JP7702110B2 - ヒト膵癌オルガノイドを用いたマウスモデルの樹立 - Google Patents

ヒト膵癌オルガノイドを用いたマウスモデルの樹立 Download PDF

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JP7702110B2
JP7702110B2 JP2022518164A JP2022518164A JP7702110B2 JP 7702110 B2 JP7702110 B2 JP 7702110B2 JP 2022518164 A JP2022518164 A JP 2022518164A JP 2022518164 A JP2022518164 A JP 2022518164A JP 7702110 B2 JP7702110 B2 JP 7702110B2
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pancreatic cancer
human pancreatic
mouse model
cells
human
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JPWO2021221179A1 (https=
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恵介 谷内
英樹 谷口
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Kochi University NUC
Yokohama City University
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Kochi University NUC
Yokohama City University
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Ecology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Urology & Nephrology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2022518164A 2020-04-28 2021-04-27 ヒト膵癌オルガノイドを用いたマウスモデルの樹立 Active JP7702110B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020078771 2020-04-28
JP2020078771 2020-04-28
PCT/JP2021/017608 WO2021221179A1 (ja) 2020-04-28 2021-04-27 ヒト膵癌オルガノイドを用いたマウスモデルの樹立

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JPWO2021221179A1 JPWO2021221179A1 (https=) 2021-11-04
JP7702110B2 true JP7702110B2 (ja) 2025-07-03

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Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024034559A1 (ja) * 2022-08-08 2024-02-15 株式会社ヘリオス 細胞凝集塊の製造方法
WO2026009994A1 (ja) * 2024-07-04 2026-01-08 国立大学法人 東京大学 癌オルガノイド及びその製造方法

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009088022A1 (ja) 2008-01-07 2009-07-16 Kagoshima University 新規癌マーカーおよびそれを用いた診断
JP2012526148A (ja) 2009-05-07 2012-10-25 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ トリプトリド製品
WO2013172105A1 (ja) 2012-05-18 2013-11-21 日東紡績株式会社 膵臓癌を検出するためのマーカー
WO2016002844A1 (ja) 2014-07-04 2016-01-07 国立大学法人高知大学 膵がん細胞浸潤転移阻害剤
JP2019516384A (ja) 2016-05-25 2019-06-20 ソーク インスティチュート フォー バイオロジカル スタディーズ オルガノイド作製および疾患モデル化のための組成物および方法
WO2019203255A1 (ja) 2018-04-19 2019-10-24 公立大学法人横浜市立大学 再構成癌組織を用いた薬剤評価方法
WO2019203254A1 (ja) 2018-04-19 2019-10-24 公立大学法人横浜市立大学 上皮間葉転換関連分子を用いた癌評価法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009088022A1 (ja) 2008-01-07 2009-07-16 Kagoshima University 新規癌マーカーおよびそれを用いた診断
JP2012526148A (ja) 2009-05-07 2012-10-25 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ トリプトリド製品
WO2013172105A1 (ja) 2012-05-18 2013-11-21 日東紡績株式会社 膵臓癌を検出するためのマーカー
WO2016002844A1 (ja) 2014-07-04 2016-01-07 国立大学法人高知大学 膵がん細胞浸潤転移阻害剤
JP2019516384A (ja) 2016-05-25 2019-06-20 ソーク インスティチュート フォー バイオロジカル スタディーズ オルガノイド作製および疾患モデル化のための組成物および方法
WO2019203255A1 (ja) 2018-04-19 2019-10-24 公立大学法人横浜市立大学 再構成癌組織を用いた薬剤評価方法
WO2019203254A1 (ja) 2018-04-19 2019-10-24 公立大学法人横浜市立大学 上皮間葉転換関連分子を用いた癌評価法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHUGH Rohit et al.，A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer，Sci Transl Med.，2012年10月17日，Vol. 4, No. 156，156ra139
IWAMURA T. et al.，Correlation between CA19-9 production in vitro and histological grades of differentiation in vivo in，Journal of Gastroenterology and Hepatology，1992年，Vol. 7，p. 512-519

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