JP7712955B2 - 癌の治療のための投薬レジメン - Google Patents

癌の治療のための投薬レジメン

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Publication number
JP7712955B2
JP7712955B2 JP2022564300A JP2022564300A JP7712955B2 JP 7712955 B2 JP7712955 B2 JP 7712955B2 JP 2022564300 A JP2022564300 A JP 2022564300A JP 2022564300 A JP2022564300 A JP 2022564300A JP 7712955 B2 JP7712955 B2 JP 7712955B2
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Prior art keywords
azd9833
cancer
dose
administered
treatment
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Japanese (ja)
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JP2023522415A (ja
JPWO2021214253A5 (https=
JP2023522415A5 (https=
Inventor
グティエレス,パブロ モレンティン
トッド ガングル,エリック
アウメイダ,カミラ ジ
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AstraZeneca AB
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AstraZeneca AB
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Publication of JP2023522415A publication Critical patent/JP2023522415A/ja
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Publication of JP2023522415A5 publication Critical patent/JP2023522415A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2022564300A 2020-04-24 2021-04-22 癌の治療のための投薬レジメン Active JP7712955B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063014914P 2020-04-24 2020-04-24
US63/014,914 2020-04-24
PCT/EP2021/060589 WO2021214253A1 (en) 2020-04-24 2021-04-22 Dosage regimen for the treatment of cancer

Publications (4)

Publication Number Publication Date
JP2023522415A JP2023522415A (ja) 2023-05-30
JPWO2021214253A5 JPWO2021214253A5 (https=) 2024-04-26
JP2023522415A5 JP2023522415A5 (https=) 2024-04-26
JP7712955B2 true JP7712955B2 (ja) 2025-07-24

Family

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Family Applications (1)

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JP2022564300A Active JP7712955B2 (ja) 2020-04-24 2021-04-22 癌の治療のための投薬レジメン

Country Status (11)

Country Link
US (3) US20210330653A1 (https=)
EP (1) EP4138834A1 (https=)
JP (1) JP7712955B2 (https=)
KR (1) KR20230005269A (https=)
CN (2) CN120267673A (https=)
AU (1) AU2021260829B2 (https=)
BR (1) BR112022021141A2 (https=)
CA (1) CA3179907A1 (https=)
IL (1) IL297216A (https=)
MX (1) MX2022013391A (https=)
WO (1) WO2021214253A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024083716A1 (en) * 2022-10-17 2024-04-25 Astrazeneca Ab Combinations of a serd for the treatment of cancer
KR102898494B1 (ko) * 2023-10-04 2025-12-09 삼성전자주식회사 양자점 조성물, 그 제조방법, 그의 경화물, 및 이를 포함하는 표시장치
TW202543650A (zh) 2024-03-08 2025-11-16 美商海爾達醫療運營公司 異雙官能化合物及其在治療疾病中之用途

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JP2018514549A (ja) 2015-04-29 2018-06-07 ラジウス ファーマシューティカルズ,インコーポレイテッド 癌を治療するための方法
JP2019508428A (ja) 2016-03-15 2019-03-28 メリマック ファーマシューティカルズ インコーポレーティッド 抗erbb3抗体を含む組み合わせ療法を用いて、er+、her2−、hrg+乳癌を治療するための方法
JP2019537570A (ja) 2016-10-24 2019-12-26 アストラゼネカ・アクチエボラーグAstrazeneca Aktiebolag 癌の治療において有用な6,7,8,9−テトラヒドロ−3H−ピラゾロ[4,3−f]イソキノリン誘導体

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JP2015522069A (ja) 2012-07-13 2015-08-03 ジーティーエックス・インコーポレイテッド 選択的アンドロゲン受容体モジュレーター(sarm)によりアンドロゲン受容体(ar)陽性乳癌を処置する方法
JP2018514549A (ja) 2015-04-29 2018-06-07 ラジウス ファーマシューティカルズ,インコーポレイテッド 癌を治療するための方法
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JP2019508428A (ja) 2016-03-15 2019-03-28 メリマック ファーマシューティカルズ インコーポレーティッド 抗erbb3抗体を含む組み合わせ療法を用いて、er+、her2−、hrg+乳癌を治療するための方法
JP2019537570A (ja) 2016-10-24 2019-12-26 アストラゼネカ・アクチエボラーグAstrazeneca Aktiebolag 癌の治療において有用な6,7,8,9−テトラヒドロ−3H−ピラゾロ[4,3−f]イソキノリン誘導体

Also Published As

Publication number Publication date
BR112022021141A2 (pt) 2022-12-06
EP4138834A1 (en) 2023-03-01
WO2021214253A1 (en) 2021-10-28
JP2023522415A (ja) 2023-05-30
US20250352531A1 (en) 2025-11-20
TW202206073A (zh) 2022-02-16
US20230248709A1 (en) 2023-08-10
IL297216A (en) 2022-12-01
CA3179907A1 (en) 2021-10-28
AU2021260829B2 (en) 2024-01-11
MX2022013391A (es) 2022-11-30
AU2021260829A1 (en) 2022-12-15
US20210330653A1 (en) 2021-10-28
US12364689B2 (en) 2025-07-22
CN120267673A (zh) 2025-07-08
KR20230005269A (ko) 2023-01-09
CN115443135A (zh) 2022-12-06

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