012-04-10 Siemens Healthcare Diagnostics Inc. Stabilization of signal generation in particles used in assays
CA2781824A1 (en) * 2009-11-30 2011-06-03 Bio-Rad Laboratories Inc. Bead reader
US8802057B2 (en) * 2010-07-22 2014-08-12 University Of Houston System Force-induced magnetization contrast for diagnosis and imaging
GB201014805D0 (en) * 2010-09-07 2010-10-20 Multi Sense Technologies Ltd Microfluidics based assay device
US9039992B2 (en) * 2011-06-06 2015-05-26 Abbott Laboratories Apparatus for closed tube sampling and open tube sampling for automated clinical analyzers
WO2013115725A1 (en) * 2012-02-03 2013-08-08 Neobios Pte Ltd A passive microfluidic device and a method of forming the same
WO2015138405A2 (en) * 2014-03-10 2015-09-17 The Board Of Trustees Of The University Of Illinois Detection and quantification of methylation in dna
CN107923877B (zh) * 2015-05-12 2021-07-09 马格雷股份有限公司 用于提高磁传感器灵敏度的装置和方法
JP6903672B2 (ja) * 2016-03-08 2021-07-14 マグアレイ，インコーポレイテッド 肺癌の診断および治療のための蛋白質と自己抗体バイオマーカー
WO2018094213A1 (en) * 2016-11-18 2018-05-24 Kansas State University Research Foundation Microfluidics-based nanobiosensors and devices
GB201707140D0 (en) * 2017-05-04 2017-06-21 Oxford Nanopore Tech Ltd Method
CN111315485B (zh) * 2017-05-16 2023-05-23 凯恩生物科学股份有限公司 用于精密培养、控制和监测活细胞的微流体启用式多孔细胞培养设备和系统

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007256024A (ja) 2006-03-22 2007-10-04 Fujifilm Corp 標的化合物の検出方法
JP2009115529A (ja) 2007-11-05 2009-05-28 Hitachi High-Technologies Corp 磁気信号計測装置および磁気信号計測方法
JP2017049257A (ja) 2010-03-12 2017-03-09 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 磁気センサに基づく結合反応速度の定量的な分析
JP2013228280A (ja) 2012-04-26 2013-11-07 Hitachi Ltd 交流磁場を用いた磁気的免疫検査方法及び検査装置

Also Published As

Publication number Publication date
EP3938785A4 (en) 2022-11-30
CN114341641A (zh) 2022-04-12
CA3180264A1 (en) 2021-12-02
TW202215051A (zh) 2022-04-16
AU2021232687A1 (en) 2021-12-09
US20220003758A1 (en) 2022-01-06
MX2022014818A (es) 2023-04-03
AU2024201129A1 (en) 2024-03-14
EP3938785A1 (en) 2022-01-19
KR20230013259A (ko) 2023-01-26
WO2021237283A1 (en) 2021-12-02
JP2023528687A (ja) 2023-07-05
US11604187B2 (en) 2023-03-14
BR112022023995A2 (pt) 2023-02-07
AU2021232687B2 (en) 2023-11-23
IL298373A (en) 2023-01-01
US20230251249A1 (en) 2023-08-10

Similar Documents

Publication Publication Date Title
JP7760582B2 (ja) 分析物の検出および定量化のための磁性ナノ粒子の使用
AU2023241336B2 (en) Superparamagnetic particle imaging and its applications in quantitative multiplex stationary phase diagnostic assays
Wang et al. Magnetoresistive performance and comparison of supermagnetic nanoparticles on giant magnetoresistive sensor-based detection system
EP2684036B1 (en) Systems and methods for high-throughput detection of an analyte in a sample
Dittmer et al. Sensitive and rapid immunoassay for parathyroid hormone using magnetic particle labels and magnetic actuation
CN104838266B (zh) 借助可磁化珠粒检测分析物并且确定分析物浓度
JP2009020097A (ja) 生化学的分析方法
Özkul et al. Unravelling the potential of magnetic nanoparticles: a comprehensive review of design and applications in analytical chemistry
EP3295163B1 (en) Devices and methods for increasing magnetic sensor sensitivity
Sun et al. Magnetic nanoparticles for magnetoresistance-based biodetection
TWI906302B (zh) 用於偵測樣本中之分析物之方法及裝置
Alcantara et al. Magnetic nanoparticles for application in biomedical sensing
TW202445131A (zh) 用於偵測分析物的方法
CN121175263A (en) Method for detecting analytes
Wu et al. Magnetic Nanoparticle-Based Biosensing
US20250020742A1 (en) Apparatus for detecting analytes
Wu Magneto-Nanosensor Platforms for Biosensing Applications
OMARY MUSTAFA Improving sensitivity biosensors by using micro/nano magnetic particles
Hawkins et al. 9 Magnetic Nanoparticles
Diez-Martin et al. Overcoming the detection limit of GMR sensors using disk-shaped nanostructures

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20240514

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20240514

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20250131

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250218

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20250515

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250818

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20250916

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20251015

R150 Certificate of patent or registration of utility model

Ref document number: 7760582

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150